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The map label for this gene is aceA [H]

Identifier: 162148232

GI number: 162148232

Start: 2539124

End: 2540464

Strand: Direct

Name: aceA [H]

Synonym: GDI_2449

Alternate gene names: 162148232

Gene position: 2539124-2540464 (Clockwise)

Preceding gene: 162148231

Following gene: 162148233

Centisome position: 64.38

GC content: 66.96

Gene sequence:

>1341_bases
ATGGAACAGACGATCGAAAAGGGAGATCCGTCAATGTCCATCGACACCATTGCCGCCTTCATGGCCGACCCCGAGCGCTT
CGCGGGCATCAAGCGCGATTATGACGCGCGCGACGTGGCGACGCTCTCCGGCTCGTTCCGCATCCGCCACACCCTGGCTG
AAATGGGTGCCGCGCGCCTGTGGCACCTGCTGAAGACCGAACCCTACATCAACGCGCTGGGCGCGCTGACGGGCAACCAG
GCGATGCAGCAGGTCAAGGCGGGGCTGAAGGCCATCTACCTGTCCGGCTGGCAGGTCGCGGCCGACGCCAACGTGGCGGG
CGAGATGTATCCCGACCAGTCGCTGTACCCCGTGAATTCGGTGCCCACCGTGGTGCGGCGCATCAACAACGCCCTGCGCC
GCTGTGACGAGATCGCGACGCAGGAGGGCGATCGCGGCCAGTACTGGATGGCCCCCATCGTCGCGGATGCCGAGGCCGGG
TTCGGCGGCCCGCTGAACGTCTTCGAGCTGATGCGCGCCCTGATCGCGGCCGGCGCGGCGGGCGTGCATTTCGAGGACCA
GTTGGCCTCGGAAAAGAAATGCGGCCATCTGGGCGGCAAGGTGCTGATCCCGATCGCGCAGCATATCCGCTCGCTGAACG
CGGCGCGGCTGGCGGCGGATGTCGAGGGGGTGCCCACGGTCCTGATCTGCCGCACCGACAGCCACGCGGCGCAGCTCCTG
ACCTCGGACATCGACGAGCGCGACCATCCGTTCCTGACCGGCGAGCGCACGCGGGAAGGCTTCTTCCGCATCCGCGAGGG
GCTGGGCGTCGAATACGCCATCGCCCGTTCGCTGGCCTATGCGCCCTATTGCGACCTGCTGTGGTGGGAGACGTCCGAGC
CGAACCTGGAGGAAGCCCGGCAGTTCGCCGAGGCCATCCACAAGCAGTTCCCCGGCAAGATGCTGGCCTATAACTGCTCG
CCGTCCTTCAACTGGAAGAAGAAGCTGTCGGCGCGCGACATCGCGGACTTCCAGCGCCGGATCGGGGCGATGGGCTACAA
GTTCCAGTTCGTCACCCTGGCGGGCTTCCACAGCCTGAACTATTCGATGTTCAAGCTGGCGCATGGCTACGCGGAACGCG
GCATGGCCGCCTATTCCGAGTTGCAGGAAGCCGAGTTCAGCGCCGAGGTCGACGGCTACACCGCCACCCGCCACCAGCGC
GAGGTCGGGACCGGCTGGTTCGACGCGGTCGCGACCGTGGCCGGCGGCGGCCATACCTCGACCGCCGCGATGGCCGGTTC
GACCGAGACCGAGCAGTTCCATGCCGACCTGTCCTTCGACCGGAACAAGACGCCGGTCTGA

Upstream 100 bases:

>100_bases
CTTTTTACAAATATTCAAAACAGTATGTAAATAATTTTACACCATTCATGATACGCTATCCTGTTTTACATGGCATATCA
TTATCCCTTCTCATTAAATG

Downstream 100 bases:

>100_bases
TGAACCGGCGGCCGGGGGCGGCCGGGCCGCGTGCCCGGCCGCCGAACCCGACCGCAGACCCGACCACAGACCAGACACCG
GAAGACAGACCCGAAAAAGG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MEQTIEKGDPSMSIDTIAAFMADPERFAGIKRDYDARDVATLSGSFRIRHTLAEMGAARLWHLLKTEPYINALGALTGNQ
AMQQVKAGLKAIYLSGWQVAADANVAGEMYPDQSLYPVNSVPTVVRRINNALRRCDEIATQEGDRGQYWMAPIVADAEAG
FGGPLNVFELMRALIAAGAAGVHFEDQLASEKKCGHLGGKVLIPIAQHIRSLNAARLAADVEGVPTVLICRTDSHAAQLL
TSDIDERDHPFLTGERTREGFFRIREGLGVEYAIARSLAYAPYCDLLWWETSEPNLEEARQFAEAIHKQFPGKMLAYNCS
PSFNWKKKLSARDIADFQRRIGAMGYKFQFVTLAGFHSLNYSMFKLAHGYAERGMAAYSELQEAEFSAEVDGYTATRHQR
EVGTGWFDAVATVAGGGHTSTAAMAGSTETEQFHADLSFDRNKTPV

Sequences:

>Translated_446_residues
MEQTIEKGDPSMSIDTIAAFMADPERFAGIKRDYDARDVATLSGSFRIRHTLAEMGAARLWHLLKTEPYINALGALTGNQ
AMQQVKAGLKAIYLSGWQVAADANVAGEMYPDQSLYPVNSVPTVVRRINNALRRCDEIATQEGDRGQYWMAPIVADAEAG
FGGPLNVFELMRALIAAGAAGVHFEDQLASEKKCGHLGGKVLIPIAQHIRSLNAARLAADVEGVPTVLICRTDSHAAQLL
TSDIDERDHPFLTGERTREGFFRIREGLGVEYAIARSLAYAPYCDLLWWETSEPNLEEARQFAEAIHKQFPGKMLAYNCS
PSFNWKKKLSARDIADFQRRIGAMGYKFQFVTLAGFHSLNYSMFKLAHGYAERGMAAYSELQEAEFSAEVDGYTATRHQR
EVGTGWFDAVATVAGGGHTSTAAMAGSTETEQFHADLSFDRNKTPV
>Mature_446_residues
MEQTIEKGDPSMSIDTIAAFMADPERFAGIKRDYDARDVATLSGSFRIRHTLAEMGAARLWHLLKTEPYINALGALTGNQ
AMQQVKAGLKAIYLSGWQVAADANVAGEMYPDQSLYPVNSVPTVVRRINNALRRCDEIATQEGDRGQYWMAPIVADAEAG
FGGPLNVFELMRALIAAGAAGVHFEDQLASEKKCGHLGGKVLIPIAQHIRSLNAARLAADVEGVPTVLICRTDSHAAQLL
TSDIDERDHPFLTGERTREGFFRIREGLGVEYAIARSLAYAPYCDLLWWETSEPNLEEARQFAEAIHKQFPGKMLAYNCS
PSFNWKKKLSARDIADFQRRIGAMGYKFQFVTLAGFHSLNYSMFKLAHGYAERGMAAYSELQEAEFSAEVDGYTATRHQR
EVGTGWFDAVATVAGGGHTSTAAMAGSTETEQFHADLSFDRNKTPV

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=418, Percent_Identity=61.4832535885168, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI1786525, Length=271, Percent_Identity=26.9372693726937, Blast_Score=83, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71982926, Length=414, Percent_Identity=63.768115942029, Blast_Score=557, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17561814, Length=414, Percent_Identity=63.768115942029, Blast_Score=556, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6320908, Length=245, Percent_Identity=35.5102040816327, Blast_Score=156, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6325263, Length=241, Percent_Identity=35.6846473029046, Blast_Score=142, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 49089; Mature: 49089

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTIEKGDPSMSIDTIAAFMADPERFAGIKRDYDARDVATLSGSFRIRHTLAEMGAARL
CCCCCCCCCCCCCHHHHHHHHCCHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHH
WHLLKTEPYINALGALTGNQAMQQVKAGLKAIYLSGWQVAADANVAGEMYPDQSLYPVNS
HHHHHCCHHHHHHHHHCCHHHHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCCCCCH
VPTVVRRINNALRRCDEIATQEGDRGQYWMAPIVADAEAGFGGPLNVFELMRALIAAGAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCC
GVHFEDQLASEKKCGHLGGKVLIPIAQHIRSLNAARLAADVEGVPTVLICRTDSHAAQLL
CCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
TSDIDERDHPFLTGERTREGFFRIREGLGVEYAIARSLAYAPYCDLLWWETSEPNLEEAR
HHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCHHHHH
QFAEAIHKQFPGKMLAYNCSPSFNWKKKLSARDIADFQRRIGAMGYKFQFVTLAGFHSLN
HHHHHHHHHCCCCEEEEECCCCCCHHHHCCHHHHHHHHHHHCCCCEEEEEEEEECHHHCC
YSMFKLAHGYAERGMAAYSELQEAEFSAEVDGYTATRHQREVGTGWFDAVATVAGGGHTS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCC
TAAMAGSTETEQFHADLSFDRNKTPV
HHEECCCCCHHHHEECCCCCCCCCCC
>Mature Secondary Structure
MEQTIEKGDPSMSIDTIAAFMADPERFAGIKRDYDARDVATLSGSFRIRHTLAEMGAARL
CCCCCCCCCCCCCHHHHHHHHCCHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHH
WHLLKTEPYINALGALTGNQAMQQVKAGLKAIYLSGWQVAADANVAGEMYPDQSLYPVNS
HHHHHCCHHHHHHHHHCCHHHHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCCCCCH
VPTVVRRINNALRRCDEIATQEGDRGQYWMAPIVADAEAGFGGPLNVFELMRALIAAGAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCC
GVHFEDQLASEKKCGHLGGKVLIPIAQHIRSLNAARLAADVEGVPTVLICRTDSHAAQLL
CCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
TSDIDERDHPFLTGERTREGFFRIREGLGVEYAIARSLAYAPYCDLLWWETSEPNLEEAR
HHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCHHHHH
QFAEAIHKQFPGKMLAYNCSPSFNWKKKLSARDIADFQRRIGAMGYKFQFVTLAGFHSLN
HHHHHHHHHCCCCEEEEECCCCCCHHHHCCHHHHHHHHHHHCCCCEEEEEEEEECHHHCC
YSMFKLAHGYAERGMAAYSELQEAEFSAEVDGYTATRHQREVGTGWFDAVATVAGGGHTS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCC
TAAMAGSTETEQFHADLSFDRNKTPV
HHEECCCCCHHHHEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]