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The map label for this gene is parC [H]

Identifier: 161870455

GI number: 161870455

Start: 1535261

End: 1537558

Strand: Direct

Name: parC [H]

Synonym: NMCC_1510

Alternate gene names: 161870455

Gene position: 1535261-1537558 (Clockwise)

Preceding gene: 161870453

Following gene: 161870456

Centisome position: 71.29

GC content: 55.66

Gene sequence:

>2298_bases
ATGCAACCGCACGCTCCACATACCGATTCCAATACGCTGATGCTCGGTCAATACGCCGAACGCGCCTATCTCGAATACGC
CATGAGCGTGGTCAAAGGCCGCGCGCTACCTGAAGTTTCAGACGGCCAGAAGCCCGTGCAGCGGCGCATTTTGTTTGCCA
TGCGCGATATGGGTTTGACGGCGGGGGCGAAGCCGGTGAAATCGGCGCGCGTGGTCGGCGAGATTTTGGGTAAATACCAC
CCGCACGGCGACAGTTCCGCCTATGAGGCGATGGTGCGGATGGCGCAGGATTTTACCTTGCGCTATCCCTTAATCGACGG
CATCGGCAACTTCGGTTCGCGCGACGGCGACGGTGCGGCGGCGATGCGTTACACCGAAGCACGGCTGACGCCGATTGCGG
AATTGCTGTTGTCCGAAATCCATCAGGGGACGGTGGATTTCGTGCCGAACTACGACGGCGCGTTTGACGAACCGCTGCAC
CTGCCTGCACGTCTGCCTATGGTGTTGCTCAACGGCGCGTCAGGCATCGCGGTAGGTATGGCGACCGAAATTCCGCCGCA
CAATTTGAACGAAGTTACGCAGGCAGCGATTGCGCTGTTGAAAAAGCCGACGCTGGAAACCGCCGACCTGATGCAATATA
TTCCTGCGCCCGATTTTGCCGGCGGCGGTCAAATCATCACGCCGGCGGACGAATTGCGCCGGATTTATGAAACCGGCAAG
GGCAGCGTGCGCGTGCGTGCGCGTTATGAAATCGAAAAATTGGCGCGCGGACAATGGCGCGTCATCGTAACCGAGCTACC
GCCGAACGCCAATTCCGCCAAAATCCTTGCCGAAATCGAAGAGCAGACCAACCCGAAACCGAAAGCGGGCAAAAAGCAGC
TCAACCAAGACCAGCTCAATACCAAAAAGCTGATGCTGGATTTAATCGACCGCGTGCGCGACGAGTCCGACGGCGAACAT
CCCGTGCGACTGGTGTTCGAACCGAAATCCAGCCGCATCGATACCGATACCTTCATCAACACGCTGATGGCGCAAACTTC
GCTGGAAGGCAATGTGTCCATGAACTTGGTGATGATGGGGCTGGACAACCGCCCCGCGCAGAAAAACCTGAAAACGATTT
TGCAGGAATGGCTGGATTTCCGCACCGTAACCGTAACACGCCGTCTGAAATTCCGTTTGAACCAAGTGGAAAAACGGCTG
CACATCCTCGAAGGCCGTCTGAAAGTCTTTCTGCACATCGACGAAGTGATTAAAGTCATCCGCGAATCAGATGACCCGAA
AGCCGATTTGATGGCGGCGTTCGGGCTGACCGAAATCCAAGCCGAAGACATTTTGGAAATCCGCCTGCGCCAGTTGGCAC
GTTTGGAAGGTTTCAAACTCGAAAAAGAATTGAACGAATTGCGCGAAGAACAAGGCCGTCTGAACATCCTTTTGGGCGAT
GAAAACGAAAAGCGCAAGCTGATTATCAAAGAGATGCAGGCGGATATGAAACAATACGGCGATGCACGCCGCACGCTGGT
GGAAGAGGCCGGACGCGCCGTGCTGACACAAACCACCGCCGACGAACCCATCACACTGATTCTGTCGGAAAAAGGCTGGA
TACGCAGCCGTGCCGGACACAATCTCGATTTGAGCCAAACCGCGTTCAAAGAAGGCGACCGCCTCAAACAAACCCTTGAA
GGCAGAACGGTTTTACCCGTCGTCATCCTCGATTCATTGGGCAGAACCTATACACTCGATGCCGCCGAAATTCCCGGCGG
ACGCGGCGACGGCGTGCCGGTTTCATCCTTGATCGAGTTGCAAAACGGCGCGAAACCCGTTGCGATGTTGACAGGATTGC
CGGAACAACATTATTTATTATCAAGCAGCGGCGGCTACGGCTTCATCGCCAAGTTGGCTGATATGGTCGGACGCGTAAAA
GCGGGCAAAGTGGTGATGACCACAGACAGTGGCGAAACCGTCCTGCCGCCGATTGCCGTCTATGCCTCCTCGTTCATCAA
CCCCGACTGCAAAATCATTGCCGCCACCAGTCAAAACCGCGCCCTCGCCTTCCCCATCGGCGAATTGAAAATTATGGCGA
AAGGCAAAGGGCTGCAAATCATCGGATTAAACGCCGGCGAATCGATGACGCATACCGCCGTTTCTTCCGAGCCGGAAATC
CTGATTGAAAGCGAAGGCAGGCGCGGCGCAGCGCACAAAGACCGCATCCCCATCTCCCTGCTTGAGGCAAAACGCGGCAA
AAAAGGCAAACTATTACCCATATCGGGCAGCCTGAAACAGCTTTCTTCCCCGAAATAA

Upstream 100 bases:

>100_bases
TGGAAGGGGTTGCCCCCTCCCAAATAAAGTCTGATTCTACCGCCCCGAAGGACAGATGTCCAAGTGGCGGGGTTTCAACC
GAAAAGGAAATACGATAAAT

Downstream 100 bases:

>100_bases
ACCCGACTCTGCACATACTATGGTAATTTCCAATACCCGCGAACTTGAGAAACTCAAAGACCGGATTCCCAATCTGATCA
ACATCGCCCGCATCGCCATC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MQPHAPHTDSNTLMLGQYAERAYLEYAMSVVKGRALPEVSDGQKPVQRRILFAMRDMGLTAGAKPVKSARVVGEILGKYH
PHGDSSAYEAMVRMAQDFTLRYPLIDGIGNFGSRDGDGAAAMRYTEARLTPIAELLLSEIHQGTVDFVPNYDGAFDEPLH
LPARLPMVLLNGASGIAVGMATEIPPHNLNEVTQAAIALLKKPTLETADLMQYIPAPDFAGGGQIITPADELRRIYETGK
GSVRVRARYEIEKLARGQWRVIVTELPPNANSAKILAEIEEQTNPKPKAGKKQLNQDQLNTKKLMLDLIDRVRDESDGEH
PVRLVFEPKSSRIDTDTFINTLMAQTSLEGNVSMNLVMMGLDNRPAQKNLKTILQEWLDFRTVTVTRRLKFRLNQVEKRL
HILEGRLKVFLHIDEVIKVIRESDDPKADLMAAFGLTEIQAEDILEIRLRQLARLEGFKLEKELNELREEQGRLNILLGD
ENEKRKLIIKEMQADMKQYGDARRTLVEEAGRAVLTQTTADEPITLILSEKGWIRSRAGHNLDLSQTAFKEGDRLKQTLE
GRTVLPVVILDSLGRTYTLDAAEIPGGRGDGVPVSSLIELQNGAKPVAMLTGLPEQHYLLSSSGGYGFIAKLADMVGRVK
AGKVVMTTDSGETVLPPIAVYASSFINPDCKIIAATSQNRALAFPIGELKIMAKGKGLQIIGLNAGESMTHTAVSSEPEI
LIESEGRRGAAHKDRIPISLLEAKRGKKGKLLPISGSLKQLSSPK

Sequences:

>Translated_765_residues
MQPHAPHTDSNTLMLGQYAERAYLEYAMSVVKGRALPEVSDGQKPVQRRILFAMRDMGLTAGAKPVKSARVVGEILGKYH
PHGDSSAYEAMVRMAQDFTLRYPLIDGIGNFGSRDGDGAAAMRYTEARLTPIAELLLSEIHQGTVDFVPNYDGAFDEPLH
LPARLPMVLLNGASGIAVGMATEIPPHNLNEVTQAAIALLKKPTLETADLMQYIPAPDFAGGGQIITPADELRRIYETGK
GSVRVRARYEIEKLARGQWRVIVTELPPNANSAKILAEIEEQTNPKPKAGKKQLNQDQLNTKKLMLDLIDRVRDESDGEH
PVRLVFEPKSSRIDTDTFINTLMAQTSLEGNVSMNLVMMGLDNRPAQKNLKTILQEWLDFRTVTVTRRLKFRLNQVEKRL
HILEGRLKVFLHIDEVIKVIRESDDPKADLMAAFGLTEIQAEDILEIRLRQLARLEGFKLEKELNELREEQGRLNILLGD
ENEKRKLIIKEMQADMKQYGDARRTLVEEAGRAVLTQTTADEPITLILSEKGWIRSRAGHNLDLSQTAFKEGDRLKQTLE
GRTVLPVVILDSLGRTYTLDAAEIPGGRGDGVPVSSLIELQNGAKPVAMLTGLPEQHYLLSSSGGYGFIAKLADMVGRVK
AGKVVMTTDSGETVLPPIAVYASSFINPDCKIIAATSQNRALAFPIGELKIMAKGKGLQIIGLNAGESMTHTAVSSEPEI
LIESEGRRGAAHKDRIPISLLEAKRGKKGKLLPISGSLKQLSSPK
>Mature_765_residues
MQPHAPHTDSNTLMLGQYAERAYLEYAMSVVKGRALPEVSDGQKPVQRRILFAMRDMGLTAGAKPVKSARVVGEILGKYH
PHGDSSAYEAMVRMAQDFTLRYPLIDGIGNFGSRDGDGAAAMRYTEARLTPIAELLLSEIHQGTVDFVPNYDGAFDEPLH
LPARLPMVLLNGASGIAVGMATEIPPHNLNEVTQAAIALLKKPTLETADLMQYIPAPDFAGGGQIITPADELRRIYETGK
GSVRVRARYEIEKLARGQWRVIVTELPPNANSAKILAEIEEQTNPKPKAGKKQLNQDQLNTKKLMLDLIDRVRDESDGEH
PVRLVFEPKSSRIDTDTFINTLMAQTSLEGNVSMNLVMMGLDNRPAQKNLKTILQEWLDFRTVTVTRRLKFRLNQVEKRL
HILEGRLKVFLHIDEVIKVIRESDDPKADLMAAFGLTEIQAEDILEIRLRQLARLEGFKLEKELNELREEQGRLNILLGD
ENEKRKLIIKEMQADMKQYGDARRTLVEEAGRAVLTQTTADEPITLILSEKGWIRSRAGHNLDLSQTAFKEGDRLKQTLE
GRTVLPVVILDSLGRTYTLDAAEIPGGRGDGVPVSSLIELQNGAKPVAMLTGLPEQHYLLSSSGGYGFIAKLADMVGRVK
AGKVVMTTDSGETVLPPIAVYASSFINPDCKIIAATSQNRALAFPIGELKIMAKGKGLQIIGLNAGESMTHTAVSSEPEI
LIESEGRRGAAHKDRIPISLLEAKRGKKGKLLPISGSLKQLSSPK

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=173, Percent_Identity=30.635838150289, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI19913406, Length=165, Percent_Identity=31.5151515151515, Blast_Score=82, Evalue=3e-15,
Organism=Escherichia coli, GI1789396, Length=700, Percent_Identity=47.4285714285714, Blast_Score=627, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=642, Percent_Identity=36.9158878504673, Blast_Score=357, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI17535065, Length=167, Percent_Identity=32.9341317365269, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI212645845, Length=225, Percent_Identity=27.5555555555556, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=166, Percent_Identity=31.3253012048193, Blast_Score=77, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=209, Percent_Identity=31.1004784688995, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17136538, Length=234, Percent_Identity=27.3504273504274, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84285; Mature: 84285

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPHAPHTDSNTLMLGQYAERAYLEYAMSVVKGRALPEVSDGQKPVQRRILFAMRDMGLT
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCC
AGAKPVKSARVVGEILGKYHPHGDSSAYEAMVRMAQDFTLRYPLIDGIGNFGSRDGDGAA
CCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCEEECCHHHCCCCCCCCCCCCHH
AMRYTEARLTPIAELLLSEIHQGTVDFVPNYDGAFDEPLHLPARLPMVLLNGASGIAVGM
HEEEHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEE
ATEIPPHNLNEVTQAAIALLKKPTLETADLMQYIPAPDFAGGGQIITPADELRRIYETGK
ECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHCCC
GSVRVRARYEIEKLARGQWRVIVTELPPNANSAKILAEIEEQTNPKPKAGKKQLNQDQLN
CCEEEEEEECHHHHCCCCEEEEEEECCCCCCCHHHHEEEHHHCCCCCCHHHHHCCHHHHH
TKKLMLDLIDRVRDESDGEHPVRLVFEPKSSRIDTDTFINTLMAQTSLEGNVSMNLVMMG
HHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEE
LDNRPAQKNLKTILQEWLDFRTVTVTRRLKFRLNQVEKRLHILEGRLKVFLHIDEVIKVI
CCCCCHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEHHHHHHHH
RESDDPKADLMAAFGLTEIQAEDILEIRLRQLARLEGFKLEKELNELREEQGRLNILLGD
HCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECC
ENEKRKLIIKEMQADMKQYGDARRTLVEEAGRAVLTQTTADEPITLILSEKGWIRSRAGH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCHHCCCC
NLDLSQTAFKEGDRLKQTLEGRTVLPVVILDSLGRTYTLDAAEIPGGRGDGVPVSSLIEL
CCCCHHHHHHCCHHHHHHHCCCEEEHHHHHHHCCCEEEEEHHHCCCCCCCCCCHHHHHHH
QNGAKPVAMLTGLPEQHYLLSSSGGYGFIAKLADMVGRVKAGKVVMTTDSGETVLPPIAV
HCCCCCCHHHCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCEECCHHHH
YASSFINPDCKIIAATSQNRALAFPIGELKIMAKGKGLQIIGLNAGESMTHTAVSSEPEI
HHHHHCCCCCEEEEECCCCCEEEEECCCEEEEECCCCEEEEEECCCCCCEEHHCCCCCCE
LIESEGRRGAAHKDRIPISLLEAKRGKKGKLLPISGSLKQLSSPK
EEECCCCCCCCCCCCCCHHHHHHCCCCCCCEEECCCCHHHCCCCC
>Mature Secondary Structure
MQPHAPHTDSNTLMLGQYAERAYLEYAMSVVKGRALPEVSDGQKPVQRRILFAMRDMGLT
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCC
AGAKPVKSARVVGEILGKYHPHGDSSAYEAMVRMAQDFTLRYPLIDGIGNFGSRDGDGAA
CCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCEEECCHHHCCCCCCCCCCCCHH
AMRYTEARLTPIAELLLSEIHQGTVDFVPNYDGAFDEPLHLPARLPMVLLNGASGIAVGM
HEEEHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEE
ATEIPPHNLNEVTQAAIALLKKPTLETADLMQYIPAPDFAGGGQIITPADELRRIYETGK
ECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHCCC
GSVRVRARYEIEKLARGQWRVIVTELPPNANSAKILAEIEEQTNPKPKAGKKQLNQDQLN
CCEEEEEEECHHHHCCCCEEEEEEECCCCCCCHHHHEEEHHHCCCCCCHHHHHCCHHHHH
TKKLMLDLIDRVRDESDGEHPVRLVFEPKSSRIDTDTFINTLMAQTSLEGNVSMNLVMMG
HHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEE
LDNRPAQKNLKTILQEWLDFRTVTVTRRLKFRLNQVEKRLHILEGRLKVFLHIDEVIKVI
CCCCCHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEHHHHHHHH
RESDDPKADLMAAFGLTEIQAEDILEIRLRQLARLEGFKLEKELNELREEQGRLNILLGD
HCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECC
ENEKRKLIIKEMQADMKQYGDARRTLVEEAGRAVLTQTTADEPITLILSEKGWIRSRAGH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCHHCCCC
NLDLSQTAFKEGDRLKQTLEGRTVLPVVILDSLGRTYTLDAAEIPGGRGDGVPVSSLIEL
CCCCHHHHHHCCHHHHHHHCCCEEEHHHHHHHCCCEEEEEHHHCCCCCCCCCCHHHHHHH
QNGAKPVAMLTGLPEQHYLLSSSGGYGFIAKLADMVGRVKAGKVVMTTDSGETVLPPIAV
HCCCCCCHHHCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCEECCHHHH
YASSFINPDCKIIAATSQNRALAFPIGELKIMAKGKGLQIIGLNAGESMTHTAVSSEPEI
HHHHHCCCCCEEEEECCCCCEEEEECCCEEEEECCCCEEEEEECCCCCCEEHHCCCCCCE
LIESEGRRGAAHKDRIPISLLEAKRGKKGKLLPISGSLKQLSSPK
EEECCCCCCCCCCCCCCHHHHHHCCCCCCCEEECCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]