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The map label for this gene is Hgd [H]

Identifier: 162147950

GI number: 162147950

Start: 2217277

End: 2218185

Strand: Direct

Name: Hgd [H]

Synonym: GDI_2166

Alternate gene names: 162147950

Gene position: 2217277-2218185 (Clockwise)

Preceding gene: 162147944

Following gene: 162147952

Centisome position: 56.22

GC content: 69.42

Gene sequence:

>909_bases
ATGTCCAATTCATCAGCCAACAGTTCGACAGCCAACGGCTCGACGGGCACCATCGGCTTTATCGGCTTCGGCGCGATGGC
CAGCCGCATGGGCCACAATCTGCGCGAAGCCGGTTACCAGATCATGGCCTACACGCCATCCGGAAAGGGTGGAGACGGCA
CCACCCGTTTCCTGCCCACGCCGCGCGCCCTGGCCGAGGCGGCGGGGACCGTCCTCGTCTGCGTGCCGGACGACGAATCC
CTGGCGAAGTCGCTGTACGGGCCGGACGGCGCGCTGGCCGGCATGACGAAGGGCGCGCTGCTGGTCAACACCAGTTCGGT
CTCGCCCGAAGCCTCGGCGGCGCTGGCCGCCGCCGCGGGTAAACAGGATGTCGCGGTGCTGGACGCCCCGGTTTCCGGCA
GCACGCCCGAGGCCGAATCCGGCACGCTGGTGGTGCTGGTGGGCGGCGATGCGGCGGTCGTCGCGCGGGCGCAGCCGATC
TTCGACGTGATCGGCAAGGCCACGATCCATGCCGGCCCGTCCGGCAGCGGCACGAAGCTGAAACTGGTGGTCAACGGCAT
CATGGGCGCGGGACTGGCCGCCGTGGCCGAGGGCGTGACCTACGGCCTGGCGGCCGGGCTGGACCGCGACATGCTGTTCG
GCGCGCTGGATTCGGTCGCGGTCATTTCGCCCCATCACAAGCGCAAGCTGAAGGCGGCGCGCGTGGGCGATTTCACGCCG
CAATTCCCGACCCGGCTGATGCAGAAGGACATGCGCCTGCTGATGACCGACGCCGCGCGGGCCGAGGCGCCGCTGGCGAC
GATGGCCGCGACCACGCAGCTTCTGTCGCTGACGCGGCGCACCCATCCCGACGACGATTATTCCGCCCTGTTCGCCGTGC
TGGAACGCACGGTGGCCAACAGCCCTTGA

Upstream 100 bases:

>100_bases
AGACACTCATGTGGCGGCCTTGCAGGGGCCCGGACGTGACGTCGCCGGGACGGTCCCGCACTGTGCCCGCGCCAGGGCAG
AAAAGGAAAGGGTCAGGATC

Downstream 100 bases:

>100_bases
CCGACACCGCGGCTGGGCGGGTCAGATCCGCCCCCGCGCCATCGCGGCCATGACCGCCAGCCGGTCGCCCAGTCCGCGCG
CCGCTCCGACTTCGCGATCA

Product: 6-phosphogluconate dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSNSSANSSTANGSTGTIGFIGFGAMASRMGHNLREAGYQIMAYTPSGKGGDGTTRFLPTPRALAEAAGTVLVCVPDDES
LAKSLYGPDGALAGMTKGALLVNTSSVSPEASAALAAAAGKQDVAVLDAPVSGSTPEAESGTLVVLVGGDAAVVARAQPI
FDVIGKATIHAGPSGSGTKLKLVVNGIMGAGLAAVAEGVTYGLAAGLDRDMLFGALDSVAVISPHHKRKLKAARVGDFTP
QFPTRLMQKDMRLLMTDAARAEAPLATMAATTQLLSLTRRTHPDDDYSALFAVLERTVANSP

Sequences:

>Translated_302_residues
MSNSSANSSTANGSTGTIGFIGFGAMASRMGHNLREAGYQIMAYTPSGKGGDGTTRFLPTPRALAEAAGTVLVCVPDDES
LAKSLYGPDGALAGMTKGALLVNTSSVSPEASAALAAAAGKQDVAVLDAPVSGSTPEAESGTLVVLVGGDAAVVARAQPI
FDVIGKATIHAGPSGSGTKLKLVVNGIMGAGLAAVAEGVTYGLAAGLDRDMLFGALDSVAVISPHHKRKLKAARVGDFTP
QFPTRLMQKDMRLLMTDAARAEAPLATMAATTQLLSLTRRTHPDDDYSALFAVLERTVANSP
>Mature_301_residues
SNSSANSSTANGSTGTIGFIGFGAMASRMGHNLREAGYQIMAYTPSGKGGDGTTRFLPTPRALAEAAGTVLVCVPDDESL
AKSLYGPDGALAGMTKGALLVNTSSVSPEASAALAAAAGKQDVAVLDAPVSGSTPEAESGTLVVLVGGDAAVVARAQPIF
DVIGKATIHAGPSGSGTKLKLVVNGIMGAGLAAVAEGVTYGLAAGLDRDMLFGALDSVAVISPHHKRKLKAARVGDFTPQ
FPTRLMQKDMRLLMTDAARAEAPLATMAATTQLLSLTRRTHPDDDYSALFAVLERTVANSP

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=301, Percent_Identity=28.2392026578073, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI23308751, Length=291, Percent_Identity=26.4604810996564, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1786719, Length=287, Percent_Identity=31.7073170731707, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI145693186, Length=287, Percent_Identity=27.5261324041812, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790315, Length=285, Percent_Identity=27.719298245614, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17557316, Length=295, Percent_Identity=24.7457627118644, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574115, Length=287, Percent_Identity=26.8292682926829, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24655230, Length=301, Percent_Identity=24.5847176079734, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19922568, Length=301, Percent_Identity=24.5847176079734, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 30613; Mature: 30482

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSSANSSTANGSTGTIGFIGFGAMASRMGHNLREAGYQIMAYTPSGKGGDGTTRFLPT
CCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCHHHHCCCEEEEECCCCCCCCCCEEECCC
PRALAEAAGTVLVCVPDDESLAKSLYGPDGALAGMTKGALLVNTSSVSPEASAALAAAAG
HHHHHHHCCEEEEEECCCHHHHHHHCCCCCCHHCCCCCEEEEECCCCCCHHHHHHHHHCC
KQDVAVLDAPVSGSTPEAESGTLVVLVGGDAAVVARAQPIFDVIGKATIHAGPSGSGTKL
CCCEEEEECCCCCCCCCCCCCEEEEEECCCEEEEECCCHHHHHHCCCEEECCCCCCCCEE
KLVVNGIMGAGLAAVAEGVTYGLAAGLDRDMLFGALDSVAVISPHHKRKLKAARVGDFTP
EEEEECHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHCCEEEECCHHHHHHHHHHCCCCCC
QFPTRLMQKDMRLLMTDAARAEAPLATMAATTQLLSLTRRTHPDDDYSALFAVLERTVAN
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
SP
CC
>Mature Secondary Structure 
SNSSANSSTANGSTGTIGFIGFGAMASRMGHNLREAGYQIMAYTPSGKGGDGTTRFLPT
CCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCHHHHCCCEEEEECCCCCCCCCCEEECCC
PRALAEAAGTVLVCVPDDESLAKSLYGPDGALAGMTKGALLVNTSSVSPEASAALAAAAG
HHHHHHHCCEEEEEECCCHHHHHHHCCCCCCHHCCCCCEEEEECCCCCCHHHHHHHHHCC
KQDVAVLDAPVSGSTPEAESGTLVVLVGGDAAVVARAQPIFDVIGKATIHAGPSGSGTKL
CCCEEEEECCCCCCCCCCCCCEEEEEECCCEEEEECCCHHHHHHCCCEEECCCCCCCCEE
KLVVNGIMGAGLAAVAEGVTYGLAAGLDRDMLFGALDSVAVISPHHKRKLKAARVGDFTP
EEEEECHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHCCEEEECCHHHHHHHHHHCCCCCC
QFPTRLMQKDMRLLMTDAARAEAPLATMAATTQLLSLTRRTHPDDDYSALFAVLERTVAN
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
SP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA