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The map label for this gene is gyrB [H]

Identifier: 162147558

GI number: 162147558

Start: 1802147

End: 1804603

Strand: Direct

Name: gyrB [H]

Synonym: GDI_1774

Alternate gene names: 162147558

Gene position: 1802147-1804603 (Clockwise)

Preceding gene: 162147557

Following gene: 162147559

Centisome position: 45.69

GC content: 67.48

Gene sequence:

>2457_bases
ATGCCAGACGCGGATATGCCCAATTCGGACGCGACCGGGACCCTGCCCGACGATTCGGACTACGACGCGGCGTCCATTTC
GGTCCTGAAAGGGCTGGATGCGGTGCGCAAGCGCCCCGGCATGTATATCGGCGATACCGATGACGGTTCGGGCCTGCACC
ACATGGCGTTCGAGATCATCGACAACGCGGTGGACGAAGCCCAGGCCGGATTCGCCACAAGCTGCATCGTGACCCTGAAC
GGTGACGGCAGCGTCACGGTGCGCGACAACGGGCGCGGCATTCCCACCGACATGCATGCCGAGGAAGGCGTCAGCGCGGC
CGAGGTCGTGCTGACCAAGCTGCATGCCGGCGGCAAGTTCAACCAGAATTCCTACAAGGTGTCGGGCGGCCTGCACGGCG
TGGGCGCCGCGGTGGTCAACGCCCTGTCGGAATGGATGGAAGTCCGGATCTGGCGCAACGGGCAGGAGCATATGATCCGC
TTCCGCCACGGCGAGCGCGACGCCCCCCTGACCGTGGTGGGGCCGAGCGACGAGCCGCGCGGCACGCAGGTGACGTTCAA
GCCCAGCATCGGGACCTTCACCAGGGTGGAGTTCGAATTCGCGATCCTGGAACGCCGGATGCGGGAACTGGCGTTCCTGA
ATTCCGGCCTGCAGATCGTGCTGCGCGACGAGCGCCACACCCCGACGCGCGAGGAGAATTTTCACTTCCAGGGCGGGCTG
GCGGCCTTCGTCGAATGGCTGGATCGCGGCAAGTCGTCGATCGTCGATCCGCCGATCACCGGCAGCCTGCAGAACGAGGA
CAACGGCATCAAGGTCGAATTCGCCCTGACCTGGAACGACAGCTTCCACGAGACGATGCTGTGCTTCACCAACAACATCC
CGCAGCGGGACGGCGGGTCGCACCTGGCGGGCTTCCGCCAGGCGCTGACGCGCGTGGTGGGCAAATATGCCGAAAGCAAC
GCCAGCAAGAAGGACAGCCAGTCCCTGGTGGGCGAGGACATGCGCGAGGGCATGACCGCCGTGCTGTCGGTCAAGGTGCC
CGACCCGAAATTCTCGTCCCAGACCAAGGACAAGCTCGTCTCGTCCGAGGTGCAGCCGGTGGTCCATGCGGCGGCGTCCG
ACATGATCGCCCATTGGTTCGAGACCCACCCCAAGGAAGCGCGCGCGATCGTCGCGAAGGTGATGGACGCCGCGGCGGCG
CGCGAGGCCGCGCGGCGCGCGCGCGAACTGACCCGGCGCAAGGGCGTGCTGGACGTGTCCTCGCTGCCCGGCAAGCTGGC
GGATTGCCAGGAACGCGACCCGGCGCGCTCGGAACTGTTCATCGTCGAGGGGGATTCGGCGGGTGGCACGGCCAAGCAGG
GACGCGACCGGCGCTTCCAGGCCATCCTGCCGCTGAAGGGCAAGATCCTGAATGTCGAGCGCGCGCGCTTCGACCGCATG
CTGGGCTCGGCCGAGGTCGGGACGCTGATCACGGCGCTGGGCACCGGCATCGGGCGCGGCGACGTCGACCAGGGCGGGTT
TTCGATCGACAAGCTGCGCTATCACCGCGTCGTCATCATGACGGACGCCGACGTGGACGGATCGCATATCCGCACGCTGC
TGCTGACGTTCTTCTTCCGCCAGATGCCCGAGCTGATCGAGCGCGGGCACCTGTATATCGCGCAGCCGCCGCTCTATCGC
GCCAAGCGCGGCAATGACGAACGCTACCTGAAGGACGATGCGGCGCTGGAGCAGTATCTGCTGGACAAGGCGCTGGCCAA
TGCGTCCCTGCGCTATGGCGACGGGCGGGTGGTCGCGGGGGCGGACCTTGCGGCCGACATGGCGTTCCTGCGGGACGTGA
CCCGCGCGCTGCAGCGCCTGACGCTGCGCGCGCCGCTCTGGATCCTGGAACAGGCGGCCATCGCCGGCGCGCTGAATGCC
GACACGGCGACGGTCCAGACCCGGGTGGCCGCCCTGCAGGCCCAACTGGACGAGGTCTCGCTGCCCAACGAGCGGGGATG
GAAGGTCGTGGCCAGCGCCGACGGGCTGGAAATGGCCCGCAGCGTGCGTGGCGTGGGCGAGGTCTATCGCCTGGACCCCG
CGACCCTGCGCAGTGCCGAGGTCCGGTGGCTGGTCGAACGCGCCGACCGGCTGGCCACGGATTTCGCCGGCAAGGTCGAA
CTGACGCTGGACAGCACGACCCGGGCGGCCGACGGCCCGGCATCGCTGTACGAGCGTATCCTGGCCCAGGGACGGCGCGG
ACTGTCGATCAATCGCTTCAAGGGCCTGGGCGAGATGAACGATGCCCAGTTGTGGGAAACCACGCTGGACCCTGCCATGC
GCACGCTGTTGCAGGTCAAGGTGGGCGACGTGGAAAACGCCGCCCAGGTTTTCTCGACCCTGATGGGCGATGTCGTGGAA
CCGCGCCGCGACTTCATCGTCGGCAACGCGCTGAAGGTCGCCAACCTCGACGTGTAG

Upstream 100 bases:

>100_bases
GGAAGCCTGTATGATCGCGTCTTTCGACCACGATCCCAATCTGGAGCATCTGCCCGGTATGTCCGATCAATCCAATCCCG
TTCAGAAAACCGATGCGGAT

Downstream 100 bases:

>100_bases
GCGATCCCGGCGGCGCCATGACACCCCCGATATCTGAGCAGAGGAGGGCACCGATGCCCCTGTCGATGCGCAGGCTTGCT
GATCTGTCCCGGAAACTTGT

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 818; Mature: 817

Protein sequence:

>818_residues
MPDADMPNSDATGTLPDDSDYDAASISVLKGLDAVRKRPGMYIGDTDDGSGLHHMAFEIIDNAVDEAQAGFATSCIVTLN
GDGSVTVRDNGRGIPTDMHAEEGVSAAEVVLTKLHAGGKFNQNSYKVSGGLHGVGAAVVNALSEWMEVRIWRNGQEHMIR
FRHGERDAPLTVVGPSDEPRGTQVTFKPSIGTFTRVEFEFAILERRMRELAFLNSGLQIVLRDERHTPTREENFHFQGGL
AAFVEWLDRGKSSIVDPPITGSLQNEDNGIKVEFALTWNDSFHETMLCFTNNIPQRDGGSHLAGFRQALTRVVGKYAESN
ASKKDSQSLVGEDMREGMTAVLSVKVPDPKFSSQTKDKLVSSEVQPVVHAAASDMIAHWFETHPKEARAIVAKVMDAAAA
REAARRARELTRRKGVLDVSSLPGKLADCQERDPARSELFIVEGDSAGGTAKQGRDRRFQAILPLKGKILNVERARFDRM
LGSAEVGTLITALGTGIGRGDVDQGGFSIDKLRYHRVVIMTDADVDGSHIRTLLLTFFFRQMPELIERGHLYIAQPPLYR
AKRGNDERYLKDDAALEQYLLDKALANASLRYGDGRVVAGADLAADMAFLRDVTRALQRLTLRAPLWILEQAAIAGALNA
DTATVQTRVAALQAQLDEVSLPNERGWKVVASADGLEMARSVRGVGEVYRLDPATLRSAEVRWLVERADRLATDFAGKVE
LTLDSTTRAADGPASLYERILAQGRRGLSINRFKGLGEMNDAQLWETTLDPAMRTLLQVKVGDVENAAQVFSTLMGDVVE
PRRDFIVGNALKVANLDV

Sequences:

>Translated_818_residues
MPDADMPNSDATGTLPDDSDYDAASISVLKGLDAVRKRPGMYIGDTDDGSGLHHMAFEIIDNAVDEAQAGFATSCIVTLN
GDGSVTVRDNGRGIPTDMHAEEGVSAAEVVLTKLHAGGKFNQNSYKVSGGLHGVGAAVVNALSEWMEVRIWRNGQEHMIR
FRHGERDAPLTVVGPSDEPRGTQVTFKPSIGTFTRVEFEFAILERRMRELAFLNSGLQIVLRDERHTPTREENFHFQGGL
AAFVEWLDRGKSSIVDPPITGSLQNEDNGIKVEFALTWNDSFHETMLCFTNNIPQRDGGSHLAGFRQALTRVVGKYAESN
ASKKDSQSLVGEDMREGMTAVLSVKVPDPKFSSQTKDKLVSSEVQPVVHAAASDMIAHWFETHPKEARAIVAKVMDAAAA
REAARRARELTRRKGVLDVSSLPGKLADCQERDPARSELFIVEGDSAGGTAKQGRDRRFQAILPLKGKILNVERARFDRM
LGSAEVGTLITALGTGIGRGDVDQGGFSIDKLRYHRVVIMTDADVDGSHIRTLLLTFFFRQMPELIERGHLYIAQPPLYR
AKRGNDERYLKDDAALEQYLLDKALANASLRYGDGRVVAGADLAADMAFLRDVTRALQRLTLRAPLWILEQAAIAGALNA
DTATVQTRVAALQAQLDEVSLPNERGWKVVASADGLEMARSVRGVGEVYRLDPATLRSAEVRWLVERADRLATDFAGKVE
LTLDSTTRAADGPASLYERILAQGRRGLSINRFKGLGEMNDAQLWETTLDPAMRTLLQVKVGDVENAAQVFSTLMGDVVE
PRRDFIVGNALKVANLDV
>Mature_817_residues
PDADMPNSDATGTLPDDSDYDAASISVLKGLDAVRKRPGMYIGDTDDGSGLHHMAFEIIDNAVDEAQAGFATSCIVTLNG
DGSVTVRDNGRGIPTDMHAEEGVSAAEVVLTKLHAGGKFNQNSYKVSGGLHGVGAAVVNALSEWMEVRIWRNGQEHMIRF
RHGERDAPLTVVGPSDEPRGTQVTFKPSIGTFTRVEFEFAILERRMRELAFLNSGLQIVLRDERHTPTREENFHFQGGLA
AFVEWLDRGKSSIVDPPITGSLQNEDNGIKVEFALTWNDSFHETMLCFTNNIPQRDGGSHLAGFRQALTRVVGKYAESNA
SKKDSQSLVGEDMREGMTAVLSVKVPDPKFSSQTKDKLVSSEVQPVVHAAASDMIAHWFETHPKEARAIVAKVMDAAAAR
EAARRARELTRRKGVLDVSSLPGKLADCQERDPARSELFIVEGDSAGGTAKQGRDRRFQAILPLKGKILNVERARFDRML
GSAEVGTLITALGTGIGRGDVDQGGFSIDKLRYHRVVIMTDADVDGSHIRTLLLTFFFRQMPELIERGHLYIAQPPLYRA
KRGNDERYLKDDAALEQYLLDKALANASLRYGDGRVVAGADLAADMAFLRDVTRALQRLTLRAPLWILEQAAIAGALNAD
TATVQTRVAALQAQLDEVSLPNERGWKVVASADGLEMARSVRGVGEVYRLDPATLRSAEVRWLVERADRLATDFAGKVEL
TLDSTTRAADGPASLYERILAQGRRGLSINRFKGLGEMNDAQLWETTLDPAMRTLLQVKVGDVENAAQVFSTLMGDVVEP
RRDFIVGNALKVANLDV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=556, Percent_Identity=24.6402877697842, Blast_Score=141, Evalue=3e-33,
Organism=Homo sapiens, GI19913406, Length=568, Percent_Identity=23.943661971831, Blast_Score=135, Evalue=1e-31,
Organism=Escherichia coli, GI48994957, Length=816, Percent_Identity=54.4117647058823, Blast_Score=813, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=583, Percent_Identity=38.4219554030875, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17535065, Length=546, Percent_Identity=24.9084249084249, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI212645845, Length=520, Percent_Identity=22.5, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI212645657, Length=158, Percent_Identity=32.2784810126582, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=578, Percent_Identity=24.3944636678201, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI17136538, Length=638, Percent_Identity=23.6677115987461, Blast_Score=134, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 89527; Mature: 89396

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDADMPNSDATGTLPDDSDYDAASISVLKGLDAVRKRPGMYIGDTDDGSGLHHMAFEII
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHH
DNAVDEAQAGFATSCIVTLNGDGSVTVRDNGRGIPTDMHAEEGVSAAEVVLTKLHAGGKF
HHHHHHHHCCCEEEEEEEECCCCEEEECCCCCCCCCCCCHHCCCHHHHHHHHHHHCCCCC
NQNSYKVSGGLHGVGAAVVNALSEWMEVRIWRNGQEHMIRFRHGERDAPLTVVGPSDEPR
CCCCEEECCCCCHHHHHHHHHHHHHHHEEHCCCCHHHHHEECCCCCCCCEEEECCCCCCC
GTQVTFKPSIGTFTRVEFEFAILERRMRELAFLNSGLQIVLRDERHTPTREENFHFQGGL
CCEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEECCCH
AAFVEWLDRGKSSIVDPPITGSLQNEDNGIKVEFALTWNDSFHETMLCFTNNIPQRDGGS
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHCCCCCCCCCCC
HLAGFRQALTRVVGKYAESNASKKDSQSLVGEDMREGMTAVLSVKVPDPKFSSQTKDKLV
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHH
SSEVQPVVHAAASDMIAHWFETHPKEARAIVAKVMDAAAAREAARRARELTRRKGVLDVS
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHH
SLPGKLADCQERDPARSELFIVEGDSAGGTAKQGRDRRFQAILPLKGKILNVERARFDRM
CCCCCHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEECHHHHHHHHH
LGSAEVGTLITALGTGIGRGDVDQGGFSIDKLRYHRVVIMTDADVDGSHIRTLLLTFFFR
HCCHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEEEEEEEEECCCCCHHHHHHHHHHHHHH
QMPELIERGHLYIAQPPLYRAKRGNDERYLKDDAALEQYLLDKALANASLRYGDGRVVAG
HHHHHHHCCCEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEC
ADLAADMAFLRDVTRALQRLTLRAPLWILEQAAIAGALNADTATVQTRVAALQAQLDEVS
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
LPNERGWKVVASADGLEMARSVRGVGEVYRLDPATLRSAEVRWLVERADRLATDFAGKVE
CCCCCCCEEEECCCHHHHHHHHHCCHHHEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LTLDSTTRAADGPASLYERILAQGRRGLSINRFKGLGEMNDAQLWETTLDPAMRTLLQVK
EEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
VGDVENAAQVFSTLMGDVVEPRRDFIVGNALKVANLDV
CCCCHHHHHHHHHHHHHHHCCHHHEEECCCEEEECCCC
>Mature Secondary Structure 
PDADMPNSDATGTLPDDSDYDAASISVLKGLDAVRKRPGMYIGDTDDGSGLHHMAFEII
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHH
DNAVDEAQAGFATSCIVTLNGDGSVTVRDNGRGIPTDMHAEEGVSAAEVVLTKLHAGGKF
HHHHHHHHCCCEEEEEEEECCCCEEEECCCCCCCCCCCCHHCCCHHHHHHHHHHHCCCCC
NQNSYKVSGGLHGVGAAVVNALSEWMEVRIWRNGQEHMIRFRHGERDAPLTVVGPSDEPR
CCCCEEECCCCCHHHHHHHHHHHHHHHEEHCCCCHHHHHEECCCCCCCCEEEECCCCCCC
GTQVTFKPSIGTFTRVEFEFAILERRMRELAFLNSGLQIVLRDERHTPTREENFHFQGGL
CCEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEECCCH
AAFVEWLDRGKSSIVDPPITGSLQNEDNGIKVEFALTWNDSFHETMLCFTNNIPQRDGGS
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHCCCCCCCCCCC
HLAGFRQALTRVVGKYAESNASKKDSQSLVGEDMREGMTAVLSVKVPDPKFSSQTKDKLV
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHH
SSEVQPVVHAAASDMIAHWFETHPKEARAIVAKVMDAAAAREAARRARELTRRKGVLDVS
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHH
SLPGKLADCQERDPARSELFIVEGDSAGGTAKQGRDRRFQAILPLKGKILNVERARFDRM
CCCCCHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEECHHHHHHHHH
LGSAEVGTLITALGTGIGRGDVDQGGFSIDKLRYHRVVIMTDADVDGSHIRTLLLTFFFR
HCCHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEEEEEEEEECCCCCHHHHHHHHHHHHHH
QMPELIERGHLYIAQPPLYRAKRGNDERYLKDDAALEQYLLDKALANASLRYGDGRVVAG
HHHHHHHCCCEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEC
ADLAADMAFLRDVTRALQRLTLRAPLWILEQAAIAGALNADTATVQTRVAALQAQLDEVS
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
LPNERGWKVVASADGLEMARSVRGVGEVYRLDPATLRSAEVRWLVERADRLATDFAGKVE
CCCCCCCEEEECCCHHHHHHHHHCCHHHEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LTLDSTTRAADGPASLYERILAQGRRGLSINRFKGLGEMNDAQLWETTLDPAMRTLLQVK
EEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
VGDVENAAQVFSTLMGDVVEPRRDFIVGNALKVANLDV
CCCCHHHHHHHHHHHHHHHCCHHHEEECCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA