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The map label for this gene is fumC [H]

Identifier: 162146674

GI number: 162146674

Start: 867597

End: 869045

Strand: Direct

Name: fumC [H]

Synonym: GDI_0852

Alternate gene names: 162146674

Gene position: 867597-869045 (Clockwise)

Preceding gene: 162146673

Following gene: 162146676

Centisome position: 22.0

GC content: 66.87

Gene sequence:

>1449_bases
ATGCCGGAAACCCGACTGCAATCCGACCTGCCCATAGGCCTGACCGCGCAGGGCGAACGGCGCGAGCACGACGCGCTGGG
TGACATCCAGGTTCCGGCCGATCGGTACTGGGGTGCACAGACCCAGCGCAGCCTGGTGCATTTTTCGATCGGCACCGACC
GGATGCCGCTGGAACTATGCCGTGCCTATGGTCTGGTAAAGAAGGCGGCGGCCCTGGTGAACCTGGCCGACGGGCGGCTG
CCGGACTGGAAGGCGGCTGCCATCATCCAGGCGGCGGAAGAAGTCGTGGACGGGAAACTGGACGATCATTTCCCGCTTTT
CGTCTGGCAGACCGGTTCGGGCACCCAGACCAACATGAACGTCAACGAGGTCATCGCCAACCGCGCCATCCAGCTTCTGG
GCGGCCGTCCGGGCAGCCAGGACCCGATACATCCCAATGACGACGTCAATATGGGGCAATCCAGCAACGACACGTTTCCC
ACCGCCATGCATGTCGCGACGGTGCGGATGGTGGATGCGCGCCTGCTGCCGGAACTGCAGGCACTGGCCGATGTGATCGA
AACGCGTGCGCGCCAGTGGCATGACGTGGTGAAGATCGGCCGGACGCACCTCCAGGATGCGGTGCCGCTGACCGTGGGCC
AGGAATGGTCGGGATGGGCGCATCAGATACGCGATGCGATGCGGACGATCGGGATGGCGCGGGAAGGGGCGCTGGAACTG
GCGGCGGGCGGAACGGCGGTGGGAACCGGCCTGAACGCCCCCGCCGGGTTCGGCCGGGCGATCGCGGCACGTCTGGCTGA
ATTGACCGGGGCGCCGTTCGTGACCGCGCCGAACAAGTTCGCGGCCCTGGCGGGGCTGGACGCGATGGTGCGCGTCTCGG
CCGCGATACGGGGGGCCGCCGTGGTGATGATGAAGATCGCCAACGACATGCGCTGGCTGGGTTCGGGGCCGCGATGCGGC
CTGGCGGAACTGCACCTGCCCGCGAACGAGCCCGGATCGTCGATCATGCCCGGCAAGGTCAACCCGACCCAGTGCGAGGC
CATGGTCATGATCTGCACCCAGATCATGGGCAACGACACGGCGGTTGCCTTCGCCGGCAGCCAGGGCCAGTTCGAATTGA
ACGTCATGCGGCCGGTGGTGATCGCGAACGTACTGCACGCGGTGCGGATCATGGCCGACGGATGCCGGTCGTTCCGGACT
TTCTCGGTCGAGGGCACGACCTTGAACGCCGAACGCATCCGTCGCTATGTCGAAGGGTCGGTGATGCTGGTGACGGCGCT
TACCCCCGCGATCGGCTATGACCGGGCATCCGCCATCGCCCATGACGCCATGGAGCATGACATCTCGCTCCGGGAGGCGG
CATTGCGGTCCGGCGTGGTGGACGCGGCGACGTTCGACCGCCTGGTCCGGCCGATCGAGATGGTGGGCGACGGAGTGGCC
GGCGCCTGA

Upstream 100 bases:

>100_bases
GGATTGCGGTGGTGGGACATGTAACGTCCCTTGGTGAATAAAGGCCTTTTTCCTTCTGTTTCGGAAGACAAAGGCAAAGA
CGACCCGGGAGGACCACACG

Downstream 100 bases:

>100_bases
GAGTATCCGTCGTAACCGGGCGGCTTCTGGCCTCCATGTGCGATTACGCCCAAGGATAAAAGGGCGTCAGACGTGCCTGG
AACGGGAATATATTGATAAT

Product: fumarate hydratase class II

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MPETRLQSDLPIGLTAQGERREHDALGDIQVPADRYWGAQTQRSLVHFSIGTDRMPLELCRAYGLVKKAAALVNLADGRL
PDWKAAAIIQAAEEVVDGKLDDHFPLFVWQTGSGTQTNMNVNEVIANRAIQLLGGRPGSQDPIHPNDDVNMGQSSNDTFP
TAMHVATVRMVDARLLPELQALADVIETRARQWHDVVKIGRTHLQDAVPLTVGQEWSGWAHQIRDAMRTIGMAREGALEL
AAGGTAVGTGLNAPAGFGRAIAARLAELTGAPFVTAPNKFAALAGLDAMVRVSAAIRGAAVVMMKIANDMRWLGSGPRCG
LAELHLPANEPGSSIMPGKVNPTQCEAMVMICTQIMGNDTAVAFAGSQGQFELNVMRPVVIANVLHAVRIMADGCRSFRT
FSVEGTTLNAERIRRYVEGSVMLVTALTPAIGYDRASAIAHDAMEHDISLREAALRSGVVDAATFDRLVRPIEMVGDGVA
GA

Sequences:

>Translated_482_residues
MPETRLQSDLPIGLTAQGERREHDALGDIQVPADRYWGAQTQRSLVHFSIGTDRMPLELCRAYGLVKKAAALVNLADGRL
PDWKAAAIIQAAEEVVDGKLDDHFPLFVWQTGSGTQTNMNVNEVIANRAIQLLGGRPGSQDPIHPNDDVNMGQSSNDTFP
TAMHVATVRMVDARLLPELQALADVIETRARQWHDVVKIGRTHLQDAVPLTVGQEWSGWAHQIRDAMRTIGMAREGALEL
AAGGTAVGTGLNAPAGFGRAIAARLAELTGAPFVTAPNKFAALAGLDAMVRVSAAIRGAAVVMMKIANDMRWLGSGPRCG
LAELHLPANEPGSSIMPGKVNPTQCEAMVMICTQIMGNDTAVAFAGSQGQFELNVMRPVVIANVLHAVRIMADGCRSFRT
FSVEGTTLNAERIRRYVEGSVMLVTALTPAIGYDRASAIAHDAMEHDISLREAALRSGVVDAATFDRLVRPIEMVGDGVA
GA
>Mature_481_residues
PETRLQSDLPIGLTAQGERREHDALGDIQVPADRYWGAQTQRSLVHFSIGTDRMPLELCRAYGLVKKAAALVNLADGRLP
DWKAAAIIQAAEEVVDGKLDDHFPLFVWQTGSGTQTNMNVNEVIANRAIQLLGGRPGSQDPIHPNDDVNMGQSSNDTFPT
AMHVATVRMVDARLLPELQALADVIETRARQWHDVVKIGRTHLQDAVPLTVGQEWSGWAHQIRDAMRTIGMAREGALELA
AGGTAVGTGLNAPAGFGRAIAARLAELTGAPFVTAPNKFAALAGLDAMVRVSAAIRGAAVVMMKIANDMRWLGSGPRCGL
AELHLPANEPGSSIMPGKVNPTQCEAMVMICTQIMGNDTAVAFAGSQGQFELNVMRPVVIANVLHAVRIMADGCRSFRTF
SVEGTTLNAERIRRYVEGSVMLVTALTPAIGYDRASAIAHDAMEHDISLREAALRSGVVDAATFDRLVRPIEMVGDGVAG
A

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=459, Percent_Identity=56.8627450980392, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI266458395, Length=73, Percent_Identity=47.945205479452, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1787896, Length=462, Percent_Identity=55.6277056277056, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI87082375, Length=456, Percent_Identity=39.4736842105263, Blast_Score=323, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI17553882, Length=459, Percent_Identity=55.5555555555556, Blast_Score=528, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=52.760736196319, Blast_Score=359, Evalue=2e-99,
Organism=Saccharomyces cerevisiae, GI6324993, Length=459, Percent_Identity=54.9019607843137, Blast_Score=522, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24640177, Length=466, Percent_Identity=54.0772532188841, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24640179, Length=466, Percent_Identity=53.862660944206, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24662684, Length=461, Percent_Identity=53.5791757049892, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=52.801724137931, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=47.5054229934924, Blast_Score=441, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 51568; Mature: 51437

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPETRLQSDLPIGLTAQGERREHDALGDIQVPADRYWGAQTQRSLVHFSIGTDRMPLELC
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCHHHHCCCHHHCCEEEEECCCCCCHHHHH
RAYGLVKKAAALVNLADGRLPDWKAAAIIQAAEEVVDGKLDDHFPLFVWQTGSGTQTNMN
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCC
VNEVIANRAIQLLGGRPGSQDPIHPNDDVNMGQSSNDTFPTAMHVATVRMVDARLLPELQ
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ALADVIETRARQWHDVVKIGRTHLQDAVPLTVGQEWSGWAHQIRDAMRTIGMAREGALEL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCHHCCCEEE
AAGGTAVGTGLNAPAGFGRAIAARLAELTGAPFVTAPNKFAALAGLDAMVRVSAAIRGAA
ECCCCEECCCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
VVMMKIANDMRWLGSGPRCGLAELHLPANEPGSSIMPGKVNPTQCEAMVMICTQIMGNDT
HHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
AVAFAGSQGQFELNVMRPVVIANVLHAVRIMADGCRSFRTFSVEGTTLNAERIRRYVEGS
EEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEECHHHHHHHHCCC
VMLVTALTPAIGYDRASAIAHDAMEHDISLREAALRSGVVDAATFDRLVRPIEMVGDGVA
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
GA
CC
>Mature Secondary Structure 
PETRLQSDLPIGLTAQGERREHDALGDIQVPADRYWGAQTQRSLVHFSIGTDRMPLELC
CCCCCCCCCCCCCCCCCCCCCCCCCCCEECCHHHHCCCHHHCCEEEEECCCCCCHHHHH
RAYGLVKKAAALVNLADGRLPDWKAAAIIQAAEEVVDGKLDDHFPLFVWQTGSGTQTNMN
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCC
VNEVIANRAIQLLGGRPGSQDPIHPNDDVNMGQSSNDTFPTAMHVATVRMVDARLLPELQ
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ALADVIETRARQWHDVVKIGRTHLQDAVPLTVGQEWSGWAHQIRDAMRTIGMAREGALEL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCHHCCCEEE
AAGGTAVGTGLNAPAGFGRAIAARLAELTGAPFVTAPNKFAALAGLDAMVRVSAAIRGAA
ECCCCEECCCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
VVMMKIANDMRWLGSGPRCGLAELHLPANEPGSSIMPGKVNPTQCEAMVMICTQIMGNDT
HHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
AVAFAGSQGQFELNVMRPVVIANVLHAVRIMADGCRSFRTFSVEGTTLNAERIRRYVEGS
EEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEECHHHHHHHHCCC
VMLVTALTPAIGYDRASAIAHDAMEHDISLREAALRSGVVDAATFDRLVRPIEMVGDGVA
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
GA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]