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The map label for this gene is accC [H]

Identifier: 162146033

GI number: 162146033

Start: 216354

End: 217712

Strand: Reverse

Name: accC [H]

Synonym: GDI_0201

Alternate gene names: 162146033

Gene position: 217712-216354 (Counterclockwise)

Preceding gene: 162146034

Following gene: 162146032

Centisome position: 5.52

GC content: 68.14

Gene sequence:

>1359_bases
ATGCGTGACGTCCGCACCGTCCTGATCGCCAATCGCGGCGAAATCGCCCTGCGCATTGCCCGCGCCTGCCGCCTGCTGGG
GCTGCGCAGCGTGGGCGTATATTCCGAAGCCGATGCCGGCCTGGCGCATCTGCGCCTGGTCGATCAGCGGATCTGCATCG
GCCCCGCATCGGCGACACGGAGCTATCTGGATGCCGGGCGGATCCTGCGCGCCGCCGCATTGACGGGGGCGGACGCGATC
CATCCCGGCTATGGCTTCCTGTCGGAAAATGCCGATTTCGCCGAAGCGGTGGAACGCGCGGGCCTGGTCCTGGTGGGACC
GCCCGCGTCCATCATGCGCATGATGGGCGACAAGATCGCCGCCAAGCGGCAGATGCGCGACAGCGGCGTACCCTGCCTGC
CCGGCTCGGACGATGCGCTGCCGGACGATATCGCCGAGGCCGTGCGGATCTGCGACGGCGTGGGCTATCCGCTGATCGTC
AAGGCGGCAGGCGGCGGCGGCGGGCGCGGCATGCGCGTCGTGCGCCGGCCCGAAAACGCGCGGGAGGCGATCGAAACCGC
GCGCGAGGAAGCCGGACGCGCCTTCGGCAACCCGTCGATCTATGCCGAGCGATTCCTGCAGCACCCACGTCATGTGGAAA
TCCAGGTCCTGGCCGACAGGGCGGGCCAGGCCGTCTGGCTGGGCGCGCGGGACTGTTCCGTACAACGCCGGCACCAGAAA
CTGATCGAGGAAGCGCCCGCCATCGGAATTCCGCCCGACCGTATCGCCGACCTGGGCGAGCGCTGTGCCCGCGCCTGCGT
CCGGATGGGGTATGTCGGAGCCGGCACGTTCGAATTCCTCTACGAGGACGGCGCGTTTTCCTTCATCGAGATGAACACGC
GCCTGCAGGTGGAACACCCGGTGACCGAAATGACGACCGGCATCGATATCGTGCGCGAACAACTGCGTATCGCCATGGGA
CATCCCCTGTCGTTCGGCCAGTCCGATATCGAAACGCGCGGCCATGCCATCGAATGCCGGATCAACGCGGAACATCCGGA
AACATTCGCCCCCTGCCCCGGCCTCGTGCGGACATGGCGCCCGCCGGGCGGCCCCGGCGTGCGGGTCGATACGCACCTGT
ATGACGGATACACGGTACCGCCGCAGTACGACTCGCTGGTCGCCAAGCTGATCGTCCATGGCGCGGACCGCGCCGATGCG
CTGGCGCGGATGCGCGCGGCGCTGGACGAGATGATGGTCGAAGGCATCACCACCACCGCCCCGCTGCATCGCCGCCTGAT
GGACGCCGCAGATTTTTGCGCCGGCGGCGTCTCCGTCCATTATCTGGAGGCACTGGCGGCCGAAGGGGCCACGCCATGA

Upstream 100 bases:

>100_bases
CGGGTCGAGGCCGAATTCCCCTGCACGATCGTCGCGATCCTGTGTGAAAACGGCCAGGCGGTGGAGCCGGGAACCGAACT
GTTCACCGTGGAGCGCCGGG

Downstream 100 bases:

>100_bases
CGATCCTGGACCAGTTGCCCGCGCTGGTCGCGGCCATGCGGCGCAATGCCGTCCGAAGCCTGACGGTGGGCGACGCCGGG
ACCAGGCTGACCCTGCGGCT

Product: biotin carboxylase (acetyl-CoA carboxylase subunit A)

