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The map label for this gene is yeiG [C]

Identifier: 162147637

GI number: 162147637

Start: 1891589

End: 1892437

Strand: Direct

Name: yeiG [C]

Synonym: GDI_1853

Alternate gene names: 162147637

Gene position: 1891589-1892437 (Clockwise)

Preceding gene: 162147636

Following gene: 162147648

Centisome position: 47.96

GC content: 68.9

Gene sequence:

>849_bases
ATGCCGATTACCACCCGCGAGACGCATGCGTGCTGCGGCGGCACGGTCGGATATTACAGCCATCTGTCCGACAGCCTGGG
GCTGGAGGCGCGCTTCGCCGTCTTCGTTCCCGATGGCGCGTCCGATGCGGCGCGGGTACCGGTCCTGCATGTCCTGGCCG
GCCTGACCTGCACCGAGGAAACCTTCCTGATCAAGGCGAACGCCATCCGCTTCGCCGCCGAATACGGGATCGCGCTGGTG
GCCACCGACACCTCGCCGCGCGGTGCCGGCATCGCGGGCGAGGACGACAGCTACGATTTCGGCAGCGGGGCCGGATTCTA
CCTGGACGCGACCCAGGCGCCGTGGGCGGCGCACTACCGGATGGGACGCTACGTCGCCGAGGAACTGCCCGCGCTGACCG
AGGCCCATTTTCCGCTGGACGGTACCCGGCGGGGAATCATGGGCCATTCCATGGGCGGCCACGGGGCGCTGGTCCATGCG
TTGCGCGCGCCCGACCGCTGGAAGTCGGTCTCGGCGTTCGCGCCCATCGTGCACCCCGCCGCCGTGCCGTGGGGCGAAAA
GGCGTTTTCAGGTTATCTGGGCCCGGACCGCGCCACCTGGGCGGCGCATGACGCCACCCTGCTGCTGCGGGCGGGACGGA
CGCATCCGACCACCATCCTGGTGGACCAGGGCGAGGCCGACCCGTTCCTGCCCGAACAGTTGCAGCCGTGGCATCTGGAA
GAGGCCGCGAAGGCGGCAGGGCAGGGCCTGATCCTGCGCCGCCACGCCGGATACGATCATTCCTACTGGTTCATCCAGTC
CTTCATCCAGGATCACCTGACCCATCACGCGGCGATCCTGCGGCGATAG

Upstream 100 bases:

>100_bases
GACCTGATCACCCACACGCTGCCGCTGTCGCGCATCAACGAGGGATTCGACCTGATGGCGCGGGGCGAGAGCATCCGCAC
CGTCGTCGAATTCTGATCCG

Downstream 100 bases:

>100_bases
GGGCCTATTCGCCTATAAGGTGCAGGATGATTTCGCGTCGATGGGGCTGGCGGCGGTGTTCGAACAGGTAAAGCCCCTGC
CATGTGCCCAGGACCGGCCG

Product: esterase protein

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MPITTRETHACCGGTVGYYSHLSDSLGLEARFAVFVPDGASDAARVPVLHVLAGLTCTEETFLIKANAIRFAAEYGIALV
ATDTSPRGAGIAGEDDSYDFGSGAGFYLDATQAPWAAHYRMGRYVAEELPALTEAHFPLDGTRRGIMGHSMGGHGALVHA
LRAPDRWKSVSAFAPIVHPAAVPWGEKAFSGYLGPDRATWAAHDATLLLRAGRTHPTTILVDQGEADPFLPEQLQPWHLE
EAAKAAGQGLILRRHAGYDHSYWFIQSFIQDHLTHHAAILRR

Sequences:

>Translated_282_residues
MPITTRETHACCGGTVGYYSHLSDSLGLEARFAVFVPDGASDAARVPVLHVLAGLTCTEETFLIKANAIRFAAEYGIALV
ATDTSPRGAGIAGEDDSYDFGSGAGFYLDATQAPWAAHYRMGRYVAEELPALTEAHFPLDGTRRGIMGHSMGGHGALVHA
LRAPDRWKSVSAFAPIVHPAAVPWGEKAFSGYLGPDRATWAAHDATLLLRAGRTHPTTILVDQGEADPFLPEQLQPWHLE
EAAKAAGQGLILRRHAGYDHSYWFIQSFIQDHLTHHAAILRR
>Mature_281_residues
PITTRETHACCGGTVGYYSHLSDSLGLEARFAVFVPDGASDAARVPVLHVLAGLTCTEETFLIKANAIRFAAEYGIALVA
TDTSPRGAGIAGEDDSYDFGSGAGFYLDATQAPWAAHYRMGRYVAEELPALTEAHFPLDGTRRGIMGHSMGGHGALVHAL
RAPDRWKSVSAFAPIVHPAAVPWGEKAFSGYLGPDRATWAAHDATLLLRAGRTHPTTILVDQGEADPFLPEQLQPWHLEE
AAKAAGQGLILRRHAGYDHSYWFIQSFIQDHLTHHAAILRR

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=282, Percent_Identity=48.5815602836879, Blast_Score=284, Evalue=8e-77,
Organism=Escherichia coli, GI1788477, Length=277, Percent_Identity=50.5415162454874, Blast_Score=259, Evalue=9e-71,
Organism=Escherichia coli, GI1786551, Length=275, Percent_Identity=47.2727272727273, Blast_Score=258, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI17510185, Length=284, Percent_Identity=43.6619718309859, Blast_Score=237, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6322393, Length=289, Percent_Identity=42.560553633218, Blast_Score=214, Evalue=1e-56,
Organism=Drosophila melanogaster, GI45551932, Length=282, Percent_Identity=46.4539007092199, Blast_Score=261, Evalue=4e-70,
Organism=Drosophila melanogaster, GI24648347, Length=282, Percent_Identity=46.4539007092199, Blast_Score=260, Evalue=6e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30503; Mature: 30371

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPITTRETHACCGGTVGYYSHLSDSLGLEARFAVFVPDGASDAARVPVLHVLAGLTCTEE
CCCCCCCCCHHCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCC
TFLIKANAIRFAAEYGIALVATDTSPRGAGIAGEDDSYDFGSGAGFYLDATQAPWAAHYR
EEEEEECCEEEHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHH
MGRYVAEELPALTEAHFPLDGTRRGIMGHSMGGHGALVHALRAPDRWKSVSAFAPIVHPA
HHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCC
AVPWGEKAFSGYLGPDRATWAAHDATLLLRAGRTHPTTILVDQGEADPFLPEQLQPWHLE
CCCCCHHHHCCCCCCCCCEEECCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCHH
EAAKAAGQGLILRRHAGYDHSYWFIQSFIQDHLTHHAAILRR
HHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PITTRETHACCGGTVGYYSHLSDSLGLEARFAVFVPDGASDAARVPVLHVLAGLTCTEE
CCCCCCCCHHCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCC
TFLIKANAIRFAAEYGIALVATDTSPRGAGIAGEDDSYDFGSGAGFYLDATQAPWAAHYR
EEEEEECCEEEHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHH
MGRYVAEELPALTEAHFPLDGTRRGIMGHSMGGHGALVHALRAPDRWKSVSAFAPIVHPA
HHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCC
AVPWGEKAFSGYLGPDRATWAAHDATLLLRAGRTHPTTILVDQGEADPFLPEQLQPWHLE
CCCCCHHHHCCCCCCCCCEEECCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCHH
EAAKAAGQGLILRRHAGYDHSYWFIQSFIQDHLTHHAAILRR
HHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]