Click here to switch to the map view.

The map label for this gene is ribAB [H]

Identifier: 162146947

GI number: 162146947

Start: 1147625

End: 1148899

Strand: Reverse

Name: ribAB [H]

Synonym: GDI_1152

Alternate gene names: 162146947

Gene position: 1148899-1147625 (Counterclockwise)

Preceding gene: 162146948

Following gene: 162146946

Centisome position: 29.13

GC content: 70.35

Gene sequence:

>1275_bases
ATGCCAGTACCGGTGATGAGTCCCGGCCTGCGGACCGCGGTGGCGGCGATCCGGGCGGGCGGCATGGTGATCCTGGTCGA
TGACGAGGATCGCGAGAACGAGGGCGACCTGGTGATGGCCGCCGACATGGTCACGCCGCAGGCGATCAATTTCATGGTCA
CGCACGGGCGCGGCCTGGTCTGCCTGCCGCTGGAGGCCGAACGGGTCGAGCAGCTTGGCCTGTCGATGATGACGCAGGTG
AATACCTGCCCGCGCGAGACCGCCTTCACGGTGTCGATCGAGGCGCGCGAGGGTGTGGAGACCGGCATTTCCGCCGCCGA
CCGCGCCCGGACCATCCAGGTCGCGGTGGCGGACGGCGCGGGACCTGCCGACCTGGTGTCGCCCGGGCATATCTTTCCGC
TGCGCGCGGTGCCGGGCGGGGTGCTGGCCCGCAACGGTCATACCGAGGCCTCGATCGAACTGGCGCGCATGGCGGGCCGC
GCGCCGTCCGCCGTGATCTGCGAGATCATGAACGAGGACGGGTCCATGGCGCGGATGTCCGACCTGCGCCCCTATGCCGA
GCGGCACGGACTGCCGATCCTGTCGATCGCGGAACTGGTGTCGTGGATGAAGGCCCAGGCCGGACAGGCATCCGGGCAGG
CCGCTGGCGATTCCGGGGAACGGATCGAGAAGGTCGCCGAGGCCGCGCTGCCGAGCTGCTATGGCGGCGAGGACCTGATG
ATCCACGCCTTCCGCGCCGCCGATGGGACCGAGCACGTGGCGCTGGTCAAGGGCGATCCCGCCGCCGGCGCGGTGCCGCT
GGTGCGGCTGCATTCGGAATGCGTCACGGGCGACGCGCTGGGCTCGCTGCGCTGCGATTGCGGGGCGCAGCTCCAGACCG
CGCTGGCGCGTATCGGCGCGGCGGAAAGCGGGGTCCTGCTGTATCTGCGCGGGCATGAGGGGCGCGGTATCGGCCTGGCG
AACAAGATCCGTGCCTATGCGCTGCAGGATCGCGGGCTGGACACGGTGGACGCCAATCACCGCCTGGGCTTCGAGACCGA
TGCGCGGGACTGGAGCGCCGCCGGCGCCATCCTGCGCACGCTTGGCGTGCGGACGCTGGACCTGATGACCAACAACCCGG
CCAAGGTCGTGGCGGTGGAGCGGCACGGCTTTACCGTGCGCGAGCGCGTCGCGGTCGAGATCCCGCCCAATCCCTTCAAC
CGCGCCTATCTGGACGCCAAGCGTACCCGGATGGGACACCATCTCTGCTCCACCGTCAGCGCGGCGGCCGAGTGA

Upstream 100 bases:

>100_bases
TCATTCCCCATACCTGGACCCATACCACGCTGGGCACCCTGTCGCCCGGCGATGGCGTGAATGTCGAGGTCGATGTCATC
GCGAAATATGTGGAGACCCT

Downstream 100 bases:

>100_bases
GGCGCCGCAGACCACCGACCGGATAGAATCGACATGAGCACCAATACGCCGTCTTCCTCACCCGACCTGACCTTCGCGCG
GCCGCCGCGCCTGGCGATCG

Product: 3,4-dihydroxy-2-butanone 4 phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MPVPVMSPGLRTAVAAIRAGGMVILVDDEDRENEGDLVMAADMVTPQAINFMVTHGRGLVCLPLEAERVEQLGLSMMTQV
NTCPRETAFTVSIEAREGVETGISAADRARTIQVAVADGAGPADLVSPGHIFPLRAVPGGVLARNGHTEASIELARMAGR
APSAVICEIMNEDGSMARMSDLRPYAERHGLPILSIAELVSWMKAQAGQASGQAAGDSGERIEKVAEAALPSCYGGEDLM
IHAFRAADGTEHVALVKGDPAAGAVPLVRLHSECVTGDALGSLRCDCGAQLQTALARIGAAESGVLLYLRGHEGRGIGLA
NKIRAYALQDRGLDTVDANHRLGFETDARDWSAAGAILRTLGVRTLDLMTNNPAKVVAVERHGFTVRERVAVEIPPNPFN
RAYLDAKRTRMGHHLCSTVSAAAE

Sequences:

>Translated_424_residues
MPVPVMSPGLRTAVAAIRAGGMVILVDDEDRENEGDLVMAADMVTPQAINFMVTHGRGLVCLPLEAERVEQLGLSMMTQV
NTCPRETAFTVSIEAREGVETGISAADRARTIQVAVADGAGPADLVSPGHIFPLRAVPGGVLARNGHTEASIELARMAGR
APSAVICEIMNEDGSMARMSDLRPYAERHGLPILSIAELVSWMKAQAGQASGQAAGDSGERIEKVAEAALPSCYGGEDLM
IHAFRAADGTEHVALVKGDPAAGAVPLVRLHSECVTGDALGSLRCDCGAQLQTALARIGAAESGVLLYLRGHEGRGIGLA
NKIRAYALQDRGLDTVDANHRLGFETDARDWSAAGAILRTLGVRTLDLMTNNPAKVVAVERHGFTVRERVAVEIPPNPFN
RAYLDAKRTRMGHHLCSTVSAAAE
>Mature_423_residues
PVPVMSPGLRTAVAAIRAGGMVILVDDEDRENEGDLVMAADMVTPQAINFMVTHGRGLVCLPLEAERVEQLGLSMMTQVN
TCPRETAFTVSIEAREGVETGISAADRARTIQVAVADGAGPADLVSPGHIFPLRAVPGGVLARNGHTEASIELARMAGRA
PSAVICEIMNEDGSMARMSDLRPYAERHGLPILSIAELVSWMKAQAGQASGQAAGDSGERIEKVAEAALPSCYGGEDLMI
HAFRAADGTEHVALVKGDPAAGAVPLVRLHSECVTGDALGSLRCDCGAQLQTALARIGAAESGVLLYLRGHEGRGIGLAN
KIRAYALQDRGLDTVDANHRLGFETDARDWSAAGAILRTLGVRTLDLMTNNPAKVVAVERHGFTVRERVAVEIPPNPFNR
AYLDAKRTRMGHHLCSTVSAAAE

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=202, Percent_Identity=48.5148514851485, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI1787533, Length=195, Percent_Identity=51.2820512820513, Blast_Score=189, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6320695, Length=207, Percent_Identity=38.6473429951691, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=43.2748538011696, Blast_Score=110, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44742; Mature: 44610

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVPVMSPGLRTAVAAIRAGGMVILVDDEDRENEGDLVMAADMVTPQAINFMVTHGRGLV
CCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCCCEEEEEECCCCEE
CLPLEAERVEQLGLSMMTQVNTCPRETAFTVSIEAREGVETGISAADRARTIQVAVADGA
EEECCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHCCCHHCCCEEEEEEEECCC
GPADLVSPGHIFPLRAVPGGVLARNGHTEASIELARMAGRAPSAVICEIMNEDGSMARMS
CCHHHCCCCCEEEECCCCCCEEECCCCCHHHHHHHHHCCCCCCCEEHEEECCCCCCHHHH
DLRPYAERHGLPILSIAELVSWMKAQAGQASGQAAGDSGERIEKVAEAALPSCYGGEDLM
HCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEE
IHAFRAADGTEHVALVKGDPAAGAVPLVRLHSECVTGDALGSLRCDCGAQLQTALARIGA
EEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCC
AESGVLLYLRGHEGRGIGLANKIRAYALQDRGLDTVDANHRLGFETDARDWSAAGAILRT
CCCCEEEEEECCCCCCCCHHHHHHHEEECCCCCCEECCCCCCCCCCCCCCHHHHHHHHHH
LGVRTLDLMTNNPAKVVAVERHGFTVRERVAVEIPPNPFNRAYLDAKRTRMGHHLCSTVS
HCCEEEEEECCCCCEEEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
AAAE
HHCC
>Mature Secondary Structure 
PVPVMSPGLRTAVAAIRAGGMVILVDDEDRENEGDLVMAADMVTPQAINFMVTHGRGLV
CCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCCCEEEEEECCCCEE
CLPLEAERVEQLGLSMMTQVNTCPRETAFTVSIEAREGVETGISAADRARTIQVAVADGA
EEECCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHCCCHHCCCEEEEEEEECCC
GPADLVSPGHIFPLRAVPGGVLARNGHTEASIELARMAGRAPSAVICEIMNEDGSMARMS
CCHHHCCCCCEEEECCCCCCEEECCCCCHHHHHHHHHCCCCCCCEEHEEECCCCCCHHHH
DLRPYAERHGLPILSIAELVSWMKAQAGQASGQAAGDSGERIEKVAEAALPSCYGGEDLM
HCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEE
IHAFRAADGTEHVALVKGDPAAGAVPLVRLHSECVTGDALGSLRCDCGAQLQTALARIGA
EEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCC
AESGVLLYLRGHEGRGIGLANKIRAYALQDRGLDTVDANHRLGFETDARDWSAAGAILRT
CCCCEEEEEECCCCCCCCHHHHHHHEEECCCCCCEECCCCCCCCCCCCCCHHHHHHHHHH
LGVRTLDLMTNNPAKVVAVERHGFTVRERVAVEIPPNPFNRAYLDAKRTRMGHHLCSTVS
HCCEEEEEECCCCCEEEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
AAAE
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]