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The map label for this gene is yeiA [H]

Identifier: 162147298

GI number: 162147298

Start: 1512055

End: 1513335

Strand: Direct

Name: yeiA [H]

Synonym: GDI_1503

Alternate gene names: 162147298

Gene position: 1512055-1513335 (Clockwise)

Preceding gene: 162147297

Following gene: 162147302

Centisome position: 38.34

GC content: 65.81

Gene sequence:

>1281_bases
ATGGCCGACCTGCGCAGCACGCTGGCGGGCATCCGCTCGCCCAACCCGTTCTGGCTGGCCTCGGCGCCTCCGACCGACAA
GGAATACAATGTCCGCCGGGGGCTGGAGGCCGGCTGGGGCGGCGTGGTGTGGAAGACGTTGGGCGAGGACCCGCCGGTGG
TCAATGTCAGCAGCCGCTACGGCGCCTTCAATTATAACGGTAACCGTCTGGTCGGGCTGAACAATATCGAACTGATCAGC
GACCGTCCGCTGGCCGTCAACCTGGCCGAGATCAAGTCGGTGAAGCGCGATTATCCCGACCGCGCCATCGTCGTCAGCCT
GATGGTGCCGTGCGTCGAGGAAAGCTGGCGGCGCATCCTGCCGCTGGTCGAGGACACCGGTGCCGACGGGATCGAACTGA
ATTTCGGCTGCCCGCACGGCATGTCGGAACGCAACATGGGGTCCGCCGTGGGGCAGGTGCCCGACTATGTCGAAATGGTC
ACGCGCTGGGTGAAGCAGAACACTCGCATGCCGACCATCGTGAAACTGACGCCCAATATCACCAACATCCTGGTGCCCGC
GCGCGCGGCCCTGCGCGGCGGGGCGGACGCGGTGTCGCTGATCAACACCATCCAGTCGGTCGTCGCCGTCGACCTGGACG
CCATGGCGCCGATGCCCGTGGTGGACGGGCTGGGGACGCATGGCGGCTATTGCGGGCCGGCGGTCAAGCCGATCGCGCTG
CGCATGGTGGGGGAAATCGCGCGCAGCCCGGACATGTCGGGCCTGCCCATCTCGGGCATCGGCGGCATTTCAACGTGGCG
CGACGCCGCCGAATTCCTGGTGATGGGGGCAACCAACGTGCAGGTCTGCACGGCGGCGATGCATCACGGATTTCGCATTG
TCGAAGACATGATCGACGGCCTGTCGAACTGGATGGACCAGAAGGGCTTCGCCGCGCTGTCCGACGTCATCGGGCGCGCG
GTGCCGAATTTCGTCAACTGGAACCAGTTGAACCTGAATTTCCGGACGATCGCGAAGATCGACCAGGAATCCTGCATCCA
GTGCGGCCTGTGCCATATCGCGTGCGAGGACACGTCGCATCAGGCCATCGCCAGGACGCGCGTGGAGGGCCGGCGTCATT
ACGCGGTGATCGACGAGGCCTGCGTCGGGTGCAATCTCTGCGCCCATGTCTGCCCCGTCGACGACTGCATCACCATGGTG
CCGCAGCCGGCGGAGGGCACGCTGACATGGTCCGACCACCCCAGCAACCCGCTTCGTCATCCGACCTCCGGCACCGGCTG
A

Upstream 100 bases:

>100_bases
CACGAAGGGCGAGGATCTGACGGTCGCCGCCGTCCGTGACGGGCGGGACGCCGCCGAAACCATTCATGCCGACCTGGCCA
GCGCGACGGGGATCTGAGAC

Downstream 100 bases:

>100_bases
CGAAGCGCCCCCGATCGGGAATGCCGGTTCAGGAATGCCGGTCGGGGCTTTCCTCCAGCAGATATTGGGACGTTTCCAGA
ATCGCGTTCCAATAGGCCAC

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MADLRSTLAGIRSPNPFWLASAPPTDKEYNVRRGLEAGWGGVVWKTLGEDPPVVNVSSRYGAFNYNGNRLVGLNNIELIS
DRPLAVNLAEIKSVKRDYPDRAIVVSLMVPCVEESWRRILPLVEDTGADGIELNFGCPHGMSERNMGSAVGQVPDYVEMV
TRWVKQNTRMPTIVKLTPNITNILVPARAALRGGADAVSLINTIQSVVAVDLDAMAPMPVVDGLGTHGGYCGPAVKPIAL
RMVGEIARSPDMSGLPISGIGGISTWRDAAEFLVMGATNVQVCTAAMHHGFRIVEDMIDGLSNWMDQKGFAALSDVIGRA
VPNFVNWNQLNLNFRTIAKIDQESCIQCGLCHIACEDTSHQAIARTRVEGRRHYAVIDEACVGCNLCAHVCPVDDCITMV
PQPAEGTLTWSDHPSNPLRHPTSGTG

Sequences:

>Translated_426_residues
MADLRSTLAGIRSPNPFWLASAPPTDKEYNVRRGLEAGWGGVVWKTLGEDPPVVNVSSRYGAFNYNGNRLVGLNNIELIS
DRPLAVNLAEIKSVKRDYPDRAIVVSLMVPCVEESWRRILPLVEDTGADGIELNFGCPHGMSERNMGSAVGQVPDYVEMV
TRWVKQNTRMPTIVKLTPNITNILVPARAALRGGADAVSLINTIQSVVAVDLDAMAPMPVVDGLGTHGGYCGPAVKPIAL
RMVGEIARSPDMSGLPISGIGGISTWRDAAEFLVMGATNVQVCTAAMHHGFRIVEDMIDGLSNWMDQKGFAALSDVIGRA
VPNFVNWNQLNLNFRTIAKIDQESCIQCGLCHIACEDTSHQAIARTRVEGRRHYAVIDEACVGCNLCAHVCPVDDCITMV
PQPAEGTLTWSDHPSNPLRHPTSGTG
>Mature_425_residues
ADLRSTLAGIRSPNPFWLASAPPTDKEYNVRRGLEAGWGGVVWKTLGEDPPVVNVSSRYGAFNYNGNRLVGLNNIELISD
RPLAVNLAEIKSVKRDYPDRAIVVSLMVPCVEESWRRILPLVEDTGADGIELNFGCPHGMSERNMGSAVGQVPDYVEMVT
RWVKQNTRMPTIVKLTPNITNILVPARAALRGGADAVSLINTIQSVVAVDLDAMAPMPVVDGLGTHGGYCGPAVKPIALR
MVGEIARSPDMSGLPISGIGGISTWRDAAEFLVMGATNVQVCTAAMHHGFRIVEDMIDGLSNWMDQKGFAALSDVIGRAV
PNFVNWNQLNLNFRTIAKIDQESCIQCGLCHIACEDTSHQAIARTRVEGRRHYAVIDEACVGCNLCAHVCPVDDCITMVP
QPAEGTLTWSDHPSNPLRHPTSGTG

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=328, Percent_Identity=38.719512195122, Blast_Score=219, Evalue=3e-57,
Organism=Escherichia coli, GI87082059, Length=398, Percent_Identity=42.4623115577889, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI71984108, Length=327, Percent_Identity=37.9204892966361, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24640763, Length=310, Percent_Identity=41.6129032258065, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI18858217, Length=310, Percent_Identity=41.6129032258065, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI281361352, Length=285, Percent_Identity=25.2631578947368, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17137316, Length=285, Percent_Identity=25.2631578947368, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 46044; Mature: 45913

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLRSTLAGIRSPNPFWLASAPPTDKEYNVRRGLEAGWGGVVWKTLGEDPPVVNVSSRY
CCCHHHHHHHCCCCCCEEEECCCCCCCCCHHHHCCCCCCCCHHHHHCCCCCCEEEECCCC
GAFNYNGNRLVGLNNIELISDRPLAVNLAEIKSVKRDYPDRAIVVSLMVPCVEESWRRIL
CEEECCCCEEEECCCEEEECCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
PLVEDTGADGIELNFGCPHGMSERNMGSAVGQVPDYVEMVTRWVKQNTRMPTIVKLTPNI
CHHHCCCCCCEEEECCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCH
TNILVPARAALRGGADAVSLINTIQSVVAVDLDAMAPMPVVDGLGTHGGYCGPAVKPIAL
HHEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCHHHHHH
RMVGEIARSPDMSGLPISGIGGISTWRDAAEFLVMGATNVQVCTAAMHHGFRIVEDMIDG
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHEEEECCCCHHHHHHHHHCCHHHHHHHHHH
LSNWMDQKGFAALSDVIGRAVPNFVNWNQLNLNFRTIAKIDQESCIQCGLCHIACEDTSH
HHHHHHHCHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHCCHHHHHHHCCEEEEECCCCH
QAIARTRVEGRRHYAVIDEACVGCNLCAHVCPVDDCITMVPQPAEGTLTWSDHPSNPLRH
HHHHHHHHCCCCEEEEHHHHHHCCHHHHHHCCHHHHHHHCCCCCCCEEEECCCCCCCCCC
PTSGTG
CCCCCC
>Mature Secondary Structure 
ADLRSTLAGIRSPNPFWLASAPPTDKEYNVRRGLEAGWGGVVWKTLGEDPPVVNVSSRY
CCHHHHHHHCCCCCCEEEECCCCCCCCCHHHHCCCCCCCCHHHHHCCCCCCEEEECCCC
GAFNYNGNRLVGLNNIELISDRPLAVNLAEIKSVKRDYPDRAIVVSLMVPCVEESWRRIL
CEEECCCCEEEECCCEEEECCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
PLVEDTGADGIELNFGCPHGMSERNMGSAVGQVPDYVEMVTRWVKQNTRMPTIVKLTPNI
CHHHCCCCCCEEEECCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCH
TNILVPARAALRGGADAVSLINTIQSVVAVDLDAMAPMPVVDGLGTHGGYCGPAVKPIAL
HHEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCHHHHHH
RMVGEIARSPDMSGLPISGIGGISTWRDAAEFLVMGATNVQVCTAAMHHGFRIVEDMIDG
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHEEEECCCCHHHHHHHHHCCHHHHHHHHHH
LSNWMDQKGFAALSDVIGRAVPNFVNWNQLNLNFRTIAKIDQESCIQCGLCHIACEDTSH
HHHHHHHCHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHCCHHHHHHHCCEEEEECCCCH
QAIARTRVEGRRHYAVIDEACVGCNLCAHVCPVDDCITMVPQPAEGTLTWSDHPSNPLRH
HHHHHHHHCCCCEEEEHHHHHHCCHHHHHHCCHHHHHHHCCCCCCCEEEECCCCCCCCCC
PTSGTG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]