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The map label for this gene is purC

Identifier: 162147740

GI number: 162147740

Start: 1992218

End: 1992982

Strand: Direct

Name: purC

Synonym: GDI_1956

Alternate gene names: 162147740

Gene position: 1992218-1992982 (Clockwise)

Preceding gene: 162147739

Following gene: 162147741

Centisome position: 50.51

GC content: 62.88

Gene sequence:

>765_bases
ATGGCCCGCCGCCGTCAGCTCTACGAAGGAAAAGCCAAGATCCTCTTCGAGGGTCCGGAACCCGGGACGCTGGTCCAGTA
TTTCAAGGACGACGCGACCGCCGGCAACGGCGCGAAGAAGGGGATCATCACCGGCAAGGGTGTGCTGAACAACCGCATCA
GCGAACATCTGATGCTGCGCCTGCACGACATCGGAATCCCGACCCACTTCATCCGCCGCCTGAACATGCGCGAGCAGTTG
ATCCGCGAAGTGGAGATCATTCCGCTGGAGGTCGTGGTGCGCAACGTCGCCGCCGGCAGCCTGGCCAAGCGGCTGGGCAT
TCCCGAGGGCACGCGCCTGCCGCGCACGATCATCGAATATTACTACAAGAACGACAGCCTGAACGACCCGATGGTCAGCG
AGGAGCACATCACCGCCTTCGGCTGGGCCTGCACGCACGACCTGGACGACATGGTGGCGCTGACCATGCGCACGAACGAC
TTCCTGTCGGGCCTGTTCGTCGGCATCGGCATCACGCTGGTCGATTTCAAGCTGGAATTCGGCCGGCTGTGGGAAGGCGA
GGACATGCGCATCGTCCTGGCCGACGAGATTTCGCCCGACAATTGCCGCCTGTGGGACGCCAAGACCAGCGAGAAGCTGG
ACAAGGACCGGTTCCGCCGCGACATGGGCCGCGTCGAGGAAGCGTATCAGGAAGTGGCATGGCGGCTGGGCATCCTGCCC
GAGGCCACGAATTCCGACATGAAGGGACCGGAGGTAATGCAATGA

Upstream 100 bases:

>100_bases
CAATCGTTGCTATGAGGCTGTCGCATTACAGGGACCTTATGGGGCCCCTCATCGGGAGGCATGCCCGCGCAGGCCTCCAC
CAGCCGTATGAAGGACGAGT

Downstream 100 bases:

>100_bases
AGGTACGCGTGACGGTCATGCTGAAGGACGGCGTGCTGGACCCGCAGGGCAAGGCCGTGGCCCATGCGCTGCATGTCCTG
GGCTTCGGTGGCGTGGGCGA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MARRRQLYEGKAKILFEGPEPGTLVQYFKDDATAGNGAKKGIITGKGVLNNRISEHLMLRLHDIGIPTHFIRRLNMREQL
IREVEIIPLEVVVRNVAAGSLAKRLGIPEGTRLPRTIIEYYYKNDSLNDPMVSEEHITAFGWACTHDLDDMVALTMRTND
FLSGLFVGIGITLVDFKLEFGRLWEGEDMRIVLADEISPDNCRLWDAKTSEKLDKDRFRRDMGRVEEAYQEVAWRLGILP
EATNSDMKGPEVMQ

Sequences:

>Translated_254_residues
MARRRQLYEGKAKILFEGPEPGTLVQYFKDDATAGNGAKKGIITGKGVLNNRISEHLMLRLHDIGIPTHFIRRLNMREQL
IREVEIIPLEVVVRNVAAGSLAKRLGIPEGTRLPRTIIEYYYKNDSLNDPMVSEEHITAFGWACTHDLDDMVALTMRTND
FLSGLFVGIGITLVDFKLEFGRLWEGEDMRIVLADEISPDNCRLWDAKTSEKLDKDRFRRDMGRVEEAYQEVAWRLGILP
EATNSDMKGPEVMQ
>Mature_253_residues
ARRRQLYEGKAKILFEGPEPGTLVQYFKDDATAGNGAKKGIITGKGVLNNRISEHLMLRLHDIGIPTHFIRRLNMREQLI
REVEIIPLEVVVRNVAAGSLAKRLGIPEGTRLPRTIIEYYYKNDSLNDPMVSEEHITAFGWACTHDLDDMVALTMRTNDF
LSGLFVGIGITLVDFKLEFGRLWEGEDMRIVLADEISPDNCRLWDAKTSEKLDKDRFRRDMGRVEEAYQEVAWRLGILPE
ATNSDMKGPEVMQ

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=224, Percent_Identity=35.2678571428571, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI5453539, Length=224, Percent_Identity=35.2678571428571, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI119220559, Length=231, Percent_Identity=33.7662337662338, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1788820, Length=238, Percent_Identity=46.6386554621849, Blast_Score=217, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17531275, Length=231, Percent_Identity=32.9004329004329, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI18860083, Length=229, Percent_Identity=31.0043668122271, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24583917, Length=209, Percent_Identity=30.622009569378, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_GLUDA (A9HJF3)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001602201.1
- RefSeq:   YP_002274594.1
- ProteinModelPortal:   A9HJF3
- SMR:   A9HJF3
- GeneID:   5789308
- GeneID:   6973573
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_0181
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 28964; Mature: 28833

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRRQLYEGKAKILFEGPEPGTLVQYFKDDATAGNGAKKGIITGKGVLNNRISEHLMLR
CCCCHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHH
LHDIGIPTHFIRRLNMREQLIREVEIIPLEVVVRNVAAGSLAKRLGIPEGTRLPRTIIEY
HHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
YYKNDSLNDPMVSEEHITAFGWACTHDLDDMVALTMRTNDFLSGLFVGIGITLVDFKLEF
HHCCCCCCCCCCCCCCCEEECEEHHCCHHHHEEEEECCHHHHHHHHHHHCEEEEEEEECC
GRLWEGEDMRIVLADEISPDNCRLWDAKTSEKLDKDRFRRDMGRVEEAYQEVAWRLGILP
CCCCCCCCCEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EATNSDMKGPEVMQ
CCCCCCCCCCCCCC
>Mature Secondary Structure 
ARRRQLYEGKAKILFEGPEPGTLVQYFKDDATAGNGAKKGIITGKGVLNNRISEHLMLR
CCCHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHH
LHDIGIPTHFIRRLNMREQLIREVEIIPLEVVVRNVAAGSLAKRLGIPEGTRLPRTIIEY
HHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
YYKNDSLNDPMVSEEHITAFGWACTHDLDDMVALTMRTNDFLSGLFVGIGITLVDFKLEF
HHCCCCCCCCCCCCCCCEEECEEHHCCHHHHEEEEECCHHHHHHHHHHHCEEEEEEEECC
GRLWEGEDMRIVLADEISPDNCRLWDAKTSEKLDKDRFRRDMGRVEEAYQEVAWRLGILP
CCCCCCCCCEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EATNSDMKGPEVMQ
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA