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The map label for this gene is nrdA [H]

Identifier: 162147607

GI number: 162147607

Start: 1855133

End: 1857130

Strand: Direct

Name: nrdA [H]

Synonym: GDI_1823

Alternate gene names: 162147607

Gene position: 1855133-1857130 (Clockwise)

Preceding gene: 162147606

Following gene: 162147608

Centisome position: 47.03

GC content: 63.56

Gene sequence:

>1998_bases
ATGACCCTGGACGACGTATCCGGAACTGTGTCTGATCATTCCGCCGGCGAGCGAGACCTGTTCCAGGACCGCGACCCCGC
CCAGTCATCAGGCCAGCCCTCCAGCCAGCAATCTTCCACCCCGCAGTCCCCCGCCCAGATGCAGGACATGTTCGACGATG
TCGTGCAGTTGCCCGGCCATCATCCGGTTCGGGTGAACCGGTCGCGCGACGCGCTGCTGACGCCGTTCGGCAAGGCGACG
CTGGATAACCGCTACCTGCTGGAAGGCGAGAGCTATCAGGACCTGTTCGGCCGTGTCTCGTCCTATTACGGCGCCGATCC
GGGCCACGCGCAGCGGCTGTACGACTATATGTCGCGCCACTGGTTCATGCCGGCCACGCCGGTCCTGTCCAATGGCGGCA
CCACGCGCGGCCTGCCGATTTCCTGCTTCCTGAACGAGGCGAACGACAGCCTGCGCGGCATCGTCGACCTGTGGAACGAG
AATGTGTGGCTGGCCAGCAAGGGCGGCGGCATCGGCTCGTACTGGGGCAACCTGCGCTCGATCGGCGAGAATGTGGGCCG
CAACGGCAAGACGTCGGGTGTCATTCCGTTCATTCGCGTCATGGACAGCCTGACGCTGGCGATCAGCCAGGGGTCGCTGC
GGCGCGGCTCGGCCGCCGTCTACCTGCCGGTCTGGCATCCCGAGATCGAGGAATTCATCGAACTGCGCCGTCCGACCGGC
GGCGATCCGAACCGCAAGGCGCTGAACCTGCATCACGGCGTTCTGGTGTCCGACGCGTTCATGCGCGCGGTGGCCGAGGA
CGGGGAATGGGCTCTGCTGTCGCCCAAGGACGGCGCGCATATCCGCAAGATTTCGGCGCGGTCGCTGTGGATTCGCATCC
TGACGGCGCGGATGGAGCAGGGCGAGCCCTACATCATCTATTCCGACCATGTGAACAACGCGCGGCCGGAACACCACAAG
ATGGCGGGGCTGGAGGTCAAGACCTCGAACCTGTGCGCGGAAATCACCCTGCCGACCGGCATGGACCATCACGGCAACGA
ACGAACCGCCGTCTGCTGCCTGTCGTCGCTGAACCTGGAAACCTGGGACGAGTGGAAGGACGATCCGCGCTTCATCGAAG
ACGTGATGCTGTTCCTGGACAACGTGCTGCAGGATTTCATCGACCGCGCCCCCGATGACATGGAGCGCGCGAAATACGCG
GCGTCGCGCGAACGGTCGGTCGGGTTGGGGGTGATGGGGTTCCATTCCTTCCTGCAGGCGAACAACATTCCCTTCGAAAG
CGTGATCGCCAAGGTCTGGAACAAGCGGATCTTCAAGCATATCCGCGAACAGGCGGACCTTGCCTCGCGCAAGCTGGCCG
AACTGCGCGGTCCGTGCCCGGATGCGGCGGAATACGGCTTCATGGAACGGTTTTCCAACAAGCTGGCCATTGCGCCCACG
GCGTCGATCTCGATCATCGCCGGCAATGCCAGCCCGGGGATCGAGCCGATCGCGGCCAACGTGTTCCTGCAGAAGACCCT
TTCGGGATCGTTCACCGTGCGCAACCGGCACCTGCTGAAGCTGCTGATCGACAAGGGACAGAATACCGAAGAGGTCTGGT
CGTCGATCACCCTGACCAAGGGCAGCGTGCAGCATCTGGATTTCCTGACCCAGCAGGAAAAGGACGTGTTCAAGACCGCC
TTCGAACTCGACCAGCGCTGGGTGGTCGAGCATGCGGCCGACCGGGCGGGCTATATCTGCCAGGCCCAGTCGATCAACCT
GTTCCTGCCGGCGGACGTGCATAAGCGCGACCTGCACCAGATCCATTATCTGGCGTGGAAGCGGGGGGTGAAGTCGCTGT
ACTATTGCCGTTCGCTGTCCATCCAGCGGGCGGACACGGTCAGCAACGTGCTGGGCAAGGTTGATGTCATGGCCGACGAA
CCTTCCGCTCCTGCTCCCGCTCCCGCCAGCCCGCCGGCATCTTCCAACAATTACGACGAATGCCTGGCCTGCCAGTGA

Upstream 100 bases:

>100_bases
TAGTGCTCTTCAGTTGCCCGGCCGCGATATGTAGGGGCATAATCACGATACGGGCATAGGGCGCATCGCTGCCATGTCCG
GCGATTCACGGAGATGATGG

Downstream 100 bases:

>100_bases
GAGACGACATGACCGACATCACCAACGCGACCGGCACGGCACCGGAGAGCGCGCCCCAGCCGACAGGGGTCGAGGCGCGC
CTCGACCTGCTGACGTCCAA

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MTLDDVSGTVSDHSAGERDLFQDRDPAQSSGQPSSQQSSTPQSPAQMQDMFDDVVQLPGHHPVRVNRSRDALLTPFGKAT
LDNRYLLEGESYQDLFGRVSSYYGADPGHAQRLYDYMSRHWFMPATPVLSNGGTTRGLPISCFLNEANDSLRGIVDLWNE
NVWLASKGGGIGSYWGNLRSIGENVGRNGKTSGVIPFIRVMDSLTLAISQGSLRRGSAAVYLPVWHPEIEEFIELRRPTG
GDPNRKALNLHHGVLVSDAFMRAVAEDGEWALLSPKDGAHIRKISARSLWIRILTARMEQGEPYIIYSDHVNNARPEHHK
MAGLEVKTSNLCAEITLPTGMDHHGNERTAVCCLSSLNLETWDEWKDDPRFIEDVMLFLDNVLQDFIDRAPDDMERAKYA
ASRERSVGLGVMGFHSFLQANNIPFESVIAKVWNKRIFKHIREQADLASRKLAELRGPCPDAAEYGFMERFSNKLAIAPT
ASISIIAGNASPGIEPIAANVFLQKTLSGSFTVRNRHLLKLLIDKGQNTEEVWSSITLTKGSVQHLDFLTQQEKDVFKTA
FELDQRWVVEHAADRAGYICQAQSINLFLPADVHKRDLHQIHYLAWKRGVKSLYYCRSLSIQRADTVSNVLGKVDVMADE
PSAPAPAPASPPASSNNYDECLACQ

Sequences:

>Translated_665_residues
MTLDDVSGTVSDHSAGERDLFQDRDPAQSSGQPSSQQSSTPQSPAQMQDMFDDVVQLPGHHPVRVNRSRDALLTPFGKAT
LDNRYLLEGESYQDLFGRVSSYYGADPGHAQRLYDYMSRHWFMPATPVLSNGGTTRGLPISCFLNEANDSLRGIVDLWNE
NVWLASKGGGIGSYWGNLRSIGENVGRNGKTSGVIPFIRVMDSLTLAISQGSLRRGSAAVYLPVWHPEIEEFIELRRPTG
GDPNRKALNLHHGVLVSDAFMRAVAEDGEWALLSPKDGAHIRKISARSLWIRILTARMEQGEPYIIYSDHVNNARPEHHK
MAGLEVKTSNLCAEITLPTGMDHHGNERTAVCCLSSLNLETWDEWKDDPRFIEDVMLFLDNVLQDFIDRAPDDMERAKYA
ASRERSVGLGVMGFHSFLQANNIPFESVIAKVWNKRIFKHIREQADLASRKLAELRGPCPDAAEYGFMERFSNKLAIAPT
ASISIIAGNASPGIEPIAANVFLQKTLSGSFTVRNRHLLKLLIDKGQNTEEVWSSITLTKGSVQHLDFLTQQEKDVFKTA
FELDQRWVVEHAADRAGYICQAQSINLFLPADVHKRDLHQIHYLAWKRGVKSLYYCRSLSIQRADTVSNVLGKVDVMADE
PSAPAPAPASPPASSNNYDECLACQ
>Mature_664_residues
TLDDVSGTVSDHSAGERDLFQDRDPAQSSGQPSSQQSSTPQSPAQMQDMFDDVVQLPGHHPVRVNRSRDALLTPFGKATL
DNRYLLEGESYQDLFGRVSSYYGADPGHAQRLYDYMSRHWFMPATPVLSNGGTTRGLPISCFLNEANDSLRGIVDLWNEN
VWLASKGGGIGSYWGNLRSIGENVGRNGKTSGVIPFIRVMDSLTLAISQGSLRRGSAAVYLPVWHPEIEEFIELRRPTGG
DPNRKALNLHHGVLVSDAFMRAVAEDGEWALLSPKDGAHIRKISARSLWIRILTARMEQGEPYIIYSDHVNNARPEHHKM
AGLEVKTSNLCAEITLPTGMDHHGNERTAVCCLSSLNLETWDEWKDDPRFIEDVMLFLDNVLQDFIDRAPDDMERAKYAA
SRERSVGLGVMGFHSFLQANNIPFESVIAKVWNKRIFKHIREQADLASRKLAELRGPCPDAAEYGFMERFSNKLAIAPTA
SISIIAGNASPGIEPIAANVFLQKTLSGSFTVRNRHLLKLLIDKGQNTEEVWSSITLTKGSVQHLDFLTQQEKDVFKTAF
ELDQRWVVEHAADRAGYICQAQSINLFLPADVHKRDLHQIHYLAWKRGVKSLYYCRSLSIQRADTVSNVLGKVDVMADEP
SAPAPAPASPPASSNNYDECLACQ

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 ATP-cone domains [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=667, Percent_Identity=30.4347826086957, Blast_Score=263, Evalue=4e-70,
Organism=Escherichia coli, GI1789030, Length=634, Percent_Identity=25.8675078864353, Blast_Score=160, Evalue=3e-40,
Organism=Escherichia coli, GI2367133, Length=440, Percent_Identity=26.3636363636364, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17555242, Length=660, Percent_Identity=31.8181818181818, Blast_Score=281, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6320914, Length=647, Percent_Identity=31.9938176197836, Blast_Score=278, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6322123, Length=618, Percent_Identity=31.2297734627832, Blast_Score=267, Evalue=3e-72,
Organism=Drosophila melanogaster, GI17352481, Length=684, Percent_Identity=29.2397660818713, Blast_Score=257, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 74012; Mature: 73881

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDDVSGTVSDHSAGERDLFQDRDPAQSSGQPSSQQSSTPQSPAQMQDMFDDVVQLPGH
CCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
HPVRVNRSRDALLTPFGKATLDNRYLLEGESYQDLFGRVSSYYGADPGHAQRLYDYMSRH
CCEEECCCCCCEECCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
WFMPATPVLSNGGTTRGLPISCFLNEANDSLRGIVDLWNENVWLASKGGGIGSYWGNLRS
CCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHH
IGENVGRNGKTSGVIPFIRVMDSLTLAISQGSLRRGSAAVYLPVWHPEIEEFIELRRPTG
HHHHHCCCCCCCCCHHHHHHHHHHHEEECCCCCCCCCEEEEEEECCCCHHHHHHHHCCCC
GDPNRKALNLHHGVLVSDAFMRAVAEDGEWALLSPKDGAHIRKISARSLWIRILTARMEQ
CCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEHHHHHHHHHHHHHHHHC
GEPYIIYSDHVNNARPEHHKMAGLEVKTSNLCAEITLPTGMDHHGNERTAVCCLSSLNLE
CCCEEEECCCCCCCCCCHHHHCCCEEECCCCEEEEECCCCCCCCCCCCEEEEEEHHCCCC
TWDEWKDDPRFIEDVMLFLDNVLQDFIDRAPDDMERAKYAASRERSVGLGVMGFHSFLQA
CCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
NNIPFESVIAKVWNKRIFKHIREQADLASRKLAELRGPCPDAAEYGFMERFSNKLAIAPT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEECC
ASISIIAGNASPGIEPIAANVFLQKTLSGSFTVRNRHLLKLLIDKGQNTEEVWSSITLTK
CEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHCCCCHHHHHHHHEECC
GSVQHLDFLTQQEKDVFKTAFELDQRWVVEHAADRAGYICQAQSINLFLPADVHKRDLHQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCCCHHHHHH
IHYLAWKRGVKSLYYCRSLSIQRADTVSNVLGKVDVMADEPSAPAPAPASPPASSNNYDE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCH
CLACQ
HCCCC
>Mature Secondary Structure 
TLDDVSGTVSDHSAGERDLFQDRDPAQSSGQPSSQQSSTPQSPAQMQDMFDDVVQLPGH
CCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
HPVRVNRSRDALLTPFGKATLDNRYLLEGESYQDLFGRVSSYYGADPGHAQRLYDYMSRH
CCEEECCCCCCEECCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
WFMPATPVLSNGGTTRGLPISCFLNEANDSLRGIVDLWNENVWLASKGGGIGSYWGNLRS
CCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHH
IGENVGRNGKTSGVIPFIRVMDSLTLAISQGSLRRGSAAVYLPVWHPEIEEFIELRRPTG
HHHHHCCCCCCCCCHHHHHHHHHHHEEECCCCCCCCCEEEEEEECCCCHHHHHHHHCCCC
GDPNRKALNLHHGVLVSDAFMRAVAEDGEWALLSPKDGAHIRKISARSLWIRILTARMEQ
CCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEHHHHHHHHHHHHHHHHC
GEPYIIYSDHVNNARPEHHKMAGLEVKTSNLCAEITLPTGMDHHGNERTAVCCLSSLNLE
CCCEEEECCCCCCCCCCHHHHCCCEEECCCCEEEEECCCCCCCCCCCCEEEEEEHHCCCC
TWDEWKDDPRFIEDVMLFLDNVLQDFIDRAPDDMERAKYAASRERSVGLGVMGFHSFLQA
CCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
NNIPFESVIAKVWNKRIFKHIREQADLASRKLAELRGPCPDAAEYGFMERFSNKLAIAPT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEECC
ASISIIAGNASPGIEPIAANVFLQKTLSGSFTVRNRHLLKLLIDKGQNTEEVWSSITLTK
CEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHCCCCHHHHHHHHEECC
GSVQHLDFLTQQEKDVFKTAFELDQRWVVEHAADRAGYICQAQSINLFLPADVHKRDLHQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCCCHHHHHH
IHYLAWKRGVKSLYYCRSLSIQRADTVSNVLGKVDVMADEPSAPAPAPASPPASSNNYDE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCH
CLACQ
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]