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The map label for this gene is tktA [H]

Identifier: 162146115

GI number: 162146115

Start: 294543

End: 296870

Strand: Direct

Name: tktA [H]

Synonym: GDI_0285

Alternate gene names: 162146115

Gene position: 294543-296870 (Clockwise)

Preceding gene: 162146111

Following gene: 162146116

Centisome position: 7.47

GC content: 67.65

Gene sequence:

>2328_bases
ATGGTATCGAAGCGTGCGTGCCGCCGCCGGGATGACCGGCGCAGCGTGGCCGCTTCATGGGCAGGGGACCCGATCGGATG
GATGAGACAGGGCAACCATAATGGAGAAGGCGATTTAATGCGTTCCATATTCACCCAACCTGTTCGGGCCTTCGAAGGCG
GGGCCACCGGCCCGTCCGCCGAGGATGTGCTGTGCATCAACACCATCCGTACCCTGTCCATGGACGGGGTGCAGAAGGCG
AATTCCGGCCATCCGGGCACGCCGATGGCCATGGCGGCGCCGGCCTACGCCCTGTGGCAGAACGTCCTCAGCTACGACCC
GGCCGATCCGCTGTGGCCGAACCGCGACCGGTTCGTGCTGTCGATCGGCCATGCCTCGATGCTGATCTATTCGCTGATCT
ACCTGGCCGGCATCCGCGACGTGAAGCACGGCACGGTGCTGGACGCGCCGTCGCTGACGCTGAAGGACCTGGAACAGTTC
CGCCAGCTCGATTCCCGCACCCCCGGCCACCCGGAATACCACCACACGGCGGGCGTCGAGACGACGACCGGCCCGCTGGG
CCAGGGCTGCGGCAATTCCGTCGGCATGGCGATGGCGGAAAAATGGCTCGCCACCCGCTTCAACAAGCCGGGCTTCCCGC
TGTTCGACTATCACGTCTACACGTTCTGCGGTGACGGCGACATGATGGAAGGCGTGGCCAGCGAGGCCGCGTCGGTGGCC
GGCCACCTGCGCCTGGGCAACCTGACCTGGATCTACGACAGCAACCGCATCTCGATCGAGGGCTCGACCGACATCGCCTT
CACCGAGAACGTGCAGAAGCGGTTCGAGGGCTATGGCTGGCACGTGCTGGAGGTCAAGGACGCCAACGACCAGGCGGCCT
TCCTGGCGGCGCTGGCGGACGCCAAGGCCGAAACCGGCCGTCCGACCCTGATCATCGTGCATTCCGTCATCGGCTGGGGC
GCGCCCCACAAGGCCGGCACCGCCTCGGCGCACGGCGAACCGCTGGGCGACGCGGAAATCCGCGGCGCGAAGAAGGCCTA
TGGCTGGCCGGAAGACAAGAGCTTCTACGTCCCCGACGGCGTGCTGGAACATTTCCAGAAGGGCCTGGGCGCCCGTGGCG
CCGCTGCCAGCGCGCAGTGGAAGGCGCTGTACGCGTCCTACGCCAGGGACTATCCCGACCTGGCGAAGGAAGTGGACGCC
ATCCTGTCCAATCGCCTGCCGGAAGGCTGGGACAAGGACATCCCGGTGTACGAGCCCAGCGCCAAGGGCGTGGCCTCGCG
CCAGAGCTCGGGCGAGGTGCTGAACGCGATCGCGCCGAACTTCCCGTGGCTGATCGGCGGCTCGGCCGACCTGTCGCCGT
CCACCAAGACCAACCTGACCTTCCAGGGCGCGGGCTCGTTCCAGCCGCCGGAATGGAACGGCACCTATGGCGGGCGCAAC
CTGCATTTCGGCGTGCGCGAACACGCCATGGGCTCGATCTGCAACGGCATCTCGCTGGCGGGCATCCGGGCCTACTGCTC
GGGCTTCCTGATCTTCTCGGACTACATGAAGCCGCCGATCCGCCTGTCGGCGCTGATGAACCAGCCGGTCGTCTATATCT
TCACGCATGATTCCATCGGCGTGGGCGAGGACGGTCCGACCCATCAGCCGATCGAACAGCTCGTGCAGCTTCGCGCCACC
CCCGGCGTGACGCTGATCCGCCCGGCGGACGCGAACGAGGTCGCGGAAGCGTGGCGCACGCTGATCCCGATGACCGACCG
CCCGTCGGTGCTGATCCTCAGCCGCCAGAACCTGCCGACGGTGGACCGCACGGTCTATGCCCCGGCGTCGGGCCTGGCCA
AAGGCGCCTACGTGCTGGGCGATTGCGACGGCACGCCGGACGTCATCCTGATGGCGACGGGCAGCGAGGTCGGGCTGGTG
GTCTCGGCGTACGAGACGCTGAAGGCCGAAGGGGTCAAGGCGCGCGTGGTCTCCATGCCGTCGTGGGACCTGTTCGAGGC
CCAGCCGAAGGAATACCGCGACAGCGTCCTGCCGCCGACGGTCACCAACCGCGTCGCGGTCGAAATGGCCTCGCCGGTCG
GCTGGGACCGCTATGTCGGCCTCAGCGGCTCGATCATCGCCATGCACGGCTTCGGGGCCCTCGGCCCCGGCCGGCGGAAC
TGTTCAAGAAATTCGGCTTCACCGTCGAAGCCGTCCTGGCCGAAGCGCGCAAGCAGGTGGCCAAGGGTTGATTCGTGGCC
GGGGCGCCCGCCACGCGGCGCGCCCCGGCCCGTTTCGGTTACCGAAAGGGGCGGGGACCGGCTTTTGGCCGGCGATAACC
CGCCATGA

Upstream 100 bases:

>100_bases
CCGGGCCCCCGGGTGGCCAGGGTCACAGAACGGCCAGGGTCGCGACCGGATGACAAAAAAATGACGAACGGGATCCCCAG
GCAAGGGCAGTCCTCAACCC

Downstream 100 bases:

>100_bases
CAACGAAGGAGCAACACCATGAACGTCGTGCAGAAGACGGGTGTTCAGGGCGCCGCCAATCCGCTCAAGGCACTGGAACA
GTTCGGCCAGTCCCCGTGGC

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 775; Mature: 775

Protein sequence:

>775_residues
MVSKRACRRRDDRRSVAASWAGDPIGWMRQGNHNGEGDLMRSIFTQPVRAFEGGATGPSAEDVLCINTIRTLSMDGVQKA
NSGHPGTPMAMAAPAYALWQNVLSYDPADPLWPNRDRFVLSIGHASMLIYSLIYLAGIRDVKHGTVLDAPSLTLKDLEQF
RQLDSRTPGHPEYHHTAGVETTTGPLGQGCGNSVGMAMAEKWLATRFNKPGFPLFDYHVYTFCGDGDMMEGVASEAASVA
GHLRLGNLTWIYDSNRISIEGSTDIAFTENVQKRFEGYGWHVLEVKDANDQAAFLAALADAKAETGRPTLIIVHSVIGWG
APHKAGTASAHGEPLGDAEIRGAKKAYGWPEDKSFYVPDGVLEHFQKGLGARGAAASAQWKALYASYARDYPDLAKEVDA
ILSNRLPEGWDKDIPVYEPSAKGVASRQSSGEVLNAIAPNFPWLIGGSADLSPSTKTNLTFQGAGSFQPPEWNGTYGGRN
LHFGVREHAMGSICNGISLAGIRAYCSGFLIFSDYMKPPIRLSALMNQPVVYIFTHDSIGVGEDGPTHQPIEQLVQLRAT
PGVTLIRPADANEVAEAWRTLIPMTDRPSVLILSRQNLPTVDRTVYAPASGLAKGAYVLGDCDGTPDVILMATGSEVGLV
VSAYETLKAEGVKARVVSMPSWDLFEAQPKEYRDSVLPPTVTNRVAVEMASPVGWDRYVGLSGSIIAMHGFGALGPGRRN
CSRNSASPSKPSWPKRASRWPRVDSWPGRPPRGAPRPVSVTERGGDRLLAGDNPP

Sequences:

>Translated_775_residues
MVSKRACRRRDDRRSVAASWAGDPIGWMRQGNHNGEGDLMRSIFTQPVRAFEGGATGPSAEDVLCINTIRTLSMDGVQKA
NSGHPGTPMAMAAPAYALWQNVLSYDPADPLWPNRDRFVLSIGHASMLIYSLIYLAGIRDVKHGTVLDAPSLTLKDLEQF
RQLDSRTPGHPEYHHTAGVETTTGPLGQGCGNSVGMAMAEKWLATRFNKPGFPLFDYHVYTFCGDGDMMEGVASEAASVA
GHLRLGNLTWIYDSNRISIEGSTDIAFTENVQKRFEGYGWHVLEVKDANDQAAFLAALADAKAETGRPTLIIVHSVIGWG
APHKAGTASAHGEPLGDAEIRGAKKAYGWPEDKSFYVPDGVLEHFQKGLGARGAAASAQWKALYASYARDYPDLAKEVDA
ILSNRLPEGWDKDIPVYEPSAKGVASRQSSGEVLNAIAPNFPWLIGGSADLSPSTKTNLTFQGAGSFQPPEWNGTYGGRN
LHFGVREHAMGSICNGISLAGIRAYCSGFLIFSDYMKPPIRLSALMNQPVVYIFTHDSIGVGEDGPTHQPIEQLVQLRAT
PGVTLIRPADANEVAEAWRTLIPMTDRPSVLILSRQNLPTVDRTVYAPASGLAKGAYVLGDCDGTPDVILMATGSEVGLV
VSAYETLKAEGVKARVVSMPSWDLFEAQPKEYRDSVLPPTVTNRVAVEMASPVGWDRYVGLSGSIIAMHGFGALGPGRRN
CSRNSASPSKPSWPKRASRWPRVDSWPGRPPRGAPRPVSVTERGGDRLLAGDNPP
>Mature_775_residues
MVSKRACRRRDDRRSVAASWAGDPIGWMRQGNHNGEGDLMRSIFTQPVRAFEGGATGPSAEDVLCINTIRTLSMDGVQKA
NSGHPGTPMAMAAPAYALWQNVLSYDPADPLWPNRDRFVLSIGHASMLIYSLIYLAGIRDVKHGTVLDAPSLTLKDLEQF
RQLDSRTPGHPEYHHTAGVETTTGPLGQGCGNSVGMAMAEKWLATRFNKPGFPLFDYHVYTFCGDGDMMEGVASEAASVA
GHLRLGNLTWIYDSNRISIEGSTDIAFTENVQKRFEGYGWHVLEVKDANDQAAFLAALADAKAETGRPTLIIVHSVIGWG
APHKAGTASAHGEPLGDAEIRGAKKAYGWPEDKSFYVPDGVLEHFQKGLGARGAAASAQWKALYASYARDYPDLAKEVDA
ILSNRLPEGWDKDIPVYEPSAKGVASRQSSGEVLNAIAPNFPWLIGGSADLSPSTKTNLTFQGAGSFQPPEWNGTYGGRN
LHFGVREHAMGSICNGISLAGIRAYCSGFLIFSDYMKPPIRLSALMNQPVVYIFTHDSIGVGEDGPTHQPIEQLVQLRAT
PGVTLIRPADANEVAEAWRTLIPMTDRPSVLILSRQNLPTVDRTVYAPASGLAKGAYVLGDCDGTPDVILMATGSEVGLV
VSAYETLKAEGVKARVVSMPSWDLFEAQPKEYRDSVLPPTVTNRVAVEMASPVGWDRYVGLSGSIIAMHGFGALGPGRRN
CSRNSASPSKPSWPKRASRWPRVDSWPGRPPRGAPRPVSVTERGGDRLLAGDNPP

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=603, Percent_Identity=27.1973466003317, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI4507521, Length=603, Percent_Identity=27.1973466003317, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI133778974, Length=270, Percent_Identity=28.8888888888889, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI225637461, Length=183, Percent_Identity=28.4153005464481, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI225637463, Length=183, Percent_Identity=28.4153005464481, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI225637459, Length=183, Percent_Identity=28.4153005464481, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI48994911, Length=657, Percent_Identity=47.6407914764079, Blast_Score=586, Evalue=1e-168,
Organism=Escherichia coli, GI1788808, Length=664, Percent_Identity=45.1807228915663, Blast_Score=559, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI17539652, Length=594, Percent_Identity=25.7575757575758, Blast_Score=145, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6325331, Length=659, Percent_Identity=47.9514415781487, Blast_Score=580, Evalue=1e-166,
Organism=Saccharomyces cerevisiae, GI6319593, Length=662, Percent_Identity=43.8066465256798, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45551847, Length=609, Percent_Identity=24.1379310344828, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45550715, Length=609, Percent_Identity=24.1379310344828, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24666278, Length=602, Percent_Identity=24.5847176079734, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24645119, Length=581, Percent_Identity=23.9242685025818, Blast_Score=129, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 83671; Mature: 83671

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSKRACRRRDDRRSVAASWAGDPIGWMRQGNHNGEGDLMRSIFTQPVRAFEGGATGPSA
CCCHHHHHCCHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
EDVLCINTIRTLSMDGVQKANSGHPGTPMAMAAPAYALWQNVLSYDPADPLWPNRDRFVL
CCEEEEEHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
SIGHASMLIYSLIYLAGIRDVKHGTVLDAPSLTLKDLEQFRQLDSRTPGHPEYHHTAGVE
EECHHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
TTTGPLGQGCGNSVGMAMAEKWLATRFNKPGFPLFDYHVYTFCGDGDMMEGVASEAASVA
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHH
GHLRLGNLTWIYDSNRISIEGSTDIAFTENVQKRFEGYGWHVLEVKDANDQAAFLAALAD
HEEEECCEEEEEECCEEEECCCCCEEEHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHH
AKAETGRPTLIIVHSVIGWGAPHKAGTASAHGEPLGDAEIRGAKKAYGWPEDKSFYVPDG
HHCCCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCCCCHHHCCCHHHCCCCCCCCEECCHH
VLEHFQKGLGARGAAASAQWKALYASYARDYPDLAKEVDAILSNRLPEGWDKDIPVYEPS
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
AKGVASRQSSGEVLNAIAPNFPWLIGGSADLSPSTKTNLTFQGAGSFQPPEWNGTYGGRN
CCCCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCE
LHFGVREHAMGSICNGISLAGIRAYCSGFLIFSDYMKPPIRLSALMNQPVVYIFTHDSIG
EECCHHHHHHHHHHCCCHHHHHHHHHCCCEEEHHHCCCCHHHHHHHCCCEEEEEECCCCC
VGEDGPTHQPIEQLVQLRATPGVTLIRPADANEVAEAWRTLIPMTDRPSVLILSRQNLPT
CCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
VDRTVYAPASGLAKGAYVLGDCDGTPDVILMATGSEVGLVVSAYETLKAEGVKARVVSMP
CCCEEECCCCCCCCCCEEEECCCCCCCEEEEECCCCCEEEEEHHHHHHCCCCEEEEEECC
SWDLFEAQPKEYRDSVLPPTVTNRVAVEMASPVGWDRYVGLSGSIIAMHGFGALGPGRRN
CCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCEECCCCCEEEEECCCCCCCCCCC
CSRNSASPSKPSWPKRASRWPRVDSWPGRPPRGAPRPVSVTERGGDRLLAGDNPP
CCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCEEECCCCCC
>Mature Secondary Structure
MVSKRACRRRDDRRSVAASWAGDPIGWMRQGNHNGEGDLMRSIFTQPVRAFEGGATGPSA
CCCHHHHHCCHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
EDVLCINTIRTLSMDGVQKANSGHPGTPMAMAAPAYALWQNVLSYDPADPLWPNRDRFVL
CCEEEEEHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
SIGHASMLIYSLIYLAGIRDVKHGTVLDAPSLTLKDLEQFRQLDSRTPGHPEYHHTAGVE
EECHHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
TTTGPLGQGCGNSVGMAMAEKWLATRFNKPGFPLFDYHVYTFCGDGDMMEGVASEAASVA
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHH
GHLRLGNLTWIYDSNRISIEGSTDIAFTENVQKRFEGYGWHVLEVKDANDQAAFLAALAD
HEEEECCEEEEEECCEEEECCCCCEEEHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHH
AKAETGRPTLIIVHSVIGWGAPHKAGTASAHGEPLGDAEIRGAKKAYGWPEDKSFYVPDG
HHCCCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCCCCHHHCCCHHHCCCCCCCCEECCHH
VLEHFQKGLGARGAAASAQWKALYASYARDYPDLAKEVDAILSNRLPEGWDKDIPVYEPS
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
AKGVASRQSSGEVLNAIAPNFPWLIGGSADLSPSTKTNLTFQGAGSFQPPEWNGTYGGRN
CCCCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCE
LHFGVREHAMGSICNGISLAGIRAYCSGFLIFSDYMKPPIRLSALMNQPVVYIFTHDSIG
EECCHHHHHHHHHHCCCHHHHHHHHHCCCEEEHHHCCCCHHHHHHHCCCEEEEEECCCCC
VGEDGPTHQPIEQLVQLRATPGVTLIRPADANEVAEAWRTLIPMTDRPSVLILSRQNLPT
CCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
VDRTVYAPASGLAKGAYVLGDCDGTPDVILMATGSEVGLVVSAYETLKAEGVKARVVSMP
CCCEEECCCCCCCCCCEEEECCCCCCCEEEEECCCCCEEEEEHHHHHHCCCCEEEEEECC
SWDLFEAQPKEYRDSVLPPTVTNRVAVEMASPVGWDRYVGLSGSIIAMHGFGALGPGRRN
CCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCEECCCCCEEEEECCCCCCCCCCC
CSRNSASPSKPSWPKRASRWPRVDSWPGRPPRGAPRPVSVTERGGDRLLAGDNPP
CCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]