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The map label for this gene is hutC [H]

Identifier: 162148257

GI number: 162148257

Start: 2565505

End: 2566218

Strand: Direct

Name: hutC [H]

Synonym: GDI_2474

Alternate gene names: 162148257

Gene position: 2565505-2566218 (Clockwise)

Preceding gene: 162148233

Following gene: 162148258

Centisome position: 65.05

GC content: 69.33

Gene sequence:

>714_bases
ATGCCCGACAGCATCCCGCCCACCCGGTACGGCCAGGTCAAGCACTATGTCCTGGACCGTGTCCGAAGCGGCGAATGGCC
CGCCGGGCACCGGTTGCCGTCCGAAAGCGCGCTGGTCGCGACGCTGGGCGTATCGCGCATGACGGTGCATCGGGCCCTGC
GCGAACTGACGGCCGAGGGCGTGGTGAACCGTGCCCAGGGGGTGGGCACGTTCGTATCGCCCCCCGCGATCGACGCGGAA
TTCCTGGAACTGCGCGACATCGCCGACGACATCGCGGCCGGCGGACAGGCCCATCACGCGCGCGTCGTGGCGCTGGAGAC
CGTACGCGCGGACATGGACCTAGCCATCGCGTTCGGCCAGCGGCCAGGGGCGCGGCTGTTCCACTCGGTCATCGTCCATG
ACGAGGGCGGTATCCCGCTGCAGGTCGAAGACCGCTTCGTGTCGCCGCATTTCGCGCCCGCCTATCTGGCGCAGGATTTC
TCGCTGGCCCATCCGCACCGGTATCTGTCGCTGATCGCCCGGCCCGAGAACGTCGAGCACGTGGTCTTCGCCATCACGCC
CGACGCGCGGCTGCGCGGGCTGCTGGACCTCGACACGCCGGAAGCCTGTCTGCAACTGGTCCGCCGCACCTGGGTGGAGG
GCCGCGTCGTCATGAAGGGCATCTTCACCTATCCGGGCAGCCGCTATAGCCTGAGCGGCCGTTCGGGGCGGTGA

Upstream 100 bases:

>100_bases
AAGCCGGCCCGCCAGGGTGCCGGAGTAGGCTCCCGTTCGGGTTTGGTTGTATAGACACCCATCGACATCCGGCAACCGCC
CCACGGAGTCCCCCCCCTCG

Downstream 100 bases:

>100_bases
CGGCCGCCCCGGCGACGACCGATCAGGACACACGCGCCGGCATGATTCGCAGAACGCTCCCCTTCCTCGCCATTCCCCTG
GCCACGACCCTGCTGGCCGC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MPDSIPPTRYGQVKHYVLDRVRSGEWPAGHRLPSESALVATLGVSRMTVHRALRELTAEGVVNRAQGVGTFVSPPAIDAE
FLELRDIADDIAAGGQAHHARVVALETVRADMDLAIAFGQRPGARLFHSVIVHDEGGIPLQVEDRFVSPHFAPAYLAQDF
SLAHPHRYLSLIARPENVEHVVFAITPDARLRGLLDLDTPEACLQLVRRTWVEGRVVMKGIFTYPGSRYSLSGRSGR

Sequences:

>Translated_237_residues
MPDSIPPTRYGQVKHYVLDRVRSGEWPAGHRLPSESALVATLGVSRMTVHRALRELTAEGVVNRAQGVGTFVSPPAIDAE
FLELRDIADDIAAGGQAHHARVVALETVRADMDLAIAFGQRPGARLFHSVIVHDEGGIPLQVEDRFVSPHFAPAYLAQDF
SLAHPHRYLSLIARPENVEHVVFAITPDARLRGLLDLDTPEACLQLVRRTWVEGRVVMKGIFTYPGSRYSLSGRSGR
>Mature_236_residues
PDSIPPTRYGQVKHYVLDRVRSGEWPAGHRLPSESALVATLGVSRMTVHRALRELTAEGVVNRAQGVGTFVSPPAIDAEF
LELRDIADDIAAGGQAHHARVVALETVRADMDLAIAFGQRPGARLFHSVIVHDEGGIPLQVEDRFVSPHFAPAYLAQDFS
LAHPHRYLSLIARPENVEHVVFAITPDARLRGLLDLDTPEACLQLVRRTWVEGRVVMKGIFTYPGSRYSLSGRSGR

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=210, Percent_Identity=25.2380952380952, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87082252, Length=101, Percent_Identity=33.6633663366337, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 26080; Mature: 25949

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSIPPTRYGQVKHYVLDRVRSGEWPAGHRLPSESALVATLGVSRMTVHRALRELTAEG
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHCHHHHHHHHHHHHHHHHH
VVNRAQGVGTFVSPPAIDAEFLELRDIADDIAAGGQAHHARVVALETVRADMDLAIAFGQ
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEHHCCCEEEEEECC
RPGARLFHSVIVHDEGGIPLQVEDRFVSPHFAPAYLAQDFSLAHPHRYLSLIARPENVEH
CCHHHHHHHHEEECCCCCEEEECCCCCCCCCCHHHHHCCCCCCCHHHHHHHHCCCCCCCE
VVFAITPDARLRGLLDLDTPEACLQLVRRTWVEGRVVMKGIFTYPGSRYSLSGRSGR
EEEEECCCHHHCEEECCCCHHHHHHHHHHHHHCCEEEEEEHCCCCCCEEECCCCCCC
>Mature Secondary Structure 
PDSIPPTRYGQVKHYVLDRVRSGEWPAGHRLPSESALVATLGVSRMTVHRALRELTAEG
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHCHHHHHHHHHHHHHHHHH
VVNRAQGVGTFVSPPAIDAEFLELRDIADDIAAGGQAHHARVVALETVRADMDLAIAFGQ
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEHHCCCEEEEEECC
RPGARLFHSVIVHDEGGIPLQVEDRFVSPHFAPAYLAQDFSLAHPHRYLSLIARPENVEH
CCHHHHHHHHEEECCCCCEEEECCCCCCCCCCHHHHHCCCCCCCHHHHHHHHCCCCCCCE
VVFAITPDARLRGLLDLDTPEACLQLVRRTWVEGRVVMKGIFTYPGSRYSLSGRSGR
EEEEECCCHHHCEEECCCCHHHHHHHHHHHHHCCEEEEEEHCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]