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MRDVRTVLIANRGEIALRIARACRLLGLRSVGVYSEADAGLAHLRLVDQRICIGPASATRSYLDAGRILRAAALTGADAI
HPGYGFLSENADFAEAVERAGLVLVGPPASIMRMMGDKIAAKRQMRDSGVPCLPGSDDALPDDIAEAVRICDGVGYPLIV
KAAGGGGGRGMRVVRRPENAREAIETAREEAGRAFGNPSIYAERFLQHPRHVEIQVLADRAGQAVWLGARDCSVQRRHQK
LIEEAPAIGIPPDRIADLGERCARACVRMGYVGAGTFEFLYEDGAFSFIEMNTRLQVEHPVTEMTTGIDIVREQLRIAMG
HPLSFGQSDIETRGHAIECRINAEHPETFAPCPGLVRTWRPPGGPGVRVDTHLYDGYTVPPQYDSLVAKLIVHGADRADA
LARMRAALDEMMVEGITTTAPLHRRLMDAADFCAGGVSVHYLEALAAEGATP

Sequences:

>Translated_452_residues
MRDVRTVLIANRGEIALRIARACRLLGLRSVGVYSEADAGLAHLRLVDQRICIGPASATRSYLDAGRILRAAALTGADAI
HPGYGFLSENADFAEAVERAGLVLVGPPASIMRMMGDKIAAKRQMRDSGVPCLPGSDDALPDDIAEAVRICDGVGYPLIV
KAAGGGGGRGMRVVRRPENAREAIETAREEAGRAFGNPSIYAERFLQHPRHVEIQVLADRAGQAVWLGARDCSVQRRHQK
LIEEAPAIGIPPDRIADLGERCARACVRMGYVGAGTFEFLYEDGAFSFIEMNTRLQVEHPVTEMTTGIDIVREQLRIAMG
HPLSFGQSDIETRGHAIECRINAEHPETFAPCPGLVRTWRPPGGPGVRVDTHLYDGYTVPPQYDSLVAKLIVHGADRADA
LARMRAALDEMMVEGITTTAPLHRRLMDAADFCAGGVSVHYLEALAAEGATP
>Mature_452_residues
MRDVRTVLIANRGEIALRIARACRLLGLRSVGVYSEADAGLAHLRLVDQRICIGPASATRSYLDAGRILRAAALTGADAI
HPGYGFLSENADFAEAVERAGLVLVGPPASIMRMMGDKIAAKRQMRDSGVPCLPGSDDALPDDIAEAVRICDGVGYPLIV
KAAGGGGGRGMRVVRRPENAREAIETAREEAGRAFGNPSIYAERFLQHPRHVEIQVLADRAGQAVWLGARDCSVQRRHQK
LIEEAPAIGIPPDRIADLGERCARACVRMGYVGAGTFEFLYEDGAFSFIEMNTRLQVEHPVTEMTTGIDIVREQLRIAMG
HPLSFGQSDIETRGHAIECRINAEHPETFAPCPGLVRTWRPPGGPGVRVDTHLYDGYTVPPQYDSLVAKLIVHGADRADA
LARMRAALDEMMVEGITTTAPLHRRLMDAADFCAGGVSVHYLEALAAEGATP

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=446, Percent_Identity=45.2914798206278, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI189095269, Length=453, Percent_Identity=41.5011037527594, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI65506442, Length=447, Percent_Identity=42.0581655480984, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI295821183, Length=447, Percent_Identity=42.0581655480984, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=41.2026726057906, Blast_Score=331, Evalue=7e-91,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=41.2026726057906, Blast_Score=331, Evalue=7e-91,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=41.2026726057906, Blast_Score=331, Evalue=7e-91,
Organism=Homo sapiens, GI38679960, Length=513, Percent_Identity=31.7738791423002, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI38679971, Length=513, Percent_Identity=31.7738791423002, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679974, Length=513, Percent_Identity=31.7738791423002, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679977, Length=513, Percent_Identity=31.7738791423002, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679967, Length=513, Percent_Identity=31.7738791423002, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI134142062, Length=516, Percent_Identity=32.3643410852713, Blast_Score=226, Evalue=4e-59,
Organism=Escherichia coli, GI1789654, Length=437, Percent_Identity=57.4370709382151, Blast_Score=512, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17567343, Length=447, Percent_Identity=42.7293064876958, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71987519, Length=465, Percent_Identity=44.3010752688172, Blast_Score=358, Evalue=4e-99,
Organism=Caenorhabditis elegans, GI17562816, Length=452, Percent_Identity=40.2654867256637, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI71997168, Length=507, Percent_Identity=28.9940828402367, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71997163, Length=507, Percent_Identity=28.7968441814596, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI133931226, Length=463, Percent_Identity=26.7818574514039, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319685, Length=446, Percent_Identity=41.0313901345291, Blast_Score=342, Evalue=5e-95,
Organism=Saccharomyces cerevisiae, GI6319695, Length=449, Percent_Identity=40.9799554565702, Blast_Score=296, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6321376, Length=449, Percent_Identity=40.9799554565702, Blast_Score=286, Evalue=5e-78,
Organism=Saccharomyces cerevisiae, GI6323863, Length=462, Percent_Identity=31.8181818181818, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6324343, Length=517, Percent_Identity=29.0135396518375, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24651757, Length=448, Percent_Identity=45.9821428571429, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651759, Length=406, Percent_Identity=46.0591133004926, Blast_Score=346, Evalue=1e-95,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=43.2071269487751, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=43.2071269487751, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=43.2071269487751, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=43.2071269487751, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=43.2071269487751, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=43.2071269487751, Blast_Score=341, Evalue=5e-94,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=43.2071269487751, Blast_Score=341, Evalue=5e-94,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=43.2071269487751, Blast_Score=341, Evalue=5e-94,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=43.2071269487751, Blast_Score=341, Evalue=5e-94,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=43.2071269487751, Blast_Score=341, Evalue=5e-94,
Organism=Drosophila melanogaster, GI161076407, Length=509, Percent_Identity=30.4518664047151, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24586460, Length=509, Percent_Identity=30.4518664047151, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI161076409, Length=509, Percent_Identity=30.4518664047151, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24586458, Length=509, Percent_Identity=30.4518664047151, Blast_Score=215, Evalue=5e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48796; Mature: 48796

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDVRTVLIANRGEIALRIARACRLLGLRSVGVYSEADAGLAHLRLVDQRICIGPASATR
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHH
SYLDAGRILRAAALTGADAIHPGYGFLSENADFAEAVERAGLVLVGPPASIMRMMGDKIA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHHHH
AKRQMRDSGVPCLPGSDDALPDDIAEAVRICDGVGYPLIVKAAGGGGGRGMRVVRRPENA
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEECCHHH
REAIETAREEAGRAFGNPSIYAERFLQHPRHVEIQVLADRAGQAVWLGARDCSVQRRHQK
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHH
LIEEAPAIGIPPDRIADLGERCARACVRMGYVGAGTFEFLYEDGAFSFIEMNTRLQVEHP
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEECCEEEECCC
VTEMTTGIDIVREQLRIAMGHPLSFGQSDIETRGHAIECRINAEHPETFAPCPGLVRTWR
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEEECCCCCCCCCCCCHHHCCC
PPGGPGVRVDTHLYDGYTVPPQYDSLVAKLIVHGADRADALARMRAALDEMMVEGITTTA
CCCCCCCEEEEEEECCEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHH
PLHRRLMDAADFCAGGVSVHYLEALAAEGATP
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRDVRTVLIANRGEIALRIARACRLLGLRSVGVYSEADAGLAHLRLVDQRICIGPASATR
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHH
SYLDAGRILRAAALTGADAIHPGYGFLSENADFAEAVERAGLVLVGPPASIMRMMGDKIA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHHHH
AKRQMRDSGVPCLPGSDDALPDDIAEAVRICDGVGYPLIVKAAGGGGGRGMRVVRRPENA
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEECCHHH
REAIETAREEAGRAFGNPSIYAERFLQHPRHVEIQVLADRAGQAVWLGARDCSVQRRHQK
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHH
LIEEAPAIGIPPDRIADLGERCARACVRMGYVGAGTFEFLYEDGAFSFIEMNTRLQVEHP
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEECCEEEECCC
VTEMTTGIDIVREQLRIAMGHPLSFGQSDIETRGHAIECRINAEHPETFAPCPGLVRTWR
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEEECCCCCCCCCCCCHHHCCC
PPGGPGVRVDTHLYDGYTVPPQYDSLVAKLIVHGADRADALARMRAALDEMMVEGITTTA
CCCCCCCEEEEEEECCEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHH
PLHRRLMDAADFCAGGVSVHYLEALAAEGATP
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]