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The map label for this gene is tdh [H]

Identifier: 162147320

GI number: 162147320

Start: 1535752

End: 1536798

Strand: Reverse

Name: tdh [H]

Synonym: GDI_1526

Alternate gene names: 162147320

Gene position: 1536798-1535752 (Counterclockwise)

Preceding gene: 162147321

Following gene: 162147318

Centisome position: 38.96

GC content: 68.77

Gene sequence:

>1047_bases
GTGACGAAGGATATCATGGATACGATGCGCGCGGCCGTCCTGGTCGCCCCCCACAGGTTCGAAGTCAGGGCCGTGCTGCT
TCCCCCGGTCGGCCCCGACGACGTGCTGGTCAAGGTCGATCGCTGCGGTATATGCGGCACCGACCTGCATATTTTCGCAG
GCCACTACGCGGCCGACCGGCTGCCGCTGGTCCCCGGTCACGAATTCACGGGGACGATCGCGCGGATGGGCGAGCGCGTC
ACCGGCCTGGAGCCGGGACAACGGGTCGTGGCCGACATCAATGTGGGATGCGGCCACTGCTTCTACTGCCGGCGCAACGA
GGTGCTCAATTGCCGGGCGGCGTGGCAGGTCGGCATCCATCGTGACGGCGCCTTCGCCGAATATGTCGCGATTCCGGCGC
GGCAGATCGTCCCGGCGCCGGCCGGCGTGGCGGCTGAAATCCTGGCCCTGACCGAACCCGTTTCCTGTGTCGTGCGCGCC
GCGCGCAAGGCGGGCGCGACCTTCGGGCAGTCGGTCGTGATCCTGGGGGCCGGGCCGATCGGCAACCTGCACGTCCAGAT
GATGCGGCTGGCCGGGGCCGCGCCGATCATCGTCGTCGAACTGTCGCCCGAGCGCGCGCGGCTGGCGGCGGAGGCCGGGG
CCGACGTGGTGGTGACCGATCCCGACCGGATGCAGGACATCGTGCGCGCCCATACCGGCGGCCGCGGCGCCGATATCGTG
ATCGAAAGCGTGGGCGTGCCGGCACTGTATGCGCGTGCGTTCGACCTGATCCGCCCGGGCGGCCATGTGGCGGCGTTCGG
CCTGACCGGGCCGGACGCCACCGTGCCCGTGGGCATCGTCGACATGATCCTGAAGGAAACGTCGATGGCCGGATCTGTGG
CCGGCATGGGGCAGGATGTCCATGACGCGCTGACGCTTCTGGTACATGACCGGTTCCGCGTGGCGCCCTTCATCGGCACC
GTCGTGCCGCTGGCCGATATCCAGCAGACCTTCGACACGATCAGGGACCGGCCGGAGGTGCTCAAGATTCAGATCGCGCC
GACATAA

Upstream 100 bases:

>100_bases
GAACATTCCCGCGACGGGACAGCAGATTTTCTTCGGTCTTGTGCTGATCACCGCCATCGCGACCACCATCGACCGGTCGA
AGATGCGCGTCGTCAAATAG

Downstream 100 bases:

>100_bases
GGGGACGGCGGGGACTGGCCCTTGCCGGGTTCGGGCAGAACCCGGCCCCTGGGCGGATCACGGGTCAGGACCTGGATGAT
GCACCAGGCCGTCAGATACG

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTKDIMDTMRAAVLVAPHRFEVRAVLLPPVGPDDVLVKVDRCGICGTDLHIFAGHYAADRLPLVPGHEFTGTIARMGERV
TGLEPGQRVVADINVGCGHCFYCRRNEVLNCRAAWQVGIHRDGAFAEYVAIPARQIVPAPAGVAAEILALTEPVSCVVRA
ARKAGATFGQSVVILGAGPIGNLHVQMMRLAGAAPIIVVELSPERARLAAEAGADVVVTDPDRMQDIVRAHTGGRGADIV
IESVGVPALYARAFDLIRPGGHVAAFGLTGPDATVPVGIVDMILKETSMAGSVAGMGQDVHDALTLLVHDRFRVAPFIGT
VVPLADIQQTFDTIRDRPEVLKIQIAPT

Sequences:

>Translated_348_residues
MTKDIMDTMRAAVLVAPHRFEVRAVLLPPVGPDDVLVKVDRCGICGTDLHIFAGHYAADRLPLVPGHEFTGTIARMGERV
TGLEPGQRVVADINVGCGHCFYCRRNEVLNCRAAWQVGIHRDGAFAEYVAIPARQIVPAPAGVAAEILALTEPVSCVVRA
ARKAGATFGQSVVILGAGPIGNLHVQMMRLAGAAPIIVVELSPERARLAAEAGADVVVTDPDRMQDIVRAHTGGRGADIV
IESVGVPALYARAFDLIRPGGHVAAFGLTGPDATVPVGIVDMILKETSMAGSVAGMGQDVHDALTLLVHDRFRVAPFIGT
VVPLADIQQTFDTIRDRPEVLKIQIAPT
>Mature_347_residues
TKDIMDTMRAAVLVAPHRFEVRAVLLPPVGPDDVLVKVDRCGICGTDLHIFAGHYAADRLPLVPGHEFTGTIARMGERVT
GLEPGQRVVADINVGCGHCFYCRRNEVLNCRAAWQVGIHRDGAFAEYVAIPARQIVPAPAGVAAEILALTEPVSCVVRAA
RKAGATFGQSVVILGAGPIGNLHVQMMRLAGAAPIIVVELSPERARLAAEAGADVVVTDPDRMQDIVRAHTGGRGADIVI
ESVGVPALYARAFDLIRPGGHVAAFGLTGPDATVPVGIVDMILKETSMAGSVAGMGQDVHDALTLLVHDRFRVAPFIGTV
VPLADIQQTFDTIRDRPEVLKIQIAPT

