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The map label for this gene is idnD [H]

Identifier: 162146997

GI number: 162146997

Start: 1196243

End: 1197442

Strand: Direct

Name: idnD [H]

Synonym: GDI_1202

Alternate gene names: 162146997

Gene position: 1196243-1197442 (Clockwise)

Preceding gene: 162146990

Following gene: 162147000

Centisome position: 30.33

GC content: 67.25

Gene sequence:

>1200_bases
ATGCGTTCCCCGATATTCGGCCTGGGGAATGTGAACGGTATCATCGGCCATACGATCCCAATGGGGAATTACTTTATCGT
GATTTCGATCCCACCAGCCCGACCGATAAAGGACTGTTTCAAAAGTCCCATTCCTGTGCGGGATACCAACATGACAGATC
TTTCGACCCACGATGCGCTGGTCATTCACGGCAAGGGCGACCTGCGGATGGACAGGATCGCGACCCCGCCGCCCGGCCCG
GGCGAGGTGCGTGTCCGCATCGCCTGGGGTGGAATATGTGGGTCCGACATGCATTATCTGCGCCATGGCGGGGTCGGCGC
GTCGGTCCTGCGGGAACCGATGGTGCTGGGGCACGAGGTCTCGGGCACCGTCGAAGCCTGCGGCCCCGACGTCCACGGAT
GGCAAGCGGGAGAGCCGGTGGCCATCCATCCGGCCAAACCGTGCGGGACATGCCCCGAATGCCGACGCGGGCTGCATAAC
CTGTGCCGCAACATGCGGTTCTTCGGCAGCGCGGCCTATCTGCCGCACACGCAGGGCGGATTCCGCCGCACGATGACCGT
GGCGGCGTCGCAATTGCACCGCCTGCCGCCTGGGCTGGACCTGCGCCGCGCCGCGCTGGCCGAACCGTTCGCGGTGGCGC
TGCACGCGATTGCCCGCGCCGGGTCGTGCGCGGGCAAATCGGTTCTGGTCCAGGGGGCCGGCCCGATCGGGGCGTTGATC
GTCGCGGGACTGGCGGTACGGGGCGCCGCGCGGATCGTCGCGGCGGACCTGCATGATTTCCCGCTGTCGGTGGCCCGCCG
CCTGGGCGCGACCGAGACGTGGAATACCGGCGCGCCCGCGCCGGACGCCTCCCGCGACGAGGAATTCGACATCGTGTTCG
AAGCCACGGGCGTCGTCGCGGCCCTGCCGTTCGCCATCGCCCACACGCGGCGTGGTGGTGTCCTGGTGCAGGTCGGCATG
TTTCCGCCCGGGACTATCGAAGTGCCGATGGCGCAGATCATCGCCCGCGAACTGGACCTGCGCGGTACGTTCCGCTTCGA
CGCCGAATTCGCCGAGGCACTGGATCTGCTGGCCGCCCATCCGCAGATCGCGGACGGGCTGGTGACCCATGAATTCGCGT
TCGACGCCTACGCGGCGGCCTTCGACGCATCGTCGAACCGGCAGGCCGCATCCAAGGTCATGCTTGAAATCGGGGGATAG

Upstream 100 bases:

>100_bases
CTGCCGGGCGATCCGTTCCAGATCGCGCGCCAGCGCCGGATCGTCCGACCTGATAATCCCTGCCCCTGCCTGTTCCGCCA
TGATGCCTCGTCCTCCGTTC

Downstream 100 bases:

>100_bases
GGATCAGGGGCTTTGCCCCTGTCTTATCACCGAATTGTGATGCAAGGACCGAGGCCCCTGCCCCGTTCGGGCAGGGCCCG
AACCGTATTACATTACAGTA

Product: L-idonate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MRSPIFGLGNVNGIIGHTIPMGNYFIVISIPPARPIKDCFKSPIPVRDTNMTDLSTHDALVIHGKGDLRMDRIATPPPGP
GEVRVRIAWGGICGSDMHYLRHGGVGASVLREPMVLGHEVSGTVEACGPDVHGWQAGEPVAIHPAKPCGTCPECRRGLHN
LCRNMRFFGSAAYLPHTQGGFRRTMTVAASQLHRLPPGLDLRRAALAEPFAVALHAIARAGSCAGKSVLVQGAGPIGALI
VAGLAVRGAARIVAADLHDFPLSVARRLGATETWNTGAPAPDASRDEEFDIVFEATGVVAALPFAIAHTRRGGVLVQVGM
FPPGTIEVPMAQIIARELDLRGTFRFDAEFAEALDLLAAHPQIADGLVTHEFAFDAYAAAFDASSNRQAASKVMLEIGG

Sequences:

>Translated_399_residues
MRSPIFGLGNVNGIIGHTIPMGNYFIVISIPPARPIKDCFKSPIPVRDTNMTDLSTHDALVIHGKGDLRMDRIATPPPGP
GEVRVRIAWGGICGSDMHYLRHGGVGASVLREPMVLGHEVSGTVEACGPDVHGWQAGEPVAIHPAKPCGTCPECRRGLHN
LCRNMRFFGSAAYLPHTQGGFRRTMTVAASQLHRLPPGLDLRRAALAEPFAVALHAIARAGSCAGKSVLVQGAGPIGALI
VAGLAVRGAARIVAADLHDFPLSVARRLGATETWNTGAPAPDASRDEEFDIVFEATGVVAALPFAIAHTRRGGVLVQVGM
FPPGTIEVPMAQIIARELDLRGTFRFDAEFAEALDLLAAHPQIADGLVTHEFAFDAYAAAFDASSNRQAASKVMLEIGG
>Mature_399_residues
MRSPIFGLGNVNGIIGHTIPMGNYFIVISIPPARPIKDCFKSPIPVRDTNMTDLSTHDALVIHGKGDLRMDRIATPPPGP
GEVRVRIAWGGICGSDMHYLRHGGVGASVLREPMVLGHEVSGTVEACGPDVHGWQAGEPVAIHPAKPCGTCPECRRGLHN
LCRNMRFFGSAAYLPHTQGGFRRTMTVAASQLHRLPPGLDLRRAALAEPFAVALHAIARAGSCAGKSVLVQGAGPIGALI
VAGLAVRGAARIVAADLHDFPLSVARRLGATETWNTGAPAPDASRDEEFDIVFEATGVVAALPFAIAHTRRGGVLVQVGM
FPPGTIEVPMAQIIARELDLRGTFRFDAEFAEALDLLAAHPQIADGLVTHEFAFDAYAAAFDASSNRQAASKVMLEIGG

Specific function: Catalyzes the NADH/NADPH-dependent oxidation of L- idonate to 5-ketogluconate (5KG) [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=345, Percent_Identity=35.9420289855072, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI4501933, Length=354, Percent_Identity=25.4237288135593, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4501929, Length=361, Percent_Identity=24.3767313019391, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI34577061, Length=358, Percent_Identity=25.1396648044693, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI71565152, Length=363, Percent_Identity=24.5179063360882, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI71565154, Length=346, Percent_Identity=24.8554913294798, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1790718, Length=313, Percent_Identity=41.85303514377, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1788073, Length=330, Percent_Identity=30, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1788407, Length=327, Percent_Identity=29.9694189602446, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI226510992, Length=358, Percent_Identity=31.2849162011173, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790045, Length=335, Percent_Identity=28.0597014925373, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1787863, Length=344, Percent_Identity=28.7790697674419, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788075, Length=361, Percent_Identity=28.808864265928, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87082125, Length=344, Percent_Identity=27.3255813953488, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=25.5102040816327, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786518, Length=295, Percent_Identity=26.1016949152542, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786552, Length=271, Percent_Identity=29.8892988929889, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87081918, Length=301, Percent_Identity=25.9136212624585, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=334, Percent_Identity=35.9281437125749, Blast_Score=221, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17562878, Length=334, Percent_Identity=38.0239520958084, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI25146526, Length=377, Percent_Identity=25.4641909814324, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=379, Percent_Identity=25.3298153034301, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=316, Percent_Identity=26.8987341772152, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=342, Percent_Identity=26.0233918128655, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=334, Percent_Identity=25.748502994012, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=324, Percent_Identity=25.6172839506173, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=347, Percent_Identity=33.1412103746398, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6319955, Length=341, Percent_Identity=34.0175953079179, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322619, Length=341, Percent_Identity=34.0175953079179, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319258, Length=332, Percent_Identity=26.5060240963855, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=330, Percent_Identity=27.2727272727273, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323729, Length=309, Percent_Identity=25.2427184466019, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=288, Percent_Identity=26.7361111111111, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=311, Percent_Identity=26.6881028938907, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=312, Percent_Identity=26.2820512820513, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=325, Percent_Identity=24.3076923076923, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737897, Length=349, Percent_Identity=36.676217765043, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17137530, Length=346, Percent_Identity=35.2601156069364, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI17737895, Length=364, Percent_Identity=25.8241758241758, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI45550770, Length=251, Percent_Identity=26.2948207171315, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221457811, Length=251, Percent_Identity=26.2948207171315, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551930, Length=196, Percent_Identity=29.0816326530612, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.264 [H]

Molecular weight: Translated: 42159; Mature: 42159

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSPIFGLGNVNGIIGHTIPMGNYFIVISIPPARPIKDCFKSPIPVRDTNMTDLSTHDAL
CCCCCCCCCCCCCEEECEECCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCCCEE
VIHGKGDLRMDRIATPPPGPGEVRVRIAWGGICGSDMHYLRHGGVGASVLREPMVLGHEV
EEECCCCEEECCCCCCCCCCCCEEEEEEECCCCCCCHHHHHCCCCCHHHHHCCHHCCCCC
SGTVEACGPDVHGWQAGEPVAIHPAKPCGTCPECRRGLHNLCRNMRFFGSAAYLPHTQGG
CCCHHHCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEECCCCCCCC
FRRTMTVAASQLHRLPPGLDLRRAALAEPFAVALHAIARAGSCAGKSVLVQGAGPIGALI
HHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHH
VAGLAVRGAARIVAADLHDFPLSVARRLGATETWNTGAPAPDASRDEEFDIVFEATGVVA
HHHHHHHCHHHEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHH
ALPFAIAHTRRGGVLVQVGMFPPGTIEVPMAQIIARELDLRGTFRFDAEFAEALDLLAAH
HHHHHHHHCCCCCEEEEECCCCCCCEECCHHHHHHHHHCCCEEEEECHHHHHHHHHHHCC
PQIADGLVTHEFAFDAYAAAFDASSNRQAASKVMLEIGG
CHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHEEEEEECC
>Mature Secondary Structure
MRSPIFGLGNVNGIIGHTIPMGNYFIVISIPPARPIKDCFKSPIPVRDTNMTDLSTHDAL
CCCCCCCCCCCCCEEECEECCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCCCEE
VIHGKGDLRMDRIATPPPGPGEVRVRIAWGGICGSDMHYLRHGGVGASVLREPMVLGHEV
EEECCCCEEECCCCCCCCCCCCEEEEEEECCCCCCCHHHHHCCCCCHHHHHCCHHCCCCC
SGTVEACGPDVHGWQAGEPVAIHPAKPCGTCPECRRGLHNLCRNMRFFGSAAYLPHTQGG
CCCHHHCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEECCCCCCCC
FRRTMTVAASQLHRLPPGLDLRRAALAEPFAVALHAIARAGSCAGKSVLVQGAGPIGALI
HHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHH
VAGLAVRGAARIVAADLHDFPLSVARRLGATETWNTGAPAPDASRDEEFDIVFEATGVVA
HHHHHHHCHHHEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHH
ALPFAIAHTRRGGVLVQVGMFPPGTIEVPMAQIIARELDLRGTFRFDAEFAEALDLLAAH
HHHHHHHHCCCCCEEEEECCCCCCCEECCHHHHHHHHHCCCEEEEECHHHHHHHHHHHCC
PQIADGLVTHEFAFDAYAAAFDASSNRQAASKVMLEIGG
CHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 9658018 [H]