Click here to switch to the map view.

The map label for this gene is zwf [H]

Identifier: 162146118

GI number: 162146118

Start: 300911

End: 302443

Strand: Direct

Name: zwf [H]

Synonym: GDI_0288

Alternate gene names: 162146118

Gene position: 300911-302443 (Clockwise)

Preceding gene: 162146117

Following gene: 162146119

Centisome position: 7.63

GC content: 67.32

Gene sequence:

>1533_bases
ATGGATGGAATCGTCGCGTCTGCATCGTCCGAAATCCAGGGGGCAGGCCTGCAGCCGCGGCGTGCTCCCCCGTGCACCTT
CGTCGTCTTCGGCGGGGGTGGGGACCTGACGAAGCGGCTGCTGGTCCCCGCCATCTACAACCTGGCCTGCGCCGGGTTGC
TGGATGACGGTTTTTCCATTGTTGCCGTCGATTGGGCCGAACTGTCCGACGACATCCTGCGCGCCCAGTTCCACGAGGCG
CTGCAGGATTTCGTGGCCAAGCGCGGCACCGCCGCCGCCGTGCTGCGTGACGACATCTGGCGCTGGCTGAACACCCGCGT
GTCCTACCTGCGCGGCTCGTTCGAGGACCCGGCGACGTTCGAACGGCTGGGCGCGCGCATCGGGAGCGGCAATGCCGTCT
TCTACCTGGCGGTGGCGGCGCGTTTCTTCGGCACCATCGTGGACCGCCTGGGCGAATCCCACCTGACGGACGAGGTGGGC
GAGACCTATCGCCGCGTCATCGTCGAAAAGCCGTTCGGCCACGACCTGAATTCGGCCCGCGAACTGAACATCCGCCTGCT
GCGCACCCTGCGCGAGCGGCAGATCTACCGGATCGACCATTACCTGGGCAAGGAAACGGTCCAGAACATCATGGCGCTGC
GGTTTTCCAACGGGTTCTTCGAACCGCTGTGGAACCGCCAGAACATCGACCATGTCCAGATCACGGCGGCCGAAACCGTG
GGCGTGGAAAAGCGCGGCCGCTTTTACGAAGGCACCGGCGCGCTGCGCGACATGGTGCCCAACCATCTGATGCAGTTGCT
GGCCATGACGGCGATGGAGGCCCCGGTCTCGTTCGACGCCGACGCGGTGCGCGACGAGAAATCCAAGGTGCTGAAGGCCA
TCCACTGCACGGGGCCGGAAGACGTGGTGCGCGGCCAGTACGGCGGCGGCGTCCTGGGGGGCACCCCGGTGCGTGGCTAT
CGGGACGAACCGGACGTGGCGCCGGCTTCGCGCACCGAAACCTATGTGGCGATGAAGCTGGCCATCGATAACTGGCGCTG
GGCCGGCGTGCCGTTCTACCTGCGCACCGGCAAGCGGCTGGCGGTGCGCAAGACCGAAATCGCGATCCATTTCCGCCGCG
CGCCCTACGCGCTGTTCCGCGACACGCCGGTCGACCGGCTGACGCCGAACATCATGACCATCCACATCCAGCCGACCGAA
GGCGTCACCCTGCAGTTCGGGGCCAAGATCCCGGGCCCGACGGTGCGGCTTGGCGGCGTGCGGATGAAGTTCGACTATTC
CGAATGGTTCAGCGAGGGGCCGAGCACCGGCTACGAAACGCTGATCTATGATTGCCTGACCGGCGATGCGACGCTGTTCC
AGCGCGCCGACAATATCGAGGCCGGATGGCGCGCCGTGCAGCCCGCCCTGGACTGGGGCGAGCGGACCGAGGCCGCGCCG
CTGTGCCCCTACGCCGCGGGATCGGCCGGCCCGATCGAGGCCGACGCCCTGCTGGCGCGCGACGGTCGCCAATGGCAGGA
CCTGGCGGAATGA

Upstream 100 bases:

>100_bases
AGGTCCTCTCCGCCATGCGGTTCGGCTTCGGCGGCCACGTCGAAAAGAAGGACTGAGTCCTCAAAACGACGGGTGGCAAC
AGTTCAGGGAAAAATCTGAC

Downstream 100 bases:

>100_bases
CGGCCACGGACCCGGGCGCGGCCCGCCGTGCCGGCCCGTCGGACCGCATCCGCCTGGTCATTTCCGATATCGACGGCACG
CTGGTCACGCCGGACAAGCG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MDGIVASASSEIQGAGLQPRRAPPCTFVVFGGGGDLTKRLLVPAIYNLACAGLLDDGFSIVAVDWAELSDDILRAQFHEA
LQDFVAKRGTAAAVLRDDIWRWLNTRVSYLRGSFEDPATFERLGARIGSGNAVFYLAVAARFFGTIVDRLGESHLTDEVG
ETYRRVIVEKPFGHDLNSARELNIRLLRTLRERQIYRIDHYLGKETVQNIMALRFSNGFFEPLWNRQNIDHVQITAAETV
GVEKRGRFYEGTGALRDMVPNHLMQLLAMTAMEAPVSFDADAVRDEKSKVLKAIHCTGPEDVVRGQYGGGVLGGTPVRGY
RDEPDVAPASRTETYVAMKLAIDNWRWAGVPFYLRTGKRLAVRKTEIAIHFRRAPYALFRDTPVDRLTPNIMTIHIQPTE
GVTLQFGAKIPGPTVRLGGVRMKFDYSEWFSEGPSTGYETLIYDCLTGDATLFQRADNIEAGWRAVQPALDWGERTEAAP
LCPYAAGSAGPIEADALLARDGRQWQDLAE

Sequences:

>Translated_510_residues
MDGIVASASSEIQGAGLQPRRAPPCTFVVFGGGGDLTKRLLVPAIYNLACAGLLDDGFSIVAVDWAELSDDILRAQFHEA
LQDFVAKRGTAAAVLRDDIWRWLNTRVSYLRGSFEDPATFERLGARIGSGNAVFYLAVAARFFGTIVDRLGESHLTDEVG
ETYRRVIVEKPFGHDLNSARELNIRLLRTLRERQIYRIDHYLGKETVQNIMALRFSNGFFEPLWNRQNIDHVQITAAETV
GVEKRGRFYEGTGALRDMVPNHLMQLLAMTAMEAPVSFDADAVRDEKSKVLKAIHCTGPEDVVRGQYGGGVLGGTPVRGY
RDEPDVAPASRTETYVAMKLAIDNWRWAGVPFYLRTGKRLAVRKTEIAIHFRRAPYALFRDTPVDRLTPNIMTIHIQPTE
GVTLQFGAKIPGPTVRLGGVRMKFDYSEWFSEGPSTGYETLIYDCLTGDATLFQRADNIEAGWRAVQPALDWGERTEAAP
LCPYAAGSAGPIEADALLARDGRQWQDLAE
>Mature_510_residues
MDGIVASASSEIQGAGLQPRRAPPCTFVVFGGGGDLTKRLLVPAIYNLACAGLLDDGFSIVAVDWAELSDDILRAQFHEA
LQDFVAKRGTAAAVLRDDIWRWLNTRVSYLRGSFEDPATFERLGARIGSGNAVFYLAVAARFFGTIVDRLGESHLTDEVG
ETYRRVIVEKPFGHDLNSARELNIRLLRTLRERQIYRIDHYLGKETVQNIMALRFSNGFFEPLWNRQNIDHVQITAAETV
GVEKRGRFYEGTGALRDMVPNHLMQLLAMTAMEAPVSFDADAVRDEKSKVLKAIHCTGPEDVVRGQYGGGVLGGTPVRGY
RDEPDVAPASRTETYVAMKLAIDNWRWAGVPFYLRTGKRLAVRKTEIAIHFRRAPYALFRDTPVDRLTPNIMTIHIQPTE
GVTLQFGAKIPGPTVRLGGVRMKFDYSEWFSEGPSTGYETLIYDCLTGDATLFQRADNIEAGWRAVQPALDWGERTEAAP
LCPYAAGSAGPIEADALLARDGRQWQDLAE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=488, Percent_Identity=37.0901639344262, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI109389365, Length=488, Percent_Identity=37.0901639344262, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI52145310, Length=482, Percent_Identity=27.5933609958506, Blast_Score=146, Evalue=3e-35,
Organism=Escherichia coli, GI1788158, Length=497, Percent_Identity=39.0342052313883, Blast_Score=350, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI17538218, Length=491, Percent_Identity=34.4195519348269, Blast_Score=287, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6324088, Length=478, Percent_Identity=37.2384937238494, Blast_Score=283, Evalue=5e-77,
Organism=Drosophila melanogaster, GI24643350, Length=483, Percent_Identity=34.9896480331263, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24643352, Length=483, Percent_Identity=34.9896480331263, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI221513548, Length=494, Percent_Identity=28.7449392712551, Blast_Score=181, Evalue=7e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56615; Mature: 56615

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00069 G6P_DEHYDROGENASE ; PS00636 DNAJ_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGIVASASSEIQGAGLQPRRAPPCTFVVFGGGGDLTKRLLVPAIYNLACAGLLDDGFSI
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
VAVDWAELSDDILRAQFHEALQDFVAKRGTAAAVLRDDIWRWLNTRVSYLRGSFEDPATF
EEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
ERLGARIGSGNAVFYLAVAARFFGTIVDRLGESHLTDEVGETYRRVIVEKPFGHDLNSAR
HHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHH
ELNIRLLRTLRERQIYRIDHYLGKETVQNIMALRFSNGFFEPLWNRQNIDHVQITAAETV
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHH
GVEKRGRFYEGTGALRDMVPNHLMQLLAMTAMEAPVSFDADAVRDEKSKVLKAIHCTGPE
CHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHH
DVVRGQYGGGVLGGTPVRGYRDEPDVAPASRTETYVAMKLAIDNWRWAGVPFYLRTGKRL
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEECCCCEEEECCCEE
AVRKTEIAIHFRRAPYALFRDTPVDRLTPNIMTIHIQPTEGVTLQFGAKIPGPTVRLGGV
EEEEEEEEEEEECCCCHHHCCCCHHHCCCCEEEEEEECCCCEEEEECCCCCCCEEEECCE
RMKFDYSEWFSEGPSTGYETLIYDCLTGDATLFQRADNIEAGWRAVQPALDWGERTEAAP
EEEEEHHHHHCCCCCCCHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCC
LCPYAAGSAGPIEADALLARDGRQWQDLAE
CCCCCCCCCCCCCHHHHHHCCCCCHHHHCC
>Mature Secondary Structure
MDGIVASASSEIQGAGLQPRRAPPCTFVVFGGGGDLTKRLLVPAIYNLACAGLLDDGFSI
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
VAVDWAELSDDILRAQFHEALQDFVAKRGTAAAVLRDDIWRWLNTRVSYLRGSFEDPATF
EEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
ERLGARIGSGNAVFYLAVAARFFGTIVDRLGESHLTDEVGETYRRVIVEKPFGHDLNSAR
HHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHH
ELNIRLLRTLRERQIYRIDHYLGKETVQNIMALRFSNGFFEPLWNRQNIDHVQITAAETV
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHH
GVEKRGRFYEGTGALRDMVPNHLMQLLAMTAMEAPVSFDADAVRDEKSKVLKAIHCTGPE
CHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHH
DVVRGQYGGGVLGGTPVRGYRDEPDVAPASRTETYVAMKLAIDNWRWAGVPFYLRTGKRL
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEECCCCEEEECCCEE
AVRKTEIAIHFRRAPYALFRDTPVDRLTPNIMTIHIQPTEGVTLQFGAKIPGPTVRLGGV
EEEEEEEEEEEECCCCHHHCCCCHHHCCCCEEEEEEECCCCEEEEECCCCCCCEEEECCE
RMKFDYSEWFSEGPSTGYETLIYDCLTGDATLFQRADNIEAGWRAVQPALDWGERTEAAP
EEEEEHHHHHCCCCCCCHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCC
LCPYAAGSAGPIEADALLARDGRQWQDLAE
CCCCCCCCCCCCCHHHHHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1643289 [H]