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=332, Percent_Identity=28.3132530120482, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI4501933, Length=362, Percent_Identity=24.585635359116, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI34577061, Length=363, Percent_Identity=26.1707988980716, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=25.2032520325203, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI4501939, Length=265, Percent_Identity=25.2830188679245, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI156523966, Length=265, Percent_Identity=25.2830188679245, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI71743840, Length=264, Percent_Identity=24.2424242424242, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI262073058, Length=264, Percent_Identity=24.2424242424242, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790045, Length=313, Percent_Identity=27.4760383386581, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1790718, Length=321, Percent_Identity=29.595015576324, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI226510992, Length=341, Percent_Identity=29.9120234604106, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1788075, Length=332, Percent_Identity=29.8192771084337, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1787863, Length=286, Percent_Identity=29.7202797202797, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI87081918, Length=334, Percent_Identity=31.1377245508982, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788073, Length=340, Percent_Identity=28.2352941176471, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1786825, Length=269, Percent_Identity=30.8550185873606, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788407, Length=297, Percent_Identity=29.2929292929293, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI87082125, Length=283, Percent_Identity=31.095406360424, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI87082401, Length=314, Percent_Identity=25.796178343949, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786552, Length=361, Percent_Identity=26.8698060941828, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786518, Length=286, Percent_Identity=26.2237762237762, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=346, Percent_Identity=26.5895953757225, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17562878, Length=245, Percent_Identity=30.2040816326531, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17562584, Length=326, Percent_Identity=28.8343558282209, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71988145, Length=345, Percent_Identity=25.2173913043478, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17562582, Length=346, Percent_Identity=27.7456647398844, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323099, Length=345, Percent_Identity=26.3768115942029, Blast_Score=122, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6319258, Length=293, Percent_Identity=30.0341296928328, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6322619, Length=327, Percent_Identity=28.4403669724771, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319955, Length=327, Percent_Identity=28.4403669724771, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323961, Length=343, Percent_Identity=28.5714285714286, Blast_Score=106, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6319621, Length=299, Percent_Identity=28.4280936454849, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323729, Length=326, Percent_Identity=26.0736196319018, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324486, Length=343, Percent_Identity=27.1137026239067, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=380, Percent_Identity=25, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323980, Length=160, Percent_Identity=30, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=340, Percent_Identity=23.5294117647059, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737897, Length=325, Percent_Identity=28.9230769230769, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17137530, Length=326, Percent_Identity=28.8343558282209, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=22.5201072386059, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 36832; Mature: 36701

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKDIMDTMRAAVLVAPHRFEVRAVLLPPVGPDDVLVKVDRCGICGTDLHIFAGHYAADR
CCHHHHHHHHHHEEECCCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCEEEECCHHCCC
LPLVPGHEFTGTIARMGERVTGLEPGQRVVADINVGCGHCFYCRRNEVLNCRAAWQVGIH
CCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEECCCCEEEEEEEEEEEEC
RDGAFAEYVAIPARQIVPAPAGVAAEILALTEPVSCVVRAARKAGATFGQSVVILGAGPI
CCCCHHHHHCCCHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCC
GNLHVQMMRLAGAAPIIVVELSPERARLAAEAGADVVVTDPDRMQDIVRAHTGGRGADIV
CCHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCEEEECHHHHHHHHHHCCCCCCCEEE
IESVGVPALYARAFDLIRPGGHVAAFGLTGPDATVPVGIVDMILKETSMAGSVAGMGQDV
EECCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHCCCCHH
HDALTLLVHDRFRVAPFIGTVVPLADIQQTFDTIRDRPEVLKIQIAPT
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECC
>Mature Secondary Structure 
TKDIMDTMRAAVLVAPHRFEVRAVLLPPVGPDDVLVKVDRCGICGTDLHIFAGHYAADR
CHHHHHHHHHHEEECCCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCEEEECCHHCCC
LPLVPGHEFTGTIARMGERVTGLEPGQRVVADINVGCGHCFYCRRNEVLNCRAAWQVGIH
CCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEECCCCEEEEEEEEEEEEC
RDGAFAEYVAIPARQIVPAPAGVAAEILALTEPVSCVVRAARKAGATFGQSVVILGAGPI
CCCCHHHHHCCCHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCC
GNLHVQMMRLAGAAPIIVVELSPERARLAAEAGADVVVTDPDRMQDIVRAHTGGRGADIV
CCHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCEEEECHHHHHHHHHHCCCCCCCEEE
IESVGVPALYARAFDLIRPGGHVAAFGLTGPDATVPVGIVDMILKETSMAGSVAGMGQDV
EECCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHCCCCHH
HDALTLLVHDRFRVAPFIGTVVPLADIQQTFDTIRDRPEVLKIQIAPT
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]