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The map label for this gene is adh [H]

Identifier: 162148256

GI number: 162148256

Start: 2564277

End: 2565341

Strand: Reverse

Name: adh [H]

Synonym: GDI_2473

Alternate gene names: 162148256

Gene position: 2565341-2564277 (Counterclockwise)

Preceding gene: 162148260

Following gene: 162148255

Centisome position: 65.04

GC content: 65.73

Gene sequence:

>1065_bases
ATGCGATCTGCGGATACAATCCTTGGGGGAACGAGCATGACTGGAAAGATGAAGGCCGCTGTCGTTCGTGAGTTCGGCAA
GCCGCTGACGATCGAAGAGCTGGATATTCCCTCGATCCGGCCGGACCAGATCCTGGTCAAGATGGACGCGTGCGGCGTCT
GCCACACCGACCTGCACGCCGCCCGGGGGGACTGGCCCGTGAAGCCGAATCCGCCCTTCATCCCGGGGCACGAGGGCGTG
GGCCACGTCGTGTCCGTGGGCAGCGCGGTCAAATGGGTCAAGCTGGGCGATGTCGTCGGCGTGCCGTGGCTGTATTCGGC
CTGCGGCCATTGCGAGCACTGCCTGGGCGGGTGGGAAACGCTGTGCGCCAGCCAGGACGATACCGGCTACACCGTCAATG
GCTGCTTCGCCGAATATGTGGTGGCCGATCCCAGTTACGTCGCCCACCTGCCGAAGACGATCGACCCGCTGCAGGTGGCG
CCCGTGCTCTGTGCCGGCCTGACGGTCTACAAGGGCCTGAAGATGACCGACACCAAGCCGGGTGACTGGGTCGCGGTGTC
GGGTGTCGGCGGGCTGGGCCAGATGGCGGTGCAATACGGCGTCGCCATGGGGATGAACGTCATCGCCGTCGATATCGACG
ACGAAAAGCTGGCCACGGCAAAGGCCCTGGGCGCGGCGCTGACGGTGAACGCGCGCGCCACCGATCCCGCCCCCTTCATC
CAGTCGCAGGTCGGCGGCGCCCATGGCGCGCTGGTCACGGCCGTGTCGCGCAGCGCGTTCTCGCAGGCGATGGGCTTTGC
CCGCCGGGGCGGCACGATCGTGCTGAACGGGCTGCCGCCGGGGGAATTCCCGATTTCCATCTTCGACATGGTCATGGCCG
GGACCACGGTGCGCGGATCGATCGTCGGCACGCGGCTGGACATGATCGAGGCGGTGTCCTTCTTCGCCGACGGCAAGGTC
AAGACGGTGATCGAGCCCGACCGGCTGGAAAACATCAACCAGATCTTCACCGACCTGGAAGAAGGCAAGATCCAGGGACG
CAAGGTGCTGGATTTCCGCCAGTAA

Upstream 100 bases:

>100_bases
AACGGGAGCCTACTCCGGCACCCTGGCGGGCCGGCTTGATGCAGATCAGGTCGTGCCGGAAGGGAGCTGTGTAAGACTAC
GCCACAGAGACGATCCGCGG

Downstream 100 bases:

>100_bases
GCCGCGCCACGACCCCAGTCGTTCCGTCGAGGCCGGCATATCCGTGGCCGGGCACGGTGTGCAGGATGGCCTGACGGGGC
GCATATGGCCTACGATGCGG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MRSADTILGGTSMTGKMKAAVVREFGKPLTIEELDIPSIRPDQILVKMDACGVCHTDLHAARGDWPVKPNPPFIPGHEGV
GHVVSVGSAVKWVKLGDVVGVPWLYSACGHCEHCLGGWETLCASQDDTGYTVNGCFAEYVVADPSYVAHLPKTIDPLQVA
PVLCAGLTVYKGLKMTDTKPGDWVAVSGVGGLGQMAVQYGVAMGMNVIAVDIDDEKLATAKALGAALTVNARATDPAPFI
QSQVGGAHGALVTAVSRSAFSQAMGFARRGGTIVLNGLPPGEFPISIFDMVMAGTTVRGSIVGTRLDMIEAVSFFADGKV
KTVIEPDRLENINQIFTDLEEGKIQGRKVLDFRQ

Sequences:

>Translated_354_residues
MRSADTILGGTSMTGKMKAAVVREFGKPLTIEELDIPSIRPDQILVKMDACGVCHTDLHAARGDWPVKPNPPFIPGHEGV
GHVVSVGSAVKWVKLGDVVGVPWLYSACGHCEHCLGGWETLCASQDDTGYTVNGCFAEYVVADPSYVAHLPKTIDPLQVA
PVLCAGLTVYKGLKMTDTKPGDWVAVSGVGGLGQMAVQYGVAMGMNVIAVDIDDEKLATAKALGAALTVNARATDPAPFI
QSQVGGAHGALVTAVSRSAFSQAMGFARRGGTIVLNGLPPGEFPISIFDMVMAGTTVRGSIVGTRLDMIEAVSFFADGKV
KTVIEPDRLENINQIFTDLEEGKIQGRKVLDFRQ
>Mature_354_residues
MRSADTILGGTSMTGKMKAAVVREFGKPLTIEELDIPSIRPDQILVKMDACGVCHTDLHAARGDWPVKPNPPFIPGHEGV
GHVVSVGSAVKWVKLGDVVGVPWLYSACGHCEHCLGGWETLCASQDDTGYTVNGCFAEYVVADPSYVAHLPKTIDPLQVA
PVLCAGLTVYKGLKMTDTKPGDWVAVSGVGGLGQMAVQYGVAMGMNVIAVDIDDEKLATAKALGAALTVNARATDPAPFI
QSQVGGAHGALVTAVSRSAFSQAMGFARRGGTIVLNGLPPGEFPISIFDMVMAGTTVRGSIVGTRLDMIEAVSFFADGKV
KTVIEPDRLENINQIFTDLEEGKIQGRKVLDFRQ

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=374, Percent_Identity=31.0160427807487, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI34577061, Length=374, Percent_Identity=30.7486631016043, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI71743840, Length=375, Percent_Identity=29.0666666666667, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI262073058, Length=375, Percent_Identity=29.0666666666667, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4501929, Length=375, Percent_Identity=29.8666666666667, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI71565154, Length=241, Percent_Identity=36.0995850622407, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI71565152, Length=321, Percent_Identity=29.595015576324, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI156523966, Length=238, Percent_Identity=29.8319327731092, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI4501939, Length=238, Percent_Identity=29.8319327731092, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI156627571, Length=274, Percent_Identity=29.1970802919708, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI87081918, Length=341, Percent_Identity=43.9882697947214, Blast_Score=250, Evalue=9e-68,
Organism=Escherichia coli, GI1786518, Length=351, Percent_Identity=32.4786324786325, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI87082401, Length=340, Percent_Identity=30.5882352941176, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788073, Length=274, Percent_Identity=32.1167883211679, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790045, Length=289, Percent_Identity=29.4117647058824, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87082125, Length=338, Percent_Identity=28.1065088757396, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1788407, Length=229, Percent_Identity=34.061135371179, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI226510992, Length=297, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787863, Length=319, Percent_Identity=28.5266457680251, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786552, Length=243, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1788075, Length=328, Percent_Identity=26.219512195122, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790718, Length=323, Percent_Identity=25.6965944272446, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786825, Length=280, Percent_Identity=27.5, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=337, Percent_Identity=37.3887240356083, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17562584, Length=349, Percent_Identity=35.5300859598854, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17562582, Length=342, Percent_Identity=38.0116959064327, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17562876, Length=300, Percent_Identity=30.6666666666667, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17562878, Length=217, Percent_Identity=34.1013824884793, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17507255, Length=336, Percent_Identity=26.7857142857143, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=379, Percent_Identity=27.4406332453826, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=381, Percent_Identity=27.2965879265092, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=340, Percent_Identity=40.5882352941176, Blast_Score=259, Evalue=5e-70,
Organism=Saccharomyces cerevisiae, GI6323729, Length=338, Percent_Identity=40.5325443786982, Blast_Score=256, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6323961, Length=344, Percent_Identity=39.8255813953488, Blast_Score=252, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6324486, Length=344, Percent_Identity=39.2441860465116, Blast_Score=246, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6319949, Length=320, Percent_Identity=30.625, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320033, Length=369, Percent_Identity=31.9783197831978, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323980, Length=320, Percent_Identity=26.875, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=328, Percent_Identity=29.2682926829268, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=328, Percent_Identity=29.2682926829268, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=363, Percent_Identity=24.7933884297521, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319257, Length=344, Percent_Identity=25.2906976744186, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17737895, Length=253, Percent_Identity=30.8300395256917, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17137530, Length=315, Percent_Identity=26.3492063492064, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17737897, Length=222, Percent_Identity=30.6306306306306, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37395; Mature: 37395

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSADTILGGTSMTGKMKAAVVREFGKPLTIEELDIPSIRPDQILVKMDACGVCHTDLHA
CCCCCCEECCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCCCCHHHH
ARGDWPVKPNPPFIPGHEGVGHVVSVGSAVKWVKLGDVVGVPWLYSACGHCEHCLGGWET
CCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHH
LCASQDDTGYTVNGCFAEYVVADPSYVAHLPKTIDPLQVAPVLCAGLTVYKGLKMTDTKP
HHCCCCCCCEEEECEEEEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEECCCCC
GDWVAVSGVGGLGQMAVQYGVAMGMNVIAVDIDDEKLATAKALGAALTVNARATDPAPFI
CCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCEEEEEECCCCCCHHHH
QSQVGGAHGALVTAVSRSAFSQAMGFARRGGTIVLNGLPPGEFPISIFDMVMAGTTVRGS
HHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCCEECC
IVGTRLDMIEAVSFFADGKVKTVIEPDRLENINQIFTDLEEGKIQGRKVLDFRQ
HHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCEECCCCC
>Mature Secondary Structure
MRSADTILGGTSMTGKMKAAVVREFGKPLTIEELDIPSIRPDQILVKMDACGVCHTDLHA
CCCCCCEECCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCCCCHHHH
ARGDWPVKPNPPFIPGHEGVGHVVSVGSAVKWVKLGDVVGVPWLYSACGHCEHCLGGWET
CCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHH
LCASQDDTGYTVNGCFAEYVVADPSYVAHLPKTIDPLQVAPVLCAGLTVYKGLKMTDTKP
HHCCCCCCCEEEECEEEEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEECCCCC
GDWVAVSGVGGLGQMAVQYGVAMGMNVIAVDIDDEKLATAKALGAALTVNARATDPAPFI
CCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCEEEEEECCCCCCHHHH
QSQVGGAHGALVTAVSRSAFSQAMGFARRGGTIVLNGLPPGEFPISIFDMVMAGTTVRGS
HHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCCEECC
IVGTRLDMIEAVSFFADGKVKTVIEPDRLENINQIFTDLEEGKIQGRKVLDFRQ
HHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9659380; 11481432 [H]