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The map label for this gene is ctaB

Identifier: 162147884

GI number: 162147884

Start: 2148484

End: 2149431

Strand: Reverse

Name: ctaB

Synonym: GDI_2100

Alternate gene names: 162147884

Gene position: 2149431-2148484 (Counterclockwise)

Preceding gene: 162147885

Following gene: 162147883

Centisome position: 54.5

GC content: 66.77

Gene sequence:

>948_bases
GTGAGCGGCGCGGCAACCACCGAAGGCGCCGTAACCCGTTTCGACGCCGCTTTGGTCGGAACCGAGGCCCGCGACTGGTT
CGCGCTGCTGAAGCCGCGGGTGATTTCGCTGGTCGTGTTCACCGGCGCGGCCGGGTTGGCCATGGCGCCGGGACCGATCA
ATCCGCTGATCGCCGCTGTCAGCATCCTGTGCATCTGCATGGCCTCCGGGGCCGCCGGTGCCATCAACATGTGGTATGAC
CGCGACATCGACGCGGTGATGACCCGCACCGCGCGGCGCCCGATCCCTGACGGCCGCATTCGTGACGACCAGGCGCTGGG
CTTCGGCATCGGCCTGTCGGTGGCGTCGGTCCTGCTGATGTGGCTGGCAGCCAACGCCCTGGCGGCGTTTATCCTGGCGT
TCTCGATCTTCTTCTATGCCGTGATCTACACGATGTGGCTGAAGCGTTCGACGCCGCAGAACATCGTGATCGGCGGGGCC
GCGGGCGCATTCCCGCCGATGATCGGGTGGGCCGCCACCACCGGGTCGCTGGGCGTGCTGCCGGTGGTAATGTTCGCCAT
CGTCTTTCTCTGGACCCCGCCGCATTTCTGGTCGCTGTCGCTGTATGCCTGCAAGGATTACGGTCGCGCCGGAATCCCGA
TGCTGCCGGTCGTGCGGGGTGCGCGGCATACGCGGTGGCAGATCCTGTTCTACACGCTGATCCTGTCGGCGGTGTCGCTG
GTGCCGTCGTTTCTGCATCAGGCGGGCTGGCTCTATACCGGTGTCGCGTCGCTGCTGGATGCCGGGTTCGTCGCCTGCGC
GGTTGGCGTGTTGACGGATCGACAGGACGAGGCCGGCGTCAGCCTGACGGGCGACCGGCCGGCGCGTCGGGCGTTCCGCT
ATTCCCTGGCCTACCTGTTCCTGCTGTTCTGCGGACTGCTGGCCGACCACTTCCTGATCATGCGATAG

Upstream 100 bases:

>100_bases
CGAATTACTGGGGGCCGGGTGCCCGGACCCTGGAATGGACGGTGCCGTCGCCCGCACCGCGTGACTCCTTCGCCGGTATC
CTGGCCCACGGAGCACGGGC

Downstream 100 bases:

>100_bases
GGGCGGGCGATGAATCAGCCACATTCCCTGACGGACGCCGAAGCCACCGAATTCGTCCGACGCCATCGCGGCCGTATTTA
CGGCGTGGCGATCACGCTGC

Product: protoheme IX farnesyltransferase

Products: heme O; pyrophosphate [C]

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSGAATTEGAVTRFDAALVGTEARDWFALLKPRVISLVVFTGAAGLAMAPGPINPLIAAVSILCICMASGAAGAINMWYD
RDIDAVMTRTARRPIPDGRIRDDQALGFGIGLSVASVLLMWLAANALAAFILAFSIFFYAVIYTMWLKRSTPQNIVIGGA
AGAFPPMIGWAATTGSLGVLPVVMFAIVFLWTPPHFWSLSLYACKDYGRAGIPMLPVVRGARHTRWQILFYTLILSAVSL
VPSFLHQAGWLYTGVASLLDAGFVACAVGVLTDRQDEAGVSLTGDRPARRAFRYSLAYLFLLFCGLLADHFLIMR

Sequences:

>Translated_315_residues
MSGAATTEGAVTRFDAALVGTEARDWFALLKPRVISLVVFTGAAGLAMAPGPINPLIAAVSILCICMASGAAGAINMWYD
RDIDAVMTRTARRPIPDGRIRDDQALGFGIGLSVASVLLMWLAANALAAFILAFSIFFYAVIYTMWLKRSTPQNIVIGGA
AGAFPPMIGWAATTGSLGVLPVVMFAIVFLWTPPHFWSLSLYACKDYGRAGIPMLPVVRGARHTRWQILFYTLILSAVSL
VPSFLHQAGWLYTGVASLLDAGFVACAVGVLTDRQDEAGVSLTGDRPARRAFRYSLAYLFLLFCGLLADHFLIMR
>Mature_314_residues
SGAATTEGAVTRFDAALVGTEARDWFALLKPRVISLVVFTGAAGLAMAPGPINPLIAAVSILCICMASGAAGAINMWYDR
DIDAVMTRTARRPIPDGRIRDDQALGFGIGLSVASVLLMWLAANALAAFILAFSIFFYAVIYTMWLKRSTPQNIVIGGAA
GAFPPMIGWAATTGSLGVLPVVMFAIVFLWTPPHFWSLSLYACKDYGRAGIPMLPVVRGARHTRWQILFYTLILSAVSLV
PSFLHQAGWLYTGVASLLDAGFVACAVGVLTDRQDEAGVSLTGDRPARRAFRYSLAYLFLLFCGLLADHFLIMR

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=191, Percent_Identity=36.6492146596859, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786631, Length=276, Percent_Identity=28.6231884057971, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71998235, Length=199, Percent_Identity=34.6733668341709, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6325085, Length=242, Percent_Identity=28.5123966942149, Blast_Score=89, Evalue=8e-19,
Organism=Drosophila melanogaster, GI19921064, Length=280, Percent_Identity=29.6428571428571, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_GLUDA (A9HKH7)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001602345.1
- RefSeq:   YP_002274730.1
- GeneID:   5792457
- GeneID:   6973711
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_0319
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- ProtClustDB:   PRK04375
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 33888; Mature: 33757

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1530fb38)-; HASH(0x16608e5c)-; HASH(0x15bfde88)-; HASH(0x15e3a5cc)-; HASH(0x1663582c)-; HASH(0x1662d034)-; HASH(0x1662cdc4)-; HASH(0x16634738)-; HASH(0x166305ac)-;

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGAATTEGAVTRFDAALVGTEARDWFALLKPRVISLVVFTGAAGLAMAPGPINPLIAAV
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHH
SILCICMASGAAGAINMWYDRDIDAVMTRTARRPIPDGRIRDDQALGFGIGLSVASVLLM
HHHHHHHHCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
WLAANALAAFILAFSIFFYAVIYTMWLKRSTPQNIVIGGAAGAFPPMIGWAATTGSLGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHCCCCCCHHH
PVVMFAIVFLWTPPHFWSLSLYACKDYGRAGIPMLPVVRGARHTRWQILFYTLILSAVSL
HHHHHHHHHHCCCCCHHEEEEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
VPSFLHQAGWLYTGVASLLDAGFVACAVGVLTDRQDEAGVSLTGDRPARRAFRYSLAYLF
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHH
LLFCGLLADHFLIMR
HHHHHHHHHHHHHCH
>Mature Secondary Structure 
SGAATTEGAVTRFDAALVGTEARDWFALLKPRVISLVVFTGAAGLAMAPGPINPLIAAV
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHH
SILCICMASGAAGAINMWYDRDIDAVMTRTARRPIPDGRIRDDQALGFGIGLSVASVLLM
HHHHHHHHCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
WLAANALAAFILAFSIFFYAVIYTMWLKRSTPQNIVIGGAAGAFPPMIGWAATTGSLGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHCCCCCCHHH
PVVMFAIVFLWTPPHFWSLSLYACKDYGRAGIPMLPVVRGARHTRWQILFYTLILSAVSL
HHHHHHHHHHCCCCCHHEEEEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
VPSFLHQAGWLYTGVASLLDAGFVACAVGVLTDRQDEAGVSLTGDRPARRAFRYSLAYLF
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHH
LLFCGLLADHFLIMR
HHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protoheme; farnesyl-PP [C]

Specific reaction: protoheme + farnesyl-PP = heme O + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA