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The map label for this gene is treA [H]

Identifier: 162147135

GI number: 162147135

Start: 1338431

End: 1340068

Strand: Direct

Name: treA [H]

Synonym: GDI_1340

Alternate gene names: 162147135

Gene position: 1338431-1340068 (Clockwise)

Preceding gene: 162147134

Following gene: 162147137

Centisome position: 33.93

GC content: 68.32

Gene sequence:

>1638_bases
ATGGCGGCGATGCAGCCGCCGCCGGCCATGCCGGCGGACGGGGCGGCCGACCTGTCGGCCGCCGACCTGCCGCCGGTGGT
CCTCTTCCTTCCGCTGTCCCCGGTGCCCGCCGGCCCCACGGTCGCGGTGCCCACCGCCGACCAGCAGGACCTGCGGCCGC
CTTCGATCGCGCTGGCCGGCCTGTTCGCCGCCATGGGGGCGGCCCATGTCTTCGCCGATGCCAAGACGGCGGCCGACGCC
ATCCCGGACGAGGCCTCGGACGCGCTGCTGGCGGATTACGAACGGCAGAAGGTCCGTCCCGGATTCGACCTGAAGGATTT
CGTGGCGCAGCATTTCGCGATCGCCCCGCGCCGGACCGTTTCCTATCGCCGCCGCCCGAACGAAAGCGTGCGTGACTATA
TCAGCGGCATGTGGGAGGTCCTCAGCCGTCCGCCCGACACGCTGGTTGCGCATTCGTCGCTGCTGCCGCTGCCCGAAACC
TATGTCGTCCCAGGCGGCCGGTTCAGCGAGCTGTATTACTGGGACACCTATTTCACGATGATCGGGCTGTACGAGGACGG
CCGGATCGACCTGATGCGCGGCATGGTGCGCGACATCGCCTCGCTGATCGACCGGTACGGGCACATGCCCAACGGCAGCC
GCACCTATTACCTCAGCCGGTCCGAACCGCCGTTCTTCGCGCTGATGATCGACCTGCTGGCGATGCATGACGGGCAGGTC
GCCTACACGACGTTCCTGCCGGAACTGCAGCGGGAATACGATTACTGGATGGACGGGGCCGATAGCGTGGCCCCCGGCGC
CGCCTGGCGGCATGTCGTGCGCCTGCCCGACGGCACGCTGATGAACCGCCACTGGGACGACATGGACACCCCCCGGGACG
AAAGCTTCCCGCAGGATATCGCCACCGCCGCCCAGTCGTCGCGTCCGGCGGCCCAGACCTACCGCGACCTGCGCGCCGGG
GCGGAAACCGGGTGGGACTATTCCTCGCGCTGGCTGGCCGACGGGCACAGCATGGCCACGATCCACACCACCGACCTGCT
GACGATCGAACTCAACTGCCTGATCGCGCACCTGGAACAGACCCTGTCCCACGCCTATGACCTGCGGGGGAACAAGGCGC
AGGCCGACCGGTACGCCACGCTGGCCACCGCGCGGATCGATGCCATCCGCCGGGTCCTGTGGGACCCGAAGCGCGGGGCG
TTCTTCGATTACGACTGGAAGACGCGCACCCTGTCGCCCGTCCTGTCGGCGGCCACCGCCATGCCGCTGTTCCTGCAGAT
GGCGACACCCGAGCAGGCCCGCGCGGTGGCCGAGACCATGCGGACGAAGCTGCTGAAAGTCGGCGGCCTGACCGCCACCG
ACCATGTCAGCGGGCAGCAATGGGATTCGCCGAACGGCTGGGCGCCGGAACAATGGATGGCGATCAAGGGGCTGAACCAG
TACGGCCTGGACGACCTGGCGCAGCAGATCGCCTCGCGCTGGATGGAGCGCGTGATCGGCACCTACGAGAAATCGGGCGT
GTTGCTGGAAAAATACGACGTGGTGAACCCGTCCATCAGCCCCACCGGCGGCAAGGGCGGCGGCGAATATCCGATGCAGG
TCGGGTTCGGCTGGACCAACGGCACGTTGCTGGGCTGA

Upstream 100 bases:

>100_bases
GTGCCTCGCGGCCGCTCTGGGGGCGTCGCTGGCGCTGTCCGCTCCGCTGGCCGCCTTCGCCGATACGCCGCCTTCCGCGC
CGGATTCCCTGGCCGCCGCC

Downstream 100 bases:

>100_bases
TGAACCGCTATCCGCAGGACACCCGCGTGGTCCTGGACCGCAATCCACGCGCCGAACAGCCCTTCGCCCAGCCCCTGCCG
CCGGTCGATGCCTACCGGGT

Product: periplasmic trehalase protein

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MAAMQPPPAMPADGAADLSAADLPPVVLFLPLSPVPAGPTVAVPTADQQDLRPPSIALAGLFAAMGAAHVFADAKTAADA
IPDEASDALLADYERQKVRPGFDLKDFVAQHFAIAPRRTVSYRRRPNESVRDYISGMWEVLSRPPDTLVAHSSLLPLPET
YVVPGGRFSELYYWDTYFTMIGLYEDGRIDLMRGMVRDIASLIDRYGHMPNGSRTYYLSRSEPPFFALMIDLLAMHDGQV
AYTTFLPELQREYDYWMDGADSVAPGAAWRHVVRLPDGTLMNRHWDDMDTPRDESFPQDIATAAQSSRPAAQTYRDLRAG
AETGWDYSSRWLADGHSMATIHTTDLLTIELNCLIAHLEQTLSHAYDLRGNKAQADRYATLATARIDAIRRVLWDPKRGA
FFDYDWKTRTLSPVLSAATAMPLFLQMATPEQARAVAETMRTKLLKVGGLTATDHVSGQQWDSPNGWAPEQWMAIKGLNQ
YGLDDLAQQIASRWMERVIGTYEKSGVLLEKYDVVNPSISPTGGKGGGEYPMQVGFGWTNGTLLG

Sequences:

>Translated_545_residues
MAAMQPPPAMPADGAADLSAADLPPVVLFLPLSPVPAGPTVAVPTADQQDLRPPSIALAGLFAAMGAAHVFADAKTAADA
IPDEASDALLADYERQKVRPGFDLKDFVAQHFAIAPRRTVSYRRRPNESVRDYISGMWEVLSRPPDTLVAHSSLLPLPET
YVVPGGRFSELYYWDTYFTMIGLYEDGRIDLMRGMVRDIASLIDRYGHMPNGSRTYYLSRSEPPFFALMIDLLAMHDGQV
AYTTFLPELQREYDYWMDGADSVAPGAAWRHVVRLPDGTLMNRHWDDMDTPRDESFPQDIATAAQSSRPAAQTYRDLRAG
AETGWDYSSRWLADGHSMATIHTTDLLTIELNCLIAHLEQTLSHAYDLRGNKAQADRYATLATARIDAIRRVLWDPKRGA
FFDYDWKTRTLSPVLSAATAMPLFLQMATPEQARAVAETMRTKLLKVGGLTATDHVSGQQWDSPNGWAPEQWMAIKGLNQ
YGLDDLAQQIASRWMERVIGTYEKSGVLLEKYDVVNPSISPTGGKGGGEYPMQVGFGWTNGTLLG
>Mature_544_residues
AAMQPPPAMPADGAADLSAADLPPVVLFLPLSPVPAGPTVAVPTADQQDLRPPSIALAGLFAAMGAAHVFADAKTAADAI
PDEASDALLADYERQKVRPGFDLKDFVAQHFAIAPRRTVSYRRRPNESVRDYISGMWEVLSRPPDTLVAHSSLLPLPETY
VVPGGRFSELYYWDTYFTMIGLYEDGRIDLMRGMVRDIASLIDRYGHMPNGSRTYYLSRSEPPFFALMIDLLAMHDGQVA
YTTFLPELQREYDYWMDGADSVAPGAAWRHVVRLPDGTLMNRHWDDMDTPRDESFPQDIATAAQSSRPAAQTYRDLRAGA
ETGWDYSSRWLADGHSMATIHTTDLLTIELNCLIAHLEQTLSHAYDLRGNKAQADRYATLATARIDAIRRVLWDPKRGAF
FDYDWKTRTLSPVLSAATAMPLFLQMATPEQARAVAETMRTKLLKVGGLTATDHVSGQQWDSPNGWAPEQWMAIKGLNQY
GLDDLAQQIASRWMERVIGTYEKSGVLLEKYDVVNPSISPTGGKGGGEYPMQVGFGWTNGTLLG

Specific function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system [H]

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family [H]

Homologues:

Organism=Homo sapiens, GI116284412, Length=422, Percent_Identity=35.5450236966825, Blast_Score=239, Evalue=6e-63,
Organism=Escherichia coli, GI1787447, Length=525, Percent_Identity=45.9047619047619, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI1789936, Length=483, Percent_Identity=47.4120082815735, Blast_Score=464, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI25148109, Length=408, Percent_Identity=33.578431372549, Blast_Score=238, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI17565078, Length=547, Percent_Identity=29.0676416819013, Blast_Score=236, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17542196, Length=404, Percent_Identity=31.9306930693069, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI25141398, Length=418, Percent_Identity=30.8612440191388, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI71987755, Length=468, Percent_Identity=27.7777777777778, Blast_Score=169, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6319473, Length=429, Percent_Identity=29.8368298368298, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6320204, Length=424, Percent_Identity=29.2452830188679, Blast_Score=154, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24656661, Length=519, Percent_Identity=28.9017341040462, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI17933716, Length=519, Percent_Identity=28.9017341040462, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24656670, Length=519, Percent_Identity=28.9017341040462, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24656680, Length=519, Percent_Identity=28.9017341040462, Blast_Score=212, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24656675, Length=519, Percent_Identity=28.9017341040462, Blast_Score=212, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24656685, Length=503, Percent_Identity=29.0258449304175, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI22024178, Length=436, Percent_Identity=27.7522935779816, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI45551104, Length=373, Percent_Identity=28.4182305630027, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI28573474, Length=203, Percent_Identity=26.6009852216749, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232 [H]

Pfam domain/function: PF01204 Trehalase [H]

EC number: =3.2.1.28 [H]

Molecular weight: Translated: 60295; Mature: 60164

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00927 TREHALASE_1 ; PS00928 TREHALASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAMQPPPAMPADGAADLSAADLPPVVLFLPLSPVPAGPTVAVPTADQQDLRPPSIALAG
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCCHHHCCCHHHHHHH
LFAAMGAAHVFADAKTAADAIPDEASDALLADYERQKVRPGFDLKDFVAQHFAIAPRRTV
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHH
SYRRRPNESVRDYISGMWEVLSRPPDTLVAHSSLLPLPETYVVPGGRFSELYYWDTYFTM
HHHCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCEEEECCCCCCEEEEEEHEEEE
IGLYEDGRIDLMRGMVRDIASLIDRYGHMPNGSRTYYLSRSEPPFFALMIDLLAMHDGQV
EEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCE
AYTTFLPELQREYDYWMDGADSVAPGAAWRHVVRLPDGTLMNRHWDDMDTPRDESFPQDI
EEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEECCCCCCCCCCCCCCCCCCCCCCHHHH
ATAAQSSRPAAQTYRDLRAGAETGWDYSSRWLADGHSMATIHTTDLLTIELNCLIAHLEQ
HHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECEEEEEEHHHHHHHHHH
TLSHAYDLRGNKAQADRYATLATARIDAIRRVLWDPKRGAFFDYDWKTRTLSPVLSAATA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHH
MPLFLQMATPEQARAVAETMRTKLLKVGGLTATDHVSGQQWDSPNGWAPEQWMAIKGLNQ
HHHHEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
YGLDDLAQQIASRWMERVIGTYEKSGVLLEKYDVVNPSISPTGGKGGGEYPMQVGFGWTN
CCHHHHHHHHHHHHHHHHHCCHHHCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCC
GTLLG
CCCCC
>Mature Secondary Structure 
AAMQPPPAMPADGAADLSAADLPPVVLFLPLSPVPAGPTVAVPTADQQDLRPPSIALAG
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCCHHHCCCHHHHHHH
LFAAMGAAHVFADAKTAADAIPDEASDALLADYERQKVRPGFDLKDFVAQHFAIAPRRTV
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHH
SYRRRPNESVRDYISGMWEVLSRPPDTLVAHSSLLPLPETYVVPGGRFSELYYWDTYFTM
HHHCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCEEEECCCCCCEEEEEEHEEEE
IGLYEDGRIDLMRGMVRDIASLIDRYGHMPNGSRTYYLSRSEPPFFALMIDLLAMHDGQV
EEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCE
AYTTFLPELQREYDYWMDGADSVAPGAAWRHVVRLPDGTLMNRHWDDMDTPRDESFPQDI
EEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEECCCCCCCCCCCCCCCCCCCCCCHHHH
ATAAQSSRPAAQTYRDLRAGAETGWDYSSRWLADGHSMATIHTTDLLTIELNCLIAHLEQ
HHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECEEEEEEHHHHHHHHHH
TLSHAYDLRGNKAQADRYATLATARIDAIRRVLWDPKRGAFFDYDWKTRTLSPVLSAATA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHH
MPLFLQMATPEQARAVAETMRTKLLKVGGLTATDHVSGQQWDSPNGWAPEQWMAIKGLNQ
HHHHEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
YGLDDLAQQIASRWMERVIGTYEKSGVLLEKYDVVNPSISPTGGKGGGEYPMQVGFGWTN
CCHHHHHHHHHHHHHHHHHCCHHHCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCC
GTLLG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA