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The map label for this gene is cls1 [H]

Identifier: 162147749

GI number: 162147749

Start: 1998154

End: 1999572

Strand: Direct

Name: cls1 [H]

Synonym: GDI_1965

Alternate gene names: 162147749

Gene position: 1998154-1999572 (Clockwise)

Preceding gene: 162147747

Following gene: 162147752

Centisome position: 50.66

GC content: 64.9

Gene sequence:

>1419_bases
ATGCTGCTGACGTACTGGCATACCGTTCTTCTGCTCGTGTTGCTGTCGCGCGTGGTCGTCGCGCTCAGCGTGGCAGTGCA
TGTCCTGCTGAACAAGCGCGATGTCGGGGCCGCGATCGGCTGGATCGGCATCTCGATTCTGATGCCGTTCACGGGCGGGG
TGCTGTACGCCATGTTCGGCATCAATCGCGTGCATCGCCGCGCGCGCAAGCTGATCGGGCGGTCGTCCTGGCACAGCCGG
ACCCTGTCCTCACGCTGGAAACGCGCCGAGCAGGGCCATTTCGCGCCGCTGTCCAACATGGTCGGCAAGCTGACCGGCCG
CCCGTTGATGAGCGGCAACGGCATTCGCATGCTCCATGACGGGGACCAGGCCTATCCCCAGATGCTCGACGCCATCGGGG
GCGCCACCAGCAGCGTACTGCTGTCGTCCTACATCTTTCGTGGTGACGATGCCGGGGACCGGTTCATCGCCGCCCTGATC
GGCGCCCATCAGCGGGGCATCGCGGTGCGCGTCCTGGTCGACGGGGTCGGCAGCGGCTATTTCCGCTGCCCCGTGACGCA
TGCGCTGCACCGGGCCGGGGTTCCCGTGGGGCGGTTCATGCATTCCCTGCTGCCCTGGCGCATGCCGTTCATCAACATGC
GCAACCACAAGAAGATCCTGGTGGTGGATGGGCAACTTGGCTTCATGGGCGGCCTGAATATCGGTGCGGAAAACGTGGTC
GCCAGCCATCCCGCCCATCCGGTATCGGACACGCATTTCCGGGTCGAAGGCCCGATCGTGCATCAATTGACCGAAGCCTT
CGCCCAGGACTGGTCCTTTACCACGGGCGAGGACCTGCCGGTCGACCCGTTCTTCCCCGAGGTCAGCCAGCATGGAGACA
TCCTGGCCCGGATCGTCACCGCCGGCCCCGATTCCGACCTGGAGAAGATCGAATTCACCATGCTGCAGGCCATCACCATG
GCACGGCATTCGGTCCGGCTGATGACGCCCTATTTCCTGCCGGGCGAGCGGTTCCTGACGGAACTGGCGCTGGCCGCCCT
GCGCGGGATCGAGGTGGATATCGTCATTCCCGGGCGCAGCAACCACACGCTGATCGACTGGGCGCGGTCGGCCAACCTGC
CGCGCTTCCTCGATTCAGGTTGCCGGGTGTGGCGGGCCAGTCCGCCCTTCAACCACTCCAAGCTGATGGTGGTGGACCAG
CACTGGGCCTTCGTCGGCAGTTCCAATCTGGACGTGCGCAGCCTGCGGCTGAATTTCGAGATCAACCTGGAAGCGTACGA
CGACGCGATGGCCGGGCTGATCGACGCGTTCATCATCCGGCATCGGCATGAACGCCTGACGCATCACGACCTGGACCGGC
GCATACTGCCGATACGCCTGCGCGATGCGGGGGCGCGGCTGTTCCTGCCCTATTTGTAG

Upstream 100 bases:

>100_bases
GCGCGTGGGTTCTGCCATCATCCCGTCATCCTCGCGGCTTGACCGCATCGTCATCCTTTCGCACCGTTTTCCCCGTCATA
TCAGGGATCGACATGATGTC

Downstream 100 bases:

>100_bases
CCCGATCGTTCCAGCCTGACCGTGATGGGACAATGGTCGGACGTGTAATTGTCCAGGACGCGGGCCTCGGTGCAGCTCAG
GCCGCGCACCAGGCAGCGGT

Product: cardiolipin synthetase 1

Products: Biphosphatidylglycerol; Glycerol. [C]

Alternate protein names: CL synthase 1 [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MLLTYWHTVLLLVLLSRVVVALSVAVHVLLNKRDVGAAIGWIGISILMPFTGGVLYAMFGINRVHRRARKLIGRSSWHSR
TLSSRWKRAEQGHFAPLSNMVGKLTGRPLMSGNGIRMLHDGDQAYPQMLDAIGGATSSVLLSSYIFRGDDAGDRFIAALI
GAHQRGIAVRVLVDGVGSGYFRCPVTHALHRAGVPVGRFMHSLLPWRMPFINMRNHKKILVVDGQLGFMGGLNIGAENVV
ASHPAHPVSDTHFRVEGPIVHQLTEAFAQDWSFTTGEDLPVDPFFPEVSQHGDILARIVTAGPDSDLEKIEFTMLQAITM
ARHSVRLMTPYFLPGERFLTELALAALRGIEVDIVIPGRSNHTLIDWARSANLPRFLDSGCRVWRASPPFNHSKLMVVDQ
HWAFVGSSNLDVRSLRLNFEINLEAYDDAMAGLIDAFIIRHRHERLTHHDLDRRILPIRLRDAGARLFLPYL

Sequences:

>Translated_472_residues
MLLTYWHTVLLLVLLSRVVVALSVAVHVLLNKRDVGAAIGWIGISILMPFTGGVLYAMFGINRVHRRARKLIGRSSWHSR
TLSSRWKRAEQGHFAPLSNMVGKLTGRPLMSGNGIRMLHDGDQAYPQMLDAIGGATSSVLLSSYIFRGDDAGDRFIAALI
GAHQRGIAVRVLVDGVGSGYFRCPVTHALHRAGVPVGRFMHSLLPWRMPFINMRNHKKILVVDGQLGFMGGLNIGAENVV
ASHPAHPVSDTHFRVEGPIVHQLTEAFAQDWSFTTGEDLPVDPFFPEVSQHGDILARIVTAGPDSDLEKIEFTMLQAITM
ARHSVRLMTPYFLPGERFLTELALAALRGIEVDIVIPGRSNHTLIDWARSANLPRFLDSGCRVWRASPPFNHSKLMVVDQ
HWAFVGSSNLDVRSLRLNFEINLEAYDDAMAGLIDAFIIRHRHERLTHHDLDRRILPIRLRDAGARLFLPYL
>Mature_472_residues
MLLTYWHTVLLLVLLSRVVVALSVAVHVLLNKRDVGAAIGWIGISILMPFTGGVLYAMFGINRVHRRARKLIGRSSWHSR
TLSSRWKRAEQGHFAPLSNMVGKLTGRPLMSGNGIRMLHDGDQAYPQMLDAIGGATSSVLLSSYIFRGDDAGDRFIAALI
GAHQRGIAVRVLVDGVGSGYFRCPVTHALHRAGVPVGRFMHSLLPWRMPFINMRNHKKILVVDGQLGFMGGLNIGAENVV
ASHPAHPVSDTHFRVEGPIVHQLTEAFAQDWSFTTGEDLPVDPFFPEVSQHGDILARIVTAGPDSDLEKIEFTMLQAITM
ARHSVRLMTPYFLPGERFLTELALAALRGIEVDIVIPGRSNHTLIDWARSANLPRFLDSGCRVWRASPPFNHSKLMVVDQ
HWAFVGSSNLDVRSLRLNFEINLEAYDDAMAGLIDAFIIRHRHERLTHHDLDRRILPIRLRDAGARLFLPYL

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=464, Percent_Identity=26.5086206896552, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1787007, Length=350, Percent_Identity=32.2857142857143, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 52651; Mature: 52651

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS50035 PLD ; PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLTYWHTVLLLVLLSRVVVALSVAVHVLLNKRDVGAAIGWIGISILMPFTGGVLYAMFG
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
INRVHRRARKLIGRSSWHSRTLSSRWKRAEQGHFAPLSNMVGKLTGRPLMSGNGIRMLHD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEECCCCEEEEEC
GDQAYPQMLDAIGGATSSVLLSSYIFRGDDAGDRFIAALIGAHQRGIAVRVLVDGVGSGY
CCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCE
FRCPVTHALHRAGVPVGRFMHSLLPWRMPFINMRNHKKILVVDGQLGFMGGLNIGAENVV
EECCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEECCCCCCCCHHH
ASHPAHPVSDTHFRVEGPIVHQLTEAFAQDWSFTTGEDLPVDPFFPEVSQHGDILARIVT
CCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCEEEEEEE
AGPDSDLEKIEFTMLQAITMARHSVRLMTPYFLPGERFLTELALAALRGIEVDIVIPGRS
CCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCC
NHTLIDWARSANLPRFLDSGCRVWRASPPFNHSKLMVVDQHWAFVGSSNLDVRSLRLNFE
CCEEEEEHHCCCCCHHHHCCCEEEECCCCCCCCEEEEEECCEEEECCCCCEEEEEEEEEE
INLEAYDDAMAGLIDAFIIRHRHERLTHHDLDRRILPIRLRDAGARLFLPYL
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEECCC
>Mature Secondary Structure
MLLTYWHTVLLLVLLSRVVVALSVAVHVLLNKRDVGAAIGWIGISILMPFTGGVLYAMFG
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
INRVHRRARKLIGRSSWHSRTLSSRWKRAEQGHFAPLSNMVGKLTGRPLMSGNGIRMLHD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEECCCCEEEEEC
GDQAYPQMLDAIGGATSSVLLSSYIFRGDDAGDRFIAALIGAHQRGIAVRVLVDGVGSGY
CCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCE
FRCPVTHALHRAGVPVGRFMHSLLPWRMPFINMRNHKKILVVDGQLGFMGGLNIGAENVV
EECCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEECCCCCCCCHHH
ASHPAHPVSDTHFRVEGPIVHQLTEAFAQDWSFTTGEDLPVDPFFPEVSQHGDILARIVT
CCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCEEEEEEE
AGPDSDLEKIEFTMLQAITMARHSVRLMTPYFLPGERFLTELALAALRGIEVDIVIPGRS
CCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCC
NHTLIDWARSANLPRFLDSGCRVWRASPPFNHSKLMVVDQHWAFVGSSNLDVRSLRLNFE
CCEEEEEHHCCCCCHHHHCCCEEEECCCCCCCCEEEEEECCEEEECCCCCEEEEEEEEEE
INLEAYDDAMAGLIDAFIIRHRHERLTHHDLDRRILPIRLRDAGARLFLPYL
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Phosphatidylglycerol [C]

Specific reaction: 2 Phosphatidylglycerol = Biphosphatidylglycerol + Glycerol. [C]

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]