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The map label for this gene is lldD [H]

Identifier: 162146137

GI number: 162146137

Start: 317211

End: 318449

Strand: Reverse

Name: lldD [H]

Synonym: GDI_0309

Alternate gene names: 162146137

Gene position: 318449-317211 (Counterclockwise)

Preceding gene: 162146138

Following gene: 162146136

Centisome position: 8.07

GC content: 72.4

Gene sequence:

>1239_bases
ATGACGGCGACGGACCAGACCCTGCCCGCCCTGGACGAACCGATCCCGGCCCGCATTCCCGGCTGGCTGCGTGCCATCCG
GGCGCGGCGGGGGGAGGCCCCGCGCTTCCTCAACCTGCATGATTATGCCCCGGCCGCCCGGCGGTTGCTGCCGCGCGCGC
TGTTCGCCTACATCAACGGGTCGGCGGGCGACGGGCGGGCGCTGGCCGCCAATCGCGCGGCCTTCGACCGCTGGTGCCTG
GTCCCGCATGTGCTGCGGGGCGTCAGCCGGCGCAGCGCGCGCACCCACCTGATGGGCCATCACTACGCCATGCCGGTGGG
GATTTCGGCCTTCGGCGCGGCGGCGGTGATCGGCTTCGACGCCGACCGGGCGATGGCGCGGGCAGCATATGCGGCGGGCG
TGCCCTACCAGCTCAGCGCCAATTCCATCACGCCGATGGAAGACGTCATCCGCGACAATCCCGATGCCTGGTTCGCCGCC
TACCTGCCCGCCAATCCGTCGCTGATCGACCGGATGCTGACGCGCATCGGCCGGGCCGGGTTCCGCACGCTGGTCATCAC
CGTGGACGTGCCCGTGGCGGCGCGGCGCGAGGACGAGACCCGCGCGCACTACGCCATGCCGCTGCGCCCGTCCGCCCGTC
TAGCGTTCGACATGCTGTCGCACCCGCGCTGGCTGCTGGGCCGGCTAGGGCGGACGCTGCTGGCGCGCGGCATTCCGCAT
ATCCAGAACATCACCCCCGGCCGGGGGCCGTCGATCTTCGCGCGGTCGGTCGGGGCGGTCGGCGGGGCGGCGGACTTCAA
CTGGGACCATATCCGCGCCATCCGCCGGTCATGGCCGGGGCGGCTGGTGCTGAAGGGCATCCTGTCGGCGCAGGACGCCG
TGACGGCGCAGCAGATCGGCGCGGACGGCATCATCGTATCCAATCACGGGGCGCGGCTGTGCGATTGCGTCATCTCGCCG
CTGGAGGCGCTGCCCGCCATCCGGCAGGCCTGCCCGGACCTGACCGTGCTGCTGGACAGCGGGGTGCGGCGGGCGGGCGA
CGTCATCACGGCCATCGCCCTGGGCGCAGACGGCGTGATGATCGGGCGGCCGTTCTTCTTCGCCACCATCCTGGGTGGGC
AGCCGGGGCTGGCGCACGCCATCGGGCTGATCGCCGGCGAACTGGACCGCGACATGGCGTTCCTGGGCCTGCTGGACCTG
CGCGAAAGCCGCGAAAACCGCCTGCATCGGCGTGGCTGA

Upstream 100 bases:

>100_bases
GACATTTCAGAGGCTGTTTCAAAAGCCTCTCGGACCGGACCGGCAACCCCGCCCCCCGCAAAACGCTGGAAAACCAGTAT
ACTGCGAGAGGCACCCGACG

Downstream 100 bases:

>100_bases
CAGGGGTGACATGATTGGTGCGTTCATGACACTGGCCTATGAAACGCTTGATATATACCATGCCGTATACCATAAAGCGC
CATATGCCACGTCACCTGTC

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L(+)-mandelate dehydrogenase; MDH [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MTATDQTLPALDEPIPARIPGWLRAIRARRGEAPRFLNLHDYAPAARRLLPRALFAYINGSAGDGRALAANRAAFDRWCL
VPHVLRGVSRRSARTHLMGHHYAMPVGISAFGAAAVIGFDADRAMARAAYAAGVPYQLSANSITPMEDVIRDNPDAWFAA
YLPANPSLIDRMLTRIGRAGFRTLVITVDVPVAARREDETRAHYAMPLRPSARLAFDMLSHPRWLLGRLGRTLLARGIPH
IQNITPGRGPSIFARSVGAVGGAADFNWDHIRAIRRSWPGRLVLKGILSAQDAVTAQQIGADGIIVSNHGARLCDCVISP
LEALPAIRQACPDLTVLLDSGVRRAGDVITAIALGADGVMIGRPFFFATILGGQPGLAHAIGLIAGELDRDMAFLGLLDL
RESRENRLHRRG

Sequences:

>Translated_412_residues
MTATDQTLPALDEPIPARIPGWLRAIRARRGEAPRFLNLHDYAPAARRLLPRALFAYINGSAGDGRALAANRAAFDRWCL
VPHVLRGVSRRSARTHLMGHHYAMPVGISAFGAAAVIGFDADRAMARAAYAAGVPYQLSANSITPMEDVIRDNPDAWFAA
YLPANPSLIDRMLTRIGRAGFRTLVITVDVPVAARREDETRAHYAMPLRPSARLAFDMLSHPRWLLGRLGRTLLARGIPH
IQNITPGRGPSIFARSVGAVGGAADFNWDHIRAIRRSWPGRLVLKGILSAQDAVTAQQIGADGIIVSNHGARLCDCVISP
LEALPAIRQACPDLTVLLDSGVRRAGDVITAIALGADGVMIGRPFFFATILGGQPGLAHAIGLIAGELDRDMAFLGLLDL
RESRENRLHRRG
>Mature_411_residues
TATDQTLPALDEPIPARIPGWLRAIRARRGEAPRFLNLHDYAPAARRLLPRALFAYINGSAGDGRALAANRAAFDRWCLV
PHVLRGVSRRSARTHLMGHHYAMPVGISAFGAAAVIGFDADRAMARAAYAAGVPYQLSANSITPMEDVIRDNPDAWFAAY
LPANPSLIDRMLTRIGRAGFRTLVITVDVPVAARREDETRAHYAMPLRPSARLAFDMLSHPRWLLGRLGRTLLARGIPHI
QNITPGRGPSIFARSVGAVGGAADFNWDHIRAIRRSWPGRLVLKGILSAQDAVTAQQIGADGIIVSNHGARLCDCVISPL
EALPAIRQACPDLTVLLDSGVRRAGDVITAIALGADGVMIGRPFFFATILGGQPGLAHAIGLIAGELDRDMAFLGLLDLR
ESRENRLHRRG

Specific function: Reduction of (S)-mandelate to benzoylformate [H]

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=373, Percent_Identity=29.2225201072386, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI54234014, Length=371, Percent_Identity=31.266846361186, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI7705393, Length=371, Percent_Identity=31.266846361186, Blast_Score=156, Evalue=3e-38,
Organism=Escherichia coli, GI1790033, Length=376, Percent_Identity=34.8404255319149, Blast_Score=187, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI193208036, Length=382, Percent_Identity=26.9633507853403, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI32566217, Length=295, Percent_Identity=25.7627118644068, Blast_Score=101, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6323587, Length=414, Percent_Identity=24.8792270531401, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI78707188, Length=365, Percent_Identity=30.958904109589, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI281363140, Length=365, Percent_Identity=30.958904109589, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI78707190, Length=365, Percent_Identity=30.958904109589, Blast_Score=156, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.99.31 [H]

Molecular weight: Translated: 44560; Mature: 44429

Theoretical pI: Translated: 11.27; Mature: 11.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATDQTLPALDEPIPARIPGWLRAIRARRGEAPRFLNLHDYAPAARRLLPRALFAYING
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEECCHHCCHHHHHHHHHHHHHHHCC
SAGDGRALAANRAAFDRWCLVPHVLRGVSRRSARTHLMGHHYAMPVGISAFGAAAVIGFD
CCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHCCCEEEECC
ADRAMARAAYAAGVPYQLSANSITPMEDVIRDNPDAWFAAYLPANPSLIDRMLTRIGRAG
HHHHHHHHHHHCCCCEEECCCCCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCC
FRTLVITVDVPVAARREDETRAHYAMPLRPSARLAFDMLSHPRWLLGRLGRTLLARGIPH
CEEEEEEEECCCCCCCCCCCCCCEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
IQNITPGRGPSIFARSVGAVGGAADFNWDHIRAIRRSWPGRLVLKGILSAQDAVTAQQIG
HHCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
ADGIIVSNHGARLCDCVISPLEALPAIRQACPDLTVLLDSGVRRAGDVITAIALGADGVM
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHHCCHHHHHHHHHHEECCCCEE
IGRPFFFATILGGQPGLAHAIGLIAGELDRDMAFLGLLDLRESRENRLHRRG
ECCHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TATDQTLPALDEPIPARIPGWLRAIRARRGEAPRFLNLHDYAPAARRLLPRALFAYING
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEECCHHCCHHHHHHHHHHHHHHHCC
SAGDGRALAANRAAFDRWCLVPHVLRGVSRRSARTHLMGHHYAMPVGISAFGAAAVIGFD
CCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHCCCEEEECC
ADRAMARAAYAAGVPYQLSANSITPMEDVIRDNPDAWFAAYLPANPSLIDRMLTRIGRAG
HHHHHHHHHHHCCCCEEECCCCCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCC
FRTLVITVDVPVAARREDETRAHYAMPLRPSARLAFDMLSHPRWLLGRLGRTLLARGIPH
CEEEEEEEECCCCCCCCCCCCCCEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
IQNITPGRGPSIFARSVGAVGGAADFNWDHIRAIRRSWPGRLVLKGILSAQDAVTAQQIG
HHCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
ADGIIVSNHGARLCDCVISPLEALPAIRQACPDLTVLLDSGVRRAGDVITAIALGADGVM
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHHCCHHHHHHHHHHEECCCCEE
IGRPFFFATILGGQPGLAHAIGLIAGELDRDMAFLGLLDLRESRENRLHRRG
ECCHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2271624 [H]