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The map label for this gene is trpF [H]

Identifier: 162147123

GI number: 162147123

Start: 1326653

End: 1327327

Strand: Reverse

Name: trpF [H]

Synonym: GDI_1328

Alternate gene names: 162147123

Gene position: 1327327-1326653 (Counterclockwise)

Preceding gene: 162147124

Following gene: 162147119

Centisome position: 33.65

GC content: 73.33

Gene sequence:

>675_bases
ATGCCCCCCCCCGCCGACACGCGGATCGGCGTCAAGATCTGTGGCCTGACCGAGCCCGCCGGGCTGGAGGCCGCCGTCAC
GCACGGGGCCGACTGGATCGGGTTCGTCTTCTTCGCGCGCTCGCCCCGCCACGTCACCCCGGCGCAGGCCGCGTCGCTGA
TCGCCCGCGTGCCGCAGGCGGGGCCACGGCGGATTGGCCTGTTCGTCGAGCCGACGGACGCCCAGATCGCGGCCGCGGTG
GATGCGGCGGCGCTGGACGGATTGCAGGTCTATGCCGCCGAGGAGCGGGCCCTGGAAATCCGCCGGCATTTCGGCCTGCC
GGTCTGGCATGCGCGCGGCGTCGCCACGGCGCCCGACCTGCCGGCGTGCAGTGCGCTCGACGGGCTGGTGATCGAATCGC
GCCCGCCTGCGGGGTCCGACCGGCCGGGGGGAAACGCCCATCCGATCGACTGGACCATCACGCGCGGCTGGACCGCCCCG
GTGCCCTGGATGCTGGCCGGCGGCCTTGCGCCCGACACCGTCGCCCGGGCAATCGCACAGAGCGGCGCTCGGGCGGTGGA
TGTGTCATCCGGCGTCGAAAGCGCGCCGGGCCTGAAGGATCCAGGCCTGATCGCACGCTTTATCCGGGCCGCCCGGGGCG
GACATAATCAGGATGGGGATTACCAGCCCCGATAG

Upstream 100 bases:

>100_bases
GGCGCCGACTGGATCGTGGTCGGGCGACCGATCACCACCGCCGCCGACCCGGCAGCCGCTGCCGCCGCCGTGGCGGCCGA
ACTGGCCGGCTGACCGCGCC

Downstream 100 bases:

>100_bases
TACGGATAACCGTATGCCGGATAGGCGGGATAGGCAGGGTACGCGGGATAGACAGGATAGGCGGGATATCCGTAGGCAGG
ATATCTATAGGGCGGGTAGC

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MPPPADTRIGVKICGLTEPAGLEAAVTHGADWIGFVFFARSPRHVTPAQAASLIARVPQAGPRRIGLFVEPTDAQIAAAV
DAAALDGLQVYAAEERALEIRRHFGLPVWHARGVATAPDLPACSALDGLVIESRPPAGSDRPGGNAHPIDWTITRGWTAP
VPWMLAGGLAPDTVARAIAQSGARAVDVSSGVESAPGLKDPGLIARFIRAARGGHNQDGDYQPR

Sequences:

>Translated_224_residues
MPPPADTRIGVKICGLTEPAGLEAAVTHGADWIGFVFFARSPRHVTPAQAASLIARVPQAGPRRIGLFVEPTDAQIAAAV
DAAALDGLQVYAAEERALEIRRHFGLPVWHARGVATAPDLPACSALDGLVIESRPPAGSDRPGGNAHPIDWTITRGWTAP
VPWMLAGGLAPDTVARAIAQSGARAVDVSSGVESAPGLKDPGLIARFIRAARGGHNQDGDYQPR
>Mature_223_residues
PPPADTRIGVKICGLTEPAGLEAAVTHGADWIGFVFFARSPRHVTPAQAASLIARVPQAGPRRIGLFVEPTDAQIAAAVD
AAALDGLQVYAAEERALEIRRHFGLPVWHARGVATAPDLPACSALDGLVIESRPPAGSDRPGGNAHPIDWTITRGWTAPV
PWMLAGGLAPDTVARAIAQSGARAVDVSSGVESAPGLKDPGLIARFIRAARGGHNQDGDYQPR

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=205, Percent_Identity=29.7560975609756, Blast_Score=78, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320210, Length=214, Percent_Identity=28.0373831775701, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 23342; Mature: 23210

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPPADTRIGVKICGLTEPAGLEAAVTHGADWIGFVFFARSPRHVTPAQAASLIARVPQA
CCCCCCCCCCEEEECCCCCCCCCHHHHCCCHHEEEEEEECCCCCCCHHHHHHHHHHCCCC
GPRRIGLFVEPTDAQIAAAVDAAALDGLQVYAAEERALEIRRHFGLPVWHARGVATAPDL
CCCEEEEEECCCCCHHHHHHHHHHHCCEEEEEHHHHHHHHHHHCCCCEEECCCCCCCCCC
PACSALDGLVIESRPPAGSDRPGGNAHPIDWTITRGWTAPVPWMLAGGLAPDTVARAIAQ
CCCHHCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHCCCCCHHHHHHHHHH
SGARAVDVSSGVESAPGLKDPGLIARFIRAARGGHNQDGDYQPR
CCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PPPADTRIGVKICGLTEPAGLEAAVTHGADWIGFVFFARSPRHVTPAQAASLIARVPQA
CCCCCCCCCEEEECCCCCCCCCHHHHCCCHHEEEEEEECCCCCCCHHHHHHHHHHCCCC
GPRRIGLFVEPTDAQIAAAVDAAALDGLQVYAAEERALEIRRHFGLPVWHARGVATAPDL
CCCEEEEEECCCCCHHHHHHHHHHHCCEEEEEHHHHHHHHHHHCCCCEEECCCCCCCCCC
PACSALDGLVIESRPPAGSDRPGGNAHPIDWTITRGWTAPVPWMLAGGLAPDTVARAIAQ
CCCHHCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHCCCCCHHHHHHHHHH
SGARAVDVSSGVESAPGLKDPGLIARFIRAARGGHNQDGDYQPR
CCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA