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The map label for this gene is rkpK [H]

Identifier: 162146935

GI number: 162146935

Start: 1132788

End: 1134101

Strand: Direct

Name: rkpK [H]

Synonym: GDI_1140

Alternate gene names: 162146935

Gene position: 1132788-1134101 (Clockwise)

Preceding gene: 162146930

Following gene: 162146938

Centisome position: 28.72

GC content: 69.18

Gene sequence:

>1314_bases
ATGATCGGCGGCGGGTATGTCGGCCTTGTCTCGGCGGCCTGCTTCGCCAAATTCGGCAACGACGTCGCCGTGGTGGAAAT
CGACCCCGACCGCCTGGCAGCCCTGCGCGAAGGGCGCATTCCCATCTACGAACCCGGGCTGGACGGGCTGGTCGCCGATA
CCATGCGGGCGGGTCGCCTGTCCTTCGGCGCCGATATCTCGGCGGCGGTCCAGGGGGCGGAGGCGATCTTCATCGCCGTG
GGAACGCCGCCGCGCAACGGCGACGGCCATGCCGACCTGACCTATGTCCACGAGGCCGCACGGCAGATCGCCCGGGCGAT
GACGGATTACGCCGTCATCGTCACCAAATCGACGGTTCCCGTCGGCACCAGCCGCCGCATTGCCGAGATCGTGCGCGACA
CCCGGCCGGACCTGGATTTCGATGTCGCGTCCAATCCCGAATTCCTGCGCGAAGGCAATGCGATCGGCGATTTCATGAAG
CCCGACCGCGTCATCGTGGGCCTGGACGAGGACGCGCCCGACGGCGGCGCGCGGGCGCGCGCGGTGCTGGGCGCGGTGTA
CCGGCCGCTCTACCTGATCGAGGCGCCGGTCCTGTTCATGAAGCTGGAAACGGCGGAACTGACCAAATACGCCTCGAACT
CGTTCCTGGCGATGAAGATTTCCTTCATCAACGAAATGGCCGACCTGTGCGAACGGGTGGGGGCCAACGTCCACGACCTG
GCGCGCGGCATGGGGCTGGACGGGCGGATCGGCCGGAAATTCCTGCATCCCGGCCCGGGCTATGGCGGATCGTGCTTCCC
CAAGGACACGCTGGCCCTGACCCGCATCGCCCAGGAAGCCGGCGCGCCGACCCGCCTGATCGAGGCGACGGTGGGCGTGA
ACGACGCCCGCAAGGTCGCGATGGCGGGACGGATCGTCGCCGCCAGCGGCGGGTCGGTGCGCGGCAGGCGGATCGCGGTG
CTGGGCCTGACCTTCAAGCCCGAGACCGACGACATGCGCGAGGCCGCGTCCATTCCCATCCTGGTCCGCCTGGCGGAACA
GGGTGCGGAGATCCGCGCCTTCGACCCGGTGGGCATGCCGGCCGCCCGGCCGCACCTGCCGCAGGCCGTCACCTATTGCG
ACAGCGCCCTGGACGCGGCGACGGACGCCGACACGCTGGTGGTGCTGACGGAATGGACCGAATTCCGTGCCCTGGCGCCG
GGCCGGCTTGCCGCGGCGATGCGGGGCCGCGTGGTCGTCGACCTGCGCAATATCTTCGACCCCGTGGCGATGCAGGAAGC
AGGGTTCGCCTATCATTCCGTAGGACGGCCCTGA

Upstream 100 bases:

>100_bases
CACCCGGCGTCTCGCTGGCCAAATCGCGGGGCACGCGCCATAGTCGCGCCGAATCCTAACGCCCCATGACAAATACAGGA
GAATGGCGGTGCGCATCGCG

Downstream 100 bases:

>100_bases
CCTTCAGCCCGCCGAATGCCGCCGGTGCCACACGGTGCAGAACAGCATGCCGACGATGCCCGCCGCCATGGTACCGGCGA
TCGGCACCGTCGTATCCAGC

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MIGGGYVGLVSAACFAKFGNDVAVVEIDPDRLAALREGRIPIYEPGLDGLVADTMRAGRLSFGADISAAVQGAEAIFIAV
GTPPRNGDGHADLTYVHEAARQIARAMTDYAVIVTKSTVPVGTSRRIAEIVRDTRPDLDFDVASNPEFLREGNAIGDFMK
PDRVIVGLDEDAPDGGARARAVLGAVYRPLYLIEAPVLFMKLETAELTKYASNSFLAMKISFINEMADLCERVGANVHDL
ARGMGLDGRIGRKFLHPGPGYGGSCFPKDTLALTRIAQEAGAPTRLIEATVGVNDARKVAMAGRIVAASGGSVRGRRIAV
LGLTFKPETDDMREAASIPILVRLAEQGAEIRAFDPVGMPAARPHLPQAVTYCDSALDAATDADTLVVLTEWTEFRALAP
GRLAAAMRGRVVVDLRNIFDPVAMQEAGFAYHSVGRP

Sequences:

>Translated_437_residues
MIGGGYVGLVSAACFAKFGNDVAVVEIDPDRLAALREGRIPIYEPGLDGLVADTMRAGRLSFGADISAAVQGAEAIFIAV
GTPPRNGDGHADLTYVHEAARQIARAMTDYAVIVTKSTVPVGTSRRIAEIVRDTRPDLDFDVASNPEFLREGNAIGDFMK
PDRVIVGLDEDAPDGGARARAVLGAVYRPLYLIEAPVLFMKLETAELTKYASNSFLAMKISFINEMADLCERVGANVHDL
ARGMGLDGRIGRKFLHPGPGYGGSCFPKDTLALTRIAQEAGAPTRLIEATVGVNDARKVAMAGRIVAASGGSVRGRRIAV
LGLTFKPETDDMREAASIPILVRLAEQGAEIRAFDPVGMPAARPHLPQAVTYCDSALDAATDADTLVVLTEWTEFRALAP
GRLAAAMRGRVVVDLRNIFDPVAMQEAGFAYHSVGRP
>Mature_437_residues
MIGGGYVGLVSAACFAKFGNDVAVVEIDPDRLAALREGRIPIYEPGLDGLVADTMRAGRLSFGADISAAVQGAEAIFIAV
GTPPRNGDGHADLTYVHEAARQIARAMTDYAVIVTKSTVPVGTSRRIAEIVRDTRPDLDFDVASNPEFLREGNAIGDFMK
PDRVIVGLDEDAPDGGARARAVLGAVYRPLYLIEAPVLFMKLETAELTKYASNSFLAMKISFINEMADLCERVGANVHDL
ARGMGLDGRIGRKFLHPGPGYGGSCFPKDTLALTRIAQEAGAPTRLIEATVGVNDARKVAMAGRIVAASGGSVRGRRIAV
LGLTFKPETDDMREAASIPILVRLAEQGAEIRAFDPVGMPAARPHLPQAVTYCDSALDAATDADTLVVLTEWTEFRALAP
GRLAAAMRGRVVVDLRNIFDPVAMQEAGFAYHSVGRP

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=459, Percent_Identity=35.5119825708061, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI296040438, Length=364, Percent_Identity=35.7142857142857, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI296040443, Length=318, Percent_Identity=35.8490566037736, Blast_Score=183, Evalue=2e-46,
Organism=Escherichia coli, GI48994968, Length=418, Percent_Identity=32.5358851674641, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1788340, Length=359, Percent_Identity=30.3621169916435, Blast_Score=151, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17560350, Length=459, Percent_Identity=34.4226579520697, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI17136908, Length=458, Percent_Identity=36.2445414847162, Blast_Score=275, Evalue=6e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 46503; Mature: 46503

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGGGYVGLVSAACFAKFGNDVAVVEIDPDRLAALREGRIPIYEPGLDGLVADTMRAGRL
CCCCHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHCCCCCEECCCCCHHHHHHHHHCCC
SFGADISAAVQGAEAIFIAVGTPPRNGDGHADLTYVHEAARQIARAMTDYAVIVTKSTVP
CCCCCHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCC
VGTSRRIAEIVRDTRPDLDFDVASNPEFLREGNAIGDFMKPDRVIVGLDEDAPDGGARAR
CCCHHHHHHHHHHCCCCCCEECCCCCHHHHCCCCCCCCCCCCEEEEECCCCCCCCCHHHH
AVLGAVYRPLYLIEAPVLFMKLETAELTKYASNSFLAMKISFINEMADLCERVGANVHDL
HHHHHHHHHHHHEECCEEEEEECHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCHHHH
ARGMGLDGRIGRKFLHPGPGYGGSCFPKDTLALTRIAQEAGAPTRLIEATVGVNDARKVA
HHCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHH
MAGRIVAASGGSVRGRRIAVLGLTFKPETDDMREAASIPILVRLAEQGAEIRAFDPVGMP
HHCEEEEECCCCCCCCEEEEEEEEECCCCHHHHHHCCCCEEEEEHHCCCEEEEECCCCCC
AARPHLPQAVTYCDSALDAATDADTLVVLTEWTEFRALAPGRLAAAMRGRVVVDLRNIFD
CCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHCCCCHHHHHHHCCEEEEEHHHHCC
PVAMQEAGFAYHSVGRP
HHHHHHCCCHHHCCCCC
>Mature Secondary Structure
MIGGGYVGLVSAACFAKFGNDVAVVEIDPDRLAALREGRIPIYEPGLDGLVADTMRAGRL
CCCCHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHCCCCCEECCCCCHHHHHHHHHCCC
SFGADISAAVQGAEAIFIAVGTPPRNGDGHADLTYVHEAARQIARAMTDYAVIVTKSTVP
CCCCCHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCC
VGTSRRIAEIVRDTRPDLDFDVASNPEFLREGNAIGDFMKPDRVIVGLDEDAPDGGARAR
CCCHHHHHHHHHHCCCCCCEECCCCCHHHHCCCCCCCCCCCCEEEEECCCCCCCCCHHHH
AVLGAVYRPLYLIEAPVLFMKLETAELTKYASNSFLAMKISFINEMADLCERVGANVHDL
HHHHHHHHHHHHEECCEEEEEECHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCHHHH
ARGMGLDGRIGRKFLHPGPGYGGSCFPKDTLALTRIAQEAGAPTRLIEATVGVNDARKVA
HHCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHH
MAGRIVAASGGSVRGRRIAVLGLTFKPETDDMREAASIPILVRLAEQGAEIRAFDPVGMP
HHCEEEEECCCCCCCCEEEEEEEEECCCCHHHHHHCCCCEEEEEHHCCCEEEEECCCCCC
AARPHLPQAVTYCDSALDAATDADTLVVLTEWTEFRALAPGRLAAAMRGRVVVDLRNIFD
CCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHCCCCHHHHHHHCCEEEEEHHHHCC
PVAMQEAGFAYHSVGRP
HHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]