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The map label for this gene is hisC

Identifier: 162146113

GI number: 162146113

Start: 291457

End: 292527

Strand: Reverse

Name: hisC

Synonym: GDI_0282

Alternate gene names: 162146113

Gene position: 292527-291457 (Counterclockwise)

Preceding gene: 162146114

Following gene: 162146112

Centisome position: 7.42

GC content: 67.41

Gene sequence:

>1071_bases
ATGAGCCGTTTCTGGAGCCCCGTCGTCCACCGCCTGACGCCCTATGTCCCGGGCGAGCAGCCGAAACTGACGAACCTGAT
CAAGCTCAACACCAACGAATCGCCCTATGGCCCGCCGCCTGGCGCGCTGGAGGCGATTCGCGCCGCCGCCGACGATACGC
TGCGGCTGTATTCCGACCCGACGTCCGAACGGCTGCGGGCCGCCATCGCGCAGGCCCACGATGTCGGCATGGACGAGATC
TTCGTCGGCAACGGATCGGACGAGGTGCTGGCCCATGCCTTCCACGCGCTGCTGCAGCATGACGCGCCGCTGCTGACGCC
CGACATCACCTACAGCTTCTATCCGGTCTATTGCGGGCTGTACGGCATCGCGCACCAGCCGGTGCCGCTGGACGACGCCA
TGCGGATCGACGTGGACGACTACCGGCGCCCCTGCGCCGGGCTGGTGCTGCCCAACCCCAACGCGCCGACCGGCATCGCG
CTGGGGCTGGGACAGATCGAGACCCTGCTGCGCGCGCAGCCCGACCGGGTGGTGGTGATCGACGAGGCCTATGTCGATTT
CGGCGCCGATACCGCGATTCCGCTGGTGCGGCGGTTTCCGAACCTGCTGGTGGTGCGCACCCTGTCGAAATCCCATGCCC
TGGCCGGGCTGCGGGTCGGGTACGCGATCGGCCATCCCGACCTGGTCGAGGCGCTGAACCGCGTCAAGGACAGCTTCAAT
TCCTATCCGCTGGACCGGCTGGCCCAGGCCGGGGCCGCCGCCGCCATCGCCGATCGGGAATGGCTTGCACGAACCACGGG
AAAGATCATAAAAACACGGATCGGGCTGACATCCAGCCTGAGGGGCCTGGGGTTCGAGGTATTGCCCTCGCAGGCGAATT
TCGTGTTCGCCCGCCATCCTGATCGTGACGCCGCACACCTGGCCGCCGCCCTGCGGGAGCGGGCCATCATCGTGCGTCAT
TTCAGGACGCCCAGGATCGCGGAATGGCTGCGCATCACGGTCGGCACCGACGAGGAATGCCGGGTCCTGACCGATGCGCT
GGGCACCATCCTGACCCGGAACGCGGACTGA

Upstream 100 bases:

>100_bases
GACGACGCTGATGCCGGCGGCGCGTTCCTGACCGCGTTCCGTTCCCGAGGATGATCCTCTAGAAGGGCACGTCCTTTCCT
TCCCGCCAGCGGAACCTGTC

Downstream 100 bases:

>100_bases
CCACACACTGTCCGGCCGCCCCCCGGCCCGACCTCTCACTTTCTGATATGGACGAGTACCATGCGCGCATTCCACGGCCA
GATGTCCGACAACCAGCCGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSRFWSPVVHRLTPYVPGEQPKLTNLIKLNTNESPYGPPPGALEAIRAAADDTLRLYSDPTSERLRAAIAQAHDVGMDEI
FVGNGSDEVLAHAFHALLQHDAPLLTPDITYSFYPVYCGLYGIAHQPVPLDDAMRIDVDDYRRPCAGLVLPNPNAPTGIA
LGLGQIETLLRAQPDRVVVIDEAYVDFGADTAIPLVRRFPNLLVVRTLSKSHALAGLRVGYAIGHPDLVEALNRVKDSFN
SYPLDRLAQAGAAAAIADREWLARTTGKIIKTRIGLTSSLRGLGFEVLPSQANFVFARHPDRDAAHLAAALRERAIIVRH
FRTPRIAEWLRITVGTDEECRVLTDALGTILTRNAD

Sequences:

>Translated_356_residues
MSRFWSPVVHRLTPYVPGEQPKLTNLIKLNTNESPYGPPPGALEAIRAAADDTLRLYSDPTSERLRAAIAQAHDVGMDEI
FVGNGSDEVLAHAFHALLQHDAPLLTPDITYSFYPVYCGLYGIAHQPVPLDDAMRIDVDDYRRPCAGLVLPNPNAPTGIA
LGLGQIETLLRAQPDRVVVIDEAYVDFGADTAIPLVRRFPNLLVVRTLSKSHALAGLRVGYAIGHPDLVEALNRVKDSFN
SYPLDRLAQAGAAAAIADREWLARTTGKIIKTRIGLTSSLRGLGFEVLPSQANFVFARHPDRDAAHLAAALRERAIIVRH
FRTPRIAEWLRITVGTDEECRVLTDALGTILTRNAD
>Mature_355_residues
SRFWSPVVHRLTPYVPGEQPKLTNLIKLNTNESPYGPPPGALEAIRAAADDTLRLYSDPTSERLRAAIAQAHDVGMDEIF
VGNGSDEVLAHAFHALLQHDAPLLTPDITYSFYPVYCGLYGIAHQPVPLDDAMRIDVDDYRRPCAGLVLPNPNAPTGIAL
GLGQIETLLRAQPDRVVVIDEAYVDFGADTAIPLVRRFPNLLVVRTLSKSHALAGLRVGYAIGHPDLVEALNRVKDSFNS
YPLDRLAQAGAAAAIADREWLARTTGKIIKTRIGLTSSLRGLGFEVLPSQANFVFARHPDRDAAHLAAALRERAIIVRHF
RTPRIAEWLRITVGTDEECRVLTDALGTILTRNAD

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=351, Percent_Identity=29.0598290598291, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1788722, Length=330, Percent_Identity=28.7878787878788, Blast_Score=75, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6322075, Length=375, Percent_Identity=29.3333333333333, Blast_Score=111, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_GLUDA (A9H311)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001600571.1
- RefSeq:   YP_002276714.1
- ProteinModelPortal:   A9H311
- SMR:   A9H311
- GeneID:   5788912
- GeneID:   6975775
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_2345
- HOGENOM:   HBG646350
- OMA:   YGIDYEM
- ProtClustDB:   PRK05387
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39008; Mature: 38877

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFWSPVVHRLTPYVPGEQPKLTNLIKLNTNESPYGPPPGALEAIRAAADDTLRLYSDP
CCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEECCCC
TSERLRAAIAQAHDVGMDEIFVGNGSDEVLAHAFHALLQHDAPLLTPDITYSFYPVYCGL
HHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
YGIAHQPVPLDDAMRIDVDDYRRPCAGLVLPNPNAPTGIALGLGQIETLLRAQPDRVVVI
HHCCCCCCCCCCCEEECHHHHCCCCCCEEECCCCCCCCEEECHHHHHHHHHCCCCCEEEE
DEAYVDFGADTAIPLVRRFPNLLVVRTLSKSHALAGLRVGYAIGHPDLVEALNRVKDSFN
ECHHHCCCCCCCHHHHHHCCCEEEEEEHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHC
SYPLDRLAQAGAAAAIADREWLARTTGKIIKTRIGLTSSLRGLGFEVLPSQANFVFARHP
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEEECCCCCCEEEEECC
DRDAAHLAAALRERAIIVRHFRTPRIAEWLRITVGTDEECRVLTDALGTILTRNAD
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SRFWSPVVHRLTPYVPGEQPKLTNLIKLNTNESPYGPPPGALEAIRAAADDTLRLYSDP
CCHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEECCCC
TSERLRAAIAQAHDVGMDEIFVGNGSDEVLAHAFHALLQHDAPLLTPDITYSFYPVYCGL
HHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
YGIAHQPVPLDDAMRIDVDDYRRPCAGLVLPNPNAPTGIALGLGQIETLLRAQPDRVVVI
HHCCCCCCCCCCCEEECHHHHCCCCCCEEECCCCCCCCEEECHHHHHHHHHCCCCCEEEE
DEAYVDFGADTAIPLVRRFPNLLVVRTLSKSHALAGLRVGYAIGHPDLVEALNRVKDSFN
ECHHHCCCCCCCHHHHHHCCCEEEEEEHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHC
SYPLDRLAQAGAAAAIADREWLARTTGKIIKTRIGLTSSLRGLGFEVLPSQANFVFARHP
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEEECCCCCCEEEEECC
DRDAAHLAAALRERAIIVRHFRTPRIAEWLRITVGTDEECRVLTDALGTILTRNAD
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA