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The map label for this gene is iorA [H]

Identifier: 162147569

GI number: 162147569

Start: 1815313

End: 1815768

Strand: Direct

Name: iorA [H]

Synonym: GDI_1785

Alternate gene names: 162147569

Gene position: 1815313-1815768 (Clockwise)

Preceding gene: 162147568

Following gene: 162147570

Centisome position: 46.03

GC content: 68.2

Gene sequence:

>456_bases
ATGCTGACATTGCAGGTTAACGGCGCGGCGCATCAGGTGGATGTTCCCGATGACATGCCGCTGCTGTGGGTCCTGCGGGA
TGTCCTGGGCCTGCCGGGCACGAAATTCGGATGCGGCATCGGCGAATGCGGGGCCTGCACCGTGCATGTCGACGGCCGGC
CGGTGCGGGCCTGTTCCCTGCCGGTTTCCCTGGTCGGCGCGCGGCCGGTCACGACGATCGAAGGCCTGTCCGACGACCCG
CTGGCAACCGGCGTGCGGCAGGCATGGCTGGAGATCGACGTCGTGCAGTGCGGATATTGCCAGACCGGGCAGATCATGGC
GGCGGTGGCGCTGCTGAAGGCCAACCCCCACCCCACCGACGAGGAGATCGAGCAGGCGATGGCCGGCAATATCTGTCGCT
GCGGCACCTATCGCCGGATTCGCGCGGCTATCCGCAACGCCGCCGGGGCTGCGTGA

Upstream 100 bases:

>100_bases
CGCCGTCCGGGGGCTGATCCCCGGTTTCACCTTCCCGGATTGTTTTGTTATCACGATGGAGTGGGTGAACGGCTATCGGT
GATTTCAACCTGGAGGGTGC

Downstream 100 bases:

>100_bases
TGGGCCGCACGATGCTGTCGCGCCGCCAGGCCCTGGCGGGCACGGGCGGCCTGCTGCTGGCGGCCATGCTGCCGCGCGGG
GCGGCCCGGGCCGCGACCCG

Product: isoquinoline 1-oxidoreductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MLTLQVNGAAHQVDVPDDMPLLWVLRDVLGLPGTKFGCGIGECGACTVHVDGRPVRACSLPVSLVGARPVTTIEGLSDDP
LATGVRQAWLEIDVVQCGYCQTGQIMAAVALLKANPHPTDEEIEQAMAGNICRCGTYRRIRAAIRNAAGAA

Sequences:

>Translated_151_residues
MLTLQVNGAAHQVDVPDDMPLLWVLRDVLGLPGTKFGCGIGECGACTVHVDGRPVRACSLPVSLVGARPVTTIEGLSDDP
LATGVRQAWLEIDVVQCGYCQTGQIMAAVALLKANPHPTDEEIEQAMAGNICRCGTYRRIRAAIRNAAGAA
>Mature_151_residues
MLTLQVNGAAHQVDVPDDMPLLWVLRDVLGLPGTKFGCGIGECGACTVHVDGRPVRACSLPVSLVGARPVTTIEGLSDDP
LATGVRQAWLEIDVVQCGYCQTGQIMAAVALLKANPHPTDEEIEQAMAGNICRCGTYRRIRAAIRNAAGAA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=139, Percent_Identity=40.2877697841727, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI71773480, Length=101, Percent_Identity=36.6336633663366, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1786480, Length=164, Percent_Identity=45.7317073170732, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI1789232, Length=137, Percent_Identity=39.4160583941606, Blast_Score=91, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17540638, Length=160, Percent_Identity=38.125, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17539860, Length=152, Percent_Identity=36.1842105263158, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI32566215, Length=152, Percent_Identity=34.8684210526316, Blast_Score=92, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24647193, Length=160, Percent_Identity=34.375, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737937, Length=152, Percent_Identity=38.8157894736842, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24647201, Length=157, Percent_Identity=33.1210191082803, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24647199, Length=154, Percent_Identity=32.4675324675325, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24647197, Length=166, Percent_Identity=30.7228915662651, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24647195, Length=166, Percent_Identity=30.7228915662651, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 15893; Mature: 15893

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLQVNGAAHQVDVPDDMPLLWVLRDVLGLPGTKFGCGIGECGACTVHVDGRPVRACSL
CEEEEECCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEEECC
PVSLVGARPVTTIEGLSDDPLATGVRQAWLEIDVVQCGYCQTGQIMAAVALLKANPHPTD
CEEEECCCCCCEECCCCCCHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHCCCCCCH
EEIEQAMAGNICRCGTYRRIRAAIRNAAGAA
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTLQVNGAAHQVDVPDDMPLLWVLRDVLGLPGTKFGCGIGECGACTVHVDGRPVRACSL
CEEEEECCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEEECC
PVSLVGARPVTTIEGLSDDPLATGVRQAWLEIDVVQCGYCQTGQIMAAVALLKANPHPTD
CEEEECCCCCCEECCCCCCHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHCCCCCCH
EEIEQAMAGNICRCGTYRRIRAAIRNAAGAA
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]