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The map label for this gene is accB [H]

Identifier: 162146034

GI number: 162146034

Start: 217705

End: 218151

Strand: Reverse

Name: accB [H]

Synonym: GDI_0202

Alternate gene names: 162146034

Gene position: 218151-217705 (Counterclockwise)

Preceding gene: 162146035

Following gene: 162146033

Centisome position: 5.53

GC content: 68.9

Gene sequence:

>447_bases
ATGACCGTCGATCTGGAGCGCATCACGATCCTCATGGACCGGATGCACGCACTCGGCATTGCCGAGCTGGAATACACCCA
TGGCGACGAGCATGTCCGCCTGGTCCGGGACACGTCCCCCCCGGCGTCCCCGGCACCGGGGACAGTGCCTGCCGCGACGC
CGGACGTGCCGCCGTCCCCCCTGCCCGCCCCGGCCCCCACATCCTGCACGATCACGGCGACGATGCATGGCCAGTTCTAC
GCCTCGCCCACGCCGGGGGGCGCCCCCTTCGTCACCGCAGGCTCGGTCGTCGCGCAGGGACAGCCCCTCTATATCCTGGA
GGTGATGAAGACCCTGACGCGGGTCGAGGCCGAATTCCCCTGCACGATCGTCGCGATCCTGTGTGAAAACGGCCAGGCGG
TGGAGCCGGGAACCGAACTGTTCACCGTGGAGCGCCGGGATGCGTGA

Upstream 100 bases:

>100_bases
GCATGGCGACAATGCCGAGTCCGTCGCGGTCGCCCGCACCGTGCGCGCCCGGCTGGAAGCGGCGGGCATCACATTGCGCG
CGCTGACCTGAGAAGCCCCG

Downstream 100 bases:

>100_bases
CGTCCGCACCGTCCTGATCGCCAATCGCGGCGAAATCGCCCTGCGCATTGCCCGCGCCTGCCGCCTGCTGGGGCTGCGCA
GCGTGGGCGTATATTCCGAA

Product: biotin carboxyl carrier protein of acetyl-CoA carboxylase

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 148; Mature: 147

Protein sequence:

>148_residues
MTVDLERITILMDRMHALGIAELEYTHGDEHVRLVRDTSPPASPAPGTVPAATPDVPPSPLPAPAPTSCTITATMHGQFY
ASPTPGGAPFVTAGSVVAQGQPLYILEVMKTLTRVEAEFPCTIVAILCENGQAVEPGTELFTVERRDA

Sequences:

>Translated_148_residues
MTVDLERITILMDRMHALGIAELEYTHGDEHVRLVRDTSPPASPAPGTVPAATPDVPPSPLPAPAPTSCTITATMHGQFY
ASPTPGGAPFVTAGSVVAQGQPLYILEVMKTLTRVEAEFPCTIVAILCENGQAVEPGTELFTVERRDA
>Mature_147_residues
TVDLERITILMDRMHALGIAELEYTHGDEHVRLVRDTSPPASPAPGTVPAATPDVPPSPLPAPAPTSCTITATMHGQFYA
SPTPGGAPFVTAGSVVAQGQPLYILEVMKTLTRVEAEFPCTIVAILCENGQAVEPGTELFTVERRDA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=157, Percent_Identity=35.031847133758, Blast_Score=76, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 15663; Mature: 15532

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVDLERITILMDRMHALGIAELEYTHGDEHVRLVRDTSPPASPAPGTVPAATPDVPPSP
CCCCHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
LPAPAPTSCTITATMHGQFYASPTPGGAPFVTAGSVVAQGQPLYILEVMKTLTRVEAEFP
CCCCCCCCEEEEEEECCEEEECCCCCCCCEEECCCEEECCCCCHHHHHHHHHHHCCCCCC
CTIVAILCENGQAVEPGTELFTVERRDA
EEEEEEEECCCCEECCCCEEEEEEECCC
>Mature Secondary Structure 
TVDLERITILMDRMHALGIAELEYTHGDEHVRLVRDTSPPASPAPGTVPAATPDVPPSP
CCCHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
LPAPAPTSCTITATMHGQFYASPTPGGAPFVTAGSVVAQGQPLYILEVMKTLTRVEAEFP
CCCCCCCCEEEEEEECCEEEECCCCCCCCEEECCCEEECCCCCHHHHHHHHHHHCCCCCC
CTIVAILCENGQAVEPGTELFTVERRDA
EEEEEEEECCCCEECCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]