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The map label for this gene is purM [H]

Identifier: 162147796

GI number: 162147796

Start: 2053130

End: 2054080

Strand: Direct

Name: purM [H]

Synonym: GDI_2012

Alternate gene names: 162147796

Gene position: 2053130-2054080 (Clockwise)

Preceding gene: 162147791

Following gene: 162147797

Centisome position: 52.05

GC content: 71.61

Gene sequence:

>951_bases
ATGGGCGGCCTGGGCGGCTTCGGGGCGCTGTTCGACCTGAAGGCGGCCGGTTTCACCGACCCGGTCCTGGTCTCGTGCAC
CGACGGGGTGGGCACCAAGCTGATGGTCGCGATCGAAAGCGGCCTGCATGAGACGGTGGGCATCGACCTGGTGGCGATGT
GCGTCAACGACCTGGTCGTGCAGGGGGCGGAACCGCTGTTCTTCCTGGATTATTTCGCGACCGGCCGCCTGGCGGTGGAA
GACGCGGCCAAGGTCGTCCGCGGCATTGCCCAGGGCTGCCGCGAATCGGGCTGCGCCCTGGTCGGGGGCGAAACGGCGGA
AATGCCCGGCATGTATGGTCCCGGCCATTACGACCTGGCCGGGTTTTCCGTGGGCGCCGCCGAACGCGCGGCCCTGCTGC
CCGCCGATATCGCGGCGGGCGACACGCTGATCGGCCTGCCGGCCAGCGGCGTGCATTCCAATGGATTTTCGCTGGTGCGC
GCCATCGTGGCGCGCAGCGGCCTGGCGTGGGACGCCCCCTGCCCCTTCGCGCCCGGCCAGACGCTGGCGCAGGCGCTGAT
GGCGCCCACGCGCCTGTATGTGAAGGCGGTGCTGGACCTGCACCGCCAGGGGCTGATCCAGGGCGCCGCGCACATTACGG
GCGGCGGCCTGCCGGGCAACCTGCCGCGCGTGCTGCCGGCGGGCCTGACGGCACTGATCGACGGCGGCGCATGGCCCATT
CCGCCGGTGTTCGGCTGGCTGGCCCGCACCGGGCAGGTCGATCCCGACGAAATGCTGAAGGTCTTCAATTGCGGCGTCGG
CATGGTGCTGATCGCCCGCGACGGGGACGCGGCGCTGCAGTCCCTGCGCGCGGCGGGTCAGGACGCGTTCGTCATCGGCC
GGCTGGAAGAGGGCACGCCCGGCGCCGCCGCCGGCCTGCGCTTCACCACCCGGCCCGACTTCACCGGATAA

Upstream 100 bases:

>100_bases
CCGGCGCCACCTACCGCGACGCGGGCGTGACATCGCGGCCGGCGATGCGCTGGTCGATGCCATCAAGCCTGCGGCCAGTG
CGACCGACCGCCCCGGCACC

Downstream 100 bases:

>100_bases
GCCTGTGACGCACGACACCCACGCCGCCGCCCGGCGGCCGATCGCGATTCTGATCAGCGGGCGCGGCAGCAACATGCGCG
CGCTGATCGATGCCTGCGCG

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MGGLGGFGALFDLKAAGFTDPVLVSCTDGVGTKLMVAIESGLHETVGIDLVAMCVNDLVVQGAEPLFFLDYFATGRLAVE
DAAKVVRGIAQGCRESGCALVGGETAEMPGMYGPGHYDLAGFSVGAAERAALLPADIAAGDTLIGLPASGVHSNGFSLVR
AIVARSGLAWDAPCPFAPGQTLAQALMAPTRLYVKAVLDLHRQGLIQGAAHITGGGLPGNLPRVLPAGLTALIDGGAWPI
PPVFGWLARTGQVDPDEMLKVFNCGVGMVLIARDGDAALQSLRAAGQDAFVIGRLEEGTPGAAAGLRFTTRPDFTG

Sequences:

>Translated_316_residues
MGGLGGFGALFDLKAAGFTDPVLVSCTDGVGTKLMVAIESGLHETVGIDLVAMCVNDLVVQGAEPLFFLDYFATGRLAVE
DAAKVVRGIAQGCRESGCALVGGETAEMPGMYGPGHYDLAGFSVGAAERAALLPADIAAGDTLIGLPASGVHSNGFSLVR
AIVARSGLAWDAPCPFAPGQTLAQALMAPTRLYVKAVLDLHRQGLIQGAAHITGGGLPGNLPRVLPAGLTALIDGGAWPI
PPVFGWLARTGQVDPDEMLKVFNCGVGMVLIARDGDAALQSLRAAGQDAFVIGRLEEGTPGAAAGLRFTTRPDFTG
>Mature_315_residues
GGLGGFGALFDLKAAGFTDPVLVSCTDGVGTKLMVAIESGLHETVGIDLVAMCVNDLVVQGAEPLFFLDYFATGRLAVED
AAKVVRGIAQGCRESGCALVGGETAEMPGMYGPGHYDLAGFSVGAAERAALLPADIAAGDTLIGLPASGVHSNGFSLVRA
IVARSGLAWDAPCPFAPGQTLAQALMAPTRLYVKAVLDLHRQGLIQGAAHITGGGLPGNLPRVLPAGLTALIDGGAWPIP
PVFGWLARTGQVDPDEMLKVFNCGVGMVLIARDGDAALQSLRAAGQDAFVIGRLEEGTPGAAAGLRFTTRPDFTG

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=305, Percent_Identity=53.4426229508197, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI209869995, Length=305, Percent_Identity=53.4426229508197, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI209869993, Length=305, Percent_Identity=53.4426229508197, Blast_Score=316, Evalue=2e-86,
Organism=Escherichia coli, GI1788845, Length=299, Percent_Identity=54.8494983277592, Blast_Score=307, Evalue=6e-85,
Organism=Caenorhabditis elegans, GI17567511, Length=308, Percent_Identity=44.8051948051948, Blast_Score=257, Evalue=6e-69,
Organism=Saccharomyces cerevisiae, GI6321203, Length=301, Percent_Identity=56.4784053156146, Blast_Score=334, Evalue=9e-93,
Organism=Drosophila melanogaster, GI24582400, Length=284, Percent_Identity=44.7183098591549, Blast_Score=242, Evalue=3e-64,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 32221; Mature: 32090

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGLGGFGALFDLKAAGFTDPVLVSCTDGVGTKLMVAIESGLHETVGIDLVAMCVNDLVV
CCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHH
QGAEPLFFLDYFATGRLAVEDAAKVVRGIAQGCRESGCALVGGETAEMPGMYGPGHYDLA
CCCCCEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCC
GFSVGAAERAALLPADIAAGDTLIGLPASGVHSNGFSLVRAIVARSGLAWDAPCPFAPGQ
CEECCCHHHHHCCCHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHH
TLAQALMAPTRLYVKAVLDLHRQGLIQGAAHITGGGLPGNLPRVLPAGLTALIDGGAWPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCHHHEECCCCCCC
PPVFGWLARTGQVDPDEMLKVFNCGVGMVLIARDGDAALQSLRAAGQDAFVIGRLEEGTP
HHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCEEEEEEECCCCC
GAAAGLRFTTRPDFTG
CCHHCCEEECCCCCCC
>Mature Secondary Structure 
GGLGGFGALFDLKAAGFTDPVLVSCTDGVGTKLMVAIESGLHETVGIDLVAMCVNDLVV
CCCCCCHHHHHHHCCCCCCCEEEEECCCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHH
QGAEPLFFLDYFATGRLAVEDAAKVVRGIAQGCRESGCALVGGETAEMPGMYGPGHYDLA
CCCCCEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCC
GFSVGAAERAALLPADIAAGDTLIGLPASGVHSNGFSLVRAIVARSGLAWDAPCPFAPGQ
CEECCCHHHHHCCCHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHH
TLAQALMAPTRLYVKAVLDLHRQGLIQGAAHITGGGLPGNLPRVLPAGLTALIDGGAWPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCHHHEECCCCCCC
PPVFGWLARTGQVDPDEMLKVFNCGVGMVLIARDGDAALQSLRAAGQDAFVIGRLEEGTP
HHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCEEEEEEECCCCC
GAAAGLRFTTRPDFTG
CCHHCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA