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The map label for this gene is serA [H]

Identifier: 162147658

GI number: 162147658

Start: 1909177

End: 1910442

Strand: Reverse

Name: serA [H]

Synonym: GDI_1874

Alternate gene names: 162147658

Gene position: 1910442-1909177 (Counterclockwise)

Preceding gene: 162147659

Following gene: 162147655

Centisome position: 48.44

GC content: 64.3

Gene sequence:

>1266_bases
ATGAGCAGCGAGACCACCAGCCACCTGTCCCTTCCCAAGGACAAGATCCGCATTCTGCTGCTTGAAGGCATTCATGACAG
CGCCGTGGCGCTGCTGAAGGCCAATGGGTACGAAAACGTCACGCGCCTGTCCAAGGCGCTGGAGGGCGCGGCCCTGCGCA
AGGCGCTGGAAGGTGTTCACATCGTGGGAATCCGCTCCCGCACCCAGTTGACCGAGGACATGATCGCCGCCGCCGATCGC
CTGATCGCCGTGGGGTGCTTCTGCATCGGGACCAACCAGGTCAACCTGCCCGCCGCGCGCGCCCATGGCATTCCGGTCTT
CAACGCCCCGTTCAGCAACACCCGCTCGGTCGCCGAACTGGTGATGGGCGAGATCGTGATGCTGATGCGGCGGATCTTCC
CCAAATCCGTGCAGTGTCATGCCGGCGACTGGAACAAATCGGCCGCCAATAGCTGGGAAGTCCGCGGCAAGACGCTGGGT
ATCGTGGGCTACGGCTCCATCGGCTCGCAATTGTCCGTCCTGGCCGAGGCGTTCGGCATGCGGGTGATCTATTTCGACGT
GATCGACAAGCTGGTGCACGGCAACGCCAGCCCGGTGGAAACGCTGAACGACCTGCTGGCGCAGAGCGACGTGGTCAGCC
TGCATGTCCCGCAATTGGCCAGCACCGCGAACCTGATCGGCGCGGAGCAGATCCGCGCGATGAAGCCCGGTTCGTTCCTG
ATCAACAATGCCCGGGGCAATGTCGTGGACCTGGAGGCGCTGGCGGCGGCCCTGCGCGACGGCCATCTGCTGGGTGCCGC
GATCGACGTATTCCCCGTCGAACCCAAGGGCGCCGGGGACAAGTTCGTCTCGCCGCTGCAGGGCCTGGAAAACGTGATCC
TGAGCCCGCATATCGGCGGCTCCACCGCCGAGGCGCAGGAGCGGATCGGCGTCGAGGTGGCGCGCAAGCTGATCGAATAT
TCCGATGTGGGCTCGACCCTCGGCGCGGTCAATTTCCCGACGGTGCAACTGCCCGAAAGCCCGCGCGGCACGCGCTTCAT
GCACGTCCACAGCAATGTTCCCGGCATCATGCTGCAGATCAACGAGATCTTCATGAGCGAGAACAGCAACATCACCGCCC
AGTACCTGCAGACCGACGGCGAGCTGGGCTATGTGGTGGTCGAGGCCGATACCGGCCGGGATATCGACAAGGACAATCGC
ATCCTCGCCCGGTTGCGCAACCTAAAGGGCACGATCCGCGCCCGGCTGCTGTACCAGCAGCCCTGA

Upstream 100 bases:

>100_bases
CGGCCGCACCACATGGCACCGATGTCCACGTCGCCCCTAGGCATTTATCCGTCGATCGGATAGGAGCGACATCTTCTTCG
AATAGGCGCGAGTATTCGAC

Downstream 100 bases:

>100_bases
CGCAAGCCCCCCCTAAGTCCGCCGCCCTGATTCAGCAGCCCTGGTCCGGGCGGCCCCGCCGCTTCAGGACCCGGCGGAAA
TGCAGGCCCACCGCGTGGCG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSSETTSHLSLPKDKIRILLLEGIHDSAVALLKANGYENVTRLSKALEGAALRKALEGVHIVGIRSRTQLTEDMIAAADR
LIAVGCFCIGTNQVNLPAARAHGIPVFNAPFSNTRSVAELVMGEIVMLMRRIFPKSVQCHAGDWNKSAANSWEVRGKTLG
IVGYGSIGSQLSVLAEAFGMRVIYFDVIDKLVHGNASPVETLNDLLAQSDVVSLHVPQLASTANLIGAEQIRAMKPGSFL
INNARGNVVDLEALAAALRDGHLLGAAIDVFPVEPKGAGDKFVSPLQGLENVILSPHIGGSTAEAQERIGVEVARKLIEY
SDVGSTLGAVNFPTVQLPESPRGTRFMHVHSNVPGIMLQINEIFMSENSNITAQYLQTDGELGYVVVEADTGRDIDKDNR
ILARLRNLKGTIRARLLYQQP

Sequences:

>Translated_421_residues
MSSETTSHLSLPKDKIRILLLEGIHDSAVALLKANGYENVTRLSKALEGAALRKALEGVHIVGIRSRTQLTEDMIAAADR
LIAVGCFCIGTNQVNLPAARAHGIPVFNAPFSNTRSVAELVMGEIVMLMRRIFPKSVQCHAGDWNKSAANSWEVRGKTLG
IVGYGSIGSQLSVLAEAFGMRVIYFDVIDKLVHGNASPVETLNDLLAQSDVVSLHVPQLASTANLIGAEQIRAMKPGSFL
INNARGNVVDLEALAAALRDGHLLGAAIDVFPVEPKGAGDKFVSPLQGLENVILSPHIGGSTAEAQERIGVEVARKLIEY
SDVGSTLGAVNFPTVQLPESPRGTRFMHVHSNVPGIMLQINEIFMSENSNITAQYLQTDGELGYVVVEADTGRDIDKDNR
ILARLRNLKGTIRARLLYQQP
>Mature_420_residues
SSETTSHLSLPKDKIRILLLEGIHDSAVALLKANGYENVTRLSKALEGAALRKALEGVHIVGIRSRTQLTEDMIAAADRL
IAVGCFCIGTNQVNLPAARAHGIPVFNAPFSNTRSVAELVMGEIVMLMRRIFPKSVQCHAGDWNKSAANSWEVRGKTLGI
VGYGSIGSQLSVLAEAFGMRVIYFDVIDKLVHGNASPVETLNDLLAQSDVVSLHVPQLASTANLIGAEQIRAMKPGSFLI
NNARGNVVDLEALAAALRDGHLLGAAIDVFPVEPKGAGDKFVSPLQGLENVILSPHIGGSTAEAQERIGVEVARKLIEYS
DVGSTLGAVNFPTVQLPESPRGTRFMHVHSNVPGIMLQINEIFMSENSNITAQYLQTDGELGYVVVEADTGRDIDKDNRI
LARLRNLKGTIRARLLYQQP

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=34.384858044164, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI145580578, Length=242, Percent_Identity=34.297520661157, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI4557499, Length=242, Percent_Identity=34.297520661157, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI61743967, Length=238, Percent_Identity=32.3529411764706, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4557497, Length=238, Percent_Identity=32.3529411764706, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI145580575, Length=244, Percent_Identity=34.0163934426229, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI6912396, Length=254, Percent_Identity=25.9842519685039, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789279, Length=412, Percent_Identity=55.8252427184466, Blast_Score=460, Evalue=1e-131,
Organism=Escherichia coli, GI87082289, Length=249, Percent_Identity=33.7349397590361, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787645, Length=233, Percent_Identity=28.755364806867, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788660, Length=254, Percent_Identity=28.740157480315, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=318, Percent_Identity=35.5345911949685, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI25147481, Length=243, Percent_Identity=28.8065843621399, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320925, Length=416, Percent_Identity=44.4711538461538, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6322116, Length=416, Percent_Identity=44.4711538461538, Blast_Score=357, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6324964, Length=317, Percent_Identity=28.7066246056782, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=266, Percent_Identity=27.0676691729323, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324980, Length=193, Percent_Identity=28.4974093264249, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921140, Length=311, Percent_Identity=31.8327974276527, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24646446, Length=245, Percent_Identity=36.3265306122449, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24646448, Length=245, Percent_Identity=36.3265306122449, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24646452, Length=245, Percent_Identity=36.3265306122449, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24646450, Length=245, Percent_Identity=36.3265306122449, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI62472511, Length=245, Percent_Identity=36.3265306122449, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28574286, Length=259, Percent_Identity=28.1853281853282, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28571528, Length=255, Percent_Identity=29.8039215686275, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45552429, Length=246, Percent_Identity=28.0487804878049, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45551003, Length=246, Percent_Identity=28.0487804878049, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585514, Length=242, Percent_Identity=28.5123966942149, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574282, Length=242, Percent_Identity=28.5123966942149, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574284, Length=246, Percent_Identity=28.0487804878049, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24585516, Length=298, Percent_Identity=24.1610738255034, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 45349; Mature: 45218

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSETTSHLSLPKDKIRILLLEGIHDSAVALLKANGYENVTRLSKALEGAALRKALEGVH
CCCCCCCCCCCCHHHEEEEEEECCCCHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCEE
IVGIRSRTQLTEDMIAAADRLIAVGCFCIGTNQVNLPAARAHGIPVFNAPFSNTRSVAEL
EEEECCHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCHHHHCCCEEECCCCCCHHHHHHH
VMGEIVMLMRRIFPKSVQCHAGDWNKSAANSWEVRGKTLGIVGYGSIGSQLSVLAEAFGM
HHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEECCEEEEEEEECCCCHHHHHHHHHHCC
RVIYFDVIDKLVHGNASPVETLNDLLAQSDVVSLHVPQLASTANLIGAEQIRAMKPGSFL
EEEHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHCHHHHHHCCCCCEE
INNARGNVVDLEALAAALRDGHLLGAAIDVFPVEPKGAGDKFVSPLQGLENVILSPHIGG
EECCCCCEEEHHHHHHHHHCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHEECCCCCC
STAEAQERIGVEVARKLIEYSDVGSTLGAVNFPTVQLPESPRGTRFMHVHSNVPGIMLQI
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEEEEECCCCEEEEEE
NEIFMSENSNITAQYLQTDGELGYVVVEADTGRDIDKDNRILARLRNLKGTIRARLLYQQ
EEHHCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCEEEEEEEECC
P
C
>Mature Secondary Structure 
SSETTSHLSLPKDKIRILLLEGIHDSAVALLKANGYENVTRLSKALEGAALRKALEGVH
CCCCCCCCCCCHHHEEEEEEECCCCHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCEE
IVGIRSRTQLTEDMIAAADRLIAVGCFCIGTNQVNLPAARAHGIPVFNAPFSNTRSVAEL
EEEECCHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCHHHHCCCEEECCCCCCHHHHHHH
VMGEIVMLMRRIFPKSVQCHAGDWNKSAANSWEVRGKTLGIVGYGSIGSQLSVLAEAFGM
HHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEECCEEEEEEEECCCCHHHHHHHHHHCC
RVIYFDVIDKLVHGNASPVETLNDLLAQSDVVSLHVPQLASTANLIGAEQIRAMKPGSFL
EEEHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHCHHHHHHCCCCCEE
INNARGNVVDLEALAAALRDGHLLGAAIDVFPVEPKGAGDKFVSPLQGLENVILSPHIGG
EECCCCCEEEHHHHHHHHHCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHEECCCCCC
STAEAQERIGVEVARKLIEYSDVGSTLGAVNFPTVQLPESPRGTRFMHVHSNVPGIMLQI
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEEEEECCCCEEEEEE
NEIFMSENSNITAQYLQTDGELGYVVVEADTGRDIDKDNRILARLRNLKGTIRARLLYQQ
EEHHCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCEEEEEEEECC
P
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]