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The map label for this gene is zwf [H]

Identifier: 162147203

GI number: 162147203

Start: 1409856

End: 1411400

Strand: Direct

Name: zwf [H]

Synonym: GDI_1408

Alternate gene names: 162147203

Gene position: 1409856-1411400 (Clockwise)

Preceding gene: 162147196

Following gene: 162147204

Centisome position: 35.75

GC content: 68.03

Gene sequence:

>1545_bases
ATGTCCTTCTCTCGCGACATATCGTCGCCGGCGCGCGCCCGGCATGCCATCCCCCCCTCGGGCAGCAAGCCGGCCCCGGC
CTCCACGCTGGTGGTGTTCGGCGCCCATGGCGACCTGACGAAGCGGCTGTTGATGCCGGCCCTGTACAACCTGGCGGGCA
GCGGATTGCTGGACCCGGATTTCCGCATTATCGGCATCGACCGCGTGCCGGGCAGCACGGCGGAATGGCGCGACGGGCTG
GCCGCGACGATGCAGGAATTCACCCGCGACCGCGATGCCGAATTCTACACCCCCAGCATCGACGCCAAAGCCTGGGGCTG
GGTCGCGGACAGGCTGGAATACGTCCAGACCGATTTCTCGGACCTGGCGCAGGTGCGGGCCCTGGGCGAGAAACTACCGG
GCAGCGCCGTGTTCTACCTGGCGGTGCCATCGCGTTTCTTCGGGTCGCTGGTGGCCACGCTGGGCCAGGCCGGGCTGCTG
GCGGAACAGGACGGCAGGTTCCGCCGCGTGGTGATCGAAAAGCCGTTCGGCTCGGACCTCGCGACCGCGCGGGCGCTGAA
CGCGCAGATCCTGTCGGTGCTGGACGAACGCCAGATCTATCGGATCGACCATTTCCTGGGCAAGGAAACGGTCCAGAACA
TCCTGGCCATGCGCTTCGGCAACCTGATCTTCGAGCCGCTGTGGCGGAACGAGTATATCGACCATGTCGAAATCACCGCC
GCCGAGACCATCGGGGTCGAGCAGCGGGGTGCGTTCTACGAACCGACGGGCGCGCTGCGCGACATGGTGCCGAACCACCT
GTTCCAGCTCTTCGCCATGGTGGCGATGGAACCGCCGGCCTCGTTCTCGGCCGACACGGTGCGCACGGCGAAGGAGCAGC
TGTTCGAATCCGTCCGCCCGGTGGCGCCGGAGGACGCGGTGCGCGGCCAGTACCGGGCCGGGACCGTCGACGGAAAGCCC
GTGGCCGCCTATCGCGACAGCCCGGGCGTCGCCCCCGACAGCGTGACGGAAACCTATGTCGCGCTGAAGCTGCATGTGGA
TAACTGGCGCTGGTCGGGCGTGCCGTTCTATCTGCGCACCGGCAAGTCGCTGGGCGGCCGCCGGACCGAGGTCGTGGTGC
AGTTCAAGAAGCCGCCGGTCGCCATCTTCCGCGGCACCGCGACCGACGCGCTGCCGCCCAACCGCATGATCCTGAACATC
CAGCCCTCGCAGGGCCTGACCATCGGGATGGCGGCCAAGCATCCGGGCCCGGCAATGGACCTGGCCGAGGTGCAGGTCCG
CTTCCGGTACGAGGACGCGTTCGACCTGCAGCCCAATGTCGGCTACGAAACGCTGCTGTATGACTGCCTCAGCGGCGATG
CGACGCTGTTCCAGCGCGCGGACAATATCGACGCCGCCTGGGCGGCAGTGGACCCGGTCCTGCAAGCCTGGGCCAAATCG
TCCGATAGCCTGGAATTCTACGATGCCGGCGCCACCGGCCCGGCCGGGGCGGACGCCCTGCTGGCCCGCGACGGCCGAAG
CTGGTACCCGCTGGACGGCGTTTAA

Upstream 100 bases:

>100_bases
TGATGGCCGGACATGACAGCCGTTCGTGATCTGGCGCAAGGTCTTCCCCCGCGCCGGCGTCTATGCTCGGGCTGCTGGCT
GTTCAGGAGAACTATCCGTC

Downstream 100 bases:

>100_bases
GAACCGGGCTTGTCTTATGACTTTTTTGTCGCGGTGAGCGATAAAGGGCCGTTCAGCCGGGGTGGCCACCCCGGCTGAAC
GGGAAGGGGACGGGTCGCCT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MSFSRDISSPARARHAIPPSGSKPAPASTLVVFGAHGDLTKRLLMPALYNLAGSGLLDPDFRIIGIDRVPGSTAEWRDGL
AATMQEFTRDRDAEFYTPSIDAKAWGWVADRLEYVQTDFSDLAQVRALGEKLPGSAVFYLAVPSRFFGSLVATLGQAGLL
AEQDGRFRRVVIEKPFGSDLATARALNAQILSVLDERQIYRIDHFLGKETVQNILAMRFGNLIFEPLWRNEYIDHVEITA
AETIGVEQRGAFYEPTGALRDMVPNHLFQLFAMVAMEPPASFSADTVRTAKEQLFESVRPVAPEDAVRGQYRAGTVDGKP
VAAYRDSPGVAPDSVTETYVALKLHVDNWRWSGVPFYLRTGKSLGGRRTEVVVQFKKPPVAIFRGTATDALPPNRMILNI
QPSQGLTIGMAAKHPGPAMDLAEVQVRFRYEDAFDLQPNVGYETLLYDCLSGDATLFQRADNIDAAWAAVDPVLQAWAKS
SDSLEFYDAGATGPAGADALLARDGRSWYPLDGV

Sequences:

>Translated_514_residues
MSFSRDISSPARARHAIPPSGSKPAPASTLVVFGAHGDLTKRLLMPALYNLAGSGLLDPDFRIIGIDRVPGSTAEWRDGL
AATMQEFTRDRDAEFYTPSIDAKAWGWVADRLEYVQTDFSDLAQVRALGEKLPGSAVFYLAVPSRFFGSLVATLGQAGLL
AEQDGRFRRVVIEKPFGSDLATARALNAQILSVLDERQIYRIDHFLGKETVQNILAMRFGNLIFEPLWRNEYIDHVEITA
AETIGVEQRGAFYEPTGALRDMVPNHLFQLFAMVAMEPPASFSADTVRTAKEQLFESVRPVAPEDAVRGQYRAGTVDGKP
VAAYRDSPGVAPDSVTETYVALKLHVDNWRWSGVPFYLRTGKSLGGRRTEVVVQFKKPPVAIFRGTATDALPPNRMILNI
QPSQGLTIGMAAKHPGPAMDLAEVQVRFRYEDAFDLQPNVGYETLLYDCLSGDATLFQRADNIDAAWAAVDPVLQAWAKS
SDSLEFYDAGATGPAGADALLARDGRSWYPLDGV
>Mature_513_residues
SFSRDISSPARARHAIPPSGSKPAPASTLVVFGAHGDLTKRLLMPALYNLAGSGLLDPDFRIIGIDRVPGSTAEWRDGLA
ATMQEFTRDRDAEFYTPSIDAKAWGWVADRLEYVQTDFSDLAQVRALGEKLPGSAVFYLAVPSRFFGSLVATLGQAGLLA
EQDGRFRRVVIEKPFGSDLATARALNAQILSVLDERQIYRIDHFLGKETVQNILAMRFGNLIFEPLWRNEYIDHVEITAA
ETIGVEQRGAFYEPTGALRDMVPNHLFQLFAMVAMEPPASFSADTVRTAKEQLFESVRPVAPEDAVRGQYRAGTVDGKPV
AAYRDSPGVAPDSVTETYVALKLHVDNWRWSGVPFYLRTGKSLGGRRTEVVVQFKKPPVAIFRGTATDALPPNRMILNIQ
PSQGLTIGMAAKHPGPAMDLAEVQVRFRYEDAFDLQPNVGYETLLYDCLSGDATLFQRADNIDAAWAAVDPVLQAWAKSS
DSLEFYDAGATGPAGADALLARDGRSWYPLDGV

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=488, Percent_Identity=32.9918032786885, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI109389365, Length=488, Percent_Identity=32.9918032786885, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI52145310, Length=496, Percent_Identity=27.4193548387097, Blast_Score=154, Evalue=3e-37,
Organism=Escherichia coli, GI1788158, Length=498, Percent_Identity=40.7630522088353, Blast_Score=382, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17538218, Length=489, Percent_Identity=31.9018404907975, Blast_Score=262, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6324088, Length=491, Percent_Identity=31.5682281059063, Blast_Score=250, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24643350, Length=501, Percent_Identity=32.9341317365269, Blast_Score=261, Evalue=6e-70,
Organism=Drosophila melanogaster, GI24643352, Length=477, Percent_Identity=33.7526205450734, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI221513548, Length=500, Percent_Identity=28.8, Blast_Score=203, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56347; Mature: 56216

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSRDISSPARARHAIPPSGSKPAPASTLVVFGAHGDLTKRLLMPALYNLAGSGLLDPD
CCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCC
FRIIGIDRVPGSTAEWRDGLAATMQEFTRDRDAEFYTPSIDAKAWGWVADRLEYVQTDFS
EEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHCCHH
DLAQVRALGEKLPGSAVFYLAVPSRFFGSLVATLGQAGLLAEQDGRFRRVVIEKPFGSDL
HHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCEECCCCCEEEEEEECCCCCCH
ATARALNAQILSVLDERQIYRIDHFLGKETVQNILAMRFGNLIFEPLWRNEYIDHVEITA
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
AETIGVEQRGAFYEPTGALRDMVPNHLFQLFAMVAMEPPASFSADTVRTAKEQLFESVRP
HHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
VAPEDAVRGQYRAGTVDGKPVAAYRDSPGVAPDSVTETYVALKLHVDNWRWSGVPFYLRT
CCCCHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEEEEECCEEECCCCEEEEC
GKSLGGRRTEVVVQFKKPPVAIFRGTATDALPPNRMILNIQPSQGLTIGMAAKHPGPAMD
CCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCC
LAEVQVRFRYEDAFDLQPNVGYETLLYDCLSGDATLFQRADNIDAAWAAVDPVLQAWAKS
HHHEEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHCC
SDSLEFYDAGATGPAGADALLARDGRSWYPLDGV
CCCEEEEECCCCCCCCCCHHEECCCCCCCCCCCC
>Mature Secondary Structure 
SFSRDISSPARARHAIPPSGSKPAPASTLVVFGAHGDLTKRLLMPALYNLAGSGLLDPD
CCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCC
FRIIGIDRVPGSTAEWRDGLAATMQEFTRDRDAEFYTPSIDAKAWGWVADRLEYVQTDFS
EEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHCCHH
DLAQVRALGEKLPGSAVFYLAVPSRFFGSLVATLGQAGLLAEQDGRFRRVVIEKPFGSDL
HHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCEECCCCCEEEEEEECCCCCCH
ATARALNAQILSVLDERQIYRIDHFLGKETVQNILAMRFGNLIFEPLWRNEYIDHVEITA
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
AETIGVEQRGAFYEPTGALRDMVPNHLFQLFAMVAMEPPASFSADTVRTAKEQLFESVRP
HHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
VAPEDAVRGQYRAGTVDGKPVAAYRDSPGVAPDSVTETYVALKLHVDNWRWSGVPFYLRT
CCCCHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEEEEECCEEECCCCEEEEC
GKSLGGRRTEVVVQFKKPPVAIFRGTATDALPPNRMILNIQPSQGLTIGMAAKHPGPAMD
CCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCC
LAEVQVRFRYEDAFDLQPNVGYETLLYDCLSGDATLFQRADNIDAAWAAVDPVLQAWAKS
HHHEEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHCC
SDSLEFYDAGATGPAGADALLARDGRSWYPLDGV
CCCEEEEECCCCCCCCCCHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1643289 [H]