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The map label for this gene is cobD [H]

Identifier: 162145874

GI number: 162145874

Start: 36407

End: 37423

Strand: Direct

Name: cobD [H]

Synonym: GDI_0035

Alternate gene names: 162145874

Gene position: 36407-37423 (Clockwise)

Preceding gene: 162145873

Following gene: 162145875

Centisome position: 0.92

GC content: 71.58

Gene sequence:

>1017_bases
ATGGACCCCATGCCCGCCCATGGCGGTCAGGTCCGCGCGGTCATGCGGGCATTCCCCGATGCCCCGGCGCCGTTCGTCGA
CCTTTCGACGGGGATCAGTCCCTATGCCTATCCGTTCGCGATGCCCGATGGCGCGGCACTGACGCGCCTGCCGGAACGGG
ATGATGAGGACAGGCTGCGCCGGGTGGCCGCCGAAGCCTATGGCGTGGCCGATCCCGATTGCGTTGCGGCCGGCCCGGGC
ACGCAGATGCTGATCGCCCTGCTGCCGTTCCTGCTGGGACCGCGCGCGGTAACGATCCTGGGCCCCACCTATGGCGGCCA
TGCCGACGCGTGGCGCGGGGCCGGCGCGCGGATTCATGAGGTCACAGGGATGCAGGACCTGGAAGACGCGGCGGCGGTGC
CGGGCGGCGTGTGCGTCGTGTGCAATCCGAACAATCCCGACGGCCGCGTGTGCGATGCCGCGTGGCTCGCGGCCCTGGCG
GACCGGTGCGCATCGTACAGCGGGATCCTGATCGTCGACGAGGCCTTTGCGGATTTCGAATCCTGCAGCATCGCGCCCCT
GTTGCCGCATCCGGGCCTGATCGTATTGCGTTCGTTCGGCAAGAGTTACGGACTTCCCGGCGTGCGGCTGGGATTCGCGC
TGGCCGCGCCCGCCTTGGCCGGGCGCCTGCGCGACATCATGGGGGCATGGGCGGTCGGCACGCTGGCGCTGGCGGCGGGG
TGCCAGGCGCTGGCGGATCGTCCATGGCGCGACGCCACGCGCGGGCGGGTGCGCGCGGATGCGGCGCGGCTGGCGCGCTG
CCTTGCACGGGAGGATATCGAGGTGGCAGGTCAATCGATCCTGTTTGTCCTGGCGCGGGCGGCACAGGCGCCGTCCCTGT
GGCGGTTCCTCTGCCAGCGCGGGCTGGTGGCGCGCGCCTTCCCCGAACGGCCGTCATGGTTGCGCCTGGGGCTGCCGCGC
CGGCCGGACGAATGGACTCGCCTGGAACAGGCCCTGTCCGCATGGCGGCCGGCATGA

Upstream 100 bases:

>100_bases
ATTTGACCCCGTCACGCATTCTGCTAGACGACGGAAAGGAGGAAATCGTTGAGCCGCAGAAACCATTCGAATATGACAGC
CTAGCGTGCCGGCCACGTTC

Downstream 100 bases:

>100_bases
TACGCATGACCTGCCTGGCCCTGCCGCCGCCGGCGGCCCTGCGGCGCGGCATCCTGCCCCGGCCGTCGGACCCCTGCGAC
ATGGCGCTCGCCGGATCGCT

Product: threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MDPMPAHGGQVRAVMRAFPDAPAPFVDLSTGISPYAYPFAMPDGAALTRLPERDDEDRLRRVAAEAYGVADPDCVAAGPG
TQMLIALLPFLLGPRAVTILGPTYGGHADAWRGAGARIHEVTGMQDLEDAAAVPGGVCVVCNPNNPDGRVCDAAWLAALA
DRCASYSGILIVDEAFADFESCSIAPLLPHPGLIVLRSFGKSYGLPGVRLGFALAAPALAGRLRDIMGAWAVGTLALAAG
CQALADRPWRDATRGRVRADAARLARCLAREDIEVAGQSILFVLARAAQAPSLWRFLCQRGLVARAFPERPSWLRLGLPR
RPDEWTRLEQALSAWRPA

