Click here to switch to the map view.

The map label for this gene is Hgd [H]

Identifier: 161870439

GI number: 161870439

Start: 1516558

End: 1517427

Strand: Direct

Name: Hgd [H]

Synonym: NMCC_1488

Alternate gene names: 161870439

Gene position: 1516558-1517427 (Clockwise)

Preceding gene: 229597117

Following gene: 161870440

Centisome position: 70.43

GC content: 56.78

Gene sequence:

>870_bases
ATGTCCGCAAACGAATACACACAAATCGGCTGGATAGGCTTAGGGCAAATGGGTCTGCCTATGGTAACGCGGCTCTTGGA
CGGCGGCATCGAAGTCGGCGTATACAACCGCTCGCCCGACAAAACTGCCCCCATCTCCGCCAAAGGCGCAAAAGTTTACG
GCAACACCGCCGAACTCGTCCGCGACTATCCCGTCATTTTCCTGATGGTTTCCGACTATGCCGCCGTGTGCGACATCCTG
AACGGAGTCCGCGACGGATTGGCCGGCAAAATCATCGTCAACATGAGCACCATCTCCCCGACCGAAAACCTTGCCGTCAA
AGAACTTGTCGAATCTGCCGGCGGACAATTTGCCGAAGCCCCAGTTTCTGGTTCGGTCGGTCCGGCCACCAATGGCACGC
TGCTCATTCTGTTCGGCGGAGACGAAACTGTTTTAAACCCGTTGCAGAAAGTGTTTTCCCTTGTCGGCAAAAAAACTTTC
CACTTCGGCGAAGTGGGCAAAGGCTCGGGCGCGAAACTCGTCTTAAACTCGCTCTTAGGCATTTTCGGCGAAGCGTACAG
CGAAGCGATGCTGATGGCGCGGCAGTTCGGCATCGATACCGACACCATCGTCGAAGCCATCGGCGGCTCGGCAATGGACT
CGCCCATGTTCCAAACCAAAAAATCCCTGTGGGCAAACCGCGAATTCCCGCCCGCCTTCGCCCTCAAACACGCCTCCAAA
GACCTCAACCTCGCCGTCAAAGAGCTTGAACAGGCAGGCAACACCCTGCCCGCCGTCGAAACCGTTGCTGCCAGCTACCG
CAAAGCAGTCGAAGCCGGCTACGGCGAACAGGACGTTTCCGGCGTTTACCTGAAACTGGCAGAACACTGA

Upstream 100 bases:

>100_bases
GCATAAAAAACCATACCGTCTGAAACACCCGCAGGCTTTTCAGACGGTATCGGAACAGATAAGATTACACTACACTACAA
ACAGAAAAGGAGTAAACATC

Downstream 100 bases:

>100_bases
CTTCCCTTTCCAAACAATATGCCGTCTGAAATATTTTCAGACGGCATTTTTATCGCCCCACGCTTAAAATCAGTCCCGAT
TATGACTATATAGTGGATTA

Product: 3-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSANEYTQIGWIGLGQMGLPMVTRLLDGGIEVGVYNRSPDKTAPISAKGAKVYGNTAELVRDYPVIFLMVSDYAAVCDIL
NGVRDGLAGKIIVNMSTISPTENLAVKELVESAGGQFAEAPVSGSVGPATNGTLLILFGGDETVLNPLQKVFSLVGKKTF
HFGEVGKGSGAKLVLNSLLGIFGEAYSEAMLMARQFGIDTDTIVEAIGGSAMDSPMFQTKKSLWANREFPPAFALKHASK
DLNLAVKELEQAGNTLPAVETVAASYRKAVEAGYGEQDVSGVYLKLAEH

Sequences:

>Translated_289_residues
MSANEYTQIGWIGLGQMGLPMVTRLLDGGIEVGVYNRSPDKTAPISAKGAKVYGNTAELVRDYPVIFLMVSDYAAVCDIL
NGVRDGLAGKIIVNMSTISPTENLAVKELVESAGGQFAEAPVSGSVGPATNGTLLILFGGDETVLNPLQKVFSLVGKKTF
HFGEVGKGSGAKLVLNSLLGIFGEAYSEAMLMARQFGIDTDTIVEAIGGSAMDSPMFQTKKSLWANREFPPAFALKHASK
DLNLAVKELEQAGNTLPAVETVAASYRKAVEAGYGEQDVSGVYLKLAEH
>Mature_288_residues
SANEYTQIGWIGLGQMGLPMVTRLLDGGIEVGVYNRSPDKTAPISAKGAKVYGNTAELVRDYPVIFLMVSDYAAVCDILN
GVRDGLAGKIIVNMSTISPTENLAVKELVESAGGQFAEAPVSGSVGPATNGTLLILFGGDETVLNPLQKVFSLVGKKTFH
FGEVGKGSGAKLVLNSLLGIFGEAYSEAMLMARQFGIDTDTIVEAIGGSAMDSPMFQTKKSLWANREFPPAFALKHASKD
LNLAVKELEQAGNTLPAVETVAASYRKAVEAGYGEQDVSGVYLKLAEH

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=280, Percent_Identity=31.0714285714286, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI23308751, Length=297, Percent_Identity=26.9360269360269, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI145693186, Length=288, Percent_Identity=29.1666666666667, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786719, Length=283, Percent_Identity=31.8021201413428, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790315, Length=282, Percent_Identity=28.3687943262411, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789092, Length=282, Percent_Identity=26.241134751773, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17557316, Length=251, Percent_Identity=27.0916334661355, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574115, Length=283, Percent_Identity=31.8021201413428, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24655230, Length=289, Percent_Identity=30.7958477508651, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI19922568, Length=289, Percent_Identity=30.7958477508651, Blast_Score=125, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 30540; Mature: 30409

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANEYTQIGWIGLGQMGLPMVTRLLDGGIEVGVYNRSPDKTAPISAKGAKVYGNTAELV
CCCCCCEEEEEEECCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEECCHHHHH
RDYPVIFLMVSDYAAVCDILNGVRDGLAGKIIVNMSTISPTENLAVKELVESAGGQFAEA
HCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEECC
PVSGSVGPATNGTLLILFGGDETVLNPLQKVFSLVGKKTFHFGEVGKGSGAKLVLNSLLG
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
IFGEAYSEAMLMARQFGIDTDTIVEAIGGSAMDSPMFQTKKSLWANREFPPAFALKHASK
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCC
DLNLAVKELEQAGNTLPAVETVAASYRKAVEAGYGEQDVSGVYLKLAEH
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
SANEYTQIGWIGLGQMGLPMVTRLLDGGIEVGVYNRSPDKTAPISAKGAKVYGNTAELV
CCCCCEEEEEEECCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEECCHHHHH
RDYPVIFLMVSDYAAVCDILNGVRDGLAGKIIVNMSTISPTENLAVKELVESAGGQFAEA
HCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEECC
PVSGSVGPATNGTLLILFGGDETVLNPLQKVFSLVGKKTFHFGEVGKGSGAKLVLNSLLG
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
IFGEAYSEAMLMARQFGIDTDTIVEAIGGSAMDSPMFQTKKSLWANREFPPAFALKHASK
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCC
DLNLAVKELEQAGNTLPAVETVAASYRKAVEAGYGEQDVSGVYLKLAEH
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA