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The map label for this gene is ggt [H]

Identifier: 162148080

GI number: 162148080

Start: 2358425

End: 2359930

Strand: Reverse

Name: ggt [H]

Synonym: GDI_2297

Alternate gene names: 162148080

Gene position: 2359930-2358425 (Counterclockwise)

Preceding gene: 162148082

Following gene: 162148079

Centisome position: 59.83

GC content: 73.84

Gene sequence:

>1506_bases
GTGGTTATGGAGAATTTGTGCGTGCGTGAACGTCCCCTGTATCCCCCGTTTCGTCGATATGGGGCCCGGTTGCTGTCGAC
CGCCCTGGCGGTCGCACTGGGCGGGTGCTCCTCCACACCGGTCAGAATGGTCAGCCACGAACTGTTCGGTTTCGGCGGCG
CGGGCGCCGGCAAGACGTCGCCTTACCTGACCGGCTATATCGGCAACGTGGTCGCGGACGAACCGCAGGCGGCCATGGCG
GCGCGCGATGTTCTGGCACGGGGCGGCAATGCCGGCGATGCGGCGACGGCCCTGGGGCTGGCGCTGGCGGTGACGCTGCC
CTCGCGCGCGTCGCTTGGCGGCGGCGGGGCCTGCCTGGCCTGGCGGCCCGGCGACAGCGACGGCGGCCGGGCGTTCGTGT
TCATGCCGGCTGCCGGCGCGACGACGCCGGAGGGCGGCGCGCCGGTGGACCGGCCGGCGGCGGTGCCGATGCTGGCGCGC
GGGCTGTACCTGATGCACCTGCGCTATGGCAGCGTCGATTTCAACGAAACGATCACGCCGGCGCTGCAACTGGCGCGCGG
CGGGGCCACGGTCAGCCGCGCGCTGGCCGGCGACCTGGCCGCCGTGCAGCAGCCCCTGCTGGCCGATGCGGGCGCGCGTG
CGTTGTTCAGCCGCAACGATGGCACGGTGCTGGCCGAAGGCGACAGCCTGGTCCAGTCCCGGCTGGCCGGCGTGCTGGAG
CAGATGCGTGCCATGGGTGTGGGCGATCTGTACAACGGGGCGCTGGCGGCGTCGTTCGTCGCCGGCAGCCAGGGTGCGGG
GGGCGGCCTGATGGCGGCCGACCTGCGCGGTGCGCTTCCGTCCGAGACGATGCCGCTGACGGTGCGCGTGGACCGCATGA
CCGTGTCCTTCCTGCCCCCGCCGGCCGATGGCGGACTGGGCAGCGCCATGGCGTTCCGCGCCCTGTCCGACGGCGGGCAG
GGCGGGACCGTGGGGCAGCAGGCGGTGGCGGCATGGCGCGCGCGCGCGACCGGAACCCGGAAGGCCGGGGACCTGGTGGC
GCAGGCGCAGGCGATGGTCGATTCCGGCACCGTGTCGGGCGGCGGAATGCTGCCGCATCTGCCGGCCTCGACATCCTTCG
CGGTGGTCGACCGGCATGGCGGGGCCGTGGCGTGCAGCCTGACGATGGACAATCTGTTCGGCACCGGCCGCGTGGCCGGC
AGCACCGGCATCGTGATGGCGGCGTCGCCGCAGCGGCTGCCGCCCCCGCTGCTGACCGCCGCGATCGCAAGCCAGGGCGA
AACCTTCCGCGCGGTGGCGACGGGATCGGGGCAGAACGACGCCGCCGACGCCGTGGCGACGGAACTGCGGCAGGTTCTGG
CGGGACAGAAGCCCGGCGAACGGCCGGTGACGGCCGAGGGACGGATCAATGCGATCTCCTGCCCGGCCGGCCTGCCGGGG
GGCGAGGGCAGTTGCGTCGGCGCGTCGGACGTGCGCGCGGCGGGGCTGGCGGTCGGGTCGGATTAA

Upstream 100 bases:

>100_bases
GATGTCGCGTGTTGCCGATGGCCCGGAAGACCGCTAATTCCCGAAGGCCCGGTGGTTCGCGTCGGGGTGGTCGTGTCTGT
GGTCGTGTCCGGGATCGACG

Downstream 100 bases:

>100_bases
ACCCCCGGCCGGCAAGGGGGTCGCTTGTGGGCGATCATGTTTTGTTCTAGTCTTGGCGAACAGGGATTCGCGTCATGCGG
CCCCGGTGCCGATCCTGGAG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MVMENLCVRERPLYPPFRRYGARLLSTALAVALGGCSSTPVRMVSHELFGFGGAGAGKTSPYLTGYIGNVVADEPQAAMA
ARDVLARGGNAGDAATALGLALAVTLPSRASLGGGGACLAWRPGDSDGGRAFVFMPAAGATTPEGGAPVDRPAAVPMLAR
GLYLMHLRYGSVDFNETITPALQLARGGATVSRALAGDLAAVQQPLLADAGARALFSRNDGTVLAEGDSLVQSRLAGVLE
QMRAMGVGDLYNGALAASFVAGSQGAGGGLMAADLRGALPSETMPLTVRVDRMTVSFLPPPADGGLGSAMAFRALSDGGQ
GGTVGQQAVAAWRARATGTRKAGDLVAQAQAMVDSGTVSGGGMLPHLPASTSFAVVDRHGGAVACSLTMDNLFGTGRVAG
STGIVMAASPQRLPPPLLTAAIASQGETFRAVATGSGQNDAADAVATELRQVLAGQKPGERPVTAEGRINAISCPAGLPG
GEGSCVGASDVRAAGLAVGSD

Sequences:

>Translated_501_residues
MVMENLCVRERPLYPPFRRYGARLLSTALAVALGGCSSTPVRMVSHELFGFGGAGAGKTSPYLTGYIGNVVADEPQAAMA
ARDVLARGGNAGDAATALGLALAVTLPSRASLGGGGACLAWRPGDSDGGRAFVFMPAAGATTPEGGAPVDRPAAVPMLAR
GLYLMHLRYGSVDFNETITPALQLARGGATVSRALAGDLAAVQQPLLADAGARALFSRNDGTVLAEGDSLVQSRLAGVLE
QMRAMGVGDLYNGALAASFVAGSQGAGGGLMAADLRGALPSETMPLTVRVDRMTVSFLPPPADGGLGSAMAFRALSDGGQ
GGTVGQQAVAAWRARATGTRKAGDLVAQAQAMVDSGTVSGGGMLPHLPASTSFAVVDRHGGAVACSLTMDNLFGTGRVAG
STGIVMAASPQRLPPPLLTAAIASQGETFRAVATGSGQNDAADAVATELRQVLAGQKPGERPVTAEGRINAISCPAGLPG
GEGSCVGASDVRAAGLAVGSD
>Mature_501_residues
MVMENLCVRERPLYPPFRRYGARLLSTALAVALGGCSSTPVRMVSHELFGFGGAGAGKTSPYLTGYIGNVVADEPQAAMA
ARDVLARGGNAGDAATALGLALAVTLPSRASLGGGGACLAWRPGDSDGGRAFVFMPAAGATTPEGGAPVDRPAAVPMLAR
GLYLMHLRYGSVDFNETITPALQLARGGATVSRALAGDLAAVQQPLLADAGARALFSRNDGTVLAEGDSLVQSRLAGVLE
QMRAMGVGDLYNGALAASFVAGSQGAGGGLMAADLRGALPSETMPLTVRVDRMTVSFLPPPADGGLGSAMAFRALSDGGQ
GGTVGQQAVAAWRARATGTRKAGDLVAQAQAMVDSGTVSGGGMLPHLPASTSFAVVDRHGGAVACSLTMDNLFGTGRVAG
STGIVMAASPQRLPPPLLTAAIASQGETFRAVATGSGQNDAADAVATELRQVLAGQKPGERPVTAEGRINAISCPAGLPG
GEGSCVGASDVRAAGLAVGSD

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=223, Percent_Identity=32.7354260089686, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI73915090, Length=223, Percent_Identity=32.7354260089686, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI73915096, Length=223, Percent_Identity=32.7354260089686, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI73915094, Length=223, Percent_Identity=32.7354260089686, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI113429326, Length=223, Percent_Identity=34.0807174887892, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI113429324, Length=223, Percent_Identity=32.7354260089686, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789856, Length=365, Percent_Identity=30.958904109589, Blast_Score=132, Evalue=7e-32,
Organism=Drosophila melanogaster, GI18859893, Length=389, Percent_Identity=25.9640102827763, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 49950; Mature: 49950

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMENLCVRERPLYPPFRRYGARLLSTALAVALGGCSSTPVRMVSHELFGFGGAGAGKTS
CCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCC
PYLTGYIGNVVADEPQAAMAARDVLARGGNAGDAATALGLALAVTLPSRASLGGGGACLA
CEEEEHHCCHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCCCCCCCCCEEEE
WRPGDSDGGRAFVFMPAAGATTPEGGAPVDRPAAVPMLARGLYLMHLRYGSVDFNETITP
ECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCEEEEEEEECCCCCCCHHHH
ALQLARGGATVSRALAGDLAAVQQPLLADAGARALFSRNDGTVLAEGDSLVQSRLAGVLE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCHHHHHHHHHHHHH
QMRAMGVGDLYNGALAASFVAGSQGAGGGLMAADLRGALPSETMPLTVRVDRMTVSFLPP
HHHHCCCCHHHCCHHHHHHHCCCCCCCCCEEHHHHCCCCCCCCCEEEEEEEEEEEEECCC
PADGGLGSAMAFRALSDGGQGGTVGQQAVAAWRARATGTRKAGDLVAQAQAMVDSGTVSG
CCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCC
GGMLPHLPASTSFAVVDRHGGAVACSLTMDNLFGTGRVAGSTGIVMAASPQRLPPPLLTA
CCCCCCCCCCCCEEEEECCCCEEEEEEEHHHCCCCCEECCCCCEEEECCCCCCCCHHHHH
AIASQGETFRAVATGSGQNDAADAVATELRQVLAGQKPGERPVTAEGRINAISCPAGLPG
HHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCC
GEGSCVGASDVRAAGLAVGSD
CCCCEECCCHHHHHCEECCCC
>Mature Secondary Structure
MVMENLCVRERPLYPPFRRYGARLLSTALAVALGGCSSTPVRMVSHELFGFGGAGAGKTS
CCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCC
PYLTGYIGNVVADEPQAAMAARDVLARGGNAGDAATALGLALAVTLPSRASLGGGGACLA
CEEEEHHCCHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCCCCCCCCCEEEE
WRPGDSDGGRAFVFMPAAGATTPEGGAPVDRPAAVPMLARGLYLMHLRYGSVDFNETITP
ECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCEEEEEEEECCCCCCCHHHH
ALQLARGGATVSRALAGDLAAVQQPLLADAGARALFSRNDGTVLAEGDSLVQSRLAGVLE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCHHHHHHHHHHHHH
QMRAMGVGDLYNGALAASFVAGSQGAGGGLMAADLRGALPSETMPLTVRVDRMTVSFLPP
HHHHCCCCHHHCCHHHHHHHCCCCCCCCCEEHHHHCCCCCCCCCEEEEEEEEEEEEECCC
PADGGLGSAMAFRALSDGGQGGTVGQQAVAAWRARATGTRKAGDLVAQAQAMVDSGTVSG
CCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCC
GGMLPHLPASTSFAVVDRHGGAVACSLTMDNLFGTGRVAGSTGIVMAASPQRLPPPLLTA
CCCCCCCCCCCCEEEEECCCCEEEEEEEHHHCCCCCEECCCCCEEEECCCCCCCCHHHHH
AIASQGETFRAVATGSGQNDAADAVATELRQVLAGQKPGERPVTAEGRINAISCPAGLPG
HHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCC
GEGSCVGASDVRAAGLAVGSD
CCCCEECCCHHHHHCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]