Click here to switch to the map view.

The map label for this gene is cobT [H]

Identifier: 162147676

GI number: 162147676

Start: 1928759

End: 1930660

Strand: Reverse

Name: cobT [H]

Synonym: GDI_1892

Alternate gene names: 162147676

Gene position: 1930660-1928759 (Counterclockwise)

Preceding gene: 162147677

Following gene: 162147674

Centisome position: 48.95

GC content: 69.4

Gene sequence:

>1902_bases
ATGCGCGACCGCAAGGACACCACCCAGTCCGCACGATTGGCCGCCGCCGAGCGGGCCGACGTCTTCAAGCGCGCGACCGT
TGGCGCGCTGCGCGCGCTGGGCGGCCGGGCGACGGCCGAGGTCACGTTCCAGACCGGCCCGATTCCGCCTGCGGCGGCGG
TCAGCGGCGATCACGTCCGCCTGCCGCAGCCCGCCCTGCAACTGGCCGAGGCCGATATCCGGCGCGTGCGCGGCGCGGCG
GATGCCGTGGCGCTGCAACTGCGCCATCATGACGTGACGATCCACAACGCGACCCGGCCGGAGCAGGCCGATGCCCGGCT
GGCCTATGACGCGCTGGAACAGGCGCGGGTCGAAAGCTTCGGCGCGCGCCACATGGCGGGAGTCGCCGCCAATCTGCGGA
ATCAGGCCGAGCGGGACTATCACGACAGGGGTTATGACCGGGCGCAGGCGCGCGACCAGATTCCCGTGCAGGTTGCGCTG
TCGCTGCTGGCGCGCGAACGCATGACGGGCGAGCCCGTGCCCGAGAGCATGCGCGCGATGGCCGAACAGTGGCGTGCGCA
TCTGGGCCCCTCGGCACTGCGCGCGCTGGACGACATGGCCGCCCATCAGGACGACCAGATGGCGTTTTCGCGTGCCGCGA
AGCGGCTGCTGGTCGCCTGCGAACTGATCGAGGGCGAGGCCGAGATCGAGGAGGACGAGGACGGCGACGACAGCGCCCCC
TCGGACGAGACCGAGGAAGAACCGGGCGAAGCGCCCGAGAAGCCGCAGCCGCAGGACGAGGACGCCAGCGGCCAGCAGGA
AGACGAGACCGGCCTGCAGCCCCAGTTGGCGCAAGGTGCGGGAGCCGGCGACGACAACCCCGACGAGTCCGAACCCGGCG
GTACAGCGGGGTCCGAGGAAGCGGGCGGCCCACGCGGCACGGACGATCAGGAAGCGACCGATCCGGCGTCCCTGTATCAT
GCCTTCACCACCGCGTTCGACGAGGAAATCGCGGCCGAGGATCTGTGCGACGCCGACGAACTGGCCCGCCTGCGCCAGCA
GTTGGACCACCAGTTGCTCAGCCTGCAGGGCGTGGTGTCGCGCCTGGCCAACCGGCTGCAACGACGCCTGCTGGCACAGC
AGACGCGGGCGTGGGAGTTCGACCTGGAGGAAGGCATCCTGGATGCCGGCCGGCTGTCGCGGGTGGTGGTCAACCCGACG
CTGTCGCTGTCCTACAAGCACGAACGCGACACCGATTTCCGCGACACGGTCGTGACCCTGCTGATCGACAATTCCGGATC
GATGCGCGGCCGGCCGATTTCGGTGGCCGCGATGTGCGGCGACATCCTGGCCCGCACGCTGGAACGCTGCGCGGTGAAGG
TCGAGGTCCTGGGCTTCACCACCCGGGCCTGGAAGGGCGGGCAGAGCCGCGAGCGCTGGGTGGCGCAGGGCAAGCCGGCC
AATCCGGGGCGGCTGAACGATCTGCGGCACATCATCTACAAATCGGCGGACATGCCGTGGCGCCGGGCGCGGAAGAATCT
GGGCCTGATGCTGCGCGAGGGGCTGCTGAAGGAAAATATCGACGGCGAGGCCCTGCTGTGGGCCTGGCGGCGCCTGCAGG
GCCGGCCGGAAAGCCGGAAGATCCTGATGGTGATCTCGGACGGCGCGCCGGTGGATGACAGCACGCTGTCGGTCAATGCC
GGGTCGTATCTGGAAACGCACCTGCGGCAGGTGATCGCCCAGATCGAAAACCGCAGCGGCGTCGAACTGGTGGCCATCGG
GATCGGCCATGACGTGACGCGCTATTACCGCCGCGCGGTCACGATCTCCGACGCCGAGGAACTGGGCGGCACGATGATGC
AGAAGCTCTCCGAACTTTTCGATGAAAAGGTCGCTGTCGCGGGTCGCCGCCGAATCGCCTGA

Upstream 100 bases:

>100_bases
GAGGCCGAGCGTCGACGGTGGCGGAATATTACCAGCGCTGCTTCAACGTTCTGACCCCACCGGCACGGCGCCGCGCGCGC
GCTGATCGGCCCGGGAAGCC

Downstream 100 bases:

>100_bases
AACAATAGGGTTTCCAAAGGGCTAGGCCCTTTGGCCGAGCCCTTGCCTTTCCTGGGCCAGCCGCAGCACCGCATCGACCA
TAAGGTCGACATCCGCCGCC

Product: cobalamin biosynthesis protein cobT

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobT [H]

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MRDRKDTTQSARLAAAERADVFKRATVGALRALGGRATAEVTFQTGPIPPAAAVSGDHVRLPQPALQLAEADIRRVRGAA
DAVALQLRHHDVTIHNATRPEQADARLAYDALEQARVESFGARHMAGVAANLRNQAERDYHDRGYDRAQARDQIPVQVAL
SLLARERMTGEPVPESMRAMAEQWRAHLGPSALRALDDMAAHQDDQMAFSRAAKRLLVACELIEGEAEIEEDEDGDDSAP
SDETEEEPGEAPEKPQPQDEDASGQQEDETGLQPQLAQGAGAGDDNPDESEPGGTAGSEEAGGPRGTDDQEATDPASLYH
AFTTAFDEEIAAEDLCDADELARLRQQLDHQLLSLQGVVSRLANRLQRRLLAQQTRAWEFDLEEGILDAGRLSRVVVNPT
LSLSYKHERDTDFRDTVVTLLIDNSGSMRGRPISVAAMCGDILARTLERCAVKVEVLGFTTRAWKGGQSRERWVAQGKPA
NPGRLNDLRHIIYKSADMPWRRARKNLGLMLREGLLKENIDGEALLWAWRRLQGRPESRKILMVISDGAPVDDSTLSVNA
GSYLETHLRQVIAQIENRSGVELVAIGIGHDVTRYYRRAVTISDAEELGGTMMQKLSELFDEKVAVAGRRRIA

Sequences:

>Translated_633_residues
MRDRKDTTQSARLAAAERADVFKRATVGALRALGGRATAEVTFQTGPIPPAAAVSGDHVRLPQPALQLAEADIRRVRGAA
DAVALQLRHHDVTIHNATRPEQADARLAYDALEQARVESFGARHMAGVAANLRNQAERDYHDRGYDRAQARDQIPVQVAL
SLLARERMTGEPVPESMRAMAEQWRAHLGPSALRALDDMAAHQDDQMAFSRAAKRLLVACELIEGEAEIEEDEDGDDSAP
SDETEEEPGEAPEKPQPQDEDASGQQEDETGLQPQLAQGAGAGDDNPDESEPGGTAGSEEAGGPRGTDDQEATDPASLYH
AFTTAFDEEIAAEDLCDADELARLRQQLDHQLLSLQGVVSRLANRLQRRLLAQQTRAWEFDLEEGILDAGRLSRVVVNPT
LSLSYKHERDTDFRDTVVTLLIDNSGSMRGRPISVAAMCGDILARTLERCAVKVEVLGFTTRAWKGGQSRERWVAQGKPA
NPGRLNDLRHIIYKSADMPWRRARKNLGLMLREGLLKENIDGEALLWAWRRLQGRPESRKILMVISDGAPVDDSTLSVNA
GSYLETHLRQVIAQIENRSGVELVAIGIGHDVTRYYRRAVTISDAEELGGTMMQKLSELFDEKVAVAGRRRIA
>Mature_633_residues
MRDRKDTTQSARLAAAERADVFKRATVGALRALGGRATAEVTFQTGPIPPAAAVSGDHVRLPQPALQLAEADIRRVRGAA
DAVALQLRHHDVTIHNATRPEQADARLAYDALEQARVESFGARHMAGVAANLRNQAERDYHDRGYDRAQARDQIPVQVAL
SLLARERMTGEPVPESMRAMAEQWRAHLGPSALRALDDMAAHQDDQMAFSRAAKRLLVACELIEGEAEIEEDEDGDDSAP
SDETEEEPGEAPEKPQPQDEDASGQQEDETGLQPQLAQGAGAGDDNPDESEPGGTAGSEEAGGPRGTDDQEATDPASLYH
AFTTAFDEEIAAEDLCDADELARLRQQLDHQLLSLQGVVSRLANRLQRRLLAQQTRAWEFDLEEGILDAGRLSRVVVNPT
LSLSYKHERDTDFRDTVVTLLIDNSGSMRGRPISVAAMCGDILARTLERCAVKVEVLGFTTRAWKGGQSRERWVAQGKPA
NPGRLNDLRHIIYKSADMPWRRARKNLGLMLREGLLKENIDGEALLWAWRRLQGRPESRKILMVISDGAPVDDSTLSVNA
GSYLETHLRQVIAQIENRSGVELVAIGIGHDVTRYYRRAVTISDAEELGGTMMQKLSELFDEKVAVAGRRRIA

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG4547

COG function: function code H; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 VWFA domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006538
- InterPro:   IPR002035 [H]

Pfam domain/function: PF06213 CobT [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 69553; Mature: 69553

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50234 VWFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDRKDTTQSARLAAAERADVFKRATVGALRALGGRATAEVTFQTGPIPPAAAVSGDHVR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCC
LPQPALQLAEADIRRVRGAADAVALQLRHHDVTIHNATRPEQADARLAYDALEQARVESF
CCHHHHHHHHHHHHHHHCHHHHHHHEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
GARHMAGVAANLRNQAERDYHDRGYDRAQARDQIPVQVALSLLARERMTGEPVPESMRAM
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHH
AEQWRAHLGPSALRALDDMAAHQDDQMAFSRAAKRLLVACELIEGEAEIEEDEDGDDSAP
HHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
SDETEEEPGEAPEKPQPQDEDASGQQEDETGLQPQLAQGAGAGDDNPDESEPGGTAGSEE
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCC
AGGPRGTDDQEATDPASLYHAFTTAFDEEIAAEDLCDADELARLRQQLDHQLLSLQGVVS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RLANRLQRRLLAQQTRAWEFDLEEGILDAGRLSRVVVNPTLSLSYKHERDTDFRDTVVTL
HHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHCEEEECCCEEEEECCCCCCCHHHEEEEE
LIDNSGSMRGRPISVAAMCGDILARTLERCAVKVEVLGFTTRAWKGGQSRERWVAQGKPA
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEHEEEEEHHHCCCCCCHHHHHHCCCCC
NPGRLNDLRHIIYKSADMPWRRARKNLGLMLREGLLKENIDGEALLWAWRRLQGRPESRK
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCE
ILMVISDGAPVDDSTLSVNAGSYLETHLRQVIAQIENRSGVELVAIGIGHDVTRYYRRAV
EEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHC
TISDAEELGGTMMQKLSELFDEKVAVAGRRRIA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRDRKDTTQSARLAAAERADVFKRATVGALRALGGRATAEVTFQTGPIPPAAAVSGDHVR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCC
LPQPALQLAEADIRRVRGAADAVALQLRHHDVTIHNATRPEQADARLAYDALEQARVESF
CCHHHHHHHHHHHHHHHCHHHHHHHEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
GARHMAGVAANLRNQAERDYHDRGYDRAQARDQIPVQVALSLLARERMTGEPVPESMRAM
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHH
AEQWRAHLGPSALRALDDMAAHQDDQMAFSRAAKRLLVACELIEGEAEIEEDEDGDDSAP
HHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
SDETEEEPGEAPEKPQPQDEDASGQQEDETGLQPQLAQGAGAGDDNPDESEPGGTAGSEE
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCC
AGGPRGTDDQEATDPASLYHAFTTAFDEEIAAEDLCDADELARLRQQLDHQLLSLQGVVS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RLANRLQRRLLAQQTRAWEFDLEEGILDAGRLSRVVVNPTLSLSYKHERDTDFRDTVVTL
HHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHCEEEECCCEEEEECCCCCCCHHHEEEEE
LIDNSGSMRGRPISVAAMCGDILARTLERCAVKVEVLGFTTRAWKGGQSRERWVAQGKPA
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEHEEEEEHHHCCCCCCHHHHHHCCCCC
NPGRLNDLRHIIYKSADMPWRRARKNLGLMLREGLLKENIDGEALLWAWRRLQGRPESRK
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCE
ILMVISDGAPVDDSTLSVNAGSYLETHLRQVIAQIENRSGVELVAIGIGHDVTRYYRRAV
EEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHC
TISDAEELGGTMMQKLSELFDEKVAVAGRRRIA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]