Sequences:

>Translated_338_residues
MDPMPAHGGQVRAVMRAFPDAPAPFVDLSTGISPYAYPFAMPDGAALTRLPERDDEDRLRRVAAEAYGVADPDCVAAGPG
TQMLIALLPFLLGPRAVTILGPTYGGHADAWRGAGARIHEVTGMQDLEDAAAVPGGVCVVCNPNNPDGRVCDAAWLAALA
DRCASYSGILIVDEAFADFESCSIAPLLPHPGLIVLRSFGKSYGLPGVRLGFALAAPALAGRLRDIMGAWAVGTLALAAG
CQALADRPWRDATRGRVRADAARLARCLAREDIEVAGQSILFVLARAAQAPSLWRFLCQRGLVARAFPERPSWLRLGLPR
RPDEWTRLEQALSAWRPA
>Mature_338_residues
MDPMPAHGGQVRAVMRAFPDAPAPFVDLSTGISPYAYPFAMPDGAALTRLPERDDEDRLRRVAAEAYGVADPDCVAAGPG
TQMLIALLPFLLGPRAVTILGPTYGGHADAWRGAGARIHEVTGMQDLEDAAAVPGGVCVVCNPNNPDGRVCDAAWLAALA
DRCASYSGILIVDEAFADFESCSIAPLLPHPGLIVLRSFGKSYGLPGVRLGFALAAPALAGRLRDIMGAWAVGTLALAAG
CQALADRPWRDATRGRVRADAARLARCLAREDIEVAGQSILFVLARAAQAPSLWRFLCQRGLVARAFPERPSWLRLGLPR
RPDEWTRLEQALSAWRPA

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=328, Percent_Identity=26.5243902439024, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 36006; Mature: 36006

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPMPAHGGQVRAVMRAFPDAPAPFVDLSTGISPYAYPFAMPDGAALTRLPERDDEDRLR
CCCCCCCCHHHHHHHHHCCCCCCCCEECCCCCCCCCCCEECCCCHHHHCCCCCCCHHHHH
RVAAEAYGVADPDCVAAGPGTQMLIALLPFLLGPRAVTILGPTYGGHADAWRGAGARIHE
HHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHCCCCCEEEH
VTGMQDLEDAAAVPGGVCVVCNPNNPDGRVCDAAWLAALADRCASYSGILIVDEAFADFE
HCCCHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHHHCHH
SCSIAPLLPHPGLIVLRSFGKSYGLPGVRLGFALAAPALAGRLRDIMGAWAVGTLALAAG
HCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CQALADRPWRDATRGRVRADAARLARCLAREDIEVAGQSILFVLARAAQAPSLWRFLCQR
HHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
GLVARAFPERPSWLRLGLPRRPDEWTRLEQALSAWRPA
CCHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDPMPAHGGQVRAVMRAFPDAPAPFVDLSTGISPYAYPFAMPDGAALTRLPERDDEDRLR
CCCCCCCCHHHHHHHHHCCCCCCCCEECCCCCCCCCCCEECCCCHHHHCCCCCCCHHHHH
RVAAEAYGVADPDCVAAGPGTQMLIALLPFLLGPRAVTILGPTYGGHADAWRGAGARIHE
HHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHCCCCCEEEH
VTGMQDLEDAAAVPGGVCVVCNPNNPDGRVCDAAWLAALADRCASYSGILIVDEAFADFE
HCCCHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHHHCHH
SCSIAPLLPHPGLIVLRSFGKSYGLPGVRLGFALAAPALAGRLRDIMGAWAVGTLALAAG
HCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CQALADRPWRDATRGRVRADAARLARCLAREDIEVAGQSILFVLARAAQAPSLWRFLCQR
HHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
GLVARAFPERPSWLRLGLPRRPDEWTRLEQALSAWRPA
CCHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]