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The map label for this gene is pyrC [H]

Identifier: 162145887

GI number: 162145887

Start: 54101

End: 55393

Strand: Reverse

Name: pyrC [H]

Synonym: GDI_0048

Alternate gene names: 162145887

Gene position: 55393-54101 (Counterclockwise)

Preceding gene: 162145888

Following gene: 162145886

Centisome position: 1.4

GC content: 74.48

Gene sequence:

>1293_bases
GTGACCGCTACCCTGTTTGAAAACGTCCGCCTGATCGACCCCGCGCGGGGCCTGGACCGGCCCGGGCGGCTGCTGGTGCG
GGACGGCGTGATCGCCGGGACCGACCTGCCGGGTGCCGAAGGCGCGCCCGAGGGCGCCGGAATCGTCGACGGGGGCGGGT
CGATCCTGTGCCCCGGACTGGTGGACATGCGGGTGGCGATCGGCGAGCCCGGCTTCGAGTATCGCGAGACCGTGGCCTCC
GCCGCGCGGGCGGCGGCGGCGGGCGGCATCACCACGATGGCCGTGCTGCCCAACAGCCAGCCCGCGACCGACGACCCGGC
GCTGGTGCGCCACCTGCGCGCGCGCGGCGAGGAGACGGGCATGGTCTCGATCCTGCCCTACGGCGCGCTGACCCGGCGGT
GCGAGGGCGGCGAACTCGCCGAGATCGGCCTGTTGAACGAGGCCGGGGCCGTGGCCTTCACCGACGGGCCGCGCGCCCTG
GCCGATGCGCGGATGATGCGGCTGGCGCTGACCTATGCGCGCGGGTTCGACGCGCTGGTCGTCCAGCACCCCGAGGACCC
GTCGCTGGCGCGCGGCGGCTGCGCCACCGACGGCGAACTGGCGACACGGCTGGGCCTGCCGGGCATTCCGGCGGCGGCCG
AGGCGATCATGATCGCCCGCGACCTGCGGCTGCTGGAACTGACGCGCGGGCGGCTGCATTTCAGCCACGTCTCGACGGCG
GAGGGGCTGGCGCTGATCCGTGCGGCCAAGGCGCGCGACCTGCGCGTGACCTGCGACACCGCGCCGCCCTATTTCGACCT
GAACGAGACCGCGATCGGCGATTTCCGGACCTATGCCAAGCTGTCGCCGCCCCTGCGCGGCGAGGCCGACCGGCAGGCGG
TGTGCACGGCGCTGGCCGACGGGACGATCGACGCCATCGCATCCGACCACGCGCCGTGCGACGCCGACGACAAGCGCCAG
CCCTTCGCCGTGGCCTCGGCCGGCGGAACGGGGCTGGCGACCCTGCTGGCCGTGACGCTGGCGCAGGTCCATGGCGGCTG
CCTGCCGCTGGTCGAGGCGCTGGGCCTGCTGACCCACCGTCCCGCCGCCCTGCTGCGCAGCCGGGCCGGCACGCTGGCCG
ACGGGGCCGTGGCGGATCTGTGCCTGTTCAACCCCGACCGCGCCTGGAAGGTCGAAGCCGACCAGATGCCGGGCAAGGCG
CAGAACACGCCCTTCGACGGGCGGGCGCTGGAGGGGCGGGTATTGGGCACCTGGAAGGCCGGACGCATGGTCTTCGGACA
GGACGCGCCATGA

Upstream 100 bases:

>100_bases
TCGCCGATTCCGACCAGAGCGTCATCCGCGAGCAGGTCGAGATGGGGGTGGCCGTGCGCATGGCCGTCCTGGACCTGCTG
TCGCGTGCCGGAGATCAGTC

Downstream 100 bases:

>100_bases
ACGGCGCGATTCCGGCCTTCGCGCTGCCGCTGCTGGCCGCGATCGGCGTGCTGGCCTACTGCATCGGCAGCATTCCCTTC
GGCCTGCTGCTGACGCAGTT

Product: dihydro-orotase protein

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MTATLFENVRLIDPARGLDRPGRLLVRDGVIAGTDLPGAEGAPEGAGIVDGGGSILCPGLVDMRVAIGEPGFEYRETVAS
AARAAAAGGITTMAVLPNSQPATDDPALVRHLRARGEETGMVSILPYGALTRRCEGGELAEIGLLNEAGAVAFTDGPRAL
ADARMMRLALTYARGFDALVVQHPEDPSLARGGCATDGELATRLGLPGIPAAAEAIMIARDLRLLELTRGRLHFSHVSTA
EGLALIRAAKARDLRVTCDTAPPYFDLNETAIGDFRTYAKLSPPLRGEADRQAVCTALADGTIDAIASDHAPCDADDKRQ
PFAVASAGGTGLATLLAVTLAQVHGGCLPLVEALGLLTHRPAALLRSRAGTLADGAVADLCLFNPDRAWKVEADQMPGKA
QNTPFDGRALEGRVLGTWKAGRMVFGQDAP

Sequences:

>Translated_430_residues
MTATLFENVRLIDPARGLDRPGRLLVRDGVIAGTDLPGAEGAPEGAGIVDGGGSILCPGLVDMRVAIGEPGFEYRETVAS
AARAAAAGGITTMAVLPNSQPATDDPALVRHLRARGEETGMVSILPYGALTRRCEGGELAEIGLLNEAGAVAFTDGPRAL
ADARMMRLALTYARGFDALVVQHPEDPSLARGGCATDGELATRLGLPGIPAAAEAIMIARDLRLLELTRGRLHFSHVSTA
EGLALIRAAKARDLRVTCDTAPPYFDLNETAIGDFRTYAKLSPPLRGEADRQAVCTALADGTIDAIASDHAPCDADDKRQ
PFAVASAGGTGLATLLAVTLAQVHGGCLPLVEALGLLTHRPAALLRSRAGTLADGAVADLCLFNPDRAWKVEADQMPGKA
QNTPFDGRALEGRVLGTWKAGRMVFGQDAP
>Mature_429_residues
TATLFENVRLIDPARGLDRPGRLLVRDGVIAGTDLPGAEGAPEGAGIVDGGGSILCPGLVDMRVAIGEPGFEYRETVASA
ARAAAAGGITTMAVLPNSQPATDDPALVRHLRARGEETGMVSILPYGALTRRCEGGELAEIGLLNEAGAVAFTDGPRALA
DARMMRLALTYARGFDALVVQHPEDPSLARGGCATDGELATRLGLPGIPAAAEAIMIARDLRLLELTRGRLHFSHVSTAE
GLALIRAAKARDLRVTCDTAPPYFDLNETAIGDFRTYAKLSPPLRGEADRQAVCTALADGTIDAIASDHAPCDADDKRQP
FAVASAGGTGLATLLAVTLAQVHGGCLPLVEALGLLTHRPAALLRSRAGTLADGAVADLCLFNPDRAWKVEADQMPGKAQ
NTPFDGRALEGRVLGTWKAGRMVFGQDAP

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=369, Percent_Identity=29.810298102981, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI1786722, Length=443, Percent_Identity=28.8939051918736, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI87082175, Length=450, Percent_Identity=24.4444444444444, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI193204318, Length=357, Percent_Identity=25.2100840336134, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322218, Length=389, Percent_Identity=26.4781491002571, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24642586, Length=374, Percent_Identity=25.1336898395722, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI18859883, Length=417, Percent_Identity=28.537170263789, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 44743; Mature: 44611

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATLFENVRLIDPARGLDRPGRLLVRDGVIAGTDLPGAEGAPEGAGIVDGGGSILCPGL
CCCCHHCCEEEECCCCCCCCCCCEEEECCEEECCCCCCCCCCCCCCCEEECCCCEECCCH
VDMRVAIGEPGFEYRETVASAARAAAAGGITTMAVLPNSQPATDDPALVRHLRARGEETG
HEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCC
MVSILPYGALTRRCEGGELAEIGLLNEAGAVAFTDGPRALADARMMRLALTYARGFDALV
EEEEECCHHHHHCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCEEE
VQHPEDPSLARGGCATDGELATRLGLPGIPAAAEAIMIARDLRLLELTRGRLHFSHVSTA
EECCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCH
EGLALIRAAKARDLRVTCDTAPPYFDLNETAIGDFRTYAKLSPPLRGEADRQAVCTALAD
HHHHHHHHHCCCCEEEEECCCCCEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCC
GTIDAIASDHAPCDADDKRQPFAVASAGGTGLATLLAVTLAQVHGGCLPLVEALGLLTHR
CCHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
PAALLRSRAGTLADGAVADLCLFNPDRAWKVEADQMPGKAQNTPFDGRALEGRVLGTWKA
HHHHHHHCCCCCCCCCHHHEEEECCCCCEEEEHHCCCCCCCCCCCCCCCCCCEEEEEECC
GRMVFGQDAP
CCEEECCCCC
>Mature Secondary Structure 
TATLFENVRLIDPARGLDRPGRLLVRDGVIAGTDLPGAEGAPEGAGIVDGGGSILCPGL
CCCHHCCEEEECCCCCCCCCCCEEEECCEEECCCCCCCCCCCCCCCEEECCCCEECCCH
VDMRVAIGEPGFEYRETVASAARAAAAGGITTMAVLPNSQPATDDPALVRHLRARGEETG
HEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCC
MVSILPYGALTRRCEGGELAEIGLLNEAGAVAFTDGPRALADARMMRLALTYARGFDALV
EEEEECCHHHHHCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCEEE
VQHPEDPSLARGGCATDGELATRLGLPGIPAAAEAIMIARDLRLLELTRGRLHFSHVSTA
EECCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCH
EGLALIRAAKARDLRVTCDTAPPYFDLNETAIGDFRTYAKLSPPLRGEADRQAVCTALAD
HHHHHHHHHCCCCEEEEECCCCCEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCC
GTIDAIASDHAPCDADDKRQPFAVASAGGTGLATLLAVTLAQVHGGCLPLVEALGLLTHR
CCHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
PAALLRSRAGTLADGAVADLCLFNPDRAWKVEADQMPGKAQNTPFDGRALEGRVLGTWKA
HHHHHHHCCCCCCCCCHHHEEEECCCCCEEEEHHCCCCCCCCCCCCCCCCCCEEEEEECC
GRMVFGQDAP
CCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA