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The map label for this gene is mprB [H]

Identifier: 162147250

GI number: 162147250

Start: 1456202

End: 1457749

Strand: Reverse

Name: mprB [H]

Synonym: GDI_1455

Alternate gene names: 162147250

Gene position: 1457749-1456202 (Counterclockwise)

Preceding gene: 162147251

Following gene: 162147249

Centisome position: 36.96

GC content: 70.74

Gene sequence:

>1548_bases
ATGCAATCCGGGCAGCAGACCGCCTCGGGCACGGGCCGGCGCCGGTTCAGGCTGCCCCGTTCGGCCAGCCTGCGCTTTTC
GCTGGGCTATGGCGTGCTGTTCGCCCTGTCCTCGATCCTGTTCATGTCCTTCATCTGGTGGGGGACGATCGGCTTCCTGG
AACGGCAGGTGGAAACCGCGATCAATGCCGACGCCCGGGCGCTGAGCCAGCGCTGGGCCGAGGGCGGGCTGCCGACCCTG
GCGCTGACGATCGACGACCGGCTGGAACAGAACCTGGATGACGACGCGATCTACCTGATGGTCGACCCGACCGGCCACCG
GCTGGCGGGCAACCTGTCGGAATGGCCGGCCATGATCACCAGCACCGACCGGTGGTACGCGCTGGAGGTCACACGGGCGG
GCATGCGCGACATGGCGCAGGTCCATGCCTTCGCCCTGCCGGGCGGCTTCCGGCTGCTGGTCGGGCGGGATGTCCGGTCG
CGCGCCGTGCTGCGCCGCCTGCTGACCGATTCCCTGCTTTGGGCGTGGATGATGGTGACGCTGCTGGCGATCAGCGGCGC
GGTGCTGGTGCACGGCATGTTCCGCCGCATGATCAAGTCGATCGCCCAGACCACGTCGGCGATCGCGCATGGCGACCTGT
CGCGCCGGATGCCGCTGGTCGGCAATGGCGACGAGCTGGACCAGGTGGCCGAGGCGATCAACGAGATGCTGGACCGCATC
GTGCGGCTGATGGACGGCGTGCGCCAGGTGTCCAATTCCATCGCCCACGACCTGCGCACGCCCATCACCCGCGCCCGCAC
CCAGTTGGAGGACGCGGCCGAGCATGCAAGCGGCGAGGGCGAACTGCGCGCGGCCATCGACCGTGCCGTGGGTCACCTGG
ACAATGTGACGGCGGTGTTCGAGGCCCTGCTGCGGATCGCGCAGATCGAGGCCGGGTCCCGCCGATCGGCCTTCGCCCCG
TTCGACCTGGTGCCGCTGCTGGCCGATATCGGCGACCTGTACGAGGCCGTGGCCGAGGAACGGCAGATCCGGCTGGTGCT
GCGCCTGCCGCCCACCCTGCCCTTCTACGGCGACCAGGCGATGATGCAGCAGGCGGTGGCCAACCTGCTGGACAACGCCA
TCAAGTTTTCACCCGCCGGGGGAACGGTCACGCTGGCCGTCGCCCTGGGACCGGCCCTGCTGCCGGGGCTGAGCGGGTCC
GCCCCGGGGCGCAATGCCGTATCCATCGCCGTCACCGACGAGGGGATCGGCATGAACGAGGCCGACATGGCGCGTGCGTC
GGAACGCTTCTTCCGTGCCGAGACGGCCCGCAACACCCCCGGCGCGGGCCTGGGCCTGTCGCTGGTGCAGGCGATCGTGC
AACTGCATGGCGGCGTGCTGCGGCTGCGCAGCAATGCGCCGGGGCTGTCGGTCCGCATGGTGCTGCCCGTGGCGCGCGAG
GCCGCCCGCCCCCGCTTCGCCTCGCGCGCGCCCGTTCCGCTCCCGCCCGCGCCGCCGCCGGACGGCGTGACGGAGACTTC
ACATTCACCCCATGGGGGCGACACGTGA

Upstream 100 bases:

>100_bases
CGCCAGAAGGTGGACAAGCCGTTCGATACCCCCCTGATCCATACCATCCGCAACGCCGGCTACATGCTGCGGGCGGAATA
GGAACGCGGGACCGCGCATC

Downstream 100 bases:

>100_bases
CACGCCCTAGGCTTCGAATCATGAGCATGCAGCCTCCTCCGGTTCCAGTCCTGCTGGCCATGGGCTTCTGCCTGTGCGGT
TTCGCGCCGGCACCGGACGA

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MQSGQQTASGTGRRRFRLPRSASLRFSLGYGVLFALSSILFMSFIWWGTIGFLERQVETAINADARALSQRWAEGGLPTL
ALTIDDRLEQNLDDDAIYLMVDPTGHRLAGNLSEWPAMITSTDRWYALEVTRAGMRDMAQVHAFALPGGFRLLVGRDVRS
RAVLRRLLTDSLLWAWMMVTLLAISGAVLVHGMFRRMIKSIAQTTSAIAHGDLSRRMPLVGNGDELDQVAEAINEMLDRI
VRLMDGVRQVSNSIAHDLRTPITRARTQLEDAAEHASGEGELRAAIDRAVGHLDNVTAVFEALLRIAQIEAGSRRSAFAP
FDLVPLLADIGDLYEAVAEERQIRLVLRLPPTLPFYGDQAMMQQAVANLLDNAIKFSPAGGTVTLAVALGPALLPGLSGS
APGRNAVSIAVTDEGIGMNEADMARASERFFRAETARNTPGAGLGLSLVQAIVQLHGGVLRLRSNAPGLSVRMVLPVARE
AARPRFASRAPVPLPPAPPPDGVTETSHSPHGGDT

Sequences:

>Translated_515_residues
MQSGQQTASGTGRRRFRLPRSASLRFSLGYGVLFALSSILFMSFIWWGTIGFLERQVETAINADARALSQRWAEGGLPTL
ALTIDDRLEQNLDDDAIYLMVDPTGHRLAGNLSEWPAMITSTDRWYALEVTRAGMRDMAQVHAFALPGGFRLLVGRDVRS
RAVLRRLLTDSLLWAWMMVTLLAISGAVLVHGMFRRMIKSIAQTTSAIAHGDLSRRMPLVGNGDELDQVAEAINEMLDRI
VRLMDGVRQVSNSIAHDLRTPITRARTQLEDAAEHASGEGELRAAIDRAVGHLDNVTAVFEALLRIAQIEAGSRRSAFAP
FDLVPLLADIGDLYEAVAEERQIRLVLRLPPTLPFYGDQAMMQQAVANLLDNAIKFSPAGGTVTLAVALGPALLPGLSGS
APGRNAVSIAVTDEGIGMNEADMARASERFFRAETARNTPGAGLGLSLVQAIVQLHGGVLRLRSNAPGLSVRMVLPVARE
AARPRFASRAPVPLPPAPPPDGVTETSHSPHGGDT
>Mature_515_residues
MQSGQQTASGTGRRRFRLPRSASLRFSLGYGVLFALSSILFMSFIWWGTIGFLERQVETAINADARALSQRWAEGGLPTL
ALTIDDRLEQNLDDDAIYLMVDPTGHRLAGNLSEWPAMITSTDRWYALEVTRAGMRDMAQVHAFALPGGFRLLVGRDVRS
RAVLRRLLTDSLLWAWMMVTLLAISGAVLVHGMFRRMIKSIAQTTSAIAHGDLSRRMPLVGNGDELDQVAEAINEMLDRI
VRLMDGVRQVSNSIAHDLRTPITRARTQLEDAAEHASGEGELRAAIDRAVGHLDNVTAVFEALLRIAQIEAGSRRSAFAP
FDLVPLLADIGDLYEAVAEERQIRLVLRLPPTLPFYGDQAMMQQAVANLLDNAIKFSPAGGTVTLAVALGPALLPGLSGS
APGRNAVSIAVTDEGIGMNEADMARASERFFRAETARNTPGAGLGLSLVQAIVQLHGGVLRLRSNAPGLSVRMVLPVARE
AARPRFASRAPVPLPPAPPPDGVTETSHSPHGGDT

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=291, Percent_Identity=27.1477663230241, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1786783, Length=311, Percent_Identity=25.4019292604502, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788279, Length=296, Percent_Identity=23.3108108108108, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789808, Length=303, Percent_Identity=28.0528052805281, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790861, Length=300, Percent_Identity=27.3333333333333, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1789403, Length=314, Percent_Identity=24.8407643312102, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790551, Length=249, Percent_Identity=28.5140562248996, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790346, Length=289, Percent_Identity=24.9134948096886, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1787894, Length=305, Percent_Identity=27.2131147540984, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786600, Length=287, Percent_Identity=24.390243902439, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI145693157, Length=225, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789149, Length=218, Percent_Identity=27.0642201834862, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=27.3504273504274, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1788713, Length=251, Percent_Identity=21.9123505976096, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55646; Mature: 55646

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSGQQTASGTGRRRFRLPRSASLRFSLGYGVLFALSSILFMSFIWWGTIGFLERQVETA
CCCCCCCCCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INADARALSQRWAEGGLPTLALTIDDRLEQNLDDDAIYLMVDPTGHRLAGNLSEWPAMIT
HCHHHHHHHHHHHCCCCCEEEEEECHHHHCCCCCCEEEEEECCCCCCCCCCHHHCCHHHC
STDRWYALEVTRAGMRDMAQVHAFALPGGFRLLVGRDVRSRAVLRRLLTDSLLWAWMMVT
CCCCEEEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
LLAISGAVLVHGMFRRMIKSIAQTTSAIAHGDLSRRMPLVGNGDELDQVAEAINEMLDRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
VRLMDGVRQVSNSIAHDLRTPITRARTQLEDAAEHASGEGELRAAIDRAVGHLDNVTAVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
EALLRIAQIEAGSRRSAFAPFDLVPLLADIGDLYEAVAEERQIRLVLRLPPTLPFYGDQA
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHH
MMQQAVANLLDNAIKFSPAGGTVTLAVALGPALLPGLSGSAPGRNAVSIAVTDEGIGMNE
HHHHHHHHHHHHHHEECCCCCCEEEHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCH
ADMARASERFFRAETARNTPGAGLGLSLVQAIVQLHGGVLRLRSNAPGLSVRMVLPVARE
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEHHHHHH
AARPRFASRAPVPLPPAPPPDGVTETSHSPHGGDT
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQSGQQTASGTGRRRFRLPRSASLRFSLGYGVLFALSSILFMSFIWWGTIGFLERQVETA
CCCCCCCCCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INADARALSQRWAEGGLPTLALTIDDRLEQNLDDDAIYLMVDPTGHRLAGNLSEWPAMIT
HCHHHHHHHHHHHCCCCCEEEEEECHHHHCCCCCCEEEEEECCCCCCCCCCHHHCCHHHC
STDRWYALEVTRAGMRDMAQVHAFALPGGFRLLVGRDVRSRAVLRRLLTDSLLWAWMMVT
CCCCEEEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
LLAISGAVLVHGMFRRMIKSIAQTTSAIAHGDLSRRMPLVGNGDELDQVAEAINEMLDRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
VRLMDGVRQVSNSIAHDLRTPITRARTQLEDAAEHASGEGELRAAIDRAVGHLDNVTAVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
EALLRIAQIEAGSRRSAFAPFDLVPLLADIGDLYEAVAEERQIRLVLRLPPTLPFYGDQA
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHH
MMQQAVANLLDNAIKFSPAGGTVTLAVALGPALLPGLSGSAPGRNAVSIAVTDEGIGMNE
HHHHHHHHHHHHHHEECCCCCCEEEHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCH
ADMARASERFFRAETARNTPGAGLGLSLVQAIVQLHGGVLRLRSNAPGLSVRMVLPVARE
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEHHHHHH
AARPRFASRAPVPLPPAPPPDGVTETSHSPHGGDT
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA