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The map label for this gene is hisB

Identifier: 229597117

GI number: 229597117

Start: 1515729

End: 1516463

Strand: Direct

Name: hisB

Synonym: NMCC_1487

Alternate gene names: 229597117

Gene position: 1515729-1516463 (Clockwise)

Preceding gene: 161870437

Following gene: 161870439

Centisome position: 70.39

GC content: 57.69

Gene sequence:

>735_bases
ATGGCAAAACTCGAAAAACACACCGGCAAACCCAAAGGCTGGCTCGACAGAAAACACCGCGAACGCACTGTCCCCGAAAC
CGCCGCAGAAAGCACCGGAACTGCCGAAACCCAAATTGCCGAAACCGCATCTGCTGCCGGCTGCCGCAGCGTTACCGTCA
ACCGCAATACCTGCGAAACCCAAATCACCGTCTCCATCAACCTCGACGGCAGCGGCAAAAGCAGGCTGGATACCGGCGTA
CCCTTCCTCGAACACATGATCGATCAAATCGCCCGCCACGGCATGATTGACATCGACATCAGCTGCAAAGGCGACCTGCA
CATCGACGACCACCACACCGCCGAAGACATCGGCATCACACTCGGACAAGCAATCCGGCAGGCACTCGGCGACAAAAAAG
GCATCCGCCGTTACGGACATTCCTACGTCCCGCTCGACGAAGCCCTCAGCCGCGTCGTCATCGACCTTTCCGGCCGCCCC
GGACTCGTGTACAACATCGAATTTACCCGCGCACTAATCGGACGTTTCGATGTCGATTTGTTTGAAGAATTTTTCCACGG
CATCGTCAACCACAGTATGATGACCCTGCACATCGACAACCTCAGCGGCAAAAACGCCCACCATCAGGCGGAAACCGTAT
TCAAAGCCTTCGGGCGCGCCCTGCGTATGGCAGTCGAACACGACCCGCGCATGGCAGGACAGACCCCCTCGACCAAAGGC
ACGCTGACCGCATAA

Upstream 100 bases:

>100_bases
ACTCTGCGGCTACCGTACCCCCGTCGCACTCTACAAACTCAAACAACGCCTTGAAAAGCAGGCAGAAGACCCAGATGCAC
GCGGCATCCGTCCCAGCCTG

Downstream 100 bases:

>100_bases
AAAACCATACCGTCTGAAACACCCGCAGGCTTTTCAGACGGTATCGGAACAGATAAGATTACACTACACTACAAACAGAA
AAGGAGTAAACATCATGTCC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MAKLEKHTGKPKGWLDRKHRERTVPETAAESTGTAETQIAETASAAGCRSVTVNRNTCETQITVSINLDGSGKSRLDTGV
PFLEHMIDQIARHGMIDIDISCKGDLHIDDHHTAEDIGITLGQAIRQALGDKKGIRRYGHSYVPLDEALSRVVIDLSGRP
GLVYNIEFTRALIGRFDVDLFEEFFHGIVNHSMMTLHIDNLSGKNAHHQAETVFKAFGRALRMAVEHDPRMAGQTPSTKG
TLTA

Sequences:

>Translated_244_residues
MAKLEKHTGKPKGWLDRKHRERTVPETAAESTGTAETQIAETASAAGCRSVTVNRNTCETQITVSINLDGSGKSRLDTGV
PFLEHMIDQIARHGMIDIDISCKGDLHIDDHHTAEDIGITLGQAIRQALGDKKGIRRYGHSYVPLDEALSRVVIDLSGRP
GLVYNIEFTRALIGRFDVDLFEEFFHGIVNHSMMTLHIDNLSGKNAHHQAETVFKAFGRALRMAVEHDPRMAGQTPSTKG
TLTA
>Mature_243_residues
AKLEKHTGKPKGWLDRKHRERTVPETAAESTGTAETQIAETASAAGCRSVTVNRNTCETQITVSINLDGSGKSRLDTGVP
FLEHMIDQIARHGMIDIDISCKGDLHIDDHHTAEDIGITLGQAIRQALGDKKGIRRYGHSYVPLDEALSRVVIDLSGRPG
LVYNIEFTRALIGRFDVDLFEEFFHGIVNHSMMTLHIDNLSGKNAHHQAETVFKAFGRALRMAVEHDPRMAGQTPSTKGT
LTA

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=195, Percent_Identity=49.7435897435897, Blast_Score=184, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6324776, Length=214, Percent_Identity=40.6542056074766, Blast_Score=162, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_NEIM0 (A9M186)

Other databases:

- EMBL:   CP000381
- RefSeq:   YP_001599610.2
- ProteinModelPortal:   A9M186
- SMR:   A9M186
- EnsemblBacteria:   EBNEIT00000011343
- GeneID:   5795119
- GenomeReviews:   CP000381_GR
- KEGG:   nmn:NMCC_1487
- GeneTree:   EBGT00050000021407
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- BioCyc:   NMEN374833:NMCC_1487-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 26847; Mature: 26716

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLEKHTGKPKGWLDRKHRERTVPETAAESTGTAETQIAETASAAGCRSVTVNRNTCET
CCCCCCCCCCCCCHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCEEEECCCCCCE
QITVSINLDGSGKSRLDTGVPFLEHMIDQIARHGMIDIDISCKGDLHIDDHHTAEDIGIT
EEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCHHHHHHH
LGQAIRQALGDKKGIRRYGHSYVPLDEALSRVVIDLSGRPGLVYNIEFTRALIGRFDVDL
HHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHEEEECCCCCEEEEEHHHHHHHHHCCHHH
FEEFFHGIVNHSMMTLHIDNLSGKNAHHQAETVFKAFGRALRMAVEHDPRMAGQTPSTKG
HHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
TLTA
CCCC
>Mature Secondary Structure 
AKLEKHTGKPKGWLDRKHRERTVPETAAESTGTAETQIAETASAAGCRSVTVNRNTCET
CCCCCCCCCCCCHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCEEEECCCCCCE
QITVSINLDGSGKSRLDTGVPFLEHMIDQIARHGMIDIDISCKGDLHIDDHHTAEDIGIT
EEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCHHHHHHH
LGQAIRQALGDKKGIRRYGHSYVPLDEALSRVVIDLSGRPGLVYNIEFTRALIGRFDVDL
HHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHEEEECCCCCEEEEEHHHHHHHHHCCHHH
FEEFFHGIVNHSMMTLHIDNLSGKNAHHQAETVFKAFGRALRMAVEHDPRMAGQTPSTKG
HHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
TLTA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA