Click here to switch to the map view.

The map label for this gene is gnd [H]

Identifier: 162146117

GI number: 162146117

Start: 299868

End: 300866

Strand: Direct

Name: gnd [H]

Synonym: GDI_0287

Alternate gene names: 162146117

Gene position: 299868-300866 (Clockwise)

Preceding gene: 162146116

Following gene: 162146118

Centisome position: 7.6

GC content: 65.87

Gene sequence:

>999_bases
ATGCAAATCGGCATCATCGGCCTGGGCCGCATGGGCGGAAACATCGCCGTCCGCCTGTCGCGGCACGGGCATGACGTGGT
CCTGTTCGATCGTGACGCCGCGACGGTGTCCAAGGTTTCCGAACGGATCGAAGGCGGCCGCGGCGTCGCCGCCACCAGCC
TGCCCGACCTGGTCGCGAAGCTGACGGCCAAGCGCAAGATCGTGTGGGTCATGCTGCCGTGCGGCGAGATCACCGAGAAC
GCGGTGCAGGAACTGTACGGCCTGCTGGGCAAGGACGACATCGTCATCGATGGCGGCAACACGTACTACAAGGACGATAT
CCGCCGTGCCGCCCAGCTTGCGGACAAGGGCATCCACTATGTCGACGTCGGCACCTCCGGCGGCGTGTGGGGCCTGGAGC
GCGGCTACTGCATGATGTACGGCGGCACCAAGGATTCGACCGACCATATCGACCCGATCCTCGATGCCCTGGCGCCGGGC
AAGGGCGATGTCGCGCCGACCCCCGACCGCGGCAAGCCGGGCCTCGACCCCCGGGCGGAGAAGGGCTACCTGCATTGCGG
CCCCGCCGGGTCCGGCCATTTCGTGAAAATGGTCCATAACGGCATCGAGTACGGTATGATGCAGGCCTTCGCCGAAGGCT
TCGACATCATGAAGTCCAAGAACTCGCCCAAGCTGCCGGAAGACCAGCGCTTCGACCTGAACATGGCCGACATCGCGGAA
GTCTGGCGCCGCGGCAGCGTCGTGTCGTCCTGGCTGCTGGACCTGACGGCCGAAGCCCTGGCCAAGAACGCGTCGCTGTC
CGAATTCACGGGCGAGGTCGCGGATTCCGGCGAAGGCCGCTGGACGCTGGAAGCCGCGATCGAGGAAGCGGTGCCGGCTC
CGGTCATCACCGCCTCGCTGTTCACGCGCTTCCGCTCGCGTACCGGCAACAACTATGCGGAAAAGGTCCTCTCCGCCATG
CGGTTCGGCTTCGGCGGCCACGTCGAAAAGAAGGACTGA

Upstream 100 bases:

>100_bases
CCGTCCGTCCTGCGGACGGGGCATTTCTGCTGGCCCCCGGGCACCGCCCGGGCGGCCGAATTATGCGTGGCGAAGGGCCG
CGCCAAGGAGATTCAAGAAC

Downstream 100 bases:

>100_bases
GTCCTCAAAACGACGGGTGGCAACAGTTCAGGGAAAAATCTGACATGGATGGAATCGTCGCGTCTGCATCGTCCGAAATC
CAGGGGGCAGGCCTGCAGCC

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MQIGIIGLGRMGGNIAVRLSRHGHDVVLFDRDAATVSKVSERIEGGRGVAATSLPDLVAKLTAKRKIVWVMLPCGEITEN
AVQELYGLLGKDDIVIDGGNTYYKDDIRRAAQLADKGIHYVDVGTSGGVWGLERGYCMMYGGTKDSTDHIDPILDALAPG
KGDVAPTPDRGKPGLDPRAEKGYLHCGPAGSGHFVKMVHNGIEYGMMQAFAEGFDIMKSKNSPKLPEDQRFDLNMADIAE
VWRRGSVVSSWLLDLTAEALAKNASLSEFTGEVADSGEGRWTLEAAIEEAVPAPVITASLFTRFRSRTGNNYAEKVLSAM
RFGFGGHVEKKD

Sequences:

>Translated_332_residues
MQIGIIGLGRMGGNIAVRLSRHGHDVVLFDRDAATVSKVSERIEGGRGVAATSLPDLVAKLTAKRKIVWVMLPCGEITEN
AVQELYGLLGKDDIVIDGGNTYYKDDIRRAAQLADKGIHYVDVGTSGGVWGLERGYCMMYGGTKDSTDHIDPILDALAPG
KGDVAPTPDRGKPGLDPRAEKGYLHCGPAGSGHFVKMVHNGIEYGMMQAFAEGFDIMKSKNSPKLPEDQRFDLNMADIAE
VWRRGSVVSSWLLDLTAEALAKNASLSEFTGEVADSGEGRWTLEAAIEEAVPAPVITASLFTRFRSRTGNNYAEKVLSAM
RFGFGGHVEKKD
>Mature_332_residues
MQIGIIGLGRMGGNIAVRLSRHGHDVVLFDRDAATVSKVSERIEGGRGVAATSLPDLVAKLTAKRKIVWVMLPCGEITEN
AVQELYGLLGKDDIVIDGGNTYYKDDIRRAAQLADKGIHYVDVGTSGGVWGLERGYCMMYGGTKDSTDHIDPILDALAPG
KGDVAPTPDRGKPGLDPRAEKGYLHCGPAGSGHFVKMVHNGIEYGMMQAFAEGFDIMKSKNSPKLPEDQRFDLNMADIAE
VWRRGSVVSSWLLDLTAEALAKNASLSEFTGEVADSGEGRWTLEAAIEEAVPAPVITASLFTRFRSRTGNNYAEKVLSAM
RFGFGGHVEKKD

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=336, Percent_Identity=33.3333333333333, Blast_Score=146, Evalue=2e-35,
Organism=Escherichia coli, GI1788341, Length=327, Percent_Identity=32.4159021406728, Blast_Score=165, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17542558, Length=310, Percent_Identity=33.2258064516129, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321695, Length=311, Percent_Identity=33.4405144694534, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6321977, Length=323, Percent_Identity=32.1981424148607, Blast_Score=138, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24639279, Length=309, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 35843; Mature: 35843

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIGIIGLGRMGGNIAVRLSRHGHDVVLFDRDAATVSKVSERIEGGRGVAATSLPDLVAK
CEEEEEEECCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCEEHHHHHHHHHH
LTAKRKIVWVMLPCGEITENAVQELYGLLGKDDIVIDGGNTYYKDDIRRAAQLADKGIHY
HHHCCEEEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEE
VDVGTSGGVWGLERGYCMMYGGTKDSTDHIDPILDALAPGKGDVAPTPDRGKPGLDPRAE
EEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
KGYLHCGPAGSGHFVKMVHNGIEYGMMQAFAEGFDIMKSKNSPKLPEDQRFDLNMADIAE
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
VWRRGSVVSSWLLDLTAEALAKNASLSEFTGEVADSGEGRWTLEAAIEEAVPAPVITASL
HHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEHHHHHHHHCCCHHHHHHH
FTRFRSRTGNNYAEKVLSAMRFGFGGHVEKKD
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MQIGIIGLGRMGGNIAVRLSRHGHDVVLFDRDAATVSKVSERIEGGRGVAATSLPDLVAK
CEEEEEEECCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCEEHHHHHHHHHH
LTAKRKIVWVMLPCGEITENAVQELYGLLGKDDIVIDGGNTYYKDDIRRAAQLADKGIHY
HHHCCEEEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEE
VDVGTSGGVWGLERGYCMMYGGTKDSTDHIDPILDALAPGKGDVAPTPDRGKPGLDPRAE
EEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
KGYLHCGPAGSGHFVKMVHNGIEYGMMQAFAEGFDIMKSKNSPKLPEDQRFDLNMADIAE
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
VWRRGSVVSSWLLDLTAEALAKNASLSEFTGEVADSGEGRWTLEAAIEEAVPAPVITASL
HHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEHHHHHHHHCCCHHHHHHH
FTRFRSRTGNNYAEKVLSAMRFGFGGHVEKKD
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]