Click here to switch to the map view.

The map label for this gene is hemA [H]

Identifier: 162148082

GI number: 162148082

Start: 2360976

End: 2362211

Strand: Reverse

Name: hemA [H]

Synonym: GDI_2299

Alternate gene names: 162148082

Gene position: 2362211-2360976 (Counterclockwise)

Preceding gene: 162148083

Following gene: 162148080

Centisome position: 59.89

GC content: 69.01

Gene sequence:

>1236_bases
GTGGGTGGGCATCCTTTCTACCGTTTTTGCCGGTCGGCATTGCAGGATATTCGCCAGCAGGGTCGCTACCGCCAGTTCAC
CCCGCTGGCACGCCAGGCCGATCGGTACCCGGTCTACGAATACGGCGCCGTCCGCCCGCCCGAGGGGCGTGACGTGGTGG
TCTGGTCGGCGAACGACTATCTGGGCATGGGCGTCGAGCCCGCCGTGGCCGAGGCCGCGATCGCCGCGATCCGCGAACAC
GGGGCCGGGGCCGGGGGCACCCGCAACATCGCCGGTACCAGCCCCCTGCACGCGGCGCTGGAGGCCGAGCTGGCCGACCT
GCACGGCAAGGAAGCCGGGCTGCTGTTCGTGTCGGGCTATGTCTCGAACCAGGCCAGCCTGCAGACGATCCTGACCAGCA
TGCCGGGCTGGATCTGCTTTTCCGACCGGCAGAACCATGCCTCGATGATCGCCGGCATCAAGGGCGCGCGCGGTTCGTCC
TGCGTCATCTTCGAACATAACGACCTGGCCGACCTGGAGGCCAAGCTGGCGGCGGCCCCGCGCGACGTGCCCAAGCTGGT
CGCGTTCGAAAGCGTCTATTCGATGGATGGCGACATCGCCGATATCGGGGCGACCTGCGCCCTGGCGCGGAAATACGGCG
CCATGACCTATCTGGACGAAGTGCACGCCGTGGGGCTGTACGGTCCGCAGGGCGGCGGCGTGGCCGAGCGCGACGGCGTG
GCCGACCAGGTGGACATCATCGAGGGCACGCTGGCCAAGGGCTTCGGCGTCCATGGCGGCTATGTCACCGGGTCGGCCGA
ACTGATCGATTACCTGCGCTGCGCGGCGTCGGGTTTCATCTTCACCACATCGCTGCCGCCGTCGGTGGTGGCCGCGGCCC
TGGCCAGCGTGCGCATGGTGCGCAAGGATGCCTGGCGGCGCGAACGGATGTTCGAACGCGTGGCGGCCTTCCGCGCGCGG
CTGACCGCGGCGGGCGTGCCCTTCATGCCCACGCCCAGCCATATCGTGCCGATTCCGGTGGGCGATGCCGATCGCTGCAT
GGACATCAGCCGCCGCCTGCTGTCGGAATACGGGCTGTACGCGACGCCGATCAACTACCCCACCGTCCCGCGCGGCACCG
AGCGGCTGCGCCTGACCCCGGGCCCGTTCCACACCGACGAGATGATGGACGAAATGACCGCCGCGCTGGTCACGCTGCTG
GGGCTTTCCGACCAGCGCAAGGTCGAGGCGGCCTGA

Upstream 100 bases:

>100_bases
TCCGCACAGCGGACCCGGACGAACCGTAACGGCGAATGCCGCGCGGGCCAGTGCCCCGCAACCGGCATCGCGGGAGAATT
CCTCAGTGGCCAGTATCGAC

Downstream 100 bases:

>100_bases
AAAGGAAGCTGGGCGTAATGCCCTGCTTCCTTCATCTTTGACAGGTGCTCTGTTAGCCGCGTCGCACCTTGGCGATGGCG
GCCTTCAGTTCGTCCAGGTC

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MGGHPFYRFCRSALQDIRQQGRYRQFTPLARQADRYPVYEYGAVRPPEGRDVVVWSANDYLGMGVEPAVAEAAIAAIREH
GAGAGGTRNIAGTSPLHAALEAELADLHGKEAGLLFVSGYVSNQASLQTILTSMPGWICFSDRQNHASMIAGIKGARGSS
CVIFEHNDLADLEAKLAAAPRDVPKLVAFESVYSMDGDIADIGATCALARKYGAMTYLDEVHAVGLYGPQGGGVAERDGV
ADQVDIIEGTLAKGFGVHGGYVTGSAELIDYLRCAASGFIFTTSLPPSVVAAALASVRMVRKDAWRRERMFERVAAFRAR
LTAAGVPFMPTPSHIVPIPVGDADRCMDISRRLLSEYGLYATPINYPTVPRGTERLRLTPGPFHTDEMMDEMTAALVTLL
GLSDQRKVEAA

Sequences:

>Translated_411_residues
MGGHPFYRFCRSALQDIRQQGRYRQFTPLARQADRYPVYEYGAVRPPEGRDVVVWSANDYLGMGVEPAVAEAAIAAIREH
GAGAGGTRNIAGTSPLHAALEAELADLHGKEAGLLFVSGYVSNQASLQTILTSMPGWICFSDRQNHASMIAGIKGARGSS
CVIFEHNDLADLEAKLAAAPRDVPKLVAFESVYSMDGDIADIGATCALARKYGAMTYLDEVHAVGLYGPQGGGVAERDGV
ADQVDIIEGTLAKGFGVHGGYVTGSAELIDYLRCAASGFIFTTSLPPSVVAAALASVRMVRKDAWRRERMFERVAAFRAR
LTAAGVPFMPTPSHIVPIPVGDADRCMDISRRLLSEYGLYATPINYPTVPRGTERLRLTPGPFHTDEMMDEMTAALVTLL
GLSDQRKVEAA
>Mature_410_residues
GGHPFYRFCRSALQDIRQQGRYRQFTPLARQADRYPVYEYGAVRPPEGRDVVVWSANDYLGMGVEPAVAEAAIAAIREHG
AGAGGTRNIAGTSPLHAALEAELADLHGKEAGLLFVSGYVSNQASLQTILTSMPGWICFSDRQNHASMIAGIKGARGSSC
VIFEHNDLADLEAKLAAAPRDVPKLVAFESVYSMDGDIADIGATCALARKYGAMTYLDEVHAVGLYGPQGGGVAERDGVA
DQVDIIEGTLAKGFGVHGGYVTGSAELIDYLRCAASGFIFTTSLPPSVVAAALASVRMVRKDAWRRERMFERVAAFRARL
TAAGVPFMPTPSHIVPIPVGDADRCMDISRRLLSEYGLYATPINYPTVPRGTERLRLTPGPFHTDEMMDEMTAALVTLLG
LSDQRKVEAA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977440, Length=404, Percent_Identity=45.7920792079208, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI83977442, Length=404, Percent_Identity=45.7920792079208, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI83977444, Length=404, Percent_Identity=45.7920792079208, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI4502025, Length=394, Percent_Identity=45.6852791878173, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI40316939, Length=394, Percent_Identity=45.6852791878173, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI7657118, Length=349, Percent_Identity=36.9627507163324, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI284448556, Length=347, Percent_Identity=37.1757925072046, Blast_Score=225, Evalue=7e-59,
Organism=Homo sapiens, GI4758668, Length=359, Percent_Identity=31.1977715877437, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI119220554, Length=365, Percent_Identity=28.7671232876712, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI5454084, Length=275, Percent_Identity=28.3636363636364, Blast_Score=119, Evalue=6e-27,
Organism=Escherichia coli, GI1790046, Length=400, Percent_Identity=33.25, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1786993, Length=371, Percent_Identity=32.8840970350404, Blast_Score=162, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71994529, Length=353, Percent_Identity=33.9943342776204, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI32566772, Length=388, Percent_Identity=30.1546391752577, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17560914, Length=388, Percent_Identity=29.639175257732, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17560912, Length=388, Percent_Identity=29.639175257732, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71982617, Length=288, Percent_Identity=22.5694444444444, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71982625, Length=288, Percent_Identity=22.5694444444444, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320438, Length=407, Percent_Identity=46.6830466830467, Blast_Score=347, Evalue=3e-96,
Organism=Saccharomyces cerevisiae, GI6320267, Length=395, Percent_Identity=27.0886075949367, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323954, Length=267, Percent_Identity=24.3445692883895, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17137420, Length=405, Percent_Identity=44.6913580246914, Blast_Score=341, Evalue=6e-94,
Organism=Drosophila melanogaster, GI24662918, Length=349, Percent_Identity=36.1031518624642, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI17136286, Length=372, Percent_Identity=29.8387096774194, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24653280, Length=286, Percent_Identity=28.3216783216783, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653276, Length=286, Percent_Identity=28.3216783216783, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653278, Length=286, Percent_Identity=28.3216783216783, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44184; Mature: 44053

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGHPFYRFCRSALQDIRQQGRYRQFTPLARQADRYPVYEYGAVRPPEGRDVVVWSANDY
CCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHHCCCCCCCCCCEEEEECCCCC
LGMGVEPAVAEAAIAAIREHGAGAGGTRNIAGTSPLHAALEAELADLHGKEAGLLFVSGY
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEC
VSNQASLQTILTSMPGWICFSDRQNHASMIAGIKGARGSSCVIFEHNDLADLEAKLAAAP
CCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHCCC
RDVPKLVAFESVYSMDGDIADIGATCALARKYGAMTYLDEVHAVGLYGPQGGGVAERDGV
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHEEEEECCCCCCCCCCCCC
ADQVDIIEGTLAKGFGVHGGYVTGSAELIDYLRCAASGFIFTTSLPPSVVAAALASVRMV
CHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHH
RKDAWRRERMFERVAAFRARLTAAGVPFMPTPSHIVPIPVGDADRCMDISRRLLSEYGLY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCE
ATPINYPTVPRGTERLRLTPGPFHTDEMMDEMTAALVTLLGLSDQRKVEAA
ECCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
GGHPFYRFCRSALQDIRQQGRYRQFTPLARQADRYPVYEYGAVRPPEGRDVVVWSANDY
CCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHHCCCCCCCCCCEEEEECCCCC
LGMGVEPAVAEAAIAAIREHGAGAGGTRNIAGTSPLHAALEAELADLHGKEAGLLFVSGY
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEC
VSNQASLQTILTSMPGWICFSDRQNHASMIAGIKGARGSSCVIFEHNDLADLEAKLAAAP
CCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHCCC
RDVPKLVAFESVYSMDGDIADIGATCALARKYGAMTYLDEVHAVGLYGPQGGGVAERDGV
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHEEEEECCCCCCCCCCCCC
ADQVDIIEGTLAKGFGVHGGYVTGSAELIDYLRCAASGFIFTTSLPPSVVAAALASVRMV
CHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHH
RKDAWRRERMFERVAAFRARLTAAGVPFMPTPSHIVPIPVGDADRCMDISRRLLSEYGLY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCE
ATPINYPTVPRGTERLRLTPGPFHTDEMMDEMTAALVTLLGLSDQRKVEAA
ECCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034217 [H]