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The map label for this gene is uvrD [H]

Identifier: 162147772

GI number: 162147772

Start: 2020169

End: 2022400

Strand: Direct

Name: uvrD [H]

Synonym: GDI_1988

Alternate gene names: 162147772

Gene position: 2020169-2022400 (Clockwise)

Preceding gene: 162147770

Following gene: 162147773

Centisome position: 51.22

GC content: 68.5

Gene sequence:

>2232_bases
GTGACCCAGACCCCAGCCCCCTTCCCCGAGCGTCCCGCCGCTGATCGTCCCGACTACCTTCAGCGGCTCAATCCCGAACA
GCGGGCGGCGATCGAGACGACCGACGGTCCGTTGCTGGTCCTGGCCGGCGCCGGCACCGGCAAGACGCGCGTCCTGACCA
CCCGCTTCGCCCATATTCTGCTGTCGGGCCGGGCGCGGCCATACCAGATCCTGGCGGTGACCTTCACCAACAAGGCGGCG
CGCGAAATGCGCGAGCGGATCGGCGCCCTGCTGGGCGAGCCGGTCGAGGGATTGTGGCTGGGCACGTTCCATGCCCTGTG
CGCGCGCATGCTGCGCCGCCACGCCGAATATGTGGGCCTGGGCAGCGGCTTCACGATCCTGGACACCGACGACCAGTTGC
GCCTGCTGAAGCAGGTGATCGAACCCTTGCGCATCGACACCAAGCGCTGGCCGCCGCAGGGTATCCTGGGCGTCATCCAG
CGCTGGAAGGACCGGGGCCTGACGCCCGAACGCGTGACCCCGGCCGAGGATTGCGACTTCGCCGGCGGGCAGTGCCGCCC
GATCTATGCCACCTACCAGGCACGGCTGGTCCAGTTGAACGCCTGCGATTTCGGCGACCTGATGCTGCACGTGACCGAGA
TCCTGCGGACCCGGCCCGACGTGCTGGCCCAGTATCACCGGCTGTTCCGCTATATCCTGGTGGACGAATACCAGGACACG
AACACGATCCAGTATCTGTGGCTGCGCCTGCTGGCCCAGCGCGAGGGCCAGCCCGCCAATATCTGCTGCGTGGGCGACGA
CGACCAGTCGATCTATTCCTGGCGCGGGGCCGAGGTCGAGAACATCCTGCGCTTCGAACGGGACTTCCCCGGAGCCGCCG
TCGTGCGGCTGGAACGCAATTACCGTTCCACCGCCCAGATCCTGGGGGCGGCGTCCGGCCTGATCGCGCATAATGACGGG
CGGCTGGGCAAGACCCTGCGCCCGGGACGCGAGGACGCATCGGGCGAGAAGGTGCGCGTGGCGTCGGTCTGGGATTCGGA
CGACGAGGCCCGCCTGGTGGGCGAGGAGGTCGAGCGGCTGCGCGCCGGGGGGCATTCCCTGGCGGAAATCGCGATCCTGG
TGCGGGCCGGATTCCAGACCCGCGCGTTCGAGGAACGGCTGATCACCCTGGGCCTGCCCTATCGCGTCGTCGGCGGGCTG
CGATTCTACGAGCGGTCGGAAATCCGCGACGCCATGGCCTATATGCGGGTGCTGAACCAGCCGGCGGACGACCTGGCGTT
CGAGCGGATCATCAACGTGCCCCGGCGCGGCATCGGCGCGGCCGCGATGCAGAAATTCCATGTCGCCGCGCGCGAGGGCC
AGATGCCTCTGGCCGCCGCCGTGATGGACCTGATCGCGCGGGGCGCGCTGAAGGGCCGCGCGCGCGAGCAGATGACCGCG
CTGATGGCCTGCCTGGCGCGCGGACGCGAGGCCCTGCCGCGCGAGGGGCATGTGGTGGTGGTCGAAACGCTGCTGGAAGA
AAGCGGCTATATCGACATGTGGAAGGCCGATACCTCGCCCGAGGCGCCCGGACGGCTGGACAACCTGAAGGAACTGGTGC
GGGCCCTGGCGGATTTCGAAAGCCTGGGCGGCTTCCTGGAACACGTCGCGCTGGTCATGGAAAACGAGGAGAATGCCGGC
GCCGAGCGCCTGAGCATCATGACCCTGCACGGCGCGAAGGGCCTGGAATTCGACACCGTCTTCCTGCCGGGATGGGAGGA
AGGGGTCTTCCCGTCCCAGCGCACCCTGGACGAGGGCGGCCTGAAGGGGCTGGAGGAGGAGCGGCGCCTGGCCTATGTCG
GCATTACCCGGGCGCGGCACCGGGCCGTCATCAGCCACGCCGCCAGCCGGCGCATCTACGGCAACTGGCAATCGGCGATC
CCCAGCCGGTTCATCGAGGAACTGCCGGCCGAGCACGTCACCACCACGGGGGGCGCGGCGCAGGCACGGTCGCGGACGTT
CGGCCATGCGCCCCTCTCTTCCACCGCCTTCCCGGTCATGGCGCGGCGGCCGCGCGTGACCGATGTGGGGGAAAAGGGCC
CGACTGCCGCGATGGCGGTGGGAACGCGGGTCTTCCACCAGAAATTCGGATACGGAACCATATCGTCCGTCGAGGGCAAC
CGGCTGGAAGTCGCGTTCGAGAAAGCCGGCCCGAAACGGGTCCTGGATACATTTGTCGAGAAGATCCCATGA

Upstream 100 bases:

>100_bases
ATTCCATCCTCTCTTTCACGCCTGGCCACAGACCCGCCTGCCCGCGCGAATGCGCGCGCATAAGCTTGGTCATAATCTCC
GGACGCCCTATACGGAAATC

Downstream 100 bases:

>100_bases
CATCTCTGACCCGTCGGCATGCGACGGAACTGGAAACCATTGCCGTCACCGTCCCGGCCGAGGCCGTGATGGCGTACGAG
GACGCGCTGTCGGTCGTCTG

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 743; Mature: 742

Protein sequence:

>743_residues
MTQTPAPFPERPAADRPDYLQRLNPEQRAAIETTDGPLLVLAGAGTGKTRVLTTRFAHILLSGRARPYQILAVTFTNKAA
REMRERIGALLGEPVEGLWLGTFHALCARMLRRHAEYVGLGSGFTILDTDDQLRLLKQVIEPLRIDTKRWPPQGILGVIQ
RWKDRGLTPERVTPAEDCDFAGGQCRPIYATYQARLVQLNACDFGDLMLHVTEILRTRPDVLAQYHRLFRYILVDEYQDT
NTIQYLWLRLLAQREGQPANICCVGDDDQSIYSWRGAEVENILRFERDFPGAAVVRLERNYRSTAQILGAASGLIAHNDG
RLGKTLRPGREDASGEKVRVASVWDSDDEARLVGEEVERLRAGGHSLAEIAILVRAGFQTRAFEERLITLGLPYRVVGGL
RFYERSEIRDAMAYMRVLNQPADDLAFERIINVPRRGIGAAAMQKFHVAAREGQMPLAAAVMDLIARGALKGRAREQMTA
LMACLARGREALPREGHVVVVETLLEESGYIDMWKADTSPEAPGRLDNLKELVRALADFESLGGFLEHVALVMENEENAG
AERLSIMTLHGAKGLEFDTVFLPGWEEGVFPSQRTLDEGGLKGLEEERRLAYVGITRARHRAVISHAASRRIYGNWQSAI
PSRFIEELPAEHVTTTGGAAQARSRTFGHAPLSSTAFPVMARRPRVTDVGEKGPTAAMAVGTRVFHQKFGYGTISSVEGN
RLEVAFEKAGPKRVLDTFVEKIP

Sequences:

>Translated_743_residues
MTQTPAPFPERPAADRPDYLQRLNPEQRAAIETTDGPLLVLAGAGTGKTRVLTTRFAHILLSGRARPYQILAVTFTNKAA
REMRERIGALLGEPVEGLWLGTFHALCARMLRRHAEYVGLGSGFTILDTDDQLRLLKQVIEPLRIDTKRWPPQGILGVIQ
RWKDRGLTPERVTPAEDCDFAGGQCRPIYATYQARLVQLNACDFGDLMLHVTEILRTRPDVLAQYHRLFRYILVDEYQDT
NTIQYLWLRLLAQREGQPANICCVGDDDQSIYSWRGAEVENILRFERDFPGAAVVRLERNYRSTAQILGAASGLIAHNDG
RLGKTLRPGREDASGEKVRVASVWDSDDEARLVGEEVERLRAGGHSLAEIAILVRAGFQTRAFEERLITLGLPYRVVGGL
RFYERSEIRDAMAYMRVLNQPADDLAFERIINVPRRGIGAAAMQKFHVAAREGQMPLAAAVMDLIARGALKGRAREQMTA
LMACLARGREALPREGHVVVVETLLEESGYIDMWKADTSPEAPGRLDNLKELVRALADFESLGGFLEHVALVMENEENAG
AERLSIMTLHGAKGLEFDTVFLPGWEEGVFPSQRTLDEGGLKGLEEERRLAYVGITRARHRAVISHAASRRIYGNWQSAI
PSRFIEELPAEHVTTTGGAAQARSRTFGHAPLSSTAFPVMARRPRVTDVGEKGPTAAMAVGTRVFHQKFGYGTISSVEGN
RLEVAFEKAGPKRVLDTFVEKIP
>Mature_742_residues
TQTPAPFPERPAADRPDYLQRLNPEQRAAIETTDGPLLVLAGAGTGKTRVLTTRFAHILLSGRARPYQILAVTFTNKAAR
EMRERIGALLGEPVEGLWLGTFHALCARMLRRHAEYVGLGSGFTILDTDDQLRLLKQVIEPLRIDTKRWPPQGILGVIQR
WKDRGLTPERVTPAEDCDFAGGQCRPIYATYQARLVQLNACDFGDLMLHVTEILRTRPDVLAQYHRLFRYILVDEYQDTN
TIQYLWLRLLAQREGQPANICCVGDDDQSIYSWRGAEVENILRFERDFPGAAVVRLERNYRSTAQILGAASGLIAHNDGR
LGKTLRPGREDASGEKVRVASVWDSDDEARLVGEEVERLRAGGHSLAEIAILVRAGFQTRAFEERLITLGLPYRVVGGLR
FYERSEIRDAMAYMRVLNQPADDLAFERIINVPRRGIGAAAMQKFHVAAREGQMPLAAAVMDLIARGALKGRAREQMTAL
MACLARGREALPREGHVVVVETLLEESGYIDMWKADTSPEAPGRLDNLKELVRALADFESLGGFLEHVALVMENEENAGA
ERLSIMTLHGAKGLEFDTVFLPGWEEGVFPSQRTLDEGGLKGLEEERRLAYVGITRARHRAVISHAASRRIYGNWQSAIP
SRFIEELPAEHVTTTGGAAQARSRTFGHAPLSSTAFPVMARRPRVTDVGEKGPTAAMAVGTRVFHQKFGYGTISSVEGNR
LEVAFEKAGPKRVLDTFVEKIP

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=741, Percent_Identity=42.7800269905533, Blast_Score=539, Evalue=1e-154,
Organism=Escherichia coli, GI48994965, Length=651, Percent_Identity=38.5560675883257, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1787196, Length=341, Percent_Identity=29.9120234604106, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6322369, Length=462, Percent_Identity=32.2510822510823, Blast_Score=187, Evalue=5e-48,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 82629; Mature: 82497

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTPAPFPERPAADRPDYLQRLNPEQRAAIETTDGPLLVLAGAGTGKTRVLTTRFAHIL
CCCCCCCCCCCCCCCCCHHHHHCCCHHHCEEEECCCCEEEEEECCCCCCCHHHHHHHHHH
LSGRARPYQILAVTFTNKAAREMRERIGALLGEPVEGLWLGTFHALCARMLRRHAEYVGL
HCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEC
GSGFTILDTDDQLRLLKQVIEPLRIDTKRWPPQGILGVIQRWKDRGLTPERVTPAEDCDF
CCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
AGGQCRPIYATYQARLVQLNACDFGDLMLHVTEILRTRPDVLAQYHRLFRYILVDEYQDT
CCCCCEEEHEEEEEEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
NTIQYLWLRLLAQREGQPANICCVGDDDQSIYSWRGAEVENILRFERDFPGAAVVRLERN
CHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHCCCCCHHHHHHHHCCCCCCEEEEEHHH
YRSTAQILGAASGLIAHNDGRLGKTLRPGREDASGEKVRVASVWDSDDEARLVGEEVERL
HHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHH
RAGGHSLAEIAILVRAGFQTRAFEERLITLGLPYRVVGGLRFYERSEIRDAMAYMRVLNQ
HHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHHHHCC
PADDLAFERIINVPRRGIGAAAMQKFHVAAREGQMPLAAAVMDLIARGALKGRAREQMTA
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
LMACLARGREALPREGHVVVVETLLEESGYIDMWKADTSPEAPGRLDNLKELVRALADFE
HHHHHHCCHHCCCCCCCEEEEEHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
SLGGFLEHVALVMENEENAGAERLSIMTLHGAKGLEFDTVFLPGWEEGVFPSQRTLDEGG
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCHHCCCCCC
LKGLEEERRLAYVGITRARHRAVISHAASRRIYGNWQSAIPSRFIEELPAEHVTTTGGAA
CCCCHHHHHEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHEECCCCHH
QARSRTFGHAPLSSTAFPVMARRPRVTDVGEKGPTAAMAVGTRVFHQKFGYGTISSVEGN
HHHHCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCC
RLEVAFEKAGPKRVLDTFVEKIP
EEEEEEECCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TQTPAPFPERPAADRPDYLQRLNPEQRAAIETTDGPLLVLAGAGTGKTRVLTTRFAHIL
CCCCCCCCCCCCCCCCHHHHHCCCHHHCEEEECCCCEEEEEECCCCCCCHHHHHHHHHH
LSGRARPYQILAVTFTNKAAREMRERIGALLGEPVEGLWLGTFHALCARMLRRHAEYVGL
HCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEC
GSGFTILDTDDQLRLLKQVIEPLRIDTKRWPPQGILGVIQRWKDRGLTPERVTPAEDCDF
CCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
AGGQCRPIYATYQARLVQLNACDFGDLMLHVTEILRTRPDVLAQYHRLFRYILVDEYQDT
CCCCCEEEHEEEEEEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
NTIQYLWLRLLAQREGQPANICCVGDDDQSIYSWRGAEVENILRFERDFPGAAVVRLERN
CHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHCCCCCHHHHHHHHCCCCCCEEEEEHHH
YRSTAQILGAASGLIAHNDGRLGKTLRPGREDASGEKVRVASVWDSDDEARLVGEEVERL
HHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHH
RAGGHSLAEIAILVRAGFQTRAFEERLITLGLPYRVVGGLRFYERSEIRDAMAYMRVLNQ
HHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHHHHCC
PADDLAFERIINVPRRGIGAAAMQKFHVAAREGQMPLAAAVMDLIARGALKGRAREQMTA
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
LMACLARGREALPREGHVVVVETLLEESGYIDMWKADTSPEAPGRLDNLKELVRALADFE
HHHHHHCCHHCCCCCCCEEEEEHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
SLGGFLEHVALVMENEENAGAERLSIMTLHGAKGLEFDTVFLPGWEEGVFPSQRTLDEGG
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCHHCCCCCC
LKGLEEERRLAYVGITRARHRAVISHAASRRIYGNWQSAIPSRFIEELPAEHVTTTGGAA
CCCCHHHHHEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHEECCCCHH
QARSRTFGHAPLSSTAFPVMARRPRVTDVGEKGPTAAMAVGTRVFHQKFGYGTISSVEGN
HHHHCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCC
RLEVAFEKAGPKRVLDTFVEKIP
EEEEEEECCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA