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The map label for this gene is pdhR [H]

Identifier: 161870557

GI number: 161870557

Start: 1652120

End: 1652899

Strand: Reverse

Name: pdhR [H]

Synonym: NMCC_1623

Alternate gene names: 161870557

Gene position: 1652899-1652120 (Counterclockwise)

Preceding gene: 161870560

Following gene: 161870554

Centisome position: 76.76

GC content: 52.95

Gene sequence:

>780_bases
ATGAAACTGGTAAGGCCTCAGAAAATCAGCGATCAGGTATTGTCGGTATTGGAGGAGCGCATTGCGGAAGGGGTTTACGC
GGAAGGGGGCAAGATTCCGCCCGAACGCGTTTTGGCGGAAGAGTTCGGCGTTTCGCGCCCGTCGGTCAGGTCGGCATTGA
ATGTTTTGGTCGCCCGTCAGGTTTTGGAAGCGAGGCAGGGAGACGGTTATTATGTTTCGGTCAAGCCGCAGCAGGATTTT
TTGCAAAGTTGGCAGGAGCTTTTGGGCAAGCATTCCAATTGGGAACAGGATGTTTTTGATTTCAGTTGCCACATCGAGGG
CTGTATGGCGGCATTGGCGGCAGAACGCCGCACGGATGCCGATTTGAAGCGGATTGGGTTTTGGCTTGAAAAGTTTGAGG
AGGCGTGCGAAAGCGGCAATTTGGAACATCAGAGCGAAGCTGATGTCAGCTTTCATCAGACGATTGCCGATGCGGCGCAC
AATTTGTTGTTCAGCCATTTGTCGGGCGGTTTGTTGAAAATGCTGTACCGGCAGACGCGCAGCAGCCTTATTTATCTGAA
TCAGGAAGAAGATCCGCGTCCGAAGCTGATGGCGCAGCACCGTGTATTGTATGAGGCAATATCGAACCGTCGGCCGGGCG
AGGCTTCGGAGGCGGCAAAGGCACATTTGAATTATGTGGCAAGCAGCATCATGAAAGACAGGGAATATCAGAGCCGTAAC
CGCCACGCGGATACTTTGGCGCAAAACGATTTGAAGCGCGTGCAGGATTGGGAGGTATGA

Upstream 100 bases:

>100_bases
ACTATTTGTACTGTCTGCGGCTTCGTCACCTTGTCCTGATTTTTGTTAATCCACTATATTTCGGAAGGGTTCTGCAGGGA
ATCTTTATAAAGGAGGAGTG

Downstream 100 bases:

>100_bases
ATACCGTTTAGACGGTCTGGCATATTCGGATGTATCGGTATAGTGAACTAAATTTAAACCAGTACGTCGTTGCCTCGCCT
TAGCTCAAAGAGAACGATTC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MKLVRPQKISDQVLSVLEERIAEGVYAEGGKIPPERVLAEEFGVSRPSVRSALNVLVARQVLEARQGDGYYVSVKPQQDF
LQSWQELLGKHSNWEQDVFDFSCHIEGCMAALAAERRTDADLKRIGFWLEKFEEACESGNLEHQSEADVSFHQTIADAAH
NLLFSHLSGGLLKMLYRQTRSSLIYLNQEEDPRPKLMAQHRVLYEAISNRRPGEASEAAKAHLNYVASSIMKDREYQSRN
RHADTLAQNDLKRVQDWEV

Sequences:

>Translated_259_residues
MKLVRPQKISDQVLSVLEERIAEGVYAEGGKIPPERVLAEEFGVSRPSVRSALNVLVARQVLEARQGDGYYVSVKPQQDF
LQSWQELLGKHSNWEQDVFDFSCHIEGCMAALAAERRTDADLKRIGFWLEKFEEACESGNLEHQSEADVSFHQTIADAAH
NLLFSHLSGGLLKMLYRQTRSSLIYLNQEEDPRPKLMAQHRVLYEAISNRRPGEASEAAKAHLNYVASSIMKDREYQSRN
RHADTLAQNDLKRVQDWEV
>Mature_259_residues
MKLVRPQKISDQVLSVLEERIAEGVYAEGGKIPPERVLAEEFGVSRPSVRSALNVLVARQVLEARQGDGYYVSVKPQQDF
LQSWQELLGKHSNWEQDVFDFSCHIEGCMAALAAERRTDADLKRIGFWLEKFEEACESGNLEHQSEADVSFHQTIADAAH
NLLFSHLSGGLLKMLYRQTRSSLIYLNQEEDPRPKLMAQHRVLYEAISNRRPGEASEAAKAHLNYVASSIMKDREYQSRN
RHADTLAQNDLKRVQDWEV

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=231, Percent_Identity=36.3636363636364, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790032, Length=242, Percent_Identity=30.1652892561983, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1789353, Length=231, Percent_Identity=29.4372294372294, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI48994955, Length=233, Percent_Identity=26.1802575107296, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082208, Length=162, Percent_Identity=30.2469135802469, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789621, Length=236, Percent_Identity=27.5423728813559, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29539; Mature: 29539

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVRPQKISDQVLSVLEERIAEGVYAEGGKIPPERVLAEEFGVSRPSVRSALNVLVARQ
CCCCCCCHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
VLEARQGDGYYVSVKPQQDFLQSWQELLGKHSNWEQDVFDFSCHIEGCMAALAAERRTDA
HHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
DLKRIGFWLEKFEEACESGNLEHQSEADVSFHQTIADAAHNLLFSHLSGGLLKMLYRQTR
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLIYLNQEEDPRPKLMAQHRVLYEAISNRRPGEASEAAKAHLNYVASSIMKDREYQSRN
HHEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RHADTLAQNDLKRVQDWEV
HHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLVRPQKISDQVLSVLEERIAEGVYAEGGKIPPERVLAEEFGVSRPSVRSALNVLVARQ
CCCCCCCHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
VLEARQGDGYYVSVKPQQDFLQSWQELLGKHSNWEQDVFDFSCHIEGCMAALAAERRTDA
HHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
DLKRIGFWLEKFEEACESGNLEHQSEADVSFHQTIADAAHNLLFSHLSGGLLKMLYRQTR
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLIYLNQEEDPRPKLMAQHRVLYEAISNRRPGEASEAAKAHLNYVASSIMKDREYQSRN
HHEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RHADTLAQNDLKRVQDWEV
HHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]