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The map label for this gene is trxA [H]

Identifier: 162146540

GI number: 162146540

Start: 732103

End: 732429

Strand: Direct

Name: trxA [H]

Synonym: GDI_0716

Alternate gene names: 162146540

Gene position: 732103-732429 (Clockwise)

Preceding gene: 162146539

Following gene: 162146545

Centisome position: 18.56

GC content: 63.0

Gene sequence:

>327_bases
ATGAGCGAAAACACCGTGGCCGTCAGCGACGCCACTTTCGAAAGCGATGTCCTGAAGGCCGAAGGGCCCGTTCTGGTGGA
TTTCTGGGCCGAATGGTGCGGCCCCTGCAAGATGATCGCCCCGGCGCTGGACGAGATCGGCGCCGAGTTCAAGGGCAAGC
TGACGGTGGCCAAGGTCAATATCGACGACAATCCCGGCACGCCGAACAAATACGCCGTGCGCGGCATCCCGACCCTGATC
CTGTTCAAGAACGGCCAGCCGGCGGCCACCAAGGTCGGGGCGCTGCCCAAGAGCCAGCTCAAGGAGTGGGTCAAGAGCAG
CCTGTAA

Upstream 100 bases:

>100_bases
TCAGGCGGGCAGACGCCCGAAGGACCATAATCTTGATAACCGGGCCGTCCGGCGCCATGTCCGGACGGAAGCCGCCATCG
GAAACCCGAGGAGTGATGTG

Downstream 100 bases:

>100_bases
GGAGGCTTGGGGCTCCGCCCCAAACCCCGCCAAAGGGCAGTCGCCCTTTGGAAACCCGATTGTTATCAAATGATTGGGGT
GCAGGGCCTCAGGCCCTGCC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSENTVAVSDATFESDVLKAEGPVLVDFWAEWCGPCKMIAPALDEIGAEFKGKLTVAKVNIDDNPGTPNKYAVRGIPTLI
LFKNGQPAATKVGALPKSQLKEWVKSSL

Sequences:

>Translated_108_residues
MSENTVAVSDATFESDVLKAEGPVLVDFWAEWCGPCKMIAPALDEIGAEFKGKLTVAKVNIDDNPGTPNKYAVRGIPTLI
LFKNGQPAATKVGALPKSQLKEWVKSSL
>Mature_107_residues
SENTVAVSDATFESDVLKAEGPVLVDFWAEWCGPCKMIAPALDEIGAEFKGKLTVAKVNIDDNPGTPNKYAVRGIPTLIL
FKNGQPAATKVGALPKSQLKEWVKSSL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=106, Percent_Identity=38.6792452830189, Blast_Score=84, Evalue=3e-17,
Organism=Homo sapiens, GI21361657, Length=92, Percent_Identity=38.0434782608696, Blast_Score=70, Evalue=4e-13,
Organism=Homo sapiens, GI5031973, Length=102, Percent_Identity=30.3921568627451, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI224493972, Length=105, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=67.5925925925926, Blast_Score=161, Evalue=9e-42,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=40.2173913043478, Blast_Score=89, Evalue=8e-20,
Organism=Escherichia coli, GI87081747, Length=100, Percent_Identity=29, Blast_Score=64, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=35.4166666666667, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71998175, Length=100, Percent_Identity=40, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=90, Percent_Identity=35.5555555555556, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=107, Percent_Identity=35.5140186915888, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115532380, Length=103, Percent_Identity=33.9805825242718, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=70, Percent_Identity=41.4285714285714, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=80, Percent_Identity=37.5, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17507705, Length=71, Percent_Identity=39.4366197183099, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=73, Percent_Identity=43.8356164383562, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=100, Percent_Identity=33, Blast_Score=66, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=34.375, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24639826, Length=77, Percent_Identity=40.2597402597403, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17648013, Length=99, Percent_Identity=35.3535353535354, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24583090, Length=99, Percent_Identity=35.3535353535354, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24664269, Length=61, Percent_Identity=40.9836065573771, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11575; Mature: 11444

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENTVAVSDATFESDVLKAEGPVLVDFWAEWCGPCKMIAPALDEIGAEFKGKLTVAKVN
CCCCEEEEECCCCCCCEECCCCCEEEEEHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEEE
IDDNPGTPNKYAVRGIPTLILFKNGQPAATKVGALPKSQLKEWVKSSL
ECCCCCCCCCEEECCCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SENTVAVSDATFESDVLKAEGPVLVDFWAEWCGPCKMIAPALDEIGAEFKGKLTVAKVN
CCCEEEEECCCCCCCEECCCCCEEEEEHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEEE
IDDNPGTPNKYAVRGIPTLILFKNGQPAATKVGALPKSQLKEWVKSSL
ECCCCCCCCCEEECCCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]