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The map label for this gene is ahpC [C]

Identifier: 162146401

GI number: 162146401

Start: 584673

End: 585215

Strand: Reverse

Name: ahpC [C]

Synonym: GDI_0576

Alternate gene names: 162146401

Gene position: 585215-584673 (Counterclockwise)

Preceding gene: 162146406

Following gene: 162146400

Centisome position: 14.84

GC content: 62.62

Gene sequence:

>543_bases
ATGCTGACAGTCGGCAACAAGTTTCCGGAATTCAATCTGACCTCCGTCCCCGGTGGCCCGGAAGGGCTGAAGGGCAATTT
CGTCCAGATCTCGGACAAGAGCGATGCCGGCAAGTGGAAGCTCGTCTTCTTCTGGCCGAAGGACTTCACCTTCGTCTGCC
CGACCGAGATCGTGGCCTTCGGCAAGATGGCCGGCGAGTTCAAGGACCGCGACACCGTCGTCTATGGCGTGTCCATCGAC
AGCGAGTTCGTGCACCTGAACTGGCGCCTGCATCATGACGACCTGAAGGGTCTGCAGATTCCGATGCTGGCCGACATCAA
GCGCGAGCTGTCCGAGGCCTGCGGCGTGCTGTCGCCGGAAGCCGGCGTGGCCTATCGCGCCACCTTCCTGGTCGACCCCG
AGGGCATCATCCGCCATGTCAGCGTCAACGACCTGTCGGTCGGCCGCAACCCGCAGGAAATCCTGCGCATCCTGGACGCG
CTGCAGAGCGACGAGCTGTGCCCGTGCAACTGGAAGCAGGGCGACGACTTCCTGAAGGTCTGA

Upstream 100 bases:

>100_bases
ATAGGCTTCAACGCCATAAAATACAGTCCGAGGCCGGACCGCCTGTTCAGGGCGCCGCGCCAGGGACCACGACACGTCGT
CACTATGAGGGAGTAAACCG

Downstream 100 bases:

>100_bases
TCGGTCCCCGGTCATCACGGTCCGGCCCCGGCGGCCGGACCACTCCTTCCCCGCCGGCCGAGGACGCCCCGATGACGCCC
CGATGACGCCGGGGGGGAAC

Product: peroxiredoxin protein

Products: NA

Alternate protein names: Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MLTVGNKFPEFNLTSVPGGPEGLKGNFVQISDKSDAGKWKLVFFWPKDFTFVCPTEIVAFGKMAGEFKDRDTVVYGVSID
SEFVHLNWRLHHDDLKGLQIPMLADIKRELSEACGVLSPEAGVAYRATFLVDPEGIIRHVSVNDLSVGRNPQEILRILDA
LQSDELCPCNWKQGDDFLKV

Sequences:

>Translated_180_residues
MLTVGNKFPEFNLTSVPGGPEGLKGNFVQISDKSDAGKWKLVFFWPKDFTFVCPTEIVAFGKMAGEFKDRDTVVYGVSID
SEFVHLNWRLHHDDLKGLQIPMLADIKRELSEACGVLSPEAGVAYRATFLVDPEGIIRHVSVNDLSVGRNPQEILRILDA
LQSDELCPCNWKQGDDFLKV
>Mature_180_residues
MLTVGNKFPEFNLTSVPGGPEGLKGNFVQISDKSDAGKWKLVFFWPKDFTFVCPTEIVAFGKMAGEFKDRDTVVYGVSID
SEFVHLNWRLHHDDLKGLQIPMLADIKRELSEACGVLSPEAGVAYRATFLVDPEGIIRHVSVNDLSVGRNPQEILRILDA
LQSDELCPCNWKQGDDFLKV

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=183, Percent_Identity=42.6229508196721, Blast_Score=149, Evalue=1e-36,
Organism=Homo sapiens, GI4505591, Length=183, Percent_Identity=42.0765027322404, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI32455266, Length=183, Percent_Identity=42.0765027322404, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI32455264, Length=183, Percent_Identity=42.0765027322404, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI5802974, Length=184, Percent_Identity=40.7608695652174, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI32483377, Length=160, Percent_Identity=43.75, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI5453549, Length=165, Percent_Identity=38.7878787878788, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI4758638, Length=156, Percent_Identity=32.6923076923077, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI33188454, Length=85, Percent_Identity=42.3529411764706, Blast_Score=74, Evalue=9e-14,
Organism=Escherichia coli, GI1786822, Length=159, Percent_Identity=35.2201257861635, Blast_Score=116, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17554494, Length=181, Percent_Identity=43.0939226519337, Blast_Score=147, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI193204376, Length=183, Percent_Identity=40.9836065573771, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI32565831, Length=183, Percent_Identity=40.9836065573771, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI25153706, Length=158, Percent_Identity=29.1139240506329, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323613, Length=183, Percent_Identity=39.8907103825137, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320661, Length=183, Percent_Identity=40.9836065573771, Blast_Score=128, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6319407, Length=155, Percent_Identity=31.6129032258064, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17738015, Length=155, Percent_Identity=43.8709677419355, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17157991, Length=164, Percent_Identity=40.8536585365854, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24641739, Length=164, Percent_Identity=40.8536585365854, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24656348, Length=177, Percent_Identity=37.8531073446328, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI17864676, Length=177, Percent_Identity=37.8531073446328, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI21357347, Length=187, Percent_Identity=37.4331550802139, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI17975518, Length=154, Percent_Identity=33.7662337662338, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24652436, Length=154, Percent_Identity=33.7662337662338, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24652434, Length=154, Percent_Identity=33.7662337662338, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24581278, Length=186, Percent_Identity=29.5698924731183, Blast_Score=73, Evalue=8e-14,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20112; Mature: 20112

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTVGNKFPEFNLTSVPGGPEGLKGNFVQISDKSDAGKWKLVFFWPKDFTFVCPTEIVAF
CCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCEEECCHHHHHH
GKMAGEFKDRDTVVYGVSIDSEFVHLNWRLHHDDLKGLQIPMLADIKRELSEACGVLSPE
HHHHCCCCCCCEEEEEEEECCEEEEEEEEEECCCCCCEECCHHHHHHHHHHHHCCCCCCC
AGVAYRATFLVDPEGIIRHVSVNDLSVGRNPQEILRILDALQSDELCPCNWKQGDDFLKV
CCCEEEEEEEECCHHHEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLTVGNKFPEFNLTSVPGGPEGLKGNFVQISDKSDAGKWKLVFFWPKDFTFVCPTEIVAF
CCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCEEECCHHHHHH
GKMAGEFKDRDTVVYGVSIDSEFVHLNWRLHHDDLKGLQIPMLADIKRELSEACGVLSPE
HHHHCCCCCCCEEEEEEEECCEEEEEEEEEECCCCCCEECCHHHHHHHHHHHHCCCCCCC
AGVAYRATFLVDPEGIIRHVSVNDLSVGRNPQEILRILDALQSDELCPCNWKQGDDFLKV
CCCEEEEEEEECCHHHEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA