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The map label for this gene is hemC [H]

Identifier: 162147854

GI number: 162147854

Start: 2114727

End: 2115830

Strand: Reverse

Name: hemC [H]

Synonym: GDI_2070

Alternate gene names: 162147854

Gene position: 2115830-2114727 (Counterclockwise)

Preceding gene: 162147858

Following gene: 162147853

Centisome position: 53.64

GC content: 71.83

Gene sequence:

>1104_bases
ATGGTTTCCGCTCCTCCGTCCGTTCCTGGCCCGTCAGCCGCCCCGTCCTCCGCATTGCAGAAAATCGCGGCGCAGGCCGC
CGCGCGCCAGAAGCAGGCGGCCACGCGGGCCGCATTGCCGCACCGTCGCGAACTGCCGCTGCGCGTGGGCACGCGGGCCT
CGCCGCTGGCACTGGTGCAGACCCGGGCGTTCCTGACGATGCTGACGCGGTTCTGCCCGGTCCTGCGCGACATGGGGGCG
TTCCAGGAACACCAGATCAACACCACCGGCGACCAGGTGCAGAATCGCCGTCTGGCCGAAATCGGCGGCAAGGGACTGTT
CGCCAAGGAAATTCACGATGCCCTGTCCGACGGGCGGATCGATTTCGCGGTCCATAGCCTGAAGGACCTGGAAACCACGC
TGCCGCCCGGCCTGGTGCTGGCCTGCACCCTGCGGCGCGAGGACGCGCGCGATGCCCTGATCCTGGGTCCGGGCGCCGGC
GGGCGGCACGACGCCGCCGATGCGGCCGATCCGTATGCCGCGCTGCCGCGCAATGCGCTGGTCGGCTGCGCGTCGGTGCG
GCGCCAGGCGCAGATGCTGCATGTGCGCCCGGACCTGCGCTTCGGCCTGCTGCGCGGCAATGTGCAGACGCGGCTGGACA
AGCTGGCGGCGCGGCAGTGCGATGCGACCCTGCTGGCCCTGGCCGGCCTGCGCCGGCTGGGAATGGAAGACCGCGCGGAT
ATCGTCCTGGATCCGGAAATCATGGTCCCCGCCGCCGGCCAGGGCATCGTCGGCGTCACCGTTCGCGAAAGCGACGTGGA
ACTGCGCGAGCTTCTGGCCGCCATCGAGGATTACGAGGCCCGCGCCGTCGCCACCGCCGAGCGCGCGCTGCTGGCGGAAC
TGGACGGATCGTGCCGCACCCCGATCGGCGGCTATGCCCGCCTGGTCCCGGGACTGGCGGGCGCCGAGGCCAGCCTGCGC
CTGACCGGCCTGGTCGCGCGCGAGGACGGGTCCTTCCTGCTGCGCCGGACCGTGACCGGCCTGCGCGCCGACGCCGAGGA
AATGGGCCGCGAACTGGGCCGCAGCCTTCGGATGGACAGCCCATCGGACGTCTTTGCCGCCTGA

Upstream 100 bases:

>100_bases
GGCGTGGCAGGGGACACGGACATGATCATTGCATAAAATACAGTTCCGCCGGGCGCTATGTCATCTTTCCTTCGTGTCGT
CGCGGTAATAGAGACATCGC

Downstream 100 bases:

>100_bases
CGCACCGCCCCGCACCGGCGTTCTGGTCACACGGCCGGAACCCGGGCTGGCCGACACCATGGCGGCGGTCGAACGGCTGG
GCTGGCAGGCCCATGCCATG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MVSAPPSVPGPSAAPSSALQKIAAQAAARQKQAATRAALPHRRELPLRVGTRASPLALVQTRAFLTMLTRFCPVLRDMGA
FQEHQINTTGDQVQNRRLAEIGGKGLFAKEIHDALSDGRIDFAVHSLKDLETTLPPGLVLACTLRREDARDALILGPGAG
GRHDAADAADPYAALPRNALVGCASVRRQAQMLHVRPDLRFGLLRGNVQTRLDKLAARQCDATLLALAGLRRLGMEDRAD
IVLDPEIMVPAAGQGIVGVTVRESDVELRELLAAIEDYEARAVATAERALLAELDGSCRTPIGGYARLVPGLAGAEASLR
LTGLVAREDGSFLLRRTVTGLRADAEEMGRELGRSLRMDSPSDVFAA

Sequences:

>Translated_367_residues
MVSAPPSVPGPSAAPSSALQKIAAQAAARQKQAATRAALPHRRELPLRVGTRASPLALVQTRAFLTMLTRFCPVLRDMGA
FQEHQINTTGDQVQNRRLAEIGGKGLFAKEIHDALSDGRIDFAVHSLKDLETTLPPGLVLACTLRREDARDALILGPGAG
GRHDAADAADPYAALPRNALVGCASVRRQAQMLHVRPDLRFGLLRGNVQTRLDKLAARQCDATLLALAGLRRLGMEDRAD
IVLDPEIMVPAAGQGIVGVTVRESDVELRELLAAIEDYEARAVATAERALLAELDGSCRTPIGGYARLVPGLAGAEASLR
LTGLVAREDGSFLLRRTVTGLRADAEEMGRELGRSLRMDSPSDVFAA
>Mature_367_residues
MVSAPPSVPGPSAAPSSALQKIAAQAAARQKQAATRAALPHRRELPLRVGTRASPLALVQTRAFLTMLTRFCPVLRDMGA
FQEHQINTTGDQVQNRRLAEIGGKGLFAKEIHDALSDGRIDFAVHSLKDLETTLPPGLVLACTLRREDARDALILGPGAG
GRHDAADAADPYAALPRNALVGCASVRRQAQMLHVRPDLRFGLLRGNVQTRLDKLAARQCDATLLALAGLRRLGMEDRAD
IVLDPEIMVPAAGQGIVGVTVRESDVELRELLAAIEDYEARAVATAERALLAELDGSCRTPIGGYARLVPGLAGAEASLR
LTGLVAREDGSFLLRRTVTGLRADAEEMGRELGRSLRMDSPSDVFAA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=293, Percent_Identity=37.8839590443686, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI66933009, Length=293, Percent_Identity=37.8839590443686, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI48994974, Length=320, Percent_Identity=41.875, Blast_Score=209, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6319996, Length=265, Percent_Identity=36.9811320754717, Blast_Score=154, Evalue=2e-38,
Organism=Drosophila melanogaster, GI20130425, Length=299, Percent_Identity=37.7926421404682, Blast_Score=176, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 39142; Mature: 39142

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSAPPSVPGPSAAPSSALQKIAAQAAARQKQAATRAALPHRRELPLRVGTRASPLALVQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHH
TRAFLTMLTRFCPVLRDMGAFQEHQINTTGDQVQNRRLAEIGGKGLFAKEIHDALSDGRI
HHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
DFAVHSLKDLETTLPPGLVLACTLRREDARDALILGPGAGGRHDAADAADPYAALPRNAL
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCHHHCCCHHH
VGCASVRRQAQMLHVRPDLRFGLLRGNVQTRLDKLAARQCDATLLALAGLRRLGMEDRAD
HHHHHHHHHHHHEECCCCCEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IVLDPEIMVPAAGQGIVGVTVRESDVELRELLAAIEDYEARAVATAERALLAELDGSCRT
EEECCCEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PIGGYARLVPGLAGAEASLRLTGLVAREDGSFLLRRTVTGLRADAEEMGRELGRSLRMDS
CCCHHHHHHCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
PSDVFAA
CCHHHCC
>Mature Secondary Structure
MVSAPPSVPGPSAAPSSALQKIAAQAAARQKQAATRAALPHRRELPLRVGTRASPLALVQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHH
TRAFLTMLTRFCPVLRDMGAFQEHQINTTGDQVQNRRLAEIGGKGLFAKEIHDALSDGRI
HHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
DFAVHSLKDLETTLPPGLVLACTLRREDARDALILGPGAGGRHDAADAADPYAALPRNAL
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCHHHCCCHHH
VGCASVRRQAQMLHVRPDLRFGLLRGNVQTRLDKLAARQCDATLLALAGLRRLGMEDRAD
HHHHHHHHHHHHEECCCCCEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IVLDPEIMVPAAGQGIVGVTVRESDVELRELLAAIEDYEARAVATAERALLAELDGSCRT
EEECCCEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PIGGYARLVPGLAGAEASLRLTGLVAREDGSFLLRRTVTGLRADAEEMGRELGRSLRMDS
CCCHHHHHHCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
PSDVFAA
CCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA