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The map label for this gene is rmlA [H]

Identifier: 162147416

GI number: 162147416

Start: 1643939

End: 1644811

Strand: Direct

Name: rmlA [H]

Synonym: GDI_1631

Alternate gene names: 162147416

Gene position: 1643939-1644811 (Clockwise)

Preceding gene: 162147412

Following gene: 162147417

Centisome position: 41.68

GC content: 69.42

Gene sequence:

>873_bases
ATGAAGGGCATCCTGCTGGCCGGCGGGTCGGGCACGCGGCTGCACCCGATGACGCTGGCGACCAGCAAGCAGTTGCTGCC
GGTCTATGACAAGCCGATGATCTACTACCCGCTTTCGACGCTGATGCTGGCGGGCATCCGGGACATCATGATCATCTCGA
CGCCCGACGACCTGCCGCAGTTCCGCCGCCTGCTGGGCGACGGGACGCAGTATGGGGTGCGCTTCACCTATCGCGTCCAG
CCTTCGCCGGACGGCATCGCCCAGGCCTTCCTGATCGCGGAGGACTGGCTGCAGGGCGCGGCCTGCGCGCTGGCGCTGGG
CGACAACCTGATCTTCGCCGACCATCTGAGCGTGCTGCTGCAGGCGGCGGCGCGGCGCGATGTCGGCGCCACGGTGTTCG
CCTACCAGGTGCAGGACCCCGAACGCTATGGCGTGGTGAGCTTCGACGCCGACGGCCGCGCCCGGGACCTGGTGGAAAAG
CCCGCCCAGCCGACGTCGCGCTGGGCGGTGACGGGGCTGTATTTCTACGACTCCCGCGTCAGCGCCTTCGCCCGCGCGAT
CCGCCCCTCGGCCCGGGGCGAGCTGGAGATCACGGACCTGAACCGGATCTATCTGGAAGAAGGCTCGCTGCAGGTGGAAA
AGCTGGGCCGGGGCTGCGCCTGGCTGGATGCCGGGGTACCCGACGCGCTGATGCAGGCCGGGATGTTCGTGCAGACCATC
CAGTCCCGCCAGGGCATGCTGGTCGGATCGCCCGCCGAGGTCGCCTTCCGCATGGGCTTCATCGACGCCGCGCAACTGCG
CGACGTCGCGGGCGCGATCCGCAAGACCGATCTGGGCCGCCTGCTGCGCGACATGGCGGAGGACGCCGCATAG

Upstream 100 bases:

>100_bases
GCGACGGCGCGAGCCAGCAGCAACGGAACGCAGCATGTGGAAGTCGATGAACGCGCCTGTATCCCGAACCGCCCTATCCG
GCACCGCCGCCCCGCCCGCG

Downstream 100 bases:

>100_bases
ACGATCAAAATTTTGACAATCCAGTCCTCGGCATTTACCAACGCGAGAGTCGAGAACAAGGCACCCCGCTGCCACCATGG
CCCGCGTCCTGCATCCTGCG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MKGILLAGGSGTRLHPMTLATSKQLLPVYDKPMIYYPLSTLMLAGIRDIMIISTPDDLPQFRRLLGDGTQYGVRFTYRVQ
PSPDGIAQAFLIAEDWLQGAACALALGDNLIFADHLSVLLQAAARRDVGATVFAYQVQDPERYGVVSFDADGRARDLVEK
PAQPTSRWAVTGLYFYDSRVSAFARAIRPSARGELEITDLNRIYLEEGSLQVEKLGRGCAWLDAGVPDALMQAGMFVQTI
QSRQGMLVGSPAEVAFRMGFIDAAQLRDVAGAIRKTDLGRLLRDMAEDAA

Sequences:

>Translated_290_residues
MKGILLAGGSGTRLHPMTLATSKQLLPVYDKPMIYYPLSTLMLAGIRDIMIISTPDDLPQFRRLLGDGTQYGVRFTYRVQ
PSPDGIAQAFLIAEDWLQGAACALALGDNLIFADHLSVLLQAAARRDVGATVFAYQVQDPERYGVVSFDADGRARDLVEK
PAQPTSRWAVTGLYFYDSRVSAFARAIRPSARGELEITDLNRIYLEEGSLQVEKLGRGCAWLDAGVPDALMQAGMFVQTI
QSRQGMLVGSPAEVAFRMGFIDAAQLRDVAGAIRKTDLGRLLRDMAEDAA
>Mature_290_residues
MKGILLAGGSGTRLHPMTLATSKQLLPVYDKPMIYYPLSTLMLAGIRDIMIISTPDDLPQFRRLLGDGTQYGVRFTYRVQ
PSPDGIAQAFLIAEDWLQGAACALALGDNLIFADHLSVLLQAAARRDVGATVFAYQVQDPERYGVVSFDADGRARDLVEK
PAQPTSRWAVTGLYFYDSRVSAFARAIRPSARGELEITDLNRIYLEEGSLQVEKLGRGCAWLDAGVPDALMQAGMFVQTI
QSRQGMLVGSPAEVAFRMGFIDAAQLRDVAGAIRKTDLGRLLRDMAEDAA

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=253, Percent_Identity=26.0869565217391, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI11761619, Length=253, Percent_Identity=26.0869565217391, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=60.4166666666667, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=57.5438596491228, Blast_Score=347, Evalue=7e-97,
Organism=Caenorhabditis elegans, GI133931050, Length=183, Percent_Identity=28.9617486338798, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320148, Length=248, Percent_Identity=28.2258064516129, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355443, Length=247, Percent_Identity=24.2914979757085, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24644084, Length=247, Percent_Identity=24.2914979757085, Blast_Score=87, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 31690; Mature: 31690

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGILLAGGSGTRLHPMTLATSKQLLPVYDKPMIYYPLSTLMLAGIRDIMIISTPDDLPQ
CCCEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCHHH
FRRLLGDGTQYGVRFTYRVQPSPDGIAQAFLIAEDWLQGAACALALGDNLIFADHLSVLL
HHHHHCCCCEECEEEEEEECCCCCHHHHHHHHHHHHHCHHHEEEEECCCEEEHHHHHHHH
QAAARRDVGATVFAYQVQDPERYGVVSFDADGRARDLVEKPAQPTSRWAVTGLYFYDSRV
HHHHCCCCCCEEEEEEECCCCCCEEEEECCCCCHHHHHHCCCCCCCCEEEEEEEEEHHHH
SAFARAIRPSARGELEITDLNRIYLEEGSLQVEKLGRGCAWLDAGVPDALMQAGMFVQTI
HHHHHHHCCCCCCCEEEEECCEEEEECCCEEHHHHCCCCEEECCCCCHHHHHCCHHHHHH
QSRQGMLVGSPAEVAFRMGFIDAAQLRDVAGAIRKTDLGRLLRDMAEDAA
HHCCCEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKGILLAGGSGTRLHPMTLATSKQLLPVYDKPMIYYPLSTLMLAGIRDIMIISTPDDLPQ
CCCEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCHHH
FRRLLGDGTQYGVRFTYRVQPSPDGIAQAFLIAEDWLQGAACALALGDNLIFADHLSVLL
HHHHHCCCCEECEEEEEEECCCCCHHHHHHHHHHHHHCHHHEEEEECCCEEEHHHHHHHH
QAAARRDVGATVFAYQVQDPERYGVVSFDADGRARDLVEKPAQPTSRWAVTGLYFYDSRV
HHHHCCCCCCEEEEEEECCCCCCEEEEECCCCCHHHHHHCCCCCCCCEEEEEEEEEHHHH
SAFARAIRPSARGELEITDLNRIYLEEGSLQVEKLGRGCAWLDAGVPDALMQAGMFVQTI
HHHHHHHCCCCCCCEEEEECCEEEEECCCEEHHHHCCCCEEECCCCCHHHHHCCHHHHHH
QSRQGMLVGSPAEVAFRMGFIDAAQLRDVAGAIRKTDLGRLLRDMAEDAA
HHCCCEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]