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The map label for this gene is yjcE [H]

Identifier: 162146111

GI number: 162146111

Start: 289134

End: 290822

Strand: Direct

Name: yjcE [H]

Synonym: GDI_0280

Alternate gene names: 162146111

Gene position: 289134-290822 (Clockwise)

Preceding gene: 162146107

Following gene: 162146115

Centisome position: 7.33

GC content: 70.81

Gene sequence:

>1689_bases
ATGCACGACGTCATCGTGGGGTTGATCCTGCTGTTCGTGGCCGCGATCAGCAGCCTGTTTTCCCGGCTTCTGCCCGTGCC
CATCCCGCTGCCGCTGTGGCAGATCGCGCTGGGGGTGGTGGGGTCCGTGGCGGGGCTGCATGTCGTGCTGAACCCCGACA
TGTTCATGCTGCTGTTCATTCCGCCGCTGCTGTTCCGCGATGCGTTCCGCATGCCGACGCGCGAATTCGGCCAGTTGCGC
GGCATCATCTTCGCCCTGGCGGTGCCGATGGTGGTGGGGACCACCATCCTGTGCGGCTATGCCGTGCACTGGCTGATCCC
GGTGCTGGCGCTGCCGGCCTGCTTCGCGCTGGCCGCCGTGCTGTCGCCGACCGACGCGGTGGCCCGTGGGCGGGCATGCT
GGGGGCCGTCCGTGCCGCGCACCATCGTCCACCGCTGCTGGACGGCGAATCCCTGCTTGAACGACGCGTCCGGCCTGGTC
TGCTTCCGGTTCGCGGCGGTGGCCGCCGTAACGGGGGCGTTCTCGCTGCGCGGCGCGCTGGCCACGTTCGGCCTGCTGTC
GCTGGGCGGAATCGCGATCGGCATCCTGGTCTGCTACGCGGCGGCGCGGCTGGACCGGATGCTGCTGCGCCGGGGGTACG
ACGACCCGCCGACCCAGGTCACCTTCATGCTGCTGCTGCCCTTCGCCGCCTACCTGCTGGCCGAACTCGTGGGGTGCTCG
GGCATCCTGGCGGCGGTGGCGGGCGGCATGACGGCCAAGCTGACGGGCGTGCTGCAGGAAACCCAGATCACCACCCGCCT
GCAGGCCCGCACGACGTGGGACATGGTCGGCTTCGTGTTCAATTCCATCATCTTCCTGCTGCTGGGCCTGCAGTTGCCCG
ACCTGGCGGGAAACGGGATCGCGCTGGTGCGGCAGGCGGGCCGGTCGCCCTGGCTGCTGCTTCTGGTCATCGTCGCCATC
CACCTGGCCATGTGCGTGCTGCGCTTCGCGGGGTTGTGGATCATCCTGGCGGTGGCGGCGTGGCGGGCCCGGCACGAACG
CGGGGCGATGCACTGGCCGGGCCTGCGCACCGTGCTGGTCGGCACGGTCGCGGGGGTGCGCGGCGCGGTCACGCTGGCGG
CGGTGCTGTCCCTGCCGCAGGCGGTGGGGGACGTGCCGGGCTTTCCCGACCGCGACCTGCTGGTGACGCTGGCCACCGGG
GTCATCCTGGTGTCGCTGCTGGCGGCCAGCCTGACCCTGCCCTGGCTGGCGCGCGGCATGCCGGCCGGGCAGGTCGACCC
CCAGGCGCGCGAGGTCGACTGGGCGCGGCTGGTGCTGCTGCGCACGATGATCCGCGCCATGCGCGACGAACAGGCGGCCC
TGACCGCGCGGGCCAAGATCCGCGACGAGGCCGGCGAAACCCGGATCGAGATCATCGCCCGCCTGATGCAGGAATATGAA
AACCGCCTGGGCCAGTTGCAGCGCGACGGTGACGGCGCGGCCAGCGCGGCGCAGGTCGGGTCGATCCGGCGCATGCGCCT
GGAACTGGCGATCCGCCTGACCAACCTGCGCGCGTCGCGGATCGAACTGCGCAACCTGCGCGCCGCCCAGTACGTCAATG
ACGAAACCGAATCCCTGCTGCAGCAGGAAATGGATTACGAGGAACAGGTCCTGCGCAACCGCGCCCGGACCCTGCCACGC
GTCGCGTGA

Upstream 100 bases:

>100_bases
CCGGGACGCCCCGCATGGCCAGTCGCGGGAAATCCGTGTAGCGTGTCCGCAACCGTGATGATCTTTCGCGGATCGGCATC
GGGGAAATCGAAGCGCGGCC

Downstream 100 bases:

>100_bases
CGGCTGTTTCAAAAGCCCCGCTGCCGGCGATCCGACGCGCGTTTCCTGTGCTCCGATGCTCTCGGCCCATAAGGCCGCTC
CGCTTCGGTGCGCGGGAACA

Product: Na(+)/H(+) exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MHDVIVGLILLFVAAISSLFSRLLPVPIPLPLWQIALGVVGSVAGLHVVLNPDMFMLLFIPPLLFRDAFRMPTREFGQLR
GIIFALAVPMVVGTTILCGYAVHWLIPVLALPACFALAAVLSPTDAVARGRACWGPSVPRTIVHRCWTANPCLNDASGLV
CFRFAAVAAVTGAFSLRGALATFGLLSLGGIAIGILVCYAAARLDRMLLRRGYDDPPTQVTFMLLLPFAAYLLAELVGCS
GILAAVAGGMTAKLTGVLQETQITTRLQARTTWDMVGFVFNSIIFLLLGLQLPDLAGNGIALVRQAGRSPWLLLLVIVAI
HLAMCVLRFAGLWIILAVAAWRARHERGAMHWPGLRTVLVGTVAGVRGAVTLAAVLSLPQAVGDVPGFPDRDLLVTLATG
VILVSLLAASLTLPWLARGMPAGQVDPQAREVDWARLVLLRTMIRAMRDEQAALTARAKIRDEAGETRIEIIARLMQEYE
NRLGQLQRDGDGAASAAQVGSIRRMRLELAIRLTNLRASRIELRNLRAAQYVNDETESLLQQEMDYEEQVLRNRARTLPR
VA

Sequences:

>Translated_562_residues
MHDVIVGLILLFVAAISSLFSRLLPVPIPLPLWQIALGVVGSVAGLHVVLNPDMFMLLFIPPLLFRDAFRMPTREFGQLR
GIIFALAVPMVVGTTILCGYAVHWLIPVLALPACFALAAVLSPTDAVARGRACWGPSVPRTIVHRCWTANPCLNDASGLV
CFRFAAVAAVTGAFSLRGALATFGLLSLGGIAIGILVCYAAARLDRMLLRRGYDDPPTQVTFMLLLPFAAYLLAELVGCS
GILAAVAGGMTAKLTGVLQETQITTRLQARTTWDMVGFVFNSIIFLLLGLQLPDLAGNGIALVRQAGRSPWLLLLVIVAI
HLAMCVLRFAGLWIILAVAAWRARHERGAMHWPGLRTVLVGTVAGVRGAVTLAAVLSLPQAVGDVPGFPDRDLLVTLATG
VILVSLLAASLTLPWLARGMPAGQVDPQAREVDWARLVLLRTMIRAMRDEQAALTARAKIRDEAGETRIEIIARLMQEYE
NRLGQLQRDGDGAASAAQVGSIRRMRLELAIRLTNLRASRIELRNLRAAQYVNDETESLLQQEMDYEEQVLRNRARTLPR
VA
>Mature_562_residues
MHDVIVGLILLFVAAISSLFSRLLPVPIPLPLWQIALGVVGSVAGLHVVLNPDMFMLLFIPPLLFRDAFRMPTREFGQLR
GIIFALAVPMVVGTTILCGYAVHWLIPVLALPACFALAAVLSPTDAVARGRACWGPSVPRTIVHRCWTANPCLNDASGLV
CFRFAAVAAVTGAFSLRGALATFGLLSLGGIAIGILVCYAAARLDRMLLRRGYDDPPTQVTFMLLLPFAAYLLAELVGCS
GILAAVAGGMTAKLTGVLQETQITTRLQARTTWDMVGFVFNSIIFLLLGLQLPDLAGNGIALVRQAGRSPWLLLLVIVAI
HLAMCVLRFAGLWIILAVAAWRARHERGAMHWPGLRTVLVGTVAGVRGAVTLAAVLSLPQAVGDVPGFPDRDLLVTLATG
VILVSLLAASLTLPWLARGMPAGQVDPQAREVDWARLVLLRTMIRAMRDEQAALTARAKIRDEAGETRIEIIARLMQEYE
NRLGQLQRDGDGAASAAQVGSIRRMRLELAIRLTNLRASRIELRNLRAAQYVNDETESLLQQEMDYEEQVLRNRARTLPR
VA

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=431, Percent_Identity=22.969837587007, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790501, Length=549, Percent_Identity=39.1621129326047, Blast_Score=316, Evalue=3e-87,
Organism=Drosophila melanogaster, GI221510738, Length=522, Percent_Identity=23.7547892720307, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221510734, Length=452, Percent_Identity=23.6725663716814, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221510732, Length=387, Percent_Identity=24.8062015503876, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221510736, Length=387, Percent_Identity=24.8062015503876, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221510740, Length=387, Percent_Identity=24.8062015503876, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24585580, Length=387, Percent_Identity=24.8062015503876, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24585578, Length=387, Percent_Identity=24.8062015503876, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 60932; Mature: 60932

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure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HHHCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]