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The map label for this gene is czcR [H]

Identifier: 162147251

GI number: 162147251

Start: 1457769

End: 1458449

Strand: Reverse

Name: czcR [H]

Synonym: GDI_1456

Alternate gene names: 162147251

Gene position: 1458449-1457769 (Counterclockwise)

Preceding gene: 162147252

Following gene: 162147250

Centisome position: 36.98

GC content: 66.37

Gene sequence:

>681_bases
ATGCATATCCTGGTCGTCGAGGATGATCCGACCGTCCGCAATTTCGTCGCCAAGGGCCTGCGCGAGGCCGGGCACCTGGT
CGAGCCGGTGGACAACGGCAAGGACGGGCTGTTCCTGGCGGTCAGCGAGAATTTCGACCTGATCATCCTGGACCGCATGC
TACCGGGCGGGATCGACGGGCTGCGGCTGCTGGAAACCATCCGCGCGCAGAACAACAGCACGCCGGTCCTGCTGCTGTCG
GCGCTGGCGGACGTGGATGACCGCGTGCAGGGCCTGAAGGCCGGCGGCGACGATTACGTCACCAAGCCCTTCGCCTTCAG
CGAATTGCTGGCCCGGGTCGAGGCCCTGTCGCGCCGGGGGCGCAGCGACAACGCGCCGCTGACGCGCCTGAACGTGGCGG
ACCTGGAAATCGACCTGCTGTCGCGGTCGTCCGCCGCGGCGGGCAGCCGCATCGACCTGCAGCCCCGCGAATTCCGGCTG
CTGGAATACCTGATGCGCAATGCCGGCCAGGTCGTGACGCGCACCATGCTGCTGGAAGGCGTGTGGGACTATCATTTCGA
CCCGCAGACCAACGTCATCGACGTCCATGTGTCCCGCCTGCGCCAGAAGGTGGACAAGCCGTTCGATACCCCCCTGATCC
ATACCATCCGCAACGCCGGCTACATGCTGCGGGCGGAATAG

Upstream 100 bases:

>100_bases
GGCCGGCGGATATGGACGACTAGGTACCTCCCGCTCTGGCCAGTGCGGCCGCATGCAGCGTAAGATGATCGGCCAAGGTT
GAAACGGGAGCCGGACCGAC

Downstream 100 bases:

>100_bases
GAACGCGGGACCGCGCATCATGCAATCCGGGCAGCAGACCGCCTCGGGCACGGGCCGGCGCCGGTTCAGGCTGCCCCGTT
CGGCCAGCCTGCGCTTTTCG

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MHILVVEDDPTVRNFVAKGLREAGHLVEPVDNGKDGLFLAVSENFDLIILDRMLPGGIDGLRLLETIRAQNNSTPVLLLS
ALADVDDRVQGLKAGGDDYVTKPFAFSELLARVEALSRRGRSDNAPLTRLNVADLEIDLLSRSSAAAGSRIDLQPREFRL
LEYLMRNAGQVVTRTMLLEGVWDYHFDPQTNVIDVHVSRLRQKVDKPFDTPLIHTIRNAGYMLRAE

Sequences:

>Translated_226_residues
MHILVVEDDPTVRNFVAKGLREAGHLVEPVDNGKDGLFLAVSENFDLIILDRMLPGGIDGLRLLETIRAQNNSTPVLLLS
ALADVDDRVQGLKAGGDDYVTKPFAFSELLARVEALSRRGRSDNAPLTRLNVADLEIDLLSRSSAAAGSRIDLQPREFRL
LEYLMRNAGQVVTRTMLLEGVWDYHFDPQTNVIDVHVSRLRQKVDKPFDTPLIHTIRNAGYMLRAE
>Mature_226_residues
MHILVVEDDPTVRNFVAKGLREAGHLVEPVDNGKDGLFLAVSENFDLIILDRMLPGGIDGLRLLETIRAQNNSTPVLLLS
ALADVDDRVQGLKAGGDDYVTKPFAFSELLARVEALSRRGRSDNAPLTRLNVADLEIDLLSRSSAAAGSRIDLQPREFRL
LEYLMRNAGQVVTRTMLLEGVWDYHFDPQTNVIDVHVSRLRQKVDKPFDTPLIHTIRNAGYMLRAE

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=47.085201793722, Blast_Score=207, Evalue=3e-55,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=44.4444444444444, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=37.219730941704, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=35.5555555555556, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1786911, Length=205, Percent_Identity=35.609756097561, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=34.5291479820628, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=32.7354260089686, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=32.8947368421053, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=32.4444444444444, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=32.4444444444444, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=29.8245614035088, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI2367329, Length=181, Percent_Identity=36.4640883977901, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=31.4655172413793, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=29.004329004329, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=33.6448598130841, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1790299, Length=112, Percent_Identity=33.9285714285714, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1790437, Length=113, Percent_Identity=36.283185840708, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25225; Mature: 25225

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHILVVEDDPTVRNFVAKGLREAGHLVEPVDNGKDGLFLAVSENFDLIILDRMLPGGIDG
CEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCHH
LRLLETIRAQNNSTPVLLLSALADVDDRVQGLKAGGDDYVTKPFAFSELLARVEALSRRG
HHHHHHHHHCCCCCCEEHHHHHHCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCC
RSDNAPLTRLNVADLEIDLLSRSSAAAGSRIDLQPREFRLLEYLMRNAGQVVTRTMLLEG
CCCCCCEEEEEECCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
VWDYHFDPQTNVIDVHVSRLRQKVDKPFDTPLIHTIRNAGYMLRAE
HHCCCCCCCCCEEHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEC
>Mature Secondary Structure
MHILVVEDDPTVRNFVAKGLREAGHLVEPVDNGKDGLFLAVSENFDLIILDRMLPGGIDG
CEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCHH
LRLLETIRAQNNSTPVLLLSALADVDDRVQGLKAGGDDYVTKPFAFSELLARVEALSRRG
HHHHHHHHHCCCCCCEEHHHHHHCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCC
RSDNAPLTRLNVADLEIDLLSRSSAAAGSRIDLQPREFRLLEYLMRNAGQVVTRTMLLEG
CCCCCCEEEEEECCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
VWDYHFDPQTNVIDVHVSRLRQKVDKPFDTPLIHTIRNAGYMLRAE
HHCCCCCCCCCEEHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]