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The map label for this gene is fabF [H]

Identifier: 162146911

GI number: 162146911

Start: 1105717

End: 1107015

Strand: Direct

Name: fabF [H]

Synonym: GDI_1110

Alternate gene names: 162146911

Gene position: 1105717-1107015 (Clockwise)

Preceding gene: 162146910

Following gene: 162146913

Centisome position: 28.03

GC content: 62.89

Gene sequence:

>1299_bases
ATGCGAATTGTTATAACTGGTATGGGTATCGTAATCATGCGAAGTGTTATAACTGGTATGGGTCTCGCGCCGCCGCTCGC
CTGCGGCAGTCACGCGGCTCTGGCGCCGCCTTTGGCGCCGGTCAGTCGGGTATCCAGCGCGTTGCCGAGGATTTCGCGCG
CGGCGTCGATTGCCAGATCGCCGGTTTCGTGCCGGGGCGCGCCGATGACGCGGGTTTCAACATTGAAGGAGACGATCCCG
GTCAAGGACCGCAAGAAAATGGATCGCTTTATTCAGTTTGCTCTGGGCGCGGCGCAGGAAGCGCTGGGTCAGGCCGGCTG
GAATCCGCGAACGGAGCAGGAAAAACTACGGACCGCGACCGTCATCGCGTCTGGAATCGGCGGCTTCGGCGCGATAGCCA
ATGCCGTGCGGACGGTCGAATTACGGGGAGCTGACAAGCTTTCTCCCTTCACGGTTCCATCCTTCTTGGTCAATCTTGCG
GCGGGATGGGTGTCGATCCGGAATAGCTTCAAGGGACCGATCGGAGCCCCCGCGACTGCATGTGCAGCCGGTGTCCAGGC
ATTGGGTGACGCGGCGCGCCTGATTCGTGCGGGCGAGGCGGACATCGCCTTAGCCGGTGGATCGGAGGCGGCGATCGATC
GGGTGAGCCTTGGAGGCTTTGCGGCGGCCCGTGCCTTGTCAACTGGCTACAATGACCGGCCTGAGCAGGCATCACGCCCT
TTCGATCAGGGGCGGGACGGATTTGTGATGGGGGAAGGCGCAGGCATTCTTGTCGTTGAGCGGTTGGATCACGCGCTGGC
GCGTGGCGCGCGACCGCTTGCTGAACTCGTCGGTTACGGAACGAGCGCGGATGCTTACCATCTGACGGCTGGACCAGAAG
ACGGCGCAGGTGCCGCGGAGGCAATGCGCGCGGCGCTTGATCAGGCGGCCGTCTCTCCGCGACTGATCGGGCATCTGAAC
GCCCATGCGACTTCGACGCCGGTCGGAGATCGTGGAGAACTGGCCGCGATCCGCGCTGTATTCGGGGAAGGTGGCGGCCC
GGCTATCAGCGCCACGAAATCCGCGACTGGCCATTTGCTCGGAGCCGCCGGCGGGGTCGAGGCAATCTTCACTGTCATGG
CGCTGGGCGATCAGCTCATGCCGCCGACGCTGAATCTGAGCCGCCCGGACCCGCTGGCGGAGGGACTCGATCTTGTAGGG
CCTGAATCTCGGAAAAAGTGTTTTGATTATGCCATTTCGAATGGTTTCGGATTCGGCGGTGTGAACGCCTCCGTCGTGTT
TCGGCGCTGGCGAGAATGA

Upstream 100 bases:

>100_bases
TATCGCATCCGGCCCGAAGATGAAGAAACCATGGTTGCGACTGGCCCCACATAGACGCGTCGCGGTCGGGCACCCGCTTA
CCGAATTCAGAAAGAATATC

Downstream 100 bases:

>100_bases
GGGCGGGGATTTATCGCTTCGAGAGGTCCGGCTCTTCGAGTCGTAATGCCATGTCCCTGGTGGGGCGGCCCGTTGCACGG
TCTACGACGACAGGCTCAAC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase 2

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MRIVITGMGIVIMRSVITGMGLAPPLACGSHAALAPPLAPVSRVSSALPRISRAASIARSPVSCRGAPMTRVSTLKETIP
VKDRKKMDRFIQFALGAAQEALGQAGWNPRTEQEKLRTATVIASGIGGFGAIANAVRTVELRGADKLSPFTVPSFLVNLA
AGWVSIRNSFKGPIGAPATACAAGVQALGDAARLIRAGEADIALAGGSEAAIDRVSLGGFAAARALSTGYNDRPEQASRP
FDQGRDGFVMGEGAGILVVERLDHALARGARPLAELVGYGTSADAYHLTAGPEDGAGAAEAMRAALDQAAVSPRLIGHLN
AHATSTPVGDRGELAAIRAVFGEGGGPAISATKSATGHLLGAAGGVEAIFTVMALGDQLMPPTLNLSRPDPLAEGLDLVG
PESRKKCFDYAISNGFGFGGVNASVVFRRWRE

Sequences:

