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The map label for this gene is ppx [H]

Identifier: 162147650

GI number: 162147650

Start: 1903488

End: 1904621

Strand: Reverse

Name: ppx [H]

Synonym: GDI_1866

Alternate gene names: 162147650

Gene position: 1904621-1903488 (Counterclockwise)

Preceding gene: 162147651

Following gene: 162147649

Centisome position: 48.29

GC content: 68.34

Gene sequence:

>1134_bases
ATGGACAACACTATGTCCTGGCGCGATGGCCAGGAGGGACCACGACTCCCCCATGCCACGGGGTACAAGGCGAATCAGGG
CGTGCCCGGCATGTACGGCGCCATCGACCTCGGAACCAACAATTGCCGGCTGATGATTGCCGCCCCCCACGAGGGCGGGT
TTCGCGTCGTCGACAGCTTCAACCGCGTCGTCCGCCTGGGCGAGGGCCTGCAAAGCACCGGGCAACTCAGCGGCGATGCC
ATGGACCGCACGATCGAGGCCCTGCGCATCTGCGCCGCGCGGATGGGCCGCCGCCGGCTGCGCCGCTATCGCGCCGTGGC
GACCGAGGCCTGCCGCCGCGCGGGTAACGGCGCCGCGTTCATCGCCCGTGCGCGCCGGGAAACCGGGCTGGACATCACCG
TCATCTCGCCGCGCGAGGAAGCCGAACTGGTGATGGAAAGCTGCGGGGCGCTGCTGCATGACGACCGGCTGTCGCCTGCC
CGCACCCGCGCCATGCTGTTCGATATCGGCGGTGGCTCGACCGAAATCGCCTGGGTCCGCACGGACCACCGATCGCGCCG
GCAGGACCTGAACGGCTATCTCAGCCTGCCCGCCGGCGTGATTACGCTGGCCGAACAGTTCGGCGACGCCGCCTTTTCCG
AGGACGGCTACCAGCGGATGGTCGACCTGGTCACGCGCCAGTTGCACGCGTTCGAACGCGTGCATTGCATCGGGCGTGAA
ATCAGCCGGGGCAATGTCAGCCTGATGGGGACCAGCGGCACCGTCACCACGCTGGCCAGCATCGCCCTGTCGCTGACCCG
CTACAGCCGCACGGCGGTGGACGGCACCATCCTGCAATCCGGCCCGGCCCTGGGGGCCATCCGGACCCTGGCCGCCATGG
GGCCCATGGGCCTGCGCCAGCATCCTTGCGTCGGTCCGGACCGGGCGGCCTATGTCCTGCCCGGATGCGCGATCTTTGAG
GCGATTCATAAAATCTGGCCGGTATCCGATATCGTCGTGGCGGACCGCGGCCTGCGCGATGGTATGCTGCTGCGCATGAT
GCACGATTCGACCGCGATGGCTCTTCCCTCGCTGCCTTCCTCCCTTCCCTTCGCCCCGTCCTCGCTATCCTCGGTGGGCG
TGTCGCATCCATGA

Upstream 100 bases:

>100_bases
GCGCCTTTATGCCGAACTTTGTCTCCTCGGGCATATTTGTCTTGCCCTGCACGCGGCTGAGAACCCACTATATGCCTATT
CAGCGGCAAAGGACCGTCCG

Downstream 100 bases:

>100_bases
AGCGTCGCCCCCCCGCCGGTGGCGGCAAGAAGCGGGTTCCCGGCAAGGCACTGACCAGCAGCACGACCCCTGGCGGCGCC
AGCGCCCAGGCGGATTCCGG

Product: exopolyphosphatase protein

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MDNTMSWRDGQEGPRLPHATGYKANQGVPGMYGAIDLGTNNCRLMIAAPHEGGFRVVDSFNRVVRLGEGLQSTGQLSGDA
MDRTIEALRICAARMGRRRLRRYRAVATEACRRAGNGAAFIARARRETGLDITVISPREEAELVMESCGALLHDDRLSPA
RTRAMLFDIGGGSTEIAWVRTDHRSRRQDLNGYLSLPAGVITLAEQFGDAAFSEDGYQRMVDLVTRQLHAFERVHCIGRE
ISRGNVSLMGTSGTVTTLASIALSLTRYSRTAVDGTILQSGPALGAIRTLAAMGPMGLRQHPCVGPDRAAYVLPGCAIFE
AIHKIWPVSDIVVADRGLRDGMLLRMMHDSTAMALPSLPSSLPFAPSSLSSVGVSHP

Sequences:

>Translated_377_residues
MDNTMSWRDGQEGPRLPHATGYKANQGVPGMYGAIDLGTNNCRLMIAAPHEGGFRVVDSFNRVVRLGEGLQSTGQLSGDA
MDRTIEALRICAARMGRRRLRRYRAVATEACRRAGNGAAFIARARRETGLDITVISPREEAELVMESCGALLHDDRLSPA
RTRAMLFDIGGGSTEIAWVRTDHRSRRQDLNGYLSLPAGVITLAEQFGDAAFSEDGYQRMVDLVTRQLHAFERVHCIGRE
ISRGNVSLMGTSGTVTTLASIALSLTRYSRTAVDGTILQSGPALGAIRTLAAMGPMGLRQHPCVGPDRAAYVLPGCAIFE
AIHKIWPVSDIVVADRGLRDGMLLRMMHDSTAMALPSLPSSLPFAPSSLSSVGVSHP
>Mature_377_residues
MDNTMSWRDGQEGPRLPHATGYKANQGVPGMYGAIDLGTNNCRLMIAAPHEGGFRVVDSFNRVVRLGEGLQSTGQLSGDA
MDRTIEALRICAARMGRRRLRRYRAVATEACRRAGNGAAFIARARRETGLDITVISPREEAELVMESCGALLHDDRLSPA
RTRAMLFDIGGGSTEIAWVRTDHRSRRQDLNGYLSLPAGVITLAEQFGDAAFSEDGYQRMVDLVTRQLHAFERVHCIGRE
ISRGNVSLMGTSGTVTTLASIALSLTRYSRTAVDGTILQSGPALGAIRTLAAMGPMGLRQHPCVGPDRAAYVLPGCAIFE
AIHKIWPVSDIVVADRGLRDGMLLRMMHDSTAMALPSLPSSLPFAPSSLSSVGVSHP

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=324, Percent_Identity=27.4691358024691, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788848, Length=324, Percent_Identity=24.6913580246914, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 40698; Mature: 40698

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNTMSWRDGQEGPRLPHATGYKANQGVPGMYGAIDLGTNNCRLMIAAPHEGGFRVVDSF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCHHHHHHH
NRVVRLGEGLQSTGQLSGDAMDRTIEALRICAARMGRRRLRRYRAVATEACRRAGNGAAF
HHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IARARRETGLDITVISPREEAELVMESCGALLHDDRLSPARTRAMLFDIGGGSTEIAWVR
EEHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHEEEEEEECCCCEEEEEEE
TDHRSRRQDLNGYLSLPAGVITLAEQFGDAAFSEDGYQRMVDLVTRQLHAFERVHCIGRE
CCCHHHHHHCCCEEECCHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ISRGNVSLMGTSGTVTTLASIALSLTRYSRTAVDGTILQSGPALGAIRTLAAMGPMGLRQ
HCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHCCCCCCC
HPCVGPDRAAYVLPGCAIFEAIHKIWPVSDIVVADRGLRDGMLLRMMHDSTAMALPSLPS
CCCCCCCCCEEECCHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEECCCHHHHCCCCCC
SLPFAPSSLSSVGVSHP
CCCCCCCCHHHCCCCCC
>Mature Secondary Structure
MDNTMSWRDGQEGPRLPHATGYKANQGVPGMYGAIDLGTNNCRLMIAAPHEGGFRVVDSF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCHHHHHHH
NRVVRLGEGLQSTGQLSGDAMDRTIEALRICAARMGRRRLRRYRAVATEACRRAGNGAAF
HHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IARARRETGLDITVISPREEAELVMESCGALLHDDRLSPARTRAMLFDIGGGSTEIAWVR
EEHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHEEEEEEECCCCEEEEEEE
TDHRSRRQDLNGYLSLPAGVITLAEQFGDAAFSEDGYQRMVDLVTRQLHAFERVHCIGRE
CCCHHHHHHCCCEEECCHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ISRGNVSLMGTSGTVTTLASIALSLTRYSRTAVDGTILQSGPALGAIRTLAAMGPMGLRQ
HCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHCCCCCCC
HPCVGPDRAAYVLPGCAIFEAIHKIWPVSDIVVADRGLRDGMLLRMMHDSTAMALPSLPS
CCCCCCCCCEEECCHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEECCCHHHHCCCCCC
SLPFAPSSLSSVGVSHP
CCCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA