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The map label for this gene is gloA [H]

Identifier: 162148090

GI number: 162148090

Start: 2370402

End: 2370803

Strand: Reverse

Name: gloA [H]

Synonym: GDI_2307

Alternate gene names: 162148090

Gene position: 2370803-2370402 (Counterclockwise)

Preceding gene: 162148094

Following gene: 162148089

Centisome position: 60.11

GC content: 64.68

Gene sequence:

>402_bases
ATGGCGAAGCTGATCCATTCCATGATCCGCGTGCGCGACGAAGCCGCGTCGCTGGCATTCTACGAACGCGCCTTCGGCCT
GCGCGTGGCCGACCGGCTGGTCTTCGATGGTTTCACCCTGATCTACCTGTCCAATGCCGAACAGACATTCGAACTGGAAC
TGACGGTCAACCACGACCGCGACCGCCCCTATGACCTGGGGGACGGCTACGGCCACCTGGCGGTGTCGGTCGCGGATATC
GACGCCGAACATGACCGCTTCACGCGGGAAGGTCTGTCGCCGCTGGCGGTCAAGCAATTGTCGCTGGGCGAGCGGGTCGT
GGGGCGCTTCTTCTTCGTCGCCGACCCGGACGGCTATCGGATCGAAGTGCTGCAACGCGGCGCCCCGGGCCGGTTTCTCT
GA

Upstream 100 bases:

>100_bases
ATGCCCCGCACATGCGACAGGTCGGGCGGAAAATCCAGACCCACAATGCCGGCCGGGCCGCTATACATCCGCCACCCTGT
CGATAAAGGAGTCCGAAACG

Downstream 100 bases:

>100_bases
CGGCTGCAAGCTTGTCTCGCACTCCGCCGATGCGTGCCGTATAAGGCGCGCATGATGACCCCGTTCCACAAGATGCACGG
CCTGGGCAACGATTTCGTCG

Product: lactoylglutathione lyase

Products: NA

Alternate protein names: Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase [H]

Number of amino acids: Translated: 133; Mature: 132

Protein sequence:

>133_residues
MAKLIHSMIRVRDEAASLAFYERAFGLRVADRLVFDGFTLIYLSNAEQTFELELTVNHDRDRPYDLGDGYGHLAVSVADI
DAEHDRFTREGLSPLAVKQLSLGERVVGRFFFVADPDGYRIEVLQRGAPGRFL

Sequences:

>Translated_133_residues
MAKLIHSMIRVRDEAASLAFYERAFGLRVADRLVFDGFTLIYLSNAEQTFELELTVNHDRDRPYDLGDGYGHLAVSVADI
DAEHDRFTREGLSPLAVKQLSLGERVVGRFFFVADPDGYRIEVLQRGAPGRFL
>Mature_132_residues
AKLIHSMIRVRDEAASLAFYERAFGLRVADRLVFDGFTLIYLSNAEQTFELELTVNHDRDRPYDLGDGYGHLAVSVADID
AEHDRFTREGLSPLAVKQLSLGERVVGRFFFVADPDGYRIEVLQRGAPGRFL

Specific function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

Organism=Escherichia coli, GI1787940, Length=136, Percent_Identity=32.3529411764706, Blast_Score=62, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR004361
- InterPro:   IPR018146 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =4.4.1.5 [H]

Molecular weight: Translated: 15049; Mature: 14918

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLIHSMIRVRDEAASLAFYERAFGLRVADRLVFDGFTLIYLSNAEQTFELELTVNHDR
CHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCEEEEEEECCCEEEEEEEEEECCC
DRPYDLGDGYGHLAVSVADIDAEHDRFTREGLSPLAVKQLSLGERVVGRFFFVADPDGYR
CCCCCCCCCCCEEEEEEEECCCCHHHHHHCCCCHHHHHHHHHCHHEEEEEEEEECCCCCE
IEVLQRGAPGRFL
EEEEECCCCCCCC
>Mature Secondary Structure 
AKLIHSMIRVRDEAASLAFYERAFGLRVADRLVFDGFTLIYLSNAEQTFELELTVNHDR
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCEEEEEEECCCEEEEEEEEEECCC
DRPYDLGDGYGHLAVSVADIDAEHDRFTREGLSPLAVKQLSLGERVVGRFFFVADPDGYR
CCCCCCCCCCCEEEEEEEECCCCHHHHHHCCCCHHHHHHHHHCHHEEEEEEEEECCCCCE
IEVLQRGAPGRFL
EEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]