>Translated_432_residues
MRIVITGMGIVIMRSVITGMGLAPPLACGSHAALAPPLAPVSRVSSALPRISRAASIARSPVSCRGAPMTRVSTLKETIP
VKDRKKMDRFIQFALGAAQEALGQAGWNPRTEQEKLRTATVIASGIGGFGAIANAVRTVELRGADKLSPFTVPSFLVNLA
AGWVSIRNSFKGPIGAPATACAAGVQALGDAARLIRAGEADIALAGGSEAAIDRVSLGGFAAARALSTGYNDRPEQASRP
FDQGRDGFVMGEGAGILVVERLDHALARGARPLAELVGYGTSADAYHLTAGPEDGAGAAEAMRAALDQAAVSPRLIGHLN
AHATSTPVGDRGELAAIRAVFGEGGGPAISATKSATGHLLGAAGGVEAIFTVMALGDQLMPPTLNLSRPDPLAEGLDLVG
PESRKKCFDYAISNGFGFGGVNASVVFRRWRE
>Mature_432_residues
MRIVITGMGIVIMRSVITGMGLAPPLACGSHAALAPPLAPVSRVSSALPRISRAASIARSPVSCRGAPMTRVSTLKETIP
VKDRKKMDRFIQFALGAAQEALGQAGWNPRTEQEKLRTATVIASGIGGFGAIANAVRTVELRGADKLSPFTVPSFLVNLA
AGWVSIRNSFKGPIGAPATACAAGVQALGDAARLIRAGEADIALAGGSEAAIDRVSLGGFAAARALSTGYNDRPEQASRP
FDQGRDGFVMGEGAGILVVERLDHALARGARPLAELVGYGTSADAYHLTAGPEDGAGAAEAMRAALDQAAVSPRLIGHLN
AHATSTPVGDRGELAAIRAVFGEGGGPAISATKSATGHLLGAAGGVEAIFTVMALGDQLMPPTLNLSRPDPLAEGLDLVG
PESRKKCFDYAISNGFGFGGVNASVVFRRWRE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=42.3076923076923, Blast_Score=298, Evalue=5e-81,
Organism=Homo sapiens, GI223972627, Length=165, Percent_Identity=43.6363636363636, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI41872631, Length=359, Percent_Identity=27.2980501392758, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787337, Length=418, Percent_Identity=44.4976076555024, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI1788663, Length=365, Percent_Identity=39.4520547945205, Blast_Score=218, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI71983541, Length=354, Percent_Identity=40.6779661016949, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI71983535, Length=268, Percent_Identity=44.0298507462687, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI212642053, Length=355, Percent_Identity=26.1971830985915, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=279, Percent_Identity=25.089605734767, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320904, Length=371, Percent_Identity=40.7008086253369, Blast_Score=251, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24644341, Length=363, Percent_Identity=44.0771349862259, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI19920632, Length=360, Percent_Identity=25.2777777777778, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI221330659, Length=358, Percent_Identity=24.8603351955307, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24581345, Length=368, Percent_Identity=23.3695652173913, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44272; Mature: 44272

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVITGMGIVIMRSVITGMGLAPPLACGSHAALAPPLAPVSRVSSALPRISRAASIARS
CEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
PVSCRGAPMTRVSTLKETIPVKDRKKMDRFIQFALGAAQEALGQAGWNPRTEQEKLRTAT
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
VIASGIGGFGAIANAVRTVELRGADKLSPFTVPSFLVNLAAGWVSIRNSFKGPIGAPATA
HHHHCCCHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
CAAGVQALGDAARLIRAGEADIALAGGSEAAIDRVSLGGFAAARALSTGYNDRPEQASRP
HHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHCCC
FDQGRDGFVMGEGAGILVVERLDHALARGARPLAELVGYGTSADAYHLTAGPEDGAGAAE
CCCCCCCEEEECCCCEEEHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEECCCCCCCCHHH
AMRAALDQAAVSPRLIGHLNAHATSTPVGDRGELAAIRAVFGEGGGPAISATKSATGHLL
HHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCEE
GAAGGVEAIFTVMALGDQLMPPTLNLSRPDPLAEGLDLVGPESRKKCFDYAISNGFGFGG
ECCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
VNASVVFRRWRE
CCHHHHHHHHCC
>Mature Secondary Structure
MRIVITGMGIVIMRSVITGMGLAPPLACGSHAALAPPLAPVSRVSSALPRISRAASIARS
CEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
PVSCRGAPMTRVSTLKETIPVKDRKKMDRFIQFALGAAQEALGQAGWNPRTEQEKLRTAT
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
VIASGIGGFGAIANAVRTVELRGADKLSPFTVPSFLVNLAAGWVSIRNSFKGPIGAPATA
HHHHCCCHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
CAAGVQALGDAARLIRAGEADIALAGGSEAAIDRVSLGGFAAARALSTGYNDRPEQASRP
HHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHCCC
FDQGRDGFVMGEGAGILVVERLDHALARGARPLAELVGYGTSADAYHLTAGPEDGAGAAE
CCCCCCCEEEECCCCEEEHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEECCCCCCCCHHH
AMRAALDQAAVSPRLIGHLNAHATSTPVGDRGELAAIRAVFGEGGGPAISATKSATGHLL
HHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCEE
GAAGGVEAIFTVMALGDQLMPPTLNLSRPDPLAEGLDLVGPESRKKCFDYAISNGFGFGG
ECCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
VNASVVFRRWRE
CCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]