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The map label for this gene is purS

Identifier: 162147741

GI number: 162147741

Start: 1992979

End: 1993221

Strand: Direct

Name: purS

Synonym: GDI_1957

Alternate gene names: NA

Gene position: 1992979-1993221 (Clockwise)

Preceding gene: 162147740

Following gene: 162147742

Centisome position: 50.53

GC content: 67.49

Gene sequence:

>243_bases
ATGAAGGTACGCGTGACGGTCATGCTGAAGGACGGCGTGCTGGACCCGCAGGGCAAGGCCGTGGCCCATGCGCTGCATGT
CCTGGGCTTCGGTGGCGTGGGCGAGGTCCGCATCGGCCGCGTGATCGAACTGGAACTGGACGAGACCGATCCCGCCGCCG
CGCGCGAGAAGGCCGATGCCATGGCGCGCGGCCTGCTGGCCAACCTGGTGATCGAGGATTTCGTGACCGAGGTCGTGGCA
TGA

Upstream 100 bases:

>100_bases
ACATGGGCCGCGTCGAGGAAGCGTATCAGGAAGTGGCATGGCGGCTGGGCATCCTGCCCGAGGCCACGAATTCCGACATG
AAGGGACCGGAGGTAATGCA

Downstream 100 bases:

>100_bases
CGGCCCGGCGTTCCGTTTTCCTGCTGGCCGCCGCCCTGGCCGCTGGTAGTGCCGTCGCCAGCCTGCCGTCCAGCGCGATG
GCGCAGCGCGTCTCGACCCT

Product: phosphoribosylformylglycinamidine synthase

Products: ADP; phosphate; 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 80; Mature: 80

Protein sequence:

>80_residues
MKVRVTVMLKDGVLDPQGKAVAHALHVLGFGGVGEVRIGRVIELELDETDPAAAREKADAMARGLLANLVIEDFVTEVVA

Sequences:

>Translated_80_residues
MKVRVTVMLKDGVLDPQGKAVAHALHVLGFGGVGEVRIGRVIELELDETDPAAAREKADAMARGLLANLVIEDFVTEVVA
>Mature_80_residues
MKVRVTVMLKDGVLDPQGKAVAHALHVLGFGGVGEVRIGRVIELELDETDPAAAREKADAMARGLLANLVIEDFVTEVVA

Specific function: Unknown

COG id: COG1828

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPF0062 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003850
- ProDom:   PD010362 [H]

Pfam domain/function: PF02700 PurS [H]

EC number: 6.3.5.3

Molecular weight: Translated: 8493; Mature: 8493

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVRVTVMLKDGVLDPQGKAVAHALHVLGFGGVGEVRIGRVIELELDETDPAAAREKADA
CEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEECEEEEEEECCCCCHHHHHHHHH
MARGLLANLVIEDFVTEVVA
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVRVTVMLKDGVLDPQGKAVAHALHVLGFGGVGEVRIGRVIELELDETDPAAAREKADA
CEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEECEEEEEEECCCCCHHHHHHHHH
MARGLLANLVIEDFVTEVVA
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide; L-glutamine; H2O

Specific reaction